Immobilization stress-induced oral opioid self-administration and withdrawal in rats: role of conditioning factors and the effect of stress on "relapse" to opioid drugs.

abstract：:Progabide inhibited male rat sexual behavior at a dose of 200 mg/kg. This dose had only modest effects on ambulatory activity and no effect at all on motor coordination as evaluated by a rotarod test. The GABAA antagonist bicuculline, at a dose of 1 mg/kg, blocked the effects of progabide on sex behavior. In contrast,...

journal_title：Psychopharmacology

authors： Agmo A,Paredes RG,Sierra L,Garcés I

更新日期：1997-01-01 00:00:00

abstract：INTRODUCTION:Dopamine D2 receptor occupancy levels needed for the maintenance treatment of schizophrenia remain to be elucidated. We examined 3-year clinical outcomes of patients with schizophrenia who received long-acting injectable risperidone (LAI risperidone) at baseline and investigated their dopamine D2 receptor ...

journal_title：Psychopharmacology

authors： Ikai S,Suzuki T,Mimura M,Uchida H

更新日期：2016-12-01 00:00:00

abstract：:The phase of highly focused, repetitive behavior (stereotypy) induced by amphetamine in rats emerges after an initial period of locomotor activation. To assess the neuronal correlates of this behavioral transition, single-unit activity was recorded from the dorsal striatum of awake, unrestrained rats. Units were first...

journal_title：Psychopharmacology

authors： Rebec GV,White IM,Puotz JK

更新日期：1997-04-01 00:00:00

abstract：:These experiments were undertaken to determine if local injection of pilocarpine in the neostriatum of the rat produces oral motor activities that are similar to those produced by systemic administration. In the first experiment, IP administration of 2.0-8.0 mg/kg pilocarpine increased chewing movements and tongue pro...

journal_title：Psychopharmacology

authors： Salamone JD,Johnson CJ,McCullough LD,Steinpreis RE

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Investigations of the neural consequences of the effects of cocaine on cognition have centered on specific brain circuits including prefrontal cortex, medial temporal lobe and striatum and their roles in controlling drug dependent behavior and addiction. These regions are critical to many aspects of drug abus...

journal_title：Psychopharmacology

authors： Hampson RE,Porrino LJ,Opris I,Stanford T,Deadwyler SA

更新日期：2011-01-01 00:00:00

abstract：RATIONALE:Nicotine increases glutamate release in the ventral tegmental area and the nucleus accumbens, and thus enhances dopamine neurotransmission in the mesolimbic system that has been implicated in mediating the rewarding effects of drugs. Metabotropic glutamate receptors 5 (mGluR5) are found in the nucleus accumbe...

journal_title：Psychopharmacology

authors： Paterson NE,Semenova S,Gasparini F,Markou A

更新日期：2003-05-01 00:00:00

abstract：:Rats exhibit profound individual differences in their propensity to ingest sugar and in their locomotor response to AMP. Intrinsic variation in the responsiveness of mesolimbic dopamine mechanisms has been suggested to account for these individual differences. In light of this overlap, it might be expected that indivi...

journal_title：Psychopharmacology

authors： Sills TL,Vaccarino FJ

更新日期：1994-09-01 00:00:00

abstract：RATIONALE:Attentional bias for alcohol-related cues is associated with the motivation to drink alcohol, possibly because attentional bias increases craving. OBJECTIVES:We examined whether an experimentally induced attentional bias would influence subjective and behavioural indices of the motivation to drink. METHODS:...

journal_title：Psychopharmacology

authors： Field M,Eastwood B

更新日期：2005-12-01 00:00:00

abstract：:The behavioral performance of inbred mouse strains was examined in animal models of anxiety to evaluate the potential contribution of genetic factors to fear-motivated behaviors. The preference that randomly bred mice and rats exhibit for the enclosed as opposed to the open arms of an elevated maze has been considered...

journal_title：Psychopharmacology

authors： Trullas R,Skolnick P

更新日期：1993-01-01 00:00:00

abstract：:Three sets of experiments were carried out in a Y water maze in which mice had to swim toward the light or the dark, in two different procedures. The first procedure involved, orientation toward a light source (L procedure), corresponding to natural preference, the latter involved orientation toward the dark (D proced...

journal_title：Psychopharmacology

authors： Castellano C

更新日期：1976-08-17 00:00:00

abstract：:To investigate the role of D1 dopamine receptors in the discriminative stimulus effects of cocaine, two rhesus monkeys were trained in a two-lever, food-reinforced, drug discrimination paradigm to discriminate cocaine (0.2 mg/kg, IM) from saline. Administration of various doses of cocaine resulted in a dose-related in...

