当前位置： SCI文献检索 > PSYCHOPHARMACOLOGY期刊下所有文献 > Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus.

Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus.

Abstract：

RATIONALE:Limited access nicotine self-administration decreases hippocampal neurogenesis, providing a mechanism for the deleterious effects of nicotine on hippocampal neuronal plasticity. However, recent studies have shown that limited access nicotine self-administration does not exhibit key features of nicotine dependence such as motivational withdrawal and increased motivation for nicotine after deprivation. OBJECTIVES:The present study used extended access nicotine self-administration (0.03 mg/kg/infusion, 21 h/day, 4 days) with intermittent periods of deprivation (3 days) for 14 weeks, to test the hypothesis that this model enhances nicotine seeking and produces distinct responses in hippocampal neurogenesis when compared with limited access (1 h/day, 4 days) intake. Animals in the extended access group were either perfused prior to or following their final deprivation period, whereas animals in the limited access group were perfused after their last session. RESULTS:Limited- and extended access nicotine self-administration with periodic deprivation did not affect proliferation and differentiation of oligodendrocyte progenitors in the medial prefrontal cortex (mPFC). Conversely, extended access nicotine self-administration with periodic deprivation enhanced proliferation and differentiation of hippocampal neural progenitors. Furthermore, in the hippocampus, the number of differentiating NeuroD-labeled cells strongly and positively correlated with enhanced nicotine seeking in rats that experienced extended access nicotine self-administration. CONCLUSIONS:These findings demonstrate that extended versus limited access to nicotine self-administration differentially affects the generation of new oligodendroglia and new neurons during adulthood. The increases in the number of differentiating cells in extended access nicotine self-administering rats may consequently contribute to aberrant hippocampal neurogenesis and may contribute to maladaptive addiction-like behaviors dependent on the hippocampus.

journal_name

Psychopharmacology (Berl)

journal_title

Psychopharmacology

authors

Cohen A,Soleiman MT,Talia R,Koob GF,George O,Mandyam CD

doi

10.1007/s00213-014-3685-0

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

453-63

issue

2

eissn

0033-3158

issn

1432-2072

journal_volume

232

pub_type

杂志文章

相关文献

PSYCHOPHARMACOLOGY文献大全
  • Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonists.

    abstract：RATIONALE:Cannabinoid CB1 receptors are expressed in the prefrontal cortex, but their role in mediating executive functions such as behavioral flexibility is unclear. OBJECTIVE:The present study examined the effect of pharmacological activation or blockade of the cannabinoid CB1 receptors on behavioral flexibility usi...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-006-0421-4

    authors： Hill MN,Froese LM,Morrish AC,Sun JC,Floresco SB

    更新日期：2006-08-01 00:00:00

  • Ecstasy use and depression: a 4-year longitudinal study among an Australian general community sample.

    abstract：RATIONALE:Longitudinal, population-based studies can better assess the relationship of ecstasy use with depression. OBJECTIVES:We examined whether change in ecstasy use was associated with change in depressive symptoms/probable depression over a 4-year period, among a large Australian sample. METHODS:The Personality ...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-013-3132-7

    authors： George AM,Olesen S,Tait RJ

    更新日期：2013-10-01 00:00:00

  • Savoxepine fails to selectively influence glucose metabolism in the rat limbic system.

    abstract：:The [14C]-2-deoxyglucose method was used to map the in vivo metabolic response of glucose to savoxepine, a novel tetracyclic cyano-dibenzoxepino-azepine. Savoxepine is reported to have higher affinity for dopamine (DA) receptors in the hippocampus than in the striatum and hence should have dose-dependent, anatomically...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF02244849

    authors： Cascella NG,Tarazi FI,Shirakawa O,Tamminga CA

    更新日期：1994-03-01 00:00:00

  • Effects of nicotine and mecamylamine-induced withdrawal on extracellular dopamine and acetylcholine in the rat nucleus accumbens.

    abstract：RATIONALE:Prior research suggests that high levels of acetylcholine (ACh) in the nucleus accumbens (NAc) are associated with aversive states such as morphine withdrawal, but this has not been tested for nicotine withdrawal. OBJECTIVES:The goal was to test the hypothesis that acute nicotine decreases extracellular ACh ...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s002130100781

    authors： Rada P,Jensen K,Hoebel BG

    更新日期：2001-08-01 00:00:00

  • Context-specific morphine tolerance on the paw-pressure and tail-shock vocalization tests: evidence of associative tolerance without conditioned compensatory responding.

    abstract：RATIONALE:Demonstrations of associative tolerance to the analgesic effects of morphine, not confounded by practice or novelty effects, have been restricted to the tail-flick and flinch-jump tests. OBJECTIVES:Experiment 1 investigated whether associative tolerance would be found on two other nociceptive assessment meth...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s002130051077

    authors： Cepeda-Benito A,Tiffany ST,Cox LS

    更新日期：1999-08-01 00:00:00

  • Residual effects of chronic cannabis treatment on behavior in mature rats.

