Evidence of a role for the 5-HTTLPR genotype in the modulation of motor response to antidepressant treatment.

abstract：:Biotransformation of phenacetin via O-deethylation to acetaminophen, an index reaction reflecting activity of Cytochrome P450-1A2, was studied in microsomal preparations from a series of human livers. Acetaminophen formation was consistent with a double Michaelis-Menten system, with low-Km (mean Km1 = 68 microM) and h...

journal_title：Psychopharmacology

authors： von Moltke LL,Greenblatt DJ,Duan SX,Schmider J,Kudchadker L,Fogelman SM,Harmatz JS,Shader RI

更新日期：1996-12-01 00:00:00

abstract：:The effect of lithium on serotonin (5-HT)-mediated responses in the brain was assessed by measuring changes in the prolactin (PRL) and growth hormone (GH) responses to L-tryptophan (LTP) in eight normal subjects. On the 4th day of lithium treatment the PRL responses were significantly enhanced, and this enhancement wa...

journal_title：Psychopharmacology

authors： Glue PW,Cowen PJ,Nutt DJ,Kolakowska T,Grahame-Smith DG

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:There is a requirement to ensure that UK armed forces are provided with the best possible medical countermeasures to prevent or mitigate the effects of exposure to nerve agents. When pretreatments are under consideration, it is of particular importance to ensure that they do not in themselves give rise to adv...

journal_title：Psychopharmacology

authors： Muggleton NG,Bowditch AP,Crofts HS,Scott EA,Pearce PC

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVES:Previous studies have investigated the occupancy of the serotonin reuptake transporter (SERT) after clinical doses of citalopram and other selective serotonin reuptake inhibitors. In the present study, the occupancies of SERT after multiple doses of escitalopram and citalopram were compared using the radioli...

journal_title：Psychopharmacology

authors： Klein N,Sacher J,Geiss-Granadia T,Mossaheb N,Attarbaschi T,Lanzenberger R,Spindelegger C,Holik A,Asenbaum S,Dudczak R,Tauscher J,Kasper S

更新日期：2007-04-01 00:00:00

abstract：RATIONALE:Developmental lead exposure may alter responsiveness to cocaine well into adulthood, and ultimately influence drug-use patterns. OBJECTIVES:The present study examined the effect of perinatal lead exposure on the discriminative stimulus properties of cocaine. METHODS:Female rats were treated with 0, 8, or 16...

journal_title：Psychopharmacology

authors： Miller DK,Nation JR,Bratton GR

更新日期：2001-11-01 00:00:00

abstract：RATIONALE:Studies of the discriminative stimulus effects of drug mixtures provide an approach to polydrug abuse and studies on single drugs with multiple effects. OBJECTIVE:This study was designed to investigate whether the use of the AND-OR procedure increases the specificity of drug mixture discriminations. METHODS...

journal_title：Psychopharmacology

authors： Mariathasan EA,Stolerman IP,White JA

更新日期：1999-03-01 00:00:00

abstract：:Evaluation of the efficacy of antidepressant agents needs to take into account factors which increase the "effect size", such as dosage, treatment duration, the use of two-phase trials, and pattern analysis of responders. Although many patients are thought to receive inadequate doses of antidepressants, relatively few...

journal_title：Psychopharmacology

authors： Quitkin FM

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:The noradrenergic and dopaminergic systems are targets for antidepressants and are stimulated by serotonergic antidepressant drugs. The COMT enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Clinical studies on the effect of rs4680 on antidep...

journal_title：Psychopharmacology

authors： Benedetti F,Colombo C,Pirovano A,Marino E,Smeraldi E

更新日期：2009-03-01 00:00:00

abstract：RATIONALE:Paired-associate learning (PAL), as part of the Cambridge Neuropsychological Test Automated Battery, is able to predict who from an at-risk population will develop Alzheimer's disease. Schizophrenic patients are also impaired on this same task. An automated rodent model of PAL would be extremely beneficial in...

journal_title：Psychopharmacology

authors： Talpos JC,Winters BD,Dias R,Saksida LM,Bussey TJ

更新日期：2009-07-01 00:00:00

abstract：:Murine neuroblastoma cells (clone N1E-115) possess both high- and low-affinity muscarinic receptors. The low-affinity muscarinic receptor, when stimulated, initiates the formation of cyclic GMP by activating the enzyme guanylate cyclase; whereas stimulation of the high-affinity receptor inhibits prostaglanding E1-medi...

