Locomotor stimulation by L-dopa: relative importance of noradrenaline receptor activation.

abstract：:The mood-altering properties of amphetamine (AMPH) in humans (euphoria and depression) have been postulated to be related to the increases and decreases respectively which this drug produces in the sensitivity of the reward system of the brain. The present study further evaluated this relationship by testing the effec...

journal_title：Psychopharmacology

authors： Leith NJ,Barrett RJ

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Experienced cannabis users demonstrate tolerance to some of the impairing acute effects of cannabis. OBJECTIVES:The present study investigates whether event-related potentials (ERPs) differ between occasional and heavy cannabis users after acute Δ9-tetrahydrocannabinol (THC) administration, as a result of to...

journal_title：Psychopharmacology

authors： Theunissen EL,Kauert GF,Toennes SW,Moeller MR,Sambeth A,Blanchard MM,Ramaekers JG

更新日期：2012-03-01 00:00:00

abstract：RATIONALE:Increased anxiety is a characteristic of the acute ethanol withdrawal syndrome. Repeated exposure of rats to withdrawal from chronic ethanol increases sensitivity to seizures. OBJECTIVES:We investigated whether repeated withdrawal experience increases withdrawal-induced anxiety and stress, and if it changes ...

journal_title：Psychopharmacology

authors： Borlikova GG,Le Merrer J,Stephens DN

更新日期：2006-04-01 00:00:00

abstract：RATIONALE:Repeated administration of psychoactive drugs results in a progressive enhancement of the behavioral effects of these compounds, a phenomenon termed sensitization. OBJECTIVE:We tested whether repeated administration of the non-competitive NMDA receptor antagonist dizocilpine (MK-801) induces sensitization of...

journal_title：Psychopharmacology

authors： Schulz B,Fendt M,Pedersen V,Koch M

更新日期：2001-07-01 00:00:00

abstract：RATIONALE:Deep brain stimulation (DBS) has achieved substantial success as a treatment for movement disorders such as Parkinson's disease. The therapeutic efficacy and relative lack of serious side effects resulted in the expansion of DBS into the treatment of many other diseases, including obsessive-compulsive disorde...

journal_title：Psychopharmacology

authors： Pierce RC,Vassoler FM

更新日期：2013-10-01 00:00:00

abstract：:Platelet adenylate cyclase activity was measured in 16 control subjects and 16 patients who developed post-traumatic stress disorder (PTSD) as a result of damage inflicted on their homes during the Iraqi Scud missile attacks on Israel which occurred during the 1991 Gulf War. There were no differences in basal, NaF-sti...

journal_title：Psychopharmacology

authors： Weizmann R,Gur E,Laor N,Reiss A,Muller U,Yoresh A,Lerer B,Newman ME

更新日期：1994-04-01 00:00:00

abstract：RATIONALE:Cognitive processes underlying drug use have typically been assessed in laboratory settings. More detailed and ecologically valid data may be possible if assessments were conducted in an ecological momentary assessment (EMA) setting. OBJECTIVES:We evaluated the feasibility and utility of administering a reac...

journal_title：Psychopharmacology

authors： Waters AJ,Li Y

更新日期：2008-03-01 00:00:00

abstract：RATIONALE:N-methyl-D-aspartate (NMDA) receptors play crucial roles in learning and memory, but the role of each NMDA receptor subtype in a specific cognitive process is unclear. Non-selective blockers of NMDA receptor are used to model the cognitive impairment in schizophrenia and Alzheimer's disease. Counter-intuitive...

journal_title：Psychopharmacology

authors： Kumar G,Olley J,Steckler T,Talpos J

更新日期：2015-11-01 00:00:00

abstract：RATIONALE:Consumption of alcohol begins during late adolescence in a majority of humans, and the greatest drinking occurs at 18-25 years then decreases with age. OBJECTIVES:The present study measured the differences in ethanol intake in relation to age at the onset of ethanol access among nonhuman primates to control ...

journal_title：Psychopharmacology

authors： Helms CM,Rau A,Shaw J,Stull C,Gonzales SW,Grant KA

更新日期：2014-04-01 00:00:00

abstract：RATIONALE:Pediatric bipolar disorder (PBD) is a chronic and debilitating psychiatric illness. It is associated with many short-term and long-term complications including poor academic and social performance, legal problems and increased risk of suicide. Moreover, it is often complicated by other serious psychiatric dis...