    abstract：:Mature rats (starting weight at least 270 g) were treated daily with cannabis extract (daily THC dose 20 mg/kg) for 3 months. After a 1- to 4-month drug-free period, residual effects on a variety of behaviors were studied. No residual effects were found in learning of an eight-arm radial maze task, nor on a differenti...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00429660

    authors： Stiglick A,Kalant H

    更新日期：1985-01-01 00:00:00

  • Oxytocin modulates psychotomimetic-induced deficits in sensorimotor gating.

    abstract：:Oxytocin plays an important role in the regulation of normal cognitive functions and behaviors, which are disturbed in schizophrenia. Several studies suggest that oxytocinergic function is abnormal in schizophrenia patients. Thus, oxytocin may be involved in the pathophysiology associated with this disorder. This stud...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s002130050811

    authors： Feifel D,Reza T

    更新日期：1999-01-01 00:00:00

  • 2,4-Dithiobiuret in rats: cognitive facilitation after acute injection precedes motor impairment after repeated daily injections.

    abstract：:2,4-Dithiobiuret (DTB) is a sulfonated derivative of urea that is used as a reducing agent in chemical manufacture. Its low acute toxicity to rodents belies a peripherally mediated, delayed-onset muscle weakness which develops during repeated daily exposure. In experiment 1, a standard dose regimen of DTB (0.5 mg/kg p...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF02246581

    authors： Bushnell PJ,Oshiro WM

    更新日期：1996-02-01 00:00:00

  • [Aggressive behaviour induced by apomorphine: relations with some elements of the behavioural profile and with the sensitivity to apomorphine (author's transl)].

    abstract：:Aggressive rats could be differentiated from non-aggressive rats on a lower rate of rearing reactions in the open-field activity, as well as on a weaker aptitude for learning, increasing with the complication of the test. The two groups of rats had comparable activity, and a comparable response to pain. Apomorphine de...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00423303

    authors： Senault B

    更新日期：1976-07-09 00:00:00

  • Attentional capture by alcohol-related stimuli may be activated involuntarily by top-down search goals.

    abstract：:Previous research has found that the attention of social drinkers is preferentially oriented towards alcohol-related stimuli (attentional capture). This is argued to play a role in escalating craving for alcohol that can result in hazardous drinking. According to incentive theories of drug addiction, the stimuli assoc...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-018-4906-8

    authors： Brown CRH,Duka T,Forster S

    更新日期：2018-07-01 00:00:00

  • Dose-dependent impairment in the performance of a go-no go successive discrimination by chlordiazepoxide.

    abstract：:After learning a light-cued, go-no go successive discrimination to criterion, male Sprague-Dawley rats received 0, 5, or 10 mg/kg chlordiazepoxide on six performance sessions, followed by two drug-recovery (saline) sessions. Chlordiazepoxide impaired discrimination performance in a dose-dependent manner, with animals ...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00652237

    authors： Cole SO,Michaleski A

    更新日期：1986-01-01 00:00:00

  • 6-Hydroxydopamine and the aggressive behavior induced by marihuana in REM sleep-deprived rats.

    abstract：:6-Hydroxydopamine (6OH-DA) pretreatment increased the aggressive behavior induced by marihuana in REM sleep-deprived rats. Brain catecholamine assays revealed that 6OH-DA depleted popamine (DA) and norepinephrine (NE) to a different extent, increasing the DA/NE ratio. Intraventricular injection of NE significantly dec...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00423257

    authors： Musty RE,Lindsey CJ,Carlini EA

    更新日期：1976-07-28 00:00:00

  • Pindolol binding to 5-HT1A receptors in the human brain confirmed with positron emission tomography.

    abstract：:The augmentation effect of (-)pindolol as used in combination with SSRI to treat major depression has been ascribed to blocking of dorsal raphe nucleus cell body 5-HT autoreceptors. In this study, the radioligand [carbonyl-11C]WAY-100635 and positron emission tomography were used to establish whether pindolol at a cli...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s002130051009

    authors： Andrée B,Thorberg SO,Halldin C,Farde L

    更新日期：1999-06-01 00:00:00

  • Electrophysiological indices of acute effects of ethanol on involuntary attention shifting.

    abstract：:Dose-related effects of ethanol (placebo, 0.30, and 0.60 g/kg) on behavioral and event-related brain potential (ERP) indices of involuntary attention shifting of audition were investigated. ERPs were recorded from 11 healthy social drinkers during a forced-choice reaction-time (RT) task. Subjects were presented with 1...