journal_title：Psychopharmacology

authors： Kanba S,Pfenning M,Richelson E

更新日期：1985-01-01 00:00:00

abstract：:Recent studies indicate that morphine dependence, assessed as the severity of naloxone-precipitated opiate withdrawal in rats, is attenuated by dizocipline, a non-competitive, excitatory amino acid antagonist. Because ethanol is a putative excitatory amino acid antagonist, the present study compared the effects of co-...

journal_title：Psychopharmacology

authors： Shoemaker WJ,Kosten TA,Muly SM

更新日期：1997-11-01 00:00:00

abstract：:Adult rats that were gestationally exposed to cocaine and control offspring were examined for their sensitivity to challenge doses of cocaine. Offspring were derived from Sprague-Dawley dams that had received subcutaneous injections of 40 mg/kg per 3 cc cocaine hydrochloride daily on gestational days 8-20, pair-fed da...

journal_title：Psychopharmacology

authors： Heyser CJ,Rajachandran L,Spear NE,Spear LP

更新日期：1994-09-01 00:00:00

abstract：:Passive avoidance learning was significantly impaired by atropine (5 mg/kg, IP) or scopolamine (0.5 mg/kg), but not by methyl-atropine (5 mg/kg) or methyl-scopolamine (0.5 mg/kg), from postnatal day 15 on. In contrast, an improvement was observed, not significant at 11 days and significant at 13 days, probably due to ...

journal_title：Psychopharmacology

authors： Blozovski D,Hennocq N

更新日期：1982-01-01 00:00:00

abstract：:It has been suggested that the GAbAergic striatonigral projection may form part of the efferent pathway responsible for the expression of dopamine-related oral behaviour. Consistent with this suggestion are reports that bilateral injection of the GABA agonist muscimol can produce stereotyped gnawing and biting. We rep...

journal_title：Psychopharmacology

authors： Taha EB,Dean P,Redgrave P

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Diazepam, a benzodiazepine with a relatively rapid onset of clinical effects, has been associated with suicide and other self-aggressive acts. The evidence for this association, however, comes exclusively from retrospective non-experimental studies. Although suggestive, the results of these studies do not sup...

journal_title：Psychopharmacology

authors： Berman ME,Jones GD,McCloskey MS

更新日期：2005-02-01 00:00:00

abstract：:Dosage regimen adjustments because of poor renal function are often assumed to be unnecessary for extensively metabolized antidepressants. This assumption is being increasingly questioned in recognition of the role of active drug metabolites. The purpose of this study was to assess the steady-state accumulation of the...

journal_title：Psychopharmacology

authors： DeVane CL,Laizure SC,Cameron DF

更新日期：1986-01-01 00:00:00

abstract：:The in vivo potency of mazindol for binding to striatal dopamine transporters (DAT) was assessed by [123I]beta-CIT ([123I]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane) single photon emission computed tomography (SPECT). Cocaine-dependent subjects (n = 12) underwent three SPECT scans; one before, between, and after s...

journal_title：Psychopharmacology

authors： Malison RT,McCance E,Carpenter LL,Baldwin RM,Seibyl JP,Price LH,Kosten TR,Innis RB

更新日期：1998-06-01 00:00:00

abstract：:The action of copper (CuSO4, 5 mg/kg, oral) on selected neuropharmacological actions of cannabis resin (CI, oral) was studied on albino rats and mice. Copper potentiated the barbiturate hypnosis-potentiating activity of CI in albino rats and mice and had no effect on hypothermic activity in albino rats. Single doses o...

journal_title：Psychopharmacology

authors： Singh PP,Das PK

更新日期：1978-04-11 00:00:00

abstract：:Rats were treated once with doses of haloperidol or of droperidol below and above the acute ID50 vs the dopamine agonist apomorphine; they were later challenged with an acute dose of apomorphine (0.3 mg/kg, SC) and rated for stereotyped behavioral responses. The two neuroleptics were similar in acute anti-apomorphine ...

journal_title：Psychopharmacology

authors： Campbell A,Baldessarini RJ,Teicher MH,Kula NS

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:Cue avoidance training (CAT) reduces alcohol consumption in the laboratory. However, the neural mechanisms that underlie the effects of this intervention are poorly understood. OBJECTIVES:The present study investigated the effects of a single session of CAT on event-related and readiness potentials during pr...

