Abstract:
RATIONALE:An important goal of addiction research is to discover neurobiological markers that could predict the severity of addiction and help to determine appropriate treatment. Brain-derived neurotrophic factor (BDNF) and thiobarbituric acid reactive substances (TBARS) are being related to cerebral plasticity and impairment caused by substance abuse. OBJECTIVES:This study aims to evaluate alteration of TBARS and BDNF levels among crack cocaine users during early drug withdrawal and its relationship to severity of drug use. METHODS:Forty-nine adults crack cocaine users were recruited at a public psychiatric hospital with a specialized addiction treatment unit. Blood sample was collected at intake and discharge for the analysis of TBARS and BDNF measures. Information about drug use was assessed by the Addiction Severity Index 6th Version (ASI-6). Detailed information about crack cocaine use was obtained through the "Profile of the crack cocaine user." Severity of crack use was estimated using information from age of first crack use, years of crack use, and crack rocks used in the previous 30 days. RESULTS:There is a positive correlation between TBARS levels and severity of crack cocaine use (R = 0.304, p = 0.04) and a negative correlation between BDNF and severity of crack cocaine use (R = -0.359, p = 0.01) at discharge. Also, we found an inverse correlation between TBARS and BDNF levels (R = -0.294, p = 0.004) at discharge. CONCLUSIONS:Our findings suggest that BDNF and TBARS could be possible markers for the severity of drug use. Further studies may show how those markers could be related to staging, prognosis, and treatment in crack cocaine dependence.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Sordi AO,Pechansky F,Kessler FH,Kapczinski F,Pfaffenseller B,Gubert C,de Aguiar BW,de Magalhães Narvaez JC,Ornell F,von Diemen Ldoi
10.1007/s00213-014-3542-1subject
Has Abstractpub_date
2014-10-01 00:00:00pages
4031-9issue
20eissn
0033-3158issn
1432-2072journal_volume
231pub_type
杂志文章abstract:RATIONALE:Despite consistent evidence of the familiality of substance misuse, the mechanisms by which family history (FH) increases the risk of addiction are not well understood. One behavioral trait that may mediate the risk for substance use and addiction is delay discounting (DD), which characterizes an individual's...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4074-z
更新日期:2016-01-01 00:00:00
abstract::Maternal pup searching behaviour of lactating house mice treated with apomorphine, haloperidol or saline was examined on a running board with a central depression as a nest. Pup searching was elicited by artificial ultrasonic stimuli: a female moved out from the nest either towards a 50 kHz tone (key stimulus) which i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174523
更新日期:1988-01-01 00:00:00
abstract::The anorectic activity of the d and l isomers of d-fenfluramine (d-FF) (l-FF) were compared with d-amphetamine (d-amp) when given separately and together in 12 healthy male volunteers. The study was double blind and placebo controlled. Food intake was measured using an automated food dispenser. Anorectic activity was ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02801976
更新日期:1992-01-01 00:00:00
abstract::N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON 954) causes a reproducible rest tremor in mice, of rapid onset and short duration with no associated rigidity or akinesia and in the absence of any marked changes in body temperature or accompanying peripheral parasympathomimetic effects. This tremor ca...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439104
更新日期:1977-04-29 00:00:00
abstract::Recent studies indicate that some aspects of memory can be enhanced by the administration of oxygen or glucose. Considering the dependency of glucose metabolism upon oxygen supply, the present study predicted that administering a combination of 100% oxygen with glucose would have greater memory-enhancing effects than ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130050577
更新日期:1998-04-01 00:00:00
abstract:RATIONALE:Methylphenidate is a psychostimulant given for extended periods of time as a treatment of attention-deficit/hyperactivity disorder (ADHD). The long-term effects of the drug are not yet known, and it is speculated that repeated exposure may produce drug dependence. OBJECTIVE:To investigate the effects of repe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2564-1
更新日期:2012-05-01 00:00:00
abstract:RATIONALE:The notion that the onset of action of antidepressant drugs (ADs) takes weeks is widely accepted; however, the sequence of events necessary for therapeutic effects still remains obscure. OBJECTIVE:We aimed to evaluate a time-course of ADs-induced alterations in the expression of 95 selected genes in 4 region...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2714-0
更新日期:2012-10-01 00:00:00
abstract::The effect of 15 min/day of immobilization (IM) stress on oral self-administration (SA) of morphine (0.5 mg/ml) or fentanyl (25 micrograms/ml) and withdrawal was examined in rats. In addition, the role of conditioning factors in these effects was assessed. For each drug, four groups of subjects were exposed for 50 day...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02253539
更新日期:1993-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050711
更新日期:1998-10-01 00:00:00
abstract::Previous studies have shown that dihydropyridine (DHP) calcium channel blockers can potentiate yawning induced by apomorphine in rats. The present study was undertaken to examine whether or not this interaction was seen with other compounds that induce yawning or if it represented a specific interaction with dopaminer...