    journal_title：Psychopharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s002130050801

    authors： Jääskeläinen IP,Schröger E,Näätänen R

    更新日期：1999-01-01 00:00:00

  • Effects of mianserin in neuroleptic-induced parkinsonism.

    abstract：:It has been proposed that serotonin (5-HT) antagonists counteract neuroleptic-induced extrapyramidal symptoms by disinhibition of dopamine activity. The effects of the 5-HT antagonist mianserin, the anticholinergic drug procyclidine and placebo were evaluated in 16 psychiatric patients with chronic neuroleptic-induced...

    journal_title：Psychopharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00310523

    authors： Korsgaard S,Friis T

    更新日期：1986-01-01 00:00:00

  • Effect of apomorphine on cognitive performance and sensorimotor gating in humans.

    abstract：INTRODUCTION:Dysfunction of brain dopamine systems is involved in various neuropsychiatric disorders. Challenge studies with dopamine receptor agonists have been performed to assess dopamine receptor functioning, classically using the release of growth hormone (GH) from the hindbrain as primary outcome measure. The obj...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-009-1686-1

    authors： Schellekens AF,Grootens KP,Neef C,Movig KL,Buitelaar JK,Ellenbroek B,Verkes RJ

    更新日期：2010-01-01 00:00:00

  • Olanzapine, an atypical antipsychotic, increases rates of punished responding in pigeons.

    abstract：:The effects of olanzapine [LY 170053; 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2, 3b] [1,5]benzodiazepine), a potential atypical antipsychotic, were determined in pigeons whose keypeck responding was punished. These effects were compared to the anxiolytic agents chlordiazepoxide and pentobarbital, and to other a...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF02246153

    authors： Benvenga MJ,Leander JD

    更新日期：1995-05-01 00:00:00

  • Role of hippocampus in alcohol-induced memory impairment: implications from behavioral and immediate early gene studies.

    abstract：:Acute alcohol intoxication disrupts memory acquisition in humans and laboratory animals. This review summarizes recent behavioral and immediate early gene expression studies addressing the mechanisms of this phenomenon. Most behavioral investigations agree that the amnestic effect of alcohol is due to its preferential...

    journal_title：Psychopharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/s002130050687

    authors： Ryabinin AE

    更新日期：1998-09-01 00:00:00

  • Stress- and cue-elicited craving and reactivity in marijuana-dependent individuals.

    abstract：RATIONALE:Cue-elicited craving and stress responses have been identified as predictors of relapse in drug dependence, but little research exists on the contribution of these factors to marijuana use specifically. OBJECTIVES:The aims of the present study were to evaluate (1) responses to a psychological stressor, (2) r...

    journal_title：Psychopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00213-011-2376-3

    authors： McRae-Clark AL,Carter RE,Price KL,Baker NL,Thomas S,Saladin ME,Giarla K,Nicholas K,Brady KT

    更新日期：2011-11-01 00:00:00

  • Double blind controlled trials of cholecystokinin octapeptide in neuroleptic-refractory schizophrenia.

    abstract：:A group of 14 schizophrenics who remained symptomatic after neuroleptic treatment received either 0.02 mcg/kg CCK-8 or saline placebo intravenously. Thereafter, 13 received the alternative infusion as a crossover treatment. A second group of 16 such patients received 0.04 mcg/kg CCK-8 or saline intravenously and, ther...

    journal_title：Psychopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00690931

    authors： Peselow E,Angrist B,Sudilovsky A,Corwin J,Siekierski J,Trent F,Rotrosen J

    更新日期：1987-01-01 00:00:00

  • Aspects of amitriptyline and nortriptyline plasma levels monitoring in depression.

    abstract：:Fifty-nine depressed female inpatients were treated with 100 mg amitriptyline (AMT) IM for 4 weeks. Depression ratings and determinations of the parent drug and nortriptyline (NT) were performed weekly. No direct relationship between plasma AMT + NT concentrations and therapeutic response was apparent, but beneficial ...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF02244602

    authors： Corona GL,Cucchi ML,Frattini P,Santagostino G,Schinelli S,Zerbi F,Savoldi F

    更新日期：1990-01-01 00:00:00

  • Fluvoxamine dose-dependent interaction with haloperidol and the effects on negative symptoms in schizophrenia.

    abstract：:Augmentation with low-dose fluvoxamine (50-100 mg/day) to antipsychotic treatment may improve the negative symptoms in schizophrenic patients, but involves a risk of drug-drug interaction. We studied the effects of fluvoxamine on plasma concentrations of haloperidol and reduced haloperidol, and their clinical symptoms...