journal_title：Psychopharmacology

authors： Kleven MS,Anthony EW,Goldberg LI,Woolverton WL

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Several halogenated analogs of benztropine (BZT) have previously been characterized as potent DA uptake inhibitors with behavioral profiles that indicate diminished psychomotor stimulant effects relative to cocaine. In a previous study using a fixed-ratio 10 schedule, two chloro-analogs (3'-Cl-BZT and 4'-Cl-B...

journal_title：Psychopharmacology

authors： Woolverton WL,Hecht GS,Agoston GE,Katz JL,Newman AH

更新日期：2001-04-01 00:00:00

abstract：:The effects of serotonergic manipulations on the escape interference engendered by exposure to inescapable shock were assessed. Consistent with the view that the behavioral interference was related to reductions of serotonin (5-HT), treatment with the 5-HT receptor blocker methysergide mimicked the effects of inescapa...

journal_title：Psychopharmacology

authors： Hamilton ME,Zacharko RM,Anisman H

更新日期：1986-01-01 00:00:00

abstract：:Rats were made hyperphagic by 6-hydroxydopamine (6-OHDA) injected bilaterally into the ventral midbrain; then they were restricted to a 6 h/day feeding schedule and tested for appetite suppression with amphetamine and fenfluramine in randomized order. Amphetamine anorexia was diminished while fenfluramine anorexia was...

journal_title：Psychopharmacology

authors： Ahlskog JE,Randall PK,Hernandez L,Hoebel BG

更新日期：1984-01-01 00:00:00

abstract：:The relationship between changes in IV tyramine pressor sensitivity accompanying selective monoamine oxidase (MAO) inhibitor treatment and estimates of MAO-A and MAO-B inhibition in vivo were studied. Reductions in platelet MAO activity provided an index of MAO-B inhibition, while changes in plasma 3-methoxy-4-hydroxy...

journal_title：Psychopharmacology

authors： Pickar D,Cohen RM,Jimerson DC,Lake CR,Murphy DL

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Schizophrenia is a disorder with cognitive deficits that could stem from cholinergic dysfunction. OBJECTIVES:Our aim was to examine if donepezil administered to stable, medicated outpatients with schizophrenia improves cognition and psychopathology. METHODS:We conducted a double-blind placebo-controlled tri...

journal_title：Psychopharmacology

authors： Freudenreich O,Herz L,Deckersbach T,Evins AE,Henderson DC,Cather C,Goff DC

更新日期：2005-09-01 00:00:00

abstract：:The effects of naloxone, metenkephalin, and morphine were tested on phencyclidine(PCP)-induced stereotyped behaviors, ataxia, and hyperactivity in the rat. Naloxone (8 mg/kg) significantly decreased stereotypy, ataxia, and hyperactivity across all PCP doses tested (2.0, 4.0, and 6.0 mg/kg). Metenkephalin (40 microgram...

journal_title：Psychopharmacology

authors： Castellani S,Giannini AJ,Adams PM

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:The post-extinction exposure of rats to a sub-conditioning procedure (SCP; i.e., retraining with a shock intensity that is too weak to induce by itself significant fear conditioning) has been reported to provoke the reemergence of extinguished fear. This phenomenon can be prevented by chronic fluoxetine treat...

journal_title：Psychopharmacology

authors： Deschaux O,Zheng X,Lavigne J,Nachon O,Cleren C,Moreau JL,Garcia R

更新日期：2013-01-01 00:00:00

abstract：RATIONALE:The positive modulation of gamma-aminobutyric acid type-A (GABAA) receptors is a putative mechanism via which alcohol escalates aggressive behavior. Broad-spectrum benzodiazepine antagonists block alcohol-heightened aggression in rats and monkeys. However, the degree to which GABAA subunit composition plays a...

journal_title：Psychopharmacology

authors： de Almeida RM,Rowlett JK,Cook JM,Yin W,Miczek KA

更新日期：2004-03-01 00:00:00

abstract：:The issue of whether tolerance develops to the motivational effects of opioids was addressed by use of an unbiased place preference conditioning procedure. Administration of the mu-opioid agonists morphine or fentanyl produced dose-related preferences for the drug-associated place in control rats. In contrast, the kap...

