Synergistic interaction between baclofen administration into the median raphe nucleus and inconsequential visual stimuli on investigatory behavior of rats.

abstract：RATIONALE:Antidepressants (ADs) are slow to produce their therapeutic effect. This long latency promotes the development of new strategies to short their onset of action. Previous reports indicated that 17beta-estradiol (E(2)) promotes the antidepressant-like activity of fluoxetine (FLX) and desipramine (DMI) in the fo...

journal_title：Psychopharmacology

authors： Estrada-Camarena E,Rivera NM,Berlanga C,Fernández-Guasti A

更新日期：2008-12-01 00:00:00

abstract：RATIONALE:Research in pediatric psychopharmacology has expanded considerably in the last 10 years. Still, controversy remains about the effectiveness and safety of commonly used psychotropics and their role in child treatment, thus pointing to the need for more in-depth and targeted investigations. OBJECTIVES:To revie...

journal_title：Psychopharmacology

authors： Vitiello B

更新日期：2007-03-01 00:00:00

abstract：:The predatory behavior of ferrets (Putorius putorius furo L.) consists mainly of instinctive behavioral patterns that are elicited by simple external stimuli. For the ferret, the time needed to catch and kill rats depends on the size of the rats in relation to that of the ferret. Killing success decreases with a relat...

journal_title：Psychopharmacology

authors： Apfelbach R

更新日期：1978-10-31 00:00:00

abstract：:Changes in smooth pursuit eye tracking of targets moving sinusoidally in horizontal and vertical planes before and after up to 10 mg oral methadone were measured electrooculographically in nontolerant nondependent humans. Methadone depressed the gain of horizontal tracking movements at most frequencies tested (0.2 - 1...

journal_title：Psychopharmacology

authors： Rothenberg S,Schottenfeld S,Selkoe D,Gross K

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Understanding of the mechanisms of biotransformation of antidepressant drugs, and of their capacity to interact with other medications, is of direct relevance to rational clinical psychopharmacology. OBJECTIVES:To determine the human cytochromes P450 mediating the metabolism of nefazodone, and the inhibitory...

journal_title：Psychopharmacology

authors： von Moltke LL,Greenblatt DJ,Granda BW,Grassi JM,Schmider J,Harmatz JS,Shader RI

更新日期：1999-07-01 00:00:00

abstract：RATIONALE:New research findings in the field of neuroactive steroids strongly suggest that to understand their role in physiopathology, it is essential to accurately measure their tissue levels. Through his broad chemical expertise and extensive knowledge of steroids, Dr. Robert H. Purdy pioneered structure-activity re...

journal_title：Psychopharmacology

authors： Vallée M

更新日期：2014-09-01 00:00:00

abstract：RATIONALE:Previous studies have shown that the effect of setting on drug-taking is substance specific in both humans and rats. In particular, we have shown that when the setting of drug self-administration (SA) coincides with the home environment of the rats (resident rats), the rats tend to prefer heroin to cocaine. T...

journal_title：Psychopharmacology

authors： Montanari C,Stendardo E,De Luca MT,Meringolo M,Contu L,Badiani A

更新日期：2015-07-01 00:00:00

abstract：:Various doses of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, MK-801 (0.1-0.5 mg/kg) and ketamine (2.5-10 mg/kg), produced a dose-dependent increase in stereotypic behaviour in naive mice. MK-801 (0.1 mg/kg) and ketamine (2.5 mg/kg) potentiated the stereotypic response of apomorphine (0.1-0.5 ...

journal_title：Psychopharmacology

authors： Verma A,Kulkarni SK

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Nearly 60-80% of women experience some form of sadness, anxiety, or anhedonia in the weeks following the birth of a child (Patel et al. 23(2):534-42, 2012; Degner 10: 359;j4692, 2017); however, the exact mechanisms that precipitate these changes in mood postpartum are still unknown. It is well-known that the ...

journal_title：Psychopharmacology

authors： Gomez J,Haas NA,Schwarz JM

更新日期：2019-10-01 00:00:00

abstract：RATIONALE:Attention-deficit/hyperactivity disorder (ADHD) is thought to involve hypofunctional catecholamine systems in the striatum, nucleus accumbens, and prefrontal cortex (PFC); however, recent clinical evidence has implicated glutamate dysfunction in the pathophysiology of ADHD. Recent studies show that increased ...

