Abstract：
:Rats were treated once with doses of haloperidol or of droperidol below and above the acute ID50 vs the dopamine agonist apomorphine; they were later challenged with an acute dose of apomorphine (0.3 mg/kg, SC) and rated for stereotyped behavioral responses. The two neuroleptics were similar in acute anti-apomorphine potency (ID50 = 0.12 and 0.18 mg/kg for haloperidol and droperidol, respectively). The antidopaminergic effects of droperidol persisted for nearly 1 week and those of haloperidol lasted for 20-40 days, depending on the dose given. The computed half-time of disappearance of their antidopaminergic effects was 7.6 +/- 1.0 days and 0.59 +/- 0.17 days for haloperidol and droperidol, respectively, following a dose of 0.3 mg/kg, and these indices of duration of action did not vary significantly at doses between 0.1 and 1.0 mg/kg. Haloperidol reduced the acute entry of 3H-apomorphine into brain by 21.5% 1 week later. Treatment with apomorphine alone just prior to haloperidol (both at 0.3 mg/kg) prevented the prolonged antidopaminergic effects of the neuroleptic evaluated 1 week later. These results indicate that some neuroleptics may have very prolonged activity or retention in tissue at sites of action, even after moderate, single doses. Caution is recommended in the interpretation of studies which assume "neuroleptic-free" conditions of subjects previously exposed to a neuroleptic agent.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Campbell A,Baldessarini RJ,Teicher MH,Kula NSdoi
10.1007/BF00431801subject
Has Abstractpub_date
1985-01-01 00:00:00pages
161-6issue
2eissn
0033-3158issn
1432-2072journal_volume
87pub_type
杂志文章abstract：RATIONALE:Temporal differentiation in the free-operant psychophysical procedure is sensitive to the 5-hydroxytryptamine (5-HT)1A receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) and the 5-HT2 receptor agonist 2,5-dimethoxy-4-iodo-amphetamine (DOI); both drugs shift the psychophysical curve leftwards...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1871-1
更新日期：2004-11-01 00:00:00
abstract：:In a series of experiments, rats received the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK-801 and measures were made of motor behavior, spatial navigation in a swimming pool, and electroencephalographic (EEG) activity. High doses (0.25-10 mg/kg IV) produced somnolence and akinesia, impaired food consumpti...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00441949
更新日期：1989-01-01 00:00:00
abstract：RATIONALE:Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects. OBJECTIVES:This double-blind study evaluated the acute and longer-term psychological effects of a high dose of psilocybin relative to a comparison compound administer...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-006-0457-5
更新日期：2006-08-01 00:00:00
abstract：:Pigeons trained to discriminate between the presence and absence of delta 9-THC (0.56 mg/kg, IM, intramuscularly) were tested with diazepam (5.6-30 mg/kg), administered IG (intragastrically), and were found to generalize the response associated with the THC training to the diazepam treatment only to a limited extent. ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00174684
更新日期：1988-01-01 00:00:00
abstract：RATIONALE:The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors. Different studies have demonstrated intracellular calcium (Ca(2+))-dependent activation of the PKA cascade after ethanol administration. Thu...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3610-6
更新日期：2014-12-01 00:00:00
abstract：:The in vivo potency of mazindol for binding to striatal dopamine transporters (DAT) was assessed by [123I]beta-CIT ([123I]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane) single photon emission computed tomography (SPECT). Cocaine-dependent subjects (n = 12) underwent three SPECT scans; one before, between, and after s...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s002130050625
更新日期：1998-06-01 00:00:00
abstract：RATIONALE:The dopaminergic system, particularly D2-like dopamine receptors, has been strongly implicated in reward processing. Animal studies have emphasized the role of phasic dopamine (DA) signaling in reward-related learning, but these processes remain largely unexplored in humans. OBJECTIVES:To evaluate the effect...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-007-0957-y
更新日期：2008-02-01 00:00:00
abstract：RATIONALE:Higher rates of delay discounting, or impulsive choice, may be related to relapse during abstinence reinforcement interventions for cigarette smoking, and a transdermal nicotine patch may attenuate delay discounting. OBJECTIVE:The objectives of this study are to assess the relation between delay discounting ...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-006-0627-5
