Abstract:
:Augmentation with low-dose fluvoxamine (50-100 mg/day) to antipsychotic treatment may improve the negative symptoms in schizophrenic patients, but involves a risk of drug-drug interaction. We studied the effects of fluvoxamine on plasma concentrations of haloperidol and reduced haloperidol, and their clinical symptoms, in haloperidol treated patients. Twelve schizophrenic inpatients with prevailingly negative symptoms receiving haloperidol 6 mg/day were additionally treated with incremental doses of fluvoxamine for 6 weeks (25, 75 and 150 mg/day for 2 weeks each). Plasma drug concentrations were monitored together with clinical assessments before and after each phase of the three fluvoxamine doses. Geometric mean of haloperidol concentrations during coadministration of fluvoxamine 25, 75 and 150 mg/day were 120% (95%CI; 114-127%), 139% (95%CI; 130-149%), and 160% (95%CI; 142-178%) of those before fluvoxamine coadministration, respectively. We found positive correlations between increase in plasma haloperidol concentrations and plasma fluvoxamine concentrations. Scores in negative symptoms were significantly reduced after fluvoxamine coadministration, whereas no changes were observed in the other psychiatric symptoms or any subgrouped side effects. Therefore, this study indicates that fluvoxamine increases plasma haloperidol concentrations in a dose-dependent manner. However, relatively small elevations in haloperidol concentration did not lead to the development of extrapyramidal symptoms under the conditions of this study.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Yasui-Furukori N,Kondo T,Mihara K,Inoue Y,Kaneko Sdoi
10.1007/s00213-003-1567-ysubject
Has Abstractpub_date
2004-01-01 00:00:00pages
223-7issue
2eissn
0033-3158issn
1432-2072journal_volume
171pub_type
临床试验,杂志文章abstract:RATIONALE:In patients, ketamine is a fast-acting antidepressant that can induce long-lasting symptom relief. Similar rapid effects have been reported in rodents, but reports of lasting effects are limited. OBJECTIVES:We sought to extend past findings by examining dose-response curves that overlap with the individual d...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2169-8
更新日期:2011-06-01 00:00:00
abstract:RATIONALE:Asenapine, a psychopharmacologic agent developed for schizophrenia and bipolar disorder, has higher affinity for 5-HT(2A/C,6,7) and alpha(2) adrenergic receptors than for D(2) receptors. Asenapine exhibits potent antipsychotic-like effects without inducing catalepsy, increases cortical and subcortical dopamin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1456-5
更新日期:2009-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02244860
更新日期:1994-03-01 00:00:00
abstract:RATIONALE:The precise neural circuitry that encodes fear memory and its extinction within the brain are not yet fully understood. Fearful memories can be persistent, resistant to extinction, and associated with psychiatric disorders, especially post-traumatic stress disorder (PTSD). Here, we investigated the microtopog...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5068-4
更新日期:2019-01-01 00:00:00
abstract:RATIONALE:Nicotine displays rewarding and aversive effects, and while dopamine has been linked with nicotine's reward, the neurotransmitter(s) involved with aversion remains speculative. The kappa-dynorphinergic system has been associated with negative motivational and affective states, and whether dynorphin (Dyn) cont...
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pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245053
更新日期:1994-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051093
更新日期:1999-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246658
更新日期:1996-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1996-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00442007
更新日期:1989-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1981-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:1999-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-2268-5
更新日期:2005-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-04-01 00:00:00
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更新日期:1987-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:1994-06-01 00:00:00
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更新日期:2016-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431736
更新日期:1977-01-31 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1989-01-01 00:00:00
abstract:RATIONALE:An important goal of addiction research is to discover neurobiological markers that could predict the severity of addiction and help to determine appropriate treatment. Brain-derived neurotrophic factor (BDNF) and thiobarbituric acid reactive substances (TBARS) are being related to cerebral plasticity and imp...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
abstract:RATIONALE:The progesterone metabolite 5alpha-pregnane-3alpha-ol-20-one (3alpha,5alpha-THP) is an important modulator of the hypothalamic-pituitary-adrenal axis and stress-induced corticosterone response. Typically, 3alpha,5alpha-THP levels are increased in response to acute stress, which may then reduce corticosterone ...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2006-06-01 00:00:00