Abstract:
:Previous studies have shown that dihydropyridine (DHP) calcium channel blockers can potentiate yawning induced by apomorphine in rats. The present study was undertaken to examine whether or not this interaction was seen with other compounds that induce yawning or if it represented a specific interaction with dopaminergic mechanisms. Yawning induced by apomorphine (40 micrograms/kg SC), physostigmine (50 micrograms/kg SC) or pilocarpine (1 mg/kg SC) was dose-dependently potentiated by the DHP calcium channel blocker nifedipine (1.25-10 mg/kg IP). Nimodipine (1.25-5 mg/kg IP) and nitrendipine (1.25-5 mg/kg IP) also significantly increased the yawning response. The DHP calcium channel blockers alone induced only a low incidence of yawning. The effects of nifedipine on physostigmine-induced yawning were reversed by the DHP calcium channel activator BAY K 8644 which also inhibited yawning induced by physostigmine (100 micrograms/kg SC) and pilocarpine (2 mg/kg SC). In contrast to the DHP compounds, diltiazem (2.5-10 mg/kg IP) and verapamil (2.5-10 mg/kg IP) failed to potentiate yawning. Sulpiride (10 mg/kg SC) antagonised the nifedipine potentiation of apomorphine-induced yawning but not that of physostigmine-induced yawning; atropine (2.5 mg/kg SC) antagonised both effects. These results support the hypothesis that this effect of dihydropyridine compounds is not dependent on, nor mediated through, dopaminergic mechanisms.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Bourson A,Moser PCdoi
10.1007/BF02244401subject
Has Abstractpub_date
1990-01-01 00:00:00pages
168-72issue
2eissn
0033-3158issn
1432-2072journal_volume
100pub_type
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journal_title:Psychopharmacology
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更新日期:2003-05-01 00:00:00
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更新日期:1992-01-01 00:00:00
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更新日期:2005-03-01 00:00:00
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更新日期:2005-08-01 00:00:00
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更新日期:2011-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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更新日期:1992-01-01 00:00:00