Abstract：
RATIONALE:Prospective memory pervades our daily lives and failures can have detrimental consequences. This ability to execute delayed intentions may be impacted by stress, yet few studies have examined these effects. Moreover, as many cannabis users report using cannabis to cope with stress, it is important to understand how stress impacts memory in cannabis users. OBJECTIVES:We assessed the effects of acute and chronic stress on prospective memory to examine whether stress differentially impacts prospective memory in cannabis users vs. non-users. METHODS:Forty cannabis users and 42 non-users were assigned an episodic and a habitual prospective memory test before completing either the stress or no stress condition of the Maastricht Acute Stress Test (MAST). Participants were instructed to execute the habitual test during the MAST and the episodic test shortly after the MAST. Chronic stress was measured using the Perceived Stress Scale, and acute stress was measured using subjective ratings and cortisol. RESULTS:There was a main effect of acute stress indicating that stress detrimentally impacted habitual prospective memory performance. Although there was not a significant stress x cannabis interaction, further planned comparisons indicated the habitual prospective memory impairment was selective to cannabis users. There were also significant negative correlations between (i) episodic prospective memory and both subjective stress as well as chronic stress, and (ii) habitual prospective memory and change in subjective stress. CONCLUSIONS:This study is the first to reveal detrimental effects of acute stress on prospective memory performance, which may be exacerbated in cannabis users.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Cuttler C,Spradlin A,Nusbaum AT,Whitney P,Hinson JM,McLaughlin RJdoi
10.1007/s00213-019-5184-9subject
Has Abstractpub_date
2019-06-01 00:00:00pages
1973-1983issue
6eissn
0033-3158issn
1432-2072pii
10.1007/s00213-019-5184-9journal_volume
236pub_type
杂志文章abstract：:Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-depend...
journal_title：Psychopharmacology
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
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journal_title：Psychopharmacology
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journal_title：Psychopharmacology
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journal_title：Psychopharmacology
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更新日期：1991-01-01 00:00:00
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journal_title：Psychopharmacology
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journal_title：Psychopharmacology
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journal_title：Psychopharmacology
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：1996-11-01 00:00:00
abstract：:Muscimol, a structural analog of GABA, significantly potentiated pilocarpine-induced analgesia in rats, but failed to alter pilocarpine-induced catalepsy. It also failed to affect pilocarpine-elicited increase in homovanillic acid levels in the striatum. These findings suggest that the potentiation of pilocarpine-indu...
journal_title：Psychopharmacology
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doi：10.1007/BF00432756
更新日期：1981-01-01 00:00:00
