Abstract:
RATIONALE:Repeated administration of psychoactive drugs results in a progressive enhancement of the behavioral effects of these compounds, a phenomenon termed sensitization. OBJECTIVE:We tested whether repeated administration of the non-competitive NMDA receptor antagonist dizocilpine (MK-801) induces sensitization of the disruptive effects of this compound on prepulse inhibition (PPI) of startle. METHODS:Rats received nine daily i.p. injections of 0.1 mg/kg MK-801 in the startle cage and were tested for PPI, startle in the absence of prepulses and motor activity in the startle cage. Another group of rats received MK-801 in the home cage on 9 days without daily testing. Controls were injected with saline and tested daily, while a separate group of rats received saline in the home cage without daily testing. On day 10, all rats received saline injections and were tested. On day 11, all rats were injected with 0.1 mg/kg MK-801 and tested again. On day 12, all rats received 1 mg/kg dl-amphetamine i.p. and were tested for PPI, to assess a possible cross-sensitization. RESULTS:MK-801 had no effect on day 1 of testing but induced a PPI deficit after 6-9 days of daily treatment and testing in those rats that received the drug in the startle cage, but not in the home cage. Motor activity was increased after repeated treatment and testing. There was also a trend towards sensitization of enhancement of the startle magnitude by MK-801 in these rats. dl-Amphetamine reduced PPI in those rats that received daily MK-801 injections in the startle cage to a similar extent as saline injections. CONCLUSIONS:Since PPI is considered as a measure of sensorimotor gating, our data indicate that sensorimotor gating deficits induced by MK-801 are subject to a sensitization process. These findings may be relevant for current hypotheses relating schizophrenic symptoms to sensitization.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Schulz B,Fendt M,Pedersen V,Koch Mdoi
10.1007/s002130100776subject
Has Abstractpub_date
2001-07-01 00:00:00pages
177-81issue
2-3eissn
0033-3158issn
1432-2072journal_volume
156pub_type
杂志文章abstract::Neuroleptic-free schizophrenic patients received caerulein, a potent analogue of cholecystokinin octapeptide, in a fixed- and rising-dose schedule. In addition, neuroleptic-treated patients received a single dose of the peptide with a 4-week follow-up. No significant change in mental status was observed after any of t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00180843
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174701
更新日期:1988-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428537
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5068-4
更新日期:2019-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428423
更新日期:1985-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-013-3423-z
更新日期:2014-09-01 00:00:00
abstract:RATIONALE:We hypothesized that valerian root might prevent cognitive dysfunction in coronary artery bypass graft (CABG) surgery patients through stimulating serotonin receptors and anti-inflammatory activity. OBJECTIVES:The aim of this study was to evaluate the effect of Valeriana officinalis root extract on preventio...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-014-3716-x
更新日期:2015-03-01 00:00:00
abstract:RATIONALE:2-Bromoterguride, a dopamine D2 receptor partial agonist with antagonist properties at serotonin 5-HT2A receptors and α2C-adrenoceptors, meets the prerequisites of a putative atypical antipsychotic drug (APD). We recently showed that 2-bromoterguride is effective in tests of positive symptoms of schizophrenia...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4747-x
更新日期:2018-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431801
更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2004-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246263
更新日期:1995-12-01 00:00:00
abstract::BALB/cJ, DBA/2J, and C57BL/6J mice were injected with caffeine and tested, in the five choice Yerkes-Thompson Bryant-Bovt Nitti apparatus for patterns discrimination, in two sets of experiments. In the first the patterns were opposite oriented oblique bars, in the second U-shaped figures, one opened toward the right, ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431632
更新日期:1977-03-16 00:00:00
abstract::This study was designed to compare the therapeutic and adverse effects of tranylcypromine (a monoamine oxidase inhibitor), nortriptyline (a tricyclic antidepressant), and placebo. A total of 122 depressed outpatients randomly assigned to double-blind treatment with one of these agents completed the 4-week protocol. Tr...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00427786
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:The amygdala and insular cortex are integral to the processing of emotionally salient stimuli. We have shown in healthy volunteers that an anxiolytic agent, lorazepam, dose-dependently attenuates activation of limbic structures. OBJECTIVE:The current study investigated whether administration of a selective s...
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pub_type: 杂志文章,随机对照试验
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更新日期:2008-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100726
更新日期:2001-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4340-8
更新日期:2016-08-01 00:00:00
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doi:10.1007/s00213-012-2734-9
更新日期:2012-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1998-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2020-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439545
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:The exact role of delta opioid receptors in drug-induced conditioned place preference (CPP) remains debated. Under classical experimental conditions, morphine-induced CPP is decreased in mice lacking delta opioid receptors (Oprd1 (-/-)). Morphine self-administration, however, is maintained, suggesting that dr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2693-1
更新日期:2012-09-01 00:00:00
abstract::On the heels of clozapine, we now have a number of newer agents (risperidone, olanzapine, quetiapine, sertindole, and ziprasidone). Are they all the same? What are the differences? How do we best understand them? In this article we review current clinical evidence to compare these issues on four measures of atypicalit...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s002130050017
更新日期:2000-01-01 00:00:00
abstract:RATIONALE:Second-generation antipsychotics are the first-line medications prescribed for schizophrenic patients; however, some of them, such as olanzapine and risperidone, may induce metabolic dysfunctions during short-term treatment. Metformin is an effective adjuvant that attenuates antipsychotic-induced metabolic dy...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05524-w
更新日期:2020-08-01 00:00:00
abstract:RATIONALE:Buprenorphine is a partial mu opioid agonist under development as a sublingual (SL) medication for opioid dependence treatment in the United States. Because buprenorphine may be abused, tablets combining buprenorphine with naloxone in a 4:1 ratio have been developed to reduce that risk. Low doses of injected ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130000637
更新日期:2001-03-01 00:00:00
abstract::Recent clinical data suggest that buspirone may enhance the efficacy and/or reduce the latency to therapeutic effect of selective serotonin reuptake inhibitors (SSRIs) in unipolar major depressive disorder. The present study, using the mouse forced swimming test, was performed to investigate further the mechanisms inv...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050663
更新日期:1998-07-01 00:00:00
abstract::The benzodiazepine diazepam and the benzodiazepine antagonist Ro 15-1788 were tested alone or in combination for their influence on scopolamine-induced locomotor stimulation in mice. The benzodiazepine antagonist had no effect by itself, but prevented the enhancement of scopolamine-induced locomotor stimulation produc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00464583
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:Cue avoidance training (CAT) reduces alcohol consumption in the laboratory. However, the neural mechanisms that underlie the effects of this intervention are poorly understood. OBJECTIVES:The present study investigated the effects of a single session of CAT on event-related and readiness potentials during pr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05462-7
更新日期:2020-05-01 00:00:00
abstract::Supersensitivity to serotonin during migraine attack has been previously observed. Since the attack has been attributed to a critical lowering of morphine-like factors, we can expect serotonin supersensitivity during morphine abstinence. Slight signs of morphine abstinence have also been induced in volunteers after mi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433050
更新日期:1979-10-01 00:00:00