journal_title：Psychopharmacology

authors： Shippenberg TS,Emmett-Oglesby MW,Ayesta FJ,Herz A

更新日期：1988-01-01 00:00:00

abstract：:The aim of the present study was to investigate the locomotor stimulant effects of the atypical antipsychotic agent, olanzapine, in mice depleted of their dopamine by reserpine and alpha-methyl-DL-p-tyrosine pretreatment. Olanzapine (0.5, 1 and 2 mg/kg) dose-dependently increased locomotor activity, which was complete...

journal_title：Psychopharmacology

authors： Ninan I,Kulkarni SK

更新日期：1999-02-01 00:00:00

abstract：RATIONALE:Benzodiazepine agonists characteristically increase food intake in humans and non-human subjects, and the underlying mechanisms of this effect are not understood completely. OBJECTIVE:Compounds with selectivity for GABAA receptor subtypes were used to evaluate the role of GABAA receptors containing alpha1 an...

journal_title：Psychopharmacology

authors： Duke AN,Platt DM,Cook JM,Huang S,Yin W,Mattingly BA,Rowlett JK

更新日期：2006-08-01 00:00:00

abstract：RATIONALE:The dopaminergic system has been proposed to mediate alcohol-induced locomotor activity, yet the mechanisms underlying this behavioral response remain poorly understood. OBJECTIVES:This study was conducted to investigate the role of dopamine D2-like receptors in mediating alcohol-induced behavioral responses...

journal_title：Psychopharmacology

authors： Tran S,Facciol A,Gerlai R

更新日期：2016-06-01 00:00:00

abstract：RATIONALE:Nearly 60-80% of women experience some form of sadness, anxiety, or anhedonia in the weeks following the birth of a child (Patel et al. 23(2):534-42, 2012; Degner 10: 359;j4692, 2017); however, the exact mechanisms that precipitate these changes in mood postpartum are still unknown. It is well-known that the ...

journal_title：Psychopharmacology

authors： Gomez J,Haas NA,Schwarz JM

更新日期：2019-10-01 00:00:00

abstract：:Acamprosate (calcium-acetyl homotaurinate) is a new compound used in the treatment of alcohol abuse. Because of the putative link between alcoholism and the endogenous opioid systems in both humans and laboratory animals, we tested in rats the effects of acamprosate on behavioral and neurochemical effects of opioid dr...

journal_title：Psychopharmacology

authors： Spanagel R,Sillaber I,Zieglgänsberger W,Corrigall WA,Stewart J,Shaham Y

更新日期：1998-10-01 00:00:00

abstract：:Because of the increasing demand for refined techniques to record drug-induced motoric changes, we designed and evaluated a computer monitoring system with continuous measurement of different parameters of rat motor activity. This system is particularly useful for chronic drug studies because it can characterize patte...

journal_title：Psychopharmacology

authors： Stoff DM,Stauderman K,Wyatt RJ

更新日期：1983-01-01 00:00:00

abstract：:Selectively bred FAST mice are highly susceptible, while SLOW mice are less susceptible, to the locomotor stimulant effects of ethanol. Heritability estimates indicate that approximately 15% of the variance in the FAST lines is of additive genetic origin, while low susceptibility is ostensibly nonheritable. Inbreeding...

journal_title：Psychopharmacology

authors： Phillips TJ,Burkhart-Kasch S,Terdal ES,Crabbe JC

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Temporal differentiation of operant behaviour is sensitive to dopaminergic manipulations. Studies using the fixed-interval peak procedure implicated D2 dopamine receptors in these effects. Less is known about the effects of dopaminergic manipulations on temporal differentiation in other timing schedules. OBJ...

journal_title：Psychopharmacology

authors： Cheung TH,Bezzina G,Asgari K,Body S,Fone KC,Bradshaw CM,Szabadi E

更新日期：2006-04-01 00:00:00

abstract：:Relationships between aging effects on apomorphine (AP)-induced stereotypy and AP concentrations in plasma and brain were studied in rats. In two separate behavioral studies, four groups of male Wistar rats (3, 6, 20, and 43 weeks of age) and two groups of female Wistar rats (5 and 35 weeks of age) were used, respecti...

journal_title：Psychopharmacology

authors： Watanabe H,Nakano S,Ogawa N

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Previous work has shown that environmental enrichment alters amphetamine-induced locomotor activity and conditioned place preference. OBJECTIVE:The present study examined the effect of environmental enrichment on amphetamine self-administration. METHODS:Female and male rats were raised from 21 days of age i...

journal_title：Psychopharmacology

authors： Bardo MT,Klebaur JE,Valone JM,Deaton C

更新日期：2001-05-01 00:00:00