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVES:Although cocaine use has been linked to sexual HIV risk behavior for decades, the direct effects of cocaine on sexual desire and sexual decision-making are unexamined. Research suggests delay discounting (devaluation of future outcomes) and probability discounting (devaluation of uncertain outcomes) play rol...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4493-5
更新日期：2017-02-01 00:00:00
abstract：RATIONALE:Carbon monoxide synthetized by inducible heme oxygenase (HO-1) exerts potent anti-inflammatory and antinociceptive effects during acute and neuropathic pain, but its role in the modulation of chronic inflammatory pain and the possible involvement of nitric oxide in this action remain unknown. OBJECTIVES AND ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3302-7
更新日期：2014-03-01 00:00:00
abstract：:In order to validate a new animal model predictive of the profile of antiepileptic drugs, we studied the antagonism by standard antiepileptics of the EEG modifications induced by low-speed IV infusion of pentylenetetrazol (PTZ) in rats. The activity of the drugs was measured by their effects on temporal characteristic...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432718
更新日期：1985-01-01 00:00:00
abstract：RATIONALE:Numerous preclinical and clinical studies have reported the rapid and sustained antidepressant effects of the NMDA receptor antagonist ketamine. Because ketamine induces several undesirable and dangerous effects, a variety of strategies have been suggested to avoid such effects. OBJECTIVES:Here, we propose t...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4325-7
更新日期：2016-08-01 00:00:00
abstract：:This was a 4-week, three-center, double-blind, randomized, parallel, placebo-controlled evaluation of the efficacy and safety of bupropion in hospitalized depressed patients. Results from 27 placebo and 48 bupropion-treated patients were analyzed for efficacy and safety. Assessments of efficacy and safety were made at...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00433415
更新日期：1983-01-01 00:00:00
abstract：:Adult female offspring of C57BL/6J mice injected daily with phenobarbital for the last third of pregnancy were more active than control offspring during a 3-min test period in an open field arena, thus confirming previous reports of lasting effects of prenatal exposure to phenobarbital. These offspring habituated less...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432745
更新日期：1981-01-01 00:00:00
abstract：RATIONALE:An acute challenge with delta-9-tetrahydrocannabinol (THC) can induce psychotic symptoms including delusions. High electroencephalography (EEG) frequencies, above 20 Hz, have previously been implicated in psychosis and schizophrenia. OBJECTIVES:The objective of this study is to determine the effect of intrav...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3684-1
更新日期：2015-02-01 00:00:00
abstract：RATIONALE:Central application of MTII, a melanocortin 3/4 receptor agonist, reduces food intake. The behavioral mechanisms underlying the anorexia, however, have not been evaluated. OBJECTIVES:We examined the ingestive behavioral effects of MTII at the microstructural level using two complementary approaches. METHODS...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1022-5
更新日期：2002-04-01 00:00:00
abstract：RATIONALE:Several antipsychotic drugs are metabolised by the polymorphic cytochrome P(450) CYP2D6. The impact of the polymorphism on the plasma levels and the occurrence of side effects have not been clearly established. OBJECTIVE:To investigate the impact of the CYP2D6 polymorphism on the steady-state plasma concentr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1059-5
更新日期：2002-06-01 00:00:00
abstract：:Intraperitoneal (IP) administration of the acetylcholinesterase inhibitor, soman (10-40 micrograms/kg), suppressed in a dose-related manner response rates in rats maintained under a multiple fixed-interval 50-s fixed-ratio 25 schedule of food delivery. Chronic administration of soman at weekly intervals resulted in to...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427899
更新日期：1985-01-01 00:00:00
abstract：:Chronic treatment of rats with the antipsychotic drug molindone (2.5 mg/kg) did not elicit behavioral supersensitivity to apomorphine (AP) (0.25 mg/kg) or increased striatal 3H-spiroperidol binding, whereas treatment with haloperidol (0.5-1.0 mg/kg) produced manifestations of dopaminergic supersensitivity in both para...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432549
