Abstract：
RATIONALE:Individuals with schizophrenia have high smoking-related morbidity and mortality rates and need powerful and innovative smoking cessation interventions. OBJECTIVES:This proof-of-concept study investigated the feasibility and initial efficacy of combining a contingency management intervention with bupropion to reduce smoking in people with schizophrenia. METHODS:Using a double-blind, placebo-controlled, between-groups design, 57 non-treatment-seeking participants were randomized to receive 300 mg/day bupropion or placebo. One week later, participants were randomized to a contingency management (CM) intervention in which reductions in urinary cotinine levels were reinforced, or a non-contingent reinforcement (NR) condition in which session attendance was reinforced, regardless of cotinine level. Over the 22-day study period, participants visited the laboratory approximately three times per week to provide urine samples for analysis of cotinine levels, to give breath samples for analysis of carbon monoxide (CO) levels, and to report number of cigarettes smoked per day, nicotine withdrawal symptoms, cigarette craving, and psychiatric symptoms. RESULTS:Cotinine and CO levels significantly decreased during the study period in participants randomized to the CM condition, but not the NR condition. Bupropion did not reduce cotinine levels or increase the efficacy of CM. Cigarette craving and psychiatric symptom levels significantly decreased during the study in all groups. CONCLUSIONS:The results of this study indicate the efficacy and feasibility of this CM intervention for reducing smoking in individuals with schizophrenia.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Tidey JW,Rohsenow DJ,Kaplan GB,Swift RM,Reid Ndoi
10.1007/s00213-011-2282-8subject
Has Abstractpub_date
2011-09-01 00:00:00pages
279-87issue
2eissn
0033-3158issn
1432-2072journal_volume
217pub_type
杂志文章,随机对照试验abstract：RATIONALE:Acute alcohol intoxication induces a selective impairment of recognition memory associated with conscious recollection whilst recognition based on familiarity is left intact. OBJECTIVES:We aimed to further elucidate the acute effects of alcohol on recognition memory by assessing three different doses of alco...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-009-1709-y
更新日期：2010-01-01 00:00:00
abstract：RATIONALE:Developmental lead exposure may alter responsiveness to cocaine well into adulthood, and ultimately influence drug-use patterns. OBJECTIVES:The present study examined the effect of perinatal lead exposure on the discriminative stimulus properties of cocaine. METHODS:Female rats were treated with 0, 8, or 16...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100877
更新日期：2001-11-01 00:00:00
abstract：:The differential sensitivity of young and elderly healthy adults to the impairment effects of benzodiazepines was assessed by tasks with several levels of difficulty. Using a double-blind procedure, single doses of placebo, alprazolam (0.75 and 1.5 mg) and triazolam (0.25 and 0.5 mg) were ingested orally by 10 young m...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02245796
更新日期：1990-01-01 00:00:00
abstract：RATIONALE:Environmental context has been shown to influence responding under multiple schedules of food reinforcement and to modify the behavioral effects of drugs. However, no systematic study has been conducted under conditions of cocaine self-administration. The hypothesis was that changes in the magnitude of food r...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1202-3
更新日期：2002-10-01 00:00:00
abstract：RATIONALE:Tryptophan depletion is used to reduce central serotonergic function and to investigate its role in psychiatric illness. Despite widespread clinical use, its effects on serotonin (5-HT) receptors have not been well characterized. OBJECTIVE:The aim of this study was to examine the effect of acute (ATD) and ch...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0635-5
更新日期：2007-03-01 00:00:00
abstract：:The purpose of this review was to establish in vivo apparent pA2 and pKB values for antagonism of the discriminative stimulus effects of benzodiazepine ligands, and to compare these values to those obtained from other behavioral procedures. Articles were chosen from the Medline data base from January 1976 to August 19...
