Anti-aggressive effects of the selective high-efficacy 'biased' 5-HT₁A receptor agonists F15599 and F13714 in male WTG rats.

abstract：RATIONALE:Depressive disorders are conditions that often require continuous treatment, and it is therefore important to evaluate the consequences of prolonged administration. There are few studies assessing cognitive functions of depressed patients after long-term use of antidepressants. OBJECTIVES:This study evaluate...

journal_title：Psychopharmacology

authors： Gorenstein C,de Carvalho SC,Artes R,Moreno RA,Marcourakis T

更新日期：2006-03-01 00:00:00

abstract：:A paradigm for assessing benzodiazepine receptor sensitivity was developed using intravenous midazolam in normal volunteers. After administration of incremental doses of midazolam, alterations in saccadic eye movement parameters and psychological self ratings were assessed. Significant changes included dose-dependent ...

journal_title：Psychopharmacology

authors： Ball DM,Glue P,Wilson S,Nutt DJ

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Nicotine replacement is commonly used to treat tobacco use in heavy-drinking smokers. However, few studies have examined the effect of nicotine replacement on subjective and physiological responses to alcohol and alcohol drinking behavior. OBJECTIVE:The primary aim of this within-subject, double-blind study ...

journal_title：Psychopharmacology

authors： McKee SA,O'Malley SS,Shi J,Mase T,Krishnan-Sarin S

更新日期：2008-02-01 00:00:00

abstract：RATIONALE:Chronic pain is becoming a more common medical diagnosis and is especially prevalent in older individuals. As such, prescribed use of opioids is on the rise, even though the efficacy for pain management in older individuals is unclear. OBJECTIVES:Thus, the present preclinical study assessed the effectiveness...

journal_title：Psychopharmacology

authors： Mitzelfelt JD,Carter CS,Morgan D

更新日期：2014-01-01 00:00:00

abstract：RATIONALE:Chronic administration of nicotine in rats results in upregulation of neuronal nicotinic receptors. Upregulation has been proposed to reflect receptor desensitization, which may underlie functional tolerance to nicotine's effects. However, evidence indicates that tolerance and upregulation do not always paral...

journal_title：Psychopharmacology

authors： McCallum SE,Caggiula AR,Booth S,Breese CR,Lee MJ,Donny EC,Leonard S,Sved AF

更新日期：2000-05-01 00:00:00

abstract：:Development of tolerance to neuroleptic compounds tested in the conditional avoidance model was investigated. Since tolerance may manifest itself by a diminished potency and/or a shortened duration of effect, the complete time course of effect was registered in these experiments. Rats were pretreated approximately 2 w...

journal_title：Psychopharmacology

authors： Danneskiold-Samsøoe P,Pedersen V

更新日期：1976-12-21 00:00:00

abstract：RATIONALE:A variety of behavioral procedures have been developed to assess cannabinoid activity in mice; however, the feasibility of establishing Delta(9)-THC as a discriminative stimulus in mice has not been documented. OBJECTIVE:One goal was to establish Delta(9)-THC as a discriminative stimulus in mice; after havin...

journal_title：Psychopharmacology

authors： McMahon LR,Ginsburg BC,Lamb RJ

更新日期：2008-07-01 00:00:00

abstract：:This study examined the possibility that amphetamine-induced stereotypy and facilitation of memory consolidation are both mediated by amphetamine's stimulation of dopaminergic activity in the caudate nucleus. In the first experiment, rats were given pairings of a tone and a shock followed by SC amphetamine (2 mg/kg). ...

journal_title：Psychopharmacology

authors： Carr GD,White NM

更新日期：1984-01-01 00:00:00

abstract：:The behavioural effects of increasing doses of apomorphine and haloperidol were observed in a group of six marmosets. Behaviour was classified quantitatively into categories: Locomotion, inactivity, checking (small head movements), social interaction and purposeful activities. Statistical analysis revealed that apomor...

journal_title：Psychopharmacology

authors： Scraggs PR,Baker HF,Ridley RM

更新日期：1979-01-01 00:00:00

abstract：RATIONALE:3,4-Methylenedioxypyrovalerone (MDPV) and 3,4-methylenedioxy-N-methylcathinone (methylone) are synthetic drugs found in so-called "bath salts" products. Both drugs exert their effects by interacting with monoamine transporter proteins. MDPV is a potent uptake blocker at transporters for dopamine and norepinep...

journal_title：Psychopharmacology

authors： Schindler CW,Thorndike EB,Goldberg SR,Lehner KR,Cozzi NV,Brandt SD,Baumann MH