journal_title：Psychopharmacology

authors： Miller EM,Pomerleau F,Huettl P,Gerhardt GA,Glaser PE

更新日期：2014-08-01 00:00:00

abstract：:The topography of stereotyped behaviour produced by apomorphine in rats was studied by using either a scoring system, based on observation in a wire cage, or by quantification of horizontal and vertical activities, and of the total distances run in an open field, using an automatic recording system. The latter design ...

journal_title：Psychopharmacology

authors： Havemann U,Magnus B,Möller HG,Kuschinsky K

更新日期：1986-01-01 00:00:00

abstract：:The effects of benzodiazepine (triazolam 0.25 and 0.50 mg) on different aspects of cognitive function were assessed. Triazolam impaired free recall and recognition of information presented after drug administration. In contrast to these impairments in explicit memory, a memory function that did not require conscious a...

journal_title：Psychopharmacology

authors： Weingartner HJ,Hommer D,Lister RG,Thompson K,Wolkowitz O

更新日期：1992-01-01 00:00:00

abstract：:Patients taking lithium often report difficulties in concentration, memory, learning, and attention and many of these complaints are verified on psychometric testing. Laboratory tests of cognitive functions in healthy volunteers on chronic lithium demonstrate that disruptions in memory-learning processes are apparent ...

journal_title：Psychopharmacology

authors： Weingartner H,Rudorfer MV,Linnoila M

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:The post-extinction exposure of rats to a sub-conditioning procedure (SCP; i.e., retraining with a shock intensity that is too weak to induce by itself significant fear conditioning) has been reported to provoke the reemergence of extinguished fear. This phenomenon can be prevented by chronic fluoxetine treat...

journal_title：Psychopharmacology

authors： Deschaux O,Zheng X,Lavigne J,Nachon O,Cleren C,Moreau JL,Garcia R

更新日期：2013-01-01 00:00:00

abstract：:In experiment 1, rats (n = 12) were trained to discriminate the benzodiazepine (BDZ) compound chlordiazepoxide (CDP, 20 mg/kg, IP) from saline in a two-lever food-reinforced procedure, and subsequently were tested for stimulus control with different doses of CDP, Ro 15-1788 (a proposed BDZ receptor antagonist) and Ro ...

journal_title：Psychopharmacology

authors： De Vry J,Slangen JL

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Asenapine, a psychopharmacologic agent developed for schizophrenia and bipolar disorder, has higher affinity for 5-HT(2A/C,6,7) and alpha(2) adrenergic receptors than for D(2) receptors. Asenapine exhibits potent antipsychotic-like effects without inducing catalepsy, increases cortical and subcortical dopamin...

journal_title：Psychopharmacology

authors： Frånberg O,Marcus MM,Ivanov V,Schilström B,Shahid M,Svensson TH

更新日期：2009-06-01 00:00:00

abstract：RATIONALE:Stimulation of central beta(2) adrenergic receptors produces antidepressant-like effects on behavior. At present, it is not known what brain sites are involved in mediating such effects, although some recent evidence suggests the importance of the dorsal hippocampus. OBJECTIVE:Experiments were carried out to...

journal_title：Psychopharmacology

authors： Zhang HT,Huang Y,O'Donnell JM

更新日期：2003-10-01 00:00:00

abstract：:Under the fixed-consecutive-number schedule (FCN), pigeons were reinforced for responding eight or more times on one response key (work key), and then responding once on a second response key. In one component of this schedule, an external stimulus signalled the completion of the response requirement on the work key (...

journal_title：Psychopharmacology

authors： Picker M,Dykstra LA

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Dopamine (DA) and glutamate (Glu) interactions in the mesocorticolimbic pathway may regulate motivation and reward and contribute to schizophrenia and drug abuse. We have recently demonstrated synergistic effects of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptor blockade and ...

journal_title：Psychopharmacology

authors： Clements RL,Greenshaw AJ

更新日期：2005-10-01 00:00:00

abstract：RATIONALE:Acute nicotine abstinence is associated with disruption of executive function and reward processes; however, the neurobiological basis of these effects has not been fully elucidated. METHODS:The effects of nicotine abstinence on brain function during reward-based probabilistic decision making were preliminar...

journal_title：Psychopharmacology

authors： Addicott MA,Baranger DA,Kozink RV,Smoski MJ,Dichter GS,McClernon FJ

更新日期：2012-01-01 00:00:00

abstract：:The present study was undertaken to evaluate the effects of single and repeated doses of triazolam (1 mg/kg IP) and desipramine (DMI) (10 mg/kg IP) alone and in combination on certain pharmacologic responses and brain catecholamine levels in rats. The significant findings were: (1