更新日期：1982-01-01 00:00:00
abstract：RATIONALE:Partial dopamine receptor agonists have been proposed as candidate pharmacotherapies for cocaine dependence. OBJECTIVE:This 42-day, within-subject, human laboratory study assessed how maintenance on aripiprazole, a partial D(2) receptor agonist, influenced smoked cocaine self-administration, cardiovascular m...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-011-2231-6
更新日期：2011-08-01 00:00:00
abstract：RATIONALE:Atypical antipsychotic drugs are classically associated with lower propensity to extrapyramidal symptoms (EPS) and hyperprolactinemia than typical antipsychotic drugs. It has not been clarified why some atypical antipsychotic drugs, such as amisulpride, induce prolactin plasma concentration (PRL) elevation, b...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1826-6
更新日期：2004-09-01 00:00:00
abstract：RATIONALE:Depressive disorders are conditions that often require continuous treatment, and it is therefore important to evaluate the consequences of prolonged administration. There are few studies assessing cognitive functions of depressed patients after long-term use of antidepressants. OBJECTIVES:This study evaluate...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-0274-2
更新日期：2006-03-01 00:00:00
abstract：:The effects of vitamin B12 are compared to those of aspirin and 0.9% saline in three different experimental pain models in rats and mice; an electric shock test, the hot-plate test, and the phenylbenzoquinone writhing test. Neither cyanocobalamin nor hydroxocobalamin showed any antinociceptive activity in any of the t...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427267
更新日期：1983-01-01 00:00:00
abstract：RATIONALE:Previous work has shown that environmental enrichment alters amphetamine-induced locomotor activity and conditioned place preference. OBJECTIVE:The present study examined the effect of environmental enrichment on amphetamine self-administration. METHODS:Female and male rats were raised from 21 days of age i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100720
更新日期：2001-05-01 00:00:00
abstract：:An experiment was carried out in the pigeon to assess the effects of sodium amylobarbitone (SAB) on memory, using a delayed pair comparison task. Performance was disrupted at all delays by doses of 10 and 20 mg/kg SAB and it was concluded that this effect was not due to perceptual impairment or stereotyped responding,...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426038
更新日期：1979-03-29 00:00:00
abstract：:The present study employed an animal model of drug relapse in which previously extinguished heroin self-administration behavior was reinstated following a single reinforced trial. Male albino rats were trained to traverse a straight-alley for a reinforcer consisting of a single IV injection of 0.06 mg/kg diacetylmorph...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246658
更新日期：1996-04-01 00:00:00
abstract：RATIONALE:Clinical trials show that chronic cocaine users suffer from sleep disturbances and preclinical research has shown that acute sleep deprivation increases the rate of cocaine self-administration in rats. OBJECTIVE:This study examined the effect of cocaine self-administration on behavioral indices of sleep and ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3101-1
更新日期：2013-09-01 00:00:00
abstract：RATIONALE:Noncontingent administration of amphetamine into the ventral striatum or systemic nicotine increases responses rewarded by inconsequential visual stimuli. When these drugs are contingently administered, rats learn to self-administer them. We recently found that rats self-administer the GABA(B) receptor agonis...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-011-2450-x
更新日期：2012-03-01 00:00:00
abstract：RATIONALE:Prepulse inhibition (PPI) of the startle reflex is a model of pre-attentional inhibitory function. The dopamine baseline in the nucleus accumbens plays a key role in PPI regulation as well as in the rewarding effects of cocaine. OBJECTIVES:The aim of this study was to evaluate the predictive ability of PPI t...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-4959-8
更新日期：2018-09-01 00:00:00
abstract：RATIONALE:Recent studies suggest that orexin/hypocretin is involved in drug reward and drug-seeking behaviors, including ethanol self-administration. However, orexin's role in ethanol-induced seeking behaviors remains unclear. OBJECTIVE:These studies examined the role of orexin in the acquisition and expression of eth...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-2082-6
更新日期：2011-04-01 00:00:00