更新日期：2016-05-01 00:00:00

abstract：RATIONALE:Salvinorin A, the primary psychoactive derivative of the hallucinogenic herb Salvia divinorum, is a potent and highly selective kappa-opioid receptor (KOR) agonist. Several recent studies, however, have suggested endocannabinoid system mediation of some of its effects. OBJECTIVES:This study represents a syst...

journal_title：Psychopharmacology

authors： Walentiny DM,Vann RE,Warner JA,King LS,Seltzman HH,Navarro HA,Twine CE Jr,Thomas BF,Gilliam AF,Gilmour BP,Carroll FI,Wiley JL

更新日期：2010-06-01 00:00:00

abstract：:The effects of the benzomorphan antagonist Mr 2266 and the selective delta-antagonist ICI 154,129 on the body weight gain of 6-day-old suckling rat pups was observed. Mr 2266 significantly reduced body weight gain in these animals, though ICI 154,129 had no affect on this variable. These findings suggest that mu- and ...

journal_title：Psychopharmacology

authors： Jackson HC,Sewell RD

更新日期：1984-01-01 00:00:00

abstract：:The effects of brofaremine (CGP 11 305A), a short-acting, reversible and selective inhibitor of MAO-A, on sleep, nocturnal penile tumescence (NPT) and hormonal secretion during the night were studied during a long-term trial. Three healthy males underwent sleep-EEG and NPT recordings during consecutive nights (1) unde...

journal_title：Psychopharmacology

authors： Steiger A,Holsboer F,Benkert O

更新日期：1987-01-01 00:00:00

abstract：:Rats were chronically administered either haloperidol (HAL) or fluphenazine (FLU) via depot injections for 8 months, given these same drugs in their drinking water for the next 2 months, and then withdrawn from the drugs. Throughout the experiment the animals were tested repeatedly in an enclosed tube using a computer...

journal_title：Psychopharmacology

authors： See RE,Levin ED,Ellison GD

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Although the effects of D: -cycloserine (DCS) and valproic acid (VPA) on the facilitation of the extinction of fear-conditioned memory have been elucidated in animals, these effects have not been clearly confirmed in humans. OBJECTIVE:This study aimed to determine the effect of DCS (100 mg) and VPA (400 mg) ...

journal_title：Psychopharmacology

authors： Kuriyama K,Honma M,Soshi T,Fujii T,Kim Y

更新日期：2011-12-01 00:00:00

abstract：RATIONALE:Tryptophan depletion is used to reduce central serotonergic function and to investigate its role in psychiatric illness. Despite widespread clinical use, its effects on serotonin (5-HT) receptors have not been well characterized. OBJECTIVE:The aim of this study was to examine the effect of acute (ATD) and ch...

journal_title：Psychopharmacology

authors： Cahir M,Ardis T,Reynolds GP,Cooper SJ

更新日期：2007-03-01 00:00:00

abstract：:We have previously obtained evidence that the mesoamygdaloid dopamine projection modulates the acquisition of a conditioned response (CR) elicited by presentation of a conditioned stimulus (CS) predicting the availability of a natural (sucrose) reward. This property was found to be dependent upon D3, but not D1 or D2,...

journal_title：Psychopharmacology

authors： Hitchcott PK,Phillips GD

更新日期：1998-12-01 00:00:00

abstract：RATIONALE:The noradrenergic and dopaminergic systems are targets for antidepressants and are stimulated by serotonergic antidepressant drugs. The COMT enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Clinical studies on the effect of rs4680 on antidep...

journal_title：Psychopharmacology

authors： Benedetti F,Colombo C,Pirovano A,Marino E,Smeraldi E

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:Recent data suggest that 5-HT7 receptors (5-HT7R) are involved in memory processes and, particularly, those related to novelty-induced arousal, even though this remains so far speculative and controversial. In order to assess the role of 5-HT7R in episodic-like memory, mice were administered 5-carboxamidotryp...

journal_title：Psychopharmacology

authors： Freret T,Paizanis E,Beaudet G,Gusmao-Montaigne A,Nee G,Dauphin F,Bouet V,Boulouard M

更新日期：2014-01-01 00:00:00

abstract：RATIONALE:Stimulant medications for attention-deficit/hyperactivity disorder (ADHD) in adolescents remain controversial with respect to later development of cocaine abuse. Past research demonstrated that adolescent methylphenidate treatment increased several aspects of cocaine self-administration during adulthood using...