journal_title：Psychopharmacology

authors： Smarty S,Findling RL

更新日期：2007-03-01 00:00:00

abstract：:A study was performed on the effect of ethanol on the basal and K+-evoked efflux of endogenous GABA from rat hypothalamic fragments. The amount of GABA present in the medium and in the tissue was measured by radioreceptor assay. In vitro addition of ethanol (50 and 100 mM) enhanced the K+-evoked efflux of GABA in a Ca...

journal_title：Psychopharmacology

authors： Seilicovich A,Duvilanski BH,Lasaga M,Debeljuk L,Díaz MC

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Attention-deficit/hyperactivity disorder (ADHD) is thought to involve hypofunctional catecholamine systems in the striatum, nucleus accumbens, and prefrontal cortex (PFC); however, recent clinical evidence has implicated glutamate dysfunction in the pathophysiology of ADHD. Recent studies show that increased ...

journal_title：Psychopharmacology

authors： Miller EM,Pomerleau F,Huettl P,Gerhardt GA,Glaser PE

更新日期：2014-08-01 00:00:00

abstract：RATIONALE:The endogenous cannabinoid system is thought to play a role in reinforcement processes. OBJECTIVES:We tested the effects of five doses of the cannabinoid receptor 1 (CB1) antagonist SR141716 [0, 0.3, 1, 3 and 10 mg/kg intraperitoneal (IP)] on intracranial self-stimulation at the level of the median forebrain...

journal_title：Psychopharmacology

authors： Deroche-Gamonet V,Le Moal M,Piazza PV,Soubrié P

更新日期：2001-09-01 00:00:00

abstract：:The effects of dopamine agonists on self-stimulation are a matter of considerable dispute. Apomorphine has variously been reported to inhibit, have no effect on, or to facilitate lever-press self-stimulation. To investigate the possibility that these discrepancies may reflect peculiarities of the lever-press test situ...

journal_title：Psychopharmacology

authors： Atrens DM,Becker FT,Hunt GE

更新日期：1980-01-01 00:00:00

abstract：:A novel self-stimulation methodology involving a fixed-interval (FI-5 s) schedule of reinforcement, microanalysis and threshold evaluation was used to investigate the effects of cocaine on rats lever pressing for electrical stimulation of the prefrontal cortex. Cocaine (15 mg/kg) increased medial prefrontal cortex (MP...

journal_title：Psychopharmacology

authors： McGregor IS,Atrens DM,Jackson DM

更新日期：1992-01-01 00:00:00

abstract：:The pharmacokinetics of flumazenil in the rat were determined after 2.5 mg/kg intravenous and 25 mg/kg oral administration. Following intravenous administration flumazenil was rapidly eliminated with an extremely short terminal half-life (mean +/- SE, n = 8) of 8.3 +/- 0.3 min due to a large total blood clearance of 1...

journal_title：Psychopharmacology

authors： Mandema JW,Gubbens-Stibbe JM,Danhof M

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Intermittent social defeat stress can induce neuroadaptations that promote compulsive drug taking. Within the mesocorticolimbic circuit, repeated cocaine administration activates extracellular signal-regulated kinase (ERK). OBJECTIVE:The present experiments examine whether changes in ERK phosphorylation are ...

journal_title：Psychopharmacology

authors： Yap JJ,Chartoff EH,Holly EN,Potter DN,Carlezon WA Jr,Miczek KA

更新日期：2015-05-01 00:00:00

abstract：RATIONALE:A previous study found that a 10-min bout of moderate intensity exercise reduced cigarette withdrawal symptoms and desire to smoke in sedentary smokers but the effect may have been due to participants focusing attention on physical activity rather than the activity itself. OBJECTIVES:This study examined the ...

journal_title：Psychopharmacology

authors： Daniel J,Cropley M,Ussher M,West R

更新日期：2004-07-01 00:00:00

abstract：RATIONALE:Both central serotonergic and nicotinic systems play important roles in a variety of neurobehavioral functions; however, the interactions of these two systems have not been fully characterized. The current study served to determine the impact of a relatively selective 5-HT2A receptor antagonist, ketanserin, o...

journal_title：Psychopharmacology

authors： Rezvani AH,Caldwell DP,Levin ED

更新日期：2005-05-01 00:00:00

abstract：:In the studies reported here, we investigated the effects of nicotine on memory for unrelated word lists. Nicotine was delivered through cigarette smoking, and memory performance was assessed using both intentional and incidental recall tasks, and employing an additional, indirect measure of memory. We report the resu...

