Abstract：
:The anorectic activity of the d and l isomers of d-fenfluramine (d-FF) (l-FF) were compared with d-amphetamine (d-amp) when given separately and together in 12 healthy male volunteers. The study was double blind and placebo controlled. Food intake was measured using an automated food dispenser. Anorectic activity was examined using a) total energy intake b) nutrient selection c) selection of foods categorised by nonsweet/sweet taste. Total energy intake was significantly reduced by d-FF (17%) d-amp (26%) d-FF + d-amp (36%) and l-FF + d-amp (31%). d-Amp and both combinations significantly reduced energy intake from all macronutrients in the total food. d-FF reduced carbohydrate but not fat or protein intake derived from all foods. When nonsweet and sweet tasting foods were examined separately, l-FF also significantly reduced energy (by 19%), fat and carbohydrate intake from nonsweet food. Neither d-FF nor l-FF reduced protein from nonsweet food. No anorectic drug given alone reduced sweet food intake, only d-amp given with d-FF had this effect. In contrast to nonsweet food, d-FF did not reduce carbohydrate from sweet foods. The results are in agreement with previous work that d-FF spares protein consumption but suggest that d-FF does not selectively reduce carbohydrate intake per se.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Goodall E,Feeney S,McGuirk J,Silverstone Tdoi
10.1007/BF02801976subject
Has Abstractpub_date
1992-01-01 00:00:00pages
221-7issue
2eissn
0033-3158issn
1432-2072journal_volume
106pub_type
临床试验,杂志文章,随机对照试验abstract：:The effects of naloxone on diazepam-induced release of behavior in aversive situations were investigated in rats. Naloxone (0.5 and 1 mg/kg-1) suppressed diazepam-induced eating in an unfamiliar situation and reduced (1 mg/kg-1) spontaneous food intake. Naloxone (1 mg/kg-1) canceled the increased lever pressing produc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426529
更新日期：1980-01-01 00:00:00
abstract：RATIONALE:Reduced serotonin neurotransmission is implicated in disorders of impulse control, but the involvement of serotonin in inhibitory processes in healthy human subjects remains unclear. OBJECTIVES:To investigate the effects of an acute manipulation of serotonin and genotype at a functional polymorphism in a gen...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-005-0104-6
更新日期：2005-11-01 00:00:00
abstract：:Normal unoperated rats were tested for rotation (i.e., circling behavior) in a spherical "rotometer" and dose-response relationships were generated using d-amphetamine, apomorphine, L-Dopa, haloperidol, and scopolamine. The rotation induced by amphetamine was significantly antagonized by alpha-methyl-p-tyrosine and ha...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427609
更新日期：1976-06-23 00:00:00
abstract：:Two experiments examined the effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid intake in water-deprived rats. In the first experiment, pretreatment with 3.0 or 10.0 mg/kg zolpidem IP was found to increase consumption of a novel glucose drink (3% d-glucose and 0.15 sodium saccharine w/v in wat...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245521
更新日期：1993-01-01 00:00:00
abstract：INTRODUCTION:Prior activation of the kappa opioid system by repeated stress or agonist administration has been previously shown to potentiate the rewarding properties of subsequently administered cocaine. In the present study, intermittent and uncontrollable footshock, a single session of forced swim, or acute administ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1122-y
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:The serotonin (5-HT) deficiency hypothesis of aggression is being seriously challenged by pharmacological data showing robust anti-aggressive effects of 5-HT1A receptor agonists in dose ranges that concomitantly inhibit 5-HT neurotransmission. Hence, an adequate interpretation of the role of 5-HT activity in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4173-x
更新日期：2016-03-01 00:00:00
abstract：:Carbachol, muscarine, eserine and neostigmine injected into the cerebral ventricles of conscious cats evoked emotional behaviour with aggression, autonomic and motor phenomena as well as clonic-tonic convulsions. The main and the most impressive feature of the gross behavioural effects of intraventricular carbachol, m...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427131
更新日期：1979-04-11 00:00:00
abstract：:5-Hydroxytryptamine1A (5-HT1A) receptors have been shown to be suppressed by corticosteroid hormones in a variety of animal experimental paradigms. It has been suggested that this effect may be central to the pathophysiology of severe clinical depressive illness, a condition in which 5-HT1A receptor function is reduce...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130050711