journal_title：Psychopharmacology

authors： Jordan CJ,Lemay C,Dwoskin LP,Kantak KM

更新日期：2016-12-01 00:00:00

abstract：:The intensity of the head-twitch response and the 5-hydroxytryptamine (5-HT) syndrome (tremor, fore-paw treading, head-weaving and hind-limb abduction) was measured in male CFLP mice following IP injection of 5 mg/kg 5-methoxy-N,N-dimethyltryptamine (5-MeODMT). The results of separate experiments carried out at 1.5-h ...

journal_title：Psychopharmacology

authors： Moser PC,Redfern PH

更新日期：1985-01-01 00:00:00

abstract：:In order to assess the possible effects of central GABA activation on the consolidation of shock avoidance, the GABA-T inhibitor amino-oxyacetic acid (AOAA) was administered posttrial to adult male rats. Learning was assessed over nine widely spaced sessions of 20 trials each. AOAA-treated animals showed learning with...

journal_title：Psychopharmacology

authors： Katz RJ,Liebler L

更新日期：1978-03-01 00:00:00

abstract：:The objective of the present study was to determine whether the development of behavioral sensitization to apomorphine could be blocked by either D1 or D2 selective dopamine antagonists. In three experiments, male rats received 10-21 daily injections of a selective D1 (SCH 23390; 0 or 0.5 mg/kg IP) or D2 (sulpiride; 0...

journal_title：Psychopharmacology

authors： Mattingly BA,Rowlett JK,Graff JT,Hatton BJ

更新日期：1991-01-01 00:00:00

abstract：:Three sets of experiments were carried out in a Y water maze in which mice had to swim toward the light or the dark, in two different procedures. The first procedure involved, orientation toward a light source (L procedure), corresponding to natural preference, the latter involved orientation toward the dark (D proced...

journal_title：Psychopharmacology

authors： Castellano C

更新日期：1976-08-17 00:00:00

abstract：:Dopamine (DA), injected unilaterally into rat forebrain after pretreatment with a monoamine oxidase inhibitor, equipotently induced locomotor arousal when placed in the nucleus accumbens septi (a limbic site) and contralateral deviation of the head when placed in the corpus striatum (an extrapyramidal target); testing...

journal_title：Psychopharmacology

authors： Campbell A,Yeghiayan S,Baldessarini RJ,Neumeyer JL

更新日期：1991-01-01 00:00:00

abstract：:Adult hooded rats exposed to a repeated maternal separation procedure during the neonatal period showed a blunted expression of locomotor hyperactivity conditioned to the presentation of the daily food ration. We have demonstrated that the expression of food-conditioned anticipatory hyperactivity is sensitive to the r...

journal_title：Psychopharmacology

authors： Matthews K,Hall FS,Wilkinson LS,Robbins TW

更新日期：1996-07-01 00:00:00

abstract：RATIONALE:Piper methysticum extract (kava kava) possesses numerous therapeutic properties, but it is unknown which of its principle constituents (kavalactones) subserve such effects. OBJECTIVES:This experiment sought to characterize the putative anxiolytic properties of P. methysticum extract and its six principle kav...

journal_title：Psychopharmacology

authors： Smith KK,Dharmaratne HR,Feltenstein MW,Broom SL,Roach JT,Nanayakkara NP,Khan IA,Sufka KJ

更新日期：2001-04-01 00:00:00

abstract：RATIONALE:A number of studies have indicated a relationship between the intake of palatable foods or fluids and drug self-administration. OBJECTIVES:Two experiments were conducted to determine whether the intake of sucrose or fat was related to subsequent cocaine self-administration. METHODS:In separate groups of rat...

journal_title：Psychopharmacology

authors： Gosnell BA

更新日期：2000-04-01 00:00:00

abstract：RATIONALE:It has been suggested that GABA(B) receptors may be part of a neural substrate mediating some of the effects of ethanol. OBJECTIVE:The purpose of this experiment was to investigate, in mice, the effects of ethanol on working memory in a delayed matching-to position (DMTP) task, and additionally to determine ...

journal_title：Psychopharmacology

authors： Escher T,Mittleman G

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND RATIONALE:Despite the popularity of polysubstance abuse among recreational methylendioxymethamphetamine (MDMA) users, relatively few controlled experimental studies have documented the neurobehavioral effects of MDMA in combination with other abused substances. OBJECTIVE:In this study, the combined acut...

journal_title：Psychopharmacology

authors： Panos JJ,Baker LE

更新日期：2010-03-01 00:00:00