journal_title：Psychopharmacology

authors： Rusted J,Graupner L,Warburton D

更新日期：1995-06-01 00:00:00

abstract：RATIONALE:The party drug ecstasy is frequently used in combination with other drugs like marihuana and alcohol. In addition, a substantial proportion of the MDMA users has claimed to drive a car when under the influence of MDMA and/or other drugs. OBJECTIVE:To assess the effects of MDMA and alcohol, combined and alone...

journal_title：Psychopharmacology

authors： Kuypers KP,Samyn N,Ramaekers JG

更新日期：2006-09-01 00:00:00

abstract：RATIONALE:Perospirone is a novel second-generation antipsychotic drug with high affinity to dopamine D(2) receptor and short half-life of plasma concentration. There has been no investigation of dopamine D(2) receptor occupancy in patients with schizophrenia and the time course of occupancy by antipsychotics with peros...

journal_title：Psychopharmacology

authors： Arakawa R,Ito H,Takano A,Okumura M,Takahashi H,Takano H,Okubo Y,Suhara T

更新日期：2010-05-01 00:00:00

abstract：:A continuing challenge for preclinical research on anxiolytic drugs is to capture the affective dimension that characterizes anxiety and aggression, either in their adaptive forms or when they become of clinical concern. Experimental protocols for the preclinical study of anxiolytic drugs typically involve the suppres...

journal_title：Psychopharmacology

authors： Miczek KA,Weerts EM,Vivian JA,Barros HM

更新日期：1995-09-01 00:00:00

abstract：RATIONALE:The notion that the onset of action of antidepressant drugs (ADs) takes weeks is widely accepted; however, the sequence of events necessary for therapeutic effects still remains obscure. OBJECTIVE:We aimed to evaluate a time-course of ADs-induced alterations in the expression of 95 selected genes in 4 region...

journal_title：Psychopharmacology

authors： Gąska M,Kuśmider M,Solich J,Faron-Górecka A,Krawczyk MJ,Kułakowski K,Dziedzicka-Wasylewska M

更新日期：2012-10-01 00:00:00

abstract：RATIONALE:Modafinil is a well-tolerated psychostimulant drug with low addictive potential that is used to treat patients with narcolepsy or attention deficit disorders and to enhance vigilance in sleep-deprived military personal. So far, understanding of the cognitive enhancing effects of modafinil and the relevant neu...

journal_title：Psychopharmacology

authors： Müller U,Steffenhagen N,Regenthal R,Bublak P

更新日期：2004-12-01 00:00:00

abstract：:In a double-blind comparison of haloperidol decanoate and fluphenazine decanoate given 4-weekly for 60 weeks as maintenance therapy in 38 chronic schizophrenic in-patients, plasma haloperidol, fluphenazine and prolactin levels were measured at regular intervals by radioimmunoassay. After the first injection, the mean ...

journal_title：Psychopharmacology

authors： Wiles DH,McCreadie RG,Whitehead A

更新日期：1990-01-01 00:00:00

abstract：:The effects of chronic lithium treatment on methylphenidate-, D1 dopamine receptor agonist (A-77636)-, and tactile stimulation-induced increases in frontal cortical acetylcholine release were studied in the rat using in vivo brain microdialysis. Cortical acetylcholine release in control rats was maximally stimulated b...

journal_title：Psychopharmacology

authors： Acquas E,Fibiger HC

更新日期：1996-05-01 00:00:00

abstract：INTRODUCTION:Understanding an individual's vulnerability to drug addiction has important implications for the development of effective personal treatment plans. Although theories acknowledge impulsive behaviour as a key component of drug addiction, little is known about the influence of trait impulsivity on an individu...

journal_title：Psychopharmacology

authors： Kolokotroni KZ,Rodgers RJ,Harrison AA

更新日期：2014-02-01 00:00:00

abstract：RATIONALE:Beneficial effects of nicotine on cognitive processes including attention have potential therapeutic uses and have been proposed as incentives for tobacco smoking. OBJECTIVES:To establish task conditions under which the effects of nicotine on attention are obtained reliably and to characterise such effects f...

journal_title：Psychopharmacology

authors： Hahn B,Shoaib M,Stolerman IP

更新日期：2002-07-01 00:00:00

abstract：RATIONALE:We recently reported that simultaneous exposure to amphetamine and various stressors resulted in reduced hypothalamic-pituitary-adrenal (HPA) and glycemic responses to the stressors. Since this is a new and relevant phenomenon, we wanted to further explore this interaction. OBJECTIVES:This study aims (i) to ...

journal_title：Psychopharmacology

authors： Gagliano H,Ortega-Sanchez JA,Nadal R,Armario A

更新日期：2017-10-01 00:00:00