journal_title：Psychopharmacology
pub_type： 杂志文章,meta分析
doi：10.1007/s002130050103
更新日期：1996-11-01 00:00:00
abstract：:Methamphetamine (MAP: 1 and 2 mg/kg SC) and caffeine (CAF: 1, 3, 10 and 30 mg/kg SC) dose-dependently increased ambulation in mice. Repeated administration (5 times at 3 to 4-day intervals) of MAP, but not CAF, induced sensitization to its effect. Furthermore, the mice repeatedly receiving CAF showed no significant ch...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245053
更新日期：1994-10-01 00:00:00
abstract：RATIONALE:Caffeine is present in many widely consumed drinks and some foods. In the fairly extensive literature on the psychostimulant effects of caffeine, there are few dose-response studies and even fewer studies of the effects of doses of caffeine lower than 50 mg (the range of the amounts of caffeine contained in, ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000506
更新日期：2000-10-01 00:00:00
abstract：:This study describes specific behaviours in guinea-pigs after dopamine D-1 and D-2 receptor activation which differed to those described in other rodent species. Intraperitoneal (IP) administration of the dopamine D-2 receptor agonist quinpirole (1.5, 3 and 6 mg/kg) to guinea-pigs dose-dependently initiated locomotor ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244179
更新日期：1991-01-01 00:00:00
abstract：INTRODUCTION:The objective of this study was to examine age-, hormone-, and sex-dependent differences to the behavioral effects of nicotine using place-conditioning procedures in female rats. METHODS:Animals received nicotine in their initially non-preferred side and saline on alternate days in their initially preferr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-009-1607-3
更新日期：2009-10-01 00:00:00
abstract：:In mice that were scored for the length of time they remained immobile in awkward postures (cataleptic) on an inclined wire grid, a large IP dose of pilocarpine (80 mg/kg) caused a clear catalepsy, which was prevented by both dopamine agonists that were tested, apomorphine (4 or 8 mg/kg, IP) and bromocriptine (8 mg/kg...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431769
更新日期：1985-01-01 00:00:00
abstract：RATIONALE:Serotonin and especially serotonin 2A (5-HT(2A)) receptor signaling are important in the etiology and treatment of schizophrenia and affective disorders. We previously reported a novel 5-HT(2A) receptor effector, increased transglutaminase (TGase)-catalyzed transamidation, and activation of the small G protei...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1984-7
更新日期：2011-02-01 00:00:00
abstract：:Chronic treatment of rats with the antipsychotic drug molindone (2.5 mg/kg) did not elicit behavioral supersensitivity to apomorphine (AP) (0.25 mg/kg) or increased striatal 3H-spiroperidol binding, whereas treatment with haloperidol (0.5-1.0 mg/kg) produced manifestations of dopaminergic supersensitivity in both para...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432549
更新日期：1982-01-01 00:00:00
abstract：:Shaking movements of the body, similar to that made by a dog when wet ('wet-dog shakes'), occur in rats in response to pharmacological stimuli and in response to stimuli associated with cold and skin irritation. In this study, shaking movements, elicited by a variety of stimuli, were inhibited by central administratio...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00429002
更新日期：1983-01-01 00:00:00
abstract：RATIONALE:The role of endogenous opiate systems in cigarette smoking remains unclear. In laboratory animals, opiate antagonists block many of the effects of nicotine, but in humans they do not consistently alter smoking behavior. OBJECTIVE:This study explored the effects of naltrexone, alone and in combination with ni...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s002130050957
更新日期：1999-04-01 00:00:00
abstract：:The effects of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801, on cocaine self-administration were investigated. Forty-six male Wistar rats were trained to intravenously self-administer four unit doses of cocaine (0.19, 0.38, 0.75 and 1.5 mg/kg per injection) on a progressive-ratio schedule...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050113
更新日期：1996-11-01 00:00:00
abstract：RATIONALE:Varenicline is believed to work, in part, by reducing craving responses to smoking cues and by reducing general levels of craving; however, these hypotheses have never been evaluated with craving assessed in the natural environments of treatment-seeking smokers. OBJECTIVES:Ecological momentary assessment pro...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-012-2698-9
更新日期：2012-09-01 00:00:00
abstract：RATIONALE:Marijuana and alcohol, when used separately and in combination, contribute to automobile accidents and failed sobriety tests of standing balance. However, the extent to which the drugs have additive effects on both of these measures is unknown. OBJECTIVES:This study was designed to compare directly the separ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-002-1124-0