journal_title:Psychopharmacology
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doi:10.1007/BF02244401
更新日期:1990-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2009-11-01 00:00:00
abstract::Sixty-two DSM III chronic schizophrenic inpatients were selected for a double-blind, placebo controlled, multi-centre, relapse prevention study of remoxipride, a selective dopamine (D2)-receptor antagonist. After a 1 month placebo washout, 23 patients had relapsed and were withdrawn. Of the remaining patients 19 were ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/BF02245134
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:Synergistic or supra-additive interactions between the anorectics (dex)fenfluramine and phentermine have been reported previously in the rat and in the clinic. Studies with 5-HT2C antagonists and 5-HT2C knockouts have demonstrated dexfenfluramine hypophagia in the rodent to be mediated by actions at the 5-HT2...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3829-2
更新日期:2015-06-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2002-10-01 00:00:00
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doi:10.1007/s00213-008-1354-x
更新日期:2009-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
abstract::Effects of two dosages of rubidium chloride on exploration, locomotion, rearing and immobility were assessed for male and female rats in an exploration box and an open field. In contrast to previous findings, rubidium was found to decrease locomotion and rearing in the exploratory box, and also to decrease locomotion ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426740
更新日期:1979-03-22 00:00:00
abstract::Male volunteer subjects smoked one marijuana cigarette containing 100, 200, or 250 micrograms/kg delta-9-tetrahydrocannabinol (THC) and were tested on three perceptual-motor performance measures related to driving. Performance was measured and blood samples were collected for 24 h after smoking. The covariation betwee...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00427321
更新日期:1985-01-01 00:00:00
abstract::The glutamatergic cortico-striatal and subthalamo-entopeduncular pathways are both overactive in parkinsonism. Previous behavioural investigations have shown that intra-entopeduncular injection of either NMDA-site or glycine-site antagonists results in alleviation of parkinsonian symptoms, although injection of the fo...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246054
更新日期:1995-05-01 00:00:00
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更新日期:2019-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2322-4
更新日期:2011-11-01 00:00:00
abstract::The neurochemical specificity of physiological, biochemical, and psychological responses to dextroamphetamine was tested by pretreating volunteers with haloperidol (0.014 mg/kg IM), propranolol (0.1 mg/kg IV), thymoxamine (0.1 mg/kg IV), or placebo prior to 0.3 mg/kg IV amphetamine. Healthy volunteers (N = 12) partici...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00427446
更新日期:1984-01-01 00:00:00
abstract::The fatty acid specificity of the depressant actions associated with prostaglandin (PG) administration was studied in mice. Administration of PG-E2 (0.4 and 1.0 mg/kg) or PG-D2 (0.4 and 4 mg/kg) significantly potentiated pentobarbital sleeping time. Arachidonic acid (3.3 mg/kg) administration also significantly potent...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00555225
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:Nicotine replacement is commonly used to treat tobacco use in heavy-drinking smokers. However, few studies have examined the effect of nicotine replacement on subjective and physiological responses to alcohol and alcohol drinking behavior. OBJECTIVE:The primary aim of this within-subject, double-blind study ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-007-0952-3
更新日期:2008-02-01 00:00:00
abstract:RATIONALE:Mesocorticolimbic reactivity to alcohol-associated cues has been shown to be associated with relapse to renewed drinking and to be decreased by cue-exposure-based extinction training (CET). Evidence from preclinical studies suggests that the extinction of conditioned alcohol-seeking behavior might be facilita...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-015-3882-5
更新日期:2015-07-01 00:00:00
abstract::Rats exhibit profound individual differences in their propensity to ingest sugar and in their locomotor response to AMP. Intrinsic variation in the responsiveness of mesolimbic dopamine mechanisms has been suggested to account for these individual differences. In light of this overlap, it might be expected that indivi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244864
更新日期:1994-09-01 00:00:00
abstract::Male Sprague-Dawley rats weighing 116--241 g were injected i.p. with ketamine hydrochloride, 80 mg per kilo of body weight. Immediately after loss of righting reflex, scopolamine, physostigmine, and mecamylamine were administered i.p. to different groups of rats. Control animals received sterile saline by the same rou...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426811
更新日期:1979-03-14 00:00:00
abstract::Dopaminergic involvement in the regulation of operant behavior was examined by monitoring responding after administration of different dopaminergic agonists. A chain schedule of reinforcement was used to classify the effects of these agonists in long-tailed macaques (Macaca fascicularis). The schedule included the fol...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429014
更新日期:1983-01-01 00:00:00
abstract::Acute tolerance, defined as a decreasing drug effect relative to drug-plasma levels (DPL) over a period of minutes to a few hours, is pronounced following single doses of diazepam or pentobarbital. Both of these lipid-soluble drugs produce an early peak behavioral impairment and subsequent rapid recovery component tha...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427800
更新日期:1983-01-01 00:00:00
abstract::Rats were presented with noise bursts alone or noise bursts 60 ms after presentation of either a 60 dB or an 80 dB prepulse after injection of the dopamine agonists apomorphine (3 mg/kg) or d-amphetamine (4 mg/kg), the glycine antagonist strychnine (1.5 mg/kg) or the alpha 2 antagonist yohimbine (5 mg/kg). Presentatio...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174500
更新日期:1988-01-01 00:00:00