更新日期：1998-10-01 00:00:00
abstract：:Neuroleptic-free schizophrenic patients received caerulein, a potent analogue of cholecystokinin octapeptide, in a fixed- and rising-dose schedule. In addition, neuroleptic-treated patients received a single dose of the peptide with a 4-week follow-up. No significant change in mental status was observed after any of t...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00180843
更新日期：1986-01-01 00:00:00
abstract：RATIONALE:Exercise stimulates the release of endogenous opioid peptides and increases nociceptive (i.e. pain) thresholds in both human and animal subjects. During chronic, long-term exercise, sensitivity to the effects of morphine and other mu opioids decreases, leading some investigators to propose that exercise may l...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1471-5
更新日期：2003-08-01 00:00:00
abstract：:Rats injected with doses of d-amphetamine 0--5.0 mg/kg were observed continuously in either an enclosed Y-maze or on an elevated Y-shaped platform. Patterns of increased walking and stereotypy were unaffected by the type of apparatus, but rearing remained totally suppressed at all dose levels on the elevated platform....
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431954
更新日期：1979-04-25 00:00:00
abstract：RATIONALE:Cognitive rehabilitation is now recognized as an important tool in the treatment of schizophrenia, and findings in this area are emerging rapidly. There is a need for a systematic review of the effects of the different training programs. OBJECTIVES:To review quantitatively the controlled studies on cognitive...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-002-1326-5
更新日期：2003-09-01 00:00:00
abstract：RATIONALE:Epidemiological studies of smokers suggest that there is a link between nicotine and depression. Nonetheless, few studies have examined the potential use of nicotinic ligands in the treatment of depression. OBJECTIVES:The goal of this study was to evaluate the effects of SIB-1508Y, a novel subtype-selective ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000531
更新日期：2000-10-01 00:00:00
abstract：:The benzodiazepines are typified by a profile of side effects which includes drowsiness, ataxia and incoordination. Ro 15-1788, an imidazodiazepine derivative, exhibits marked antagonism of the behavioural and biochemical effects of the benzodiazepines in animals and man. It is devoid of any behavioural activity in an...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00427969
更新日期：1983-01-01 00:00:00
abstract：:The objective of the present study was to determine whether the development of behavioral sensitization to apomorphine could be blocked by either D1 or D2 selective dopamine antagonists. In three experiments, male rats received 10-21 daily injections of a selective D1 (SCH 23390; 0 or 0.5 mg/kg IP) or D2 (sulpiride; 0...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244370
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Alcohol drinking may lead to increased aggression in certain individuals, and both fighting and drinking increase levels of dopamine and serotonin in mesocorticolimbic structures. Assessing the dynamic changes in these neurotransmitters during the course of drinking and fighting has remained challenging. OB...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0637-3
更新日期：2007-04-01 00:00:00
abstract：RATIONALE:Previous work has shown that clozapine suppressed tacrine-induced jaw movements at lower doses than those required for suppression of lever pressing. OBJECTIVE:The novel atypical antipsychotic olanzapine was assessed in these behavioral tests. METHODS:The effect of acute olanzapine on the suppression of tac...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051063
更新日期：1999-08-01 00:00:00
abstract：RATIONALE:Studies of the discriminative stimulus effects of drug mixtures provide an approach to polydrug abuse and studies on single drugs with multiple effects. OBJECTIVE:This study was designed to investigate whether the use of the AND-OR procedure increases the specificity of drug mixture discriminations. METHODS...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050919
更新日期：1999-03-01 00:00:00
abstract：RATIONALE:State-dependent changes in physiological arousal may influence impulsive behaviours. OBJECTIVES:To examine the relationship between arousal and impulsivity, we assessed the effects of yohimbine (an α2-adrenergic receptor antagonist, which increases physiological arousal via noradrenaline release) on performa...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5160-9