journal_title：Psychopharmacology

authors： Di Lemma LCG,Stancak A,Soto V,Fallon N,Field M

更新日期：2020-05-01 00:00:00

abstract：RATIONALE:Emerging evidence from agonist-antagonist studies suggests a role for the dopamine D(3) receptor subtype in the regulation of PPI in animals, but such evidence is lacking for human subjects. OBJECTIVES:This study examines the effect of the preferential D(3) agonist ropinirole on PPI in humans. METHODS:PPI w...

journal_title：Psychopharmacology

authors： Giakoumaki SG,Roussos P,Frangou S,Bitsios P

更新日期：2007-10-01 00:00:00

abstract：RATIONALE:Each year, over 300,000 individuals in the USA enter treatment for cannabis use disorder (CUD). The development of effective pharmacotherapy for CUD is a priority. OBJECTIVE:This placebo-controlled study examined the effects of zolpidem alone and in combination with nabilone on cannabis withdrawal and a labo...

journal_title：Psychopharmacology

authors： Herrmann ES,Cooper ZD,Bedi G,Ramesh D,Reed SC,Comer SD,Foltin RW,Haney M

更新日期：2016-07-01 00:00:00

abstract：RATIONALE:Intermittent footshock stress effectively reinstates extinguished heroin-, cocaine- and alcohol-taking behaviors, but not behaviors previously maintained by food reinforcers. Here we tested further the generality of the phenomenon of stress-induced reinstatement by determining the effect of footshock on reins...

journal_title：Psychopharmacology

authors： Buczek Y,Lê AD,Wang A,Stewart J,Shaham Y

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Soda manufacturers claim that caffeine is added to soda as a flavor enhancer, but many researchers have speculated that caffeine is added to increase the hedonic and reinforcing properties of the soda. Studies in adults have demonstrated that caffeine can condition flavor preferences when added to novel-flav...

journal_title：Psychopharmacology

authors： Temple JL,Ziegler AM,Graczyk A,Bendlin A,O'Leary S,Schnittker YS

更新日期：2012-09-01 00:00:00

abstract：RATIONALE:Repeated social stress experiences engender "behavioral sensitization" and may also increase the potential for abuse of psychomotor stimulants, particularly cocaine use during "binges." OBJECTIVE:Experimental protocols were designed to induce behavioral sensitization through exposures to social-defeat stress...

journal_title：Psychopharmacology

authors： Covington HE 3rd,Miczek KA

更新日期：2001-12-01 00:00:00

abstract：RATIONAL:Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors. OBJECTIVES:We investigated the role of leptin and ghrelin in the augmentation of heroin seekin...

journal_title：Psychopharmacology

authors： D'Cunha TM,Chisholm A,Hryhorczuk C,Fulton S,Shalev U

更新日期：2020-03-01 00:00:00

abstract：RATIONALE:Individuals with schizophrenia have high smoking-related morbidity and mortality rates and need powerful and innovative smoking cessation interventions. OBJECTIVES:This proof-of-concept study investigated the feasibility and initial efficacy of combining a contingency management intervention with bupropion t...

journal_title：Psychopharmacology

authors： Tidey JW,Rohsenow DJ,Kaplan GB,Swift RM,Reid N

更新日期：2011-09-01 00:00:00

abstract：:Benzodiazepines and other compounds which act at benzodiazepine binding sites have been shown previously to attenuate the acquisition of conditioned fear in rodents when administered before the acquisition session, an effect which may parallel the disruption of human memory produced by anxiolytics and sedatives. Such ...

journal_title：Psychopharmacology

authors： Sanger DJ,Joly D,Zivkovic B

更新日期：1986-01-01 00:00:00

abstract：:Fourteen rats were trained to discriminate the effects of gamma-hydroxybutyrate (GHB) (sodium salt, 200 mg/kg) and saline in a two-lever choice task using a fixed ratio 10 schedule of water reinforcement. Intermediate responding, i.e., responding not fully appropriate for either training condition was observed in test...

journal_title：Psychopharmacology

authors： Winter JC

更新日期：1981-01-01 00:00:00

abstract：:Using a 15-s intershock interval, an increase in shock-induced fighting was observed following intraventricular 96 microgram 5,7-dihydroxytryptamine (5,7-DHT) and 90 microgram 6-hydroxydopa (6-OHdopa). The incidence of predatory mouse killing was enhanced by 5,7-DHT, but was not affected by 6-OHdopa. Pain sensitivity ...

journal_title：Psychopharmacology

authors： Kantak KM,Hegstrand LR,Eichelman B

更新日期：1981-01-01 00:00:00