更新日期：2002-10-01 00:00:00
abstract：INTRODUCTION:The majority of individuals who suffer an episode of depression go on to experience recurrences. We have proposed, based upon the observation that reducing serotonin via acute tryptophan depletion (ATD) is more likely to induce negative mood in recovered depressed individuals than never depressed individua...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-009-1533-4
更新日期：2009-08-01 00:00:00
abstract：:In order to assess the possible effects of central GABA activation on the consolidation of shock avoidance, the GABA-T inhibitor amino-oxyacetic acid (AOAA) was administered posttrial to adult male rats. Learning was assessed over nine widely spaced sessions of 20 trials each. AOAA-treated animals showed learning with...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431848
更新日期：1978-03-01 00:00:00
abstract：:Aniamls were administered increasing doses of morphine for 16 days. During withdrawal they were challenged with an apomorphine ester or lergotrile. These dopamine agonists produced quantitatively different effects on behaviour. The results suggest that chronic morphine administration leads to dopamine supersensitivity...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433570
更新日期：1979-05-15 00:00:00
abstract：RATIONALE:Nicotine and nicotinic agonists have been shown to improve attentional function. Nicotinic receptors are easily desensitized, and all nicotinic agonists are also desensitizing agents. Although both receptor activation and desensitization are components of the mechanism that mediates the overall effects of nic...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2895-6
更新日期：2013-03-01 00:00:00
abstract：:A recent study from our laboratory has demonstrated that C57BL/6 male mice that are chronically injected with nicotine develop a profound tolerance to nicotine that is not associated with changes in brain nicotinic receptors. We have proposed that alterations in the secretion of corticosterone (CCS) may regulate toler...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245877
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:Benzodiazepine agonists characteristically increase food intake in humans and non-human subjects, and the underlying mechanisms of this effect are not understood completely. OBJECTIVE:Compounds with selectivity for GABAA receptor subtypes were used to evaluate the role of GABAA receptors containing alpha1 an...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0431-2
更新日期：2006-08-01 00:00:00
abstract：RATIONALE AND OBJECTIVE:Schizophrenia displays sex differences in many aspects. Decreased brain-derived neurotrophic factor (BDNF) levels have been reported to be associated with high body weight or obesity as well as other psychopathological aspects in schizophrenia patients. This study aimed to explore sex difference...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5107-1
更新日期：2019-02-01 00:00:00
abstract：RATIONALE:Dopamine (DA) D2-like antagonists block several effects of cocaine, including its locomotor stimulant and interoceptive discriminative-stimulus effects. Because these compounds generally lack selectivity among the D2-like DA receptors, the specific roles of the subtypes remain unclear. OBJECTIVES:DA D2 recep...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1142-y
更新日期：2002-08-01 00:00:00
abstract：:Lithium elicits opposite effects on two behavioural syndromes in rats: enhancement of the 5-HT1A-linked serotonin syndrome and attenuation of the 5-HT2-linked wet dog shakes. The ability of intracerebroventricular (ICV) myo-inositol or forskolin to reverse the enhancement of the serotonin syndrome by lithium was teste...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245842
更新日期：1995-03-01 00:00:00
abstract：:Using a conditioned avoidance procedure in rats, the present study examined the ability of 8-OH-DPAT, ritanserin, and prazosin to alter the effects of the dopamine antagonists, raclopride and haloperidol, on avoidance- and on escape responding. The 5-HT1A agonist 8-OH-DPAT (0.16 mg/kg) significantly enhanced the inhib...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050124
更新日期：1996-11-01 00:00:00
abstract：RATIONALE:Elevated whole-blood serotonin (5-HT) is a robust biomarker in ~ 30% of patients with autism spectrum disorders, in which repetitive behavior is a core symptom. Furthermore, elevated whole-blood 5-HT has also been described in patients with pediatric obsessive-compulsive disorder. The 5-HT1B receptor is assoc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05758-8
更新日期：2021-01-29 00:00:00
abstract：RATIONALE:Pramipexole is a dopamine agonist which binds selectively to dopamine D(3) and D(2) receptors. There is evidence that, in addition to its beneficial effects in parkinsonism, this compound may also be of value in addressing symptomatology associated with depressive diseases. OBJECTIVES:The present study was a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1199-7
更新日期：2002-10-01 00:00:00