更新日期：2019-06-01 00:00:00
abstract：:Several studies have demonstrated a paradoxical form of antinociception induced by the repeated administration of opioid antagonists accompanied by exposure to a painful stimulus. The underlying mechanism of this naloxone-induced antinociception (NIA) is still unknown, but the results of several studies suggest that i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245234
更新日期：1994-01-01 00:00:00
abstract：RATIONALE:Recent studies have suggested that the salutary actions of clozapine in schizophrenia may be due to selective activation of M(1) muscarinic receptors by clozapine and/or its major active metabolite N-desmethylclozapine. OBJECTIVE:We systematically tested this hypothesis by screening a large number of psychoa...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-2017-1
更新日期：2005-04-01 00:00:00
abstract：:The effects of single and long-term haloperidol administration on rat open field behavior was studied. Withdrawal from long-term haloperidol treatment induced a significant increase in all parameters of activity recorded, except rearing. There was a direct relationship between the impairment of motor function induced ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00429212
更新日期：1981-01-01 00:00:00
abstract：RATIONALE:We hypothesized that valerian root might prevent cognitive dysfunction in coronary artery bypass graft (CABG) surgery patients through stimulating serotonin receptors and anti-inflammatory activity. OBJECTIVES:The aim of this study was to evaluate the effect of Valeriana officinalis root extract on preventio...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-014-3716-x
更新日期：2015-03-01 00:00:00
abstract：RATIONALE:Previous observations revealed that defeated and subsequently individually housed rats do not display behavioral anticipatory responses to the conditioned presentation of a bell/light stimulus associated with free access to a 5% sucrose solution reward. The absence of the appetitive responses suggests a decre...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1093-3
更新日期：2002-07-01 00:00:00
abstract：:This study describes specific behaviours in guinea-pigs after dopamine D-1 and D-2 receptor activation which differed to those described in other rodent species. Intraperitoneal (IP) administration of the dopamine D-2 receptor agonist quinpirole (1.5, 3 and 6 mg/kg) to guinea-pigs dose-dependently initiated locomotor ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244179
更新日期：1991-01-01 00:00:00
abstract：:Preclinical studies suggest that acoustic startle amplitude is increased during ethanol withdrawal. The current study evaluated the effects of intravenous infusion of the alpha 2-adrenergic antagonist, yohimbine (0.4 mg/kg), the serotonin partial agonist m-chlorophenylpiperazine (mCPP, 0.1 mg/kg), and placebo administ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130050285
更新日期：1997-06-01 00:00:00
abstract：:The problem of the advantage of using nortriptyline (NT) plasma level during treatment for endogenous depression has been approached. In an ordinary psychiatric department, 34 patients had their NT level checked the second week of treatment and their dosage subsequently adjusted, if it was outside the recommended ther...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00428027
更新日期：1978-09-15 00:00:00
abstract：:Buprenorphine, a partial mu opioid agonist, is an experimental medication under development for the treatment of opioid dependence as an alternative to methadone maintenance. The present study examined the relationship between level of opioid physical dependence and response to buprenorphine administration as part of ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF02246290
更新日期：1995-06-01 00:00:00
abstract：:In a phase II study the antidepressive effect of citalopram, a selective and potent serotonin reuptake inhibitor, was examined in 20 endogenously and three non-endogenously depressed hospitalized patients. Four endogenously depressed patients dropped out due to deterioration early in the treatment period. The remainin...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00464566
更新日期：1982-01-01 00:00:00
abstract：RATIONALE:Consistent sex differences are observed in human drug addiction, with females often exceeding males on drug intake. However, there is still a need for animal models for some aspects of addiction such as acquisition of drug self-administration and the subsequent development of drug-seeking. OBJECTIVES:The pre...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4183-8
更新日期：2016-03-01 00:00:00