    journal_title：Psychopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00213-003-1567-y

    authors： Yasui-Furukori N,Kondo T,Mihara K,Inoue Y,Kaneko S

    更新日期：2004-01-01 00:00:00

  • Effect of chlormethiazole, dizocilpine and pentobarbital on harmaline-induced increase of cerebellar cyclic GMP and tremor.

    abstract：:Administration to mice of harmaline (100 mg/kg SC) resulted in a greater than two-fold increase in cyclic GMP in the cerebellum 15 min later. This response was inhibited by pretreatment 5 min before the harmaline with pentobarbital (ED50 6.5 mg/kg), chlormethiazole (ED50 10.4 mg/kg) and dizocilpine (ED50 0.5 mg/kg). H...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF02257413

    authors： Cross AJ,Misra A,Sandilands A,Taylor MJ,Green AR

    更新日期：1993-01-01 00:00:00

  • Bilateral hippocampal volume increases after long-term lithium treatment in patients with bipolar disorder: a longitudinal MRI study.

    abstract：RATIONALE:The majority of volumetric magnetic resonance imaging (MRI) studies of the hippocampus in patients with bipolar disorder (BD) show no differences in hippocampal volume between patients and healthy controls. Significant variability, however, exists in the medication status of patients included in these studies...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-007-0906-9

    authors： Yucel K,McKinnon MC,Taylor VH,Macdonald K,Alda M,Young LT,MacQueen GM

    更新日期：2007-12-01 00:00:00

  • Acute tryptophan depletion evokes negative mood in healthy females who have previously experienced concurrent negative mood and tryptophan depletion.

    abstract：INTRODUCTION:The majority of individuals who suffer an episode of depression go on to experience recurrences. We have proposed, based upon the observation that reducing serotonin via acute tryptophan depletion (ATD) is more likely to induce negative mood in recovered depressed individuals than never depressed individua...

    journal_title：Psychopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00213-009-1533-4

    authors： Robinson OJ,Sahakian BJ

    更新日期：2009-08-01 00:00:00

  • Anti-aversive role of the endocannabinoid system in the periaqueductal gray stimulation model of panic attacks in rats.

    abstract：RATIONALE:Direct activation of the cannabinoid CB1 receptor in the dorsolateral periaqueductal gray (dlPAG) inhibits anxiety- and panic-related behaviours in experimental animals. It has remained unclear, however, whether the local endocannabinoid signalling is recruited as a protective mechanism against aversive stimu...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-014-3793-x

    authors： Viana TG,Hott SC,Resstel LB,Aguiar DC,Moreira FA

    更新日期：2015-05-01 00:00:00

  • Attenuation of delta 9-tetrahydrocannabinol-induced withdrawal-like behaviour by delta 9-tetrahydrocannabinol.

    abstract：:Rats chronically treated with increasing daily doses of delta 9-tetrahydrocannabinol (delta 9-THC) for up to 5 or 10 days exhibit a withdrawal-like behavioural response when challenged with clomipramine, a potent inhibitor of serotonin (5-hydroxytryptamine) reuptake, at the time when the next injection of delta 9-THC ...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00431112

    authors： Verberne AJ,Taylor DA,Fennessy MR

    更新日期：1981-01-01 00:00:00

  • Opioids for hedonic experience and dopamine to get ready for it.

    abstract：BACKGROUND AND RATIONALE:More than two decades ago, Wise proposed his "anhedonia hypothesis" to explain the role of dopamine in motivated behaviors. The hypothesis posits that dopamine mediates the pleasure experienced by reward obtainment. However, some experimental findings have contested this hypothesis and several ...

    journal_title：Psychopharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/s00213-006-0521-1

    authors： Barbano MF,Cador M

    更新日期：2007-04-01 00:00:00

  • Naltrexone blockade of nicotine effects in cigarette smokers.

    abstract：RATIONALE:The role of endogenous opiate systems in cigarette smoking remains unclear. In laboratory animals, opiate antagonists block many of the effects of nicotine, but in humans they do not consistently alter smoking behavior. OBJECTIVE:This study explored the effects of naltrexone, alone and in combination with ni...

    journal_title：Psychopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s002130050957

    authors： Brauer LH,Behm FM,Westman EC,Patel P,Rose JE

    更新日期：1999-04-01 00:00:00

  • Added donepezil for stable schizophrenia: a double-blind, placebo-controlled trial.

    abstract：RATIONALE:Schizophrenia is a disorder with cognitive deficits that could stem from cholinergic dysfunction. OBJECTIVES:Our aim was to examine if donepezil administered to stable, medicated outpatients with schizophrenia improves cognition and psychopathology. METHODS:We conducted a double-blind placebo-controlled tri...

    journal_title：Psychopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00213-005-2235-1

    authors： Freudenreich O,Herz L,Deckersbach T,Evins AE,Henderson DC,Cather C,Goff DC

    更新日期：2005-09-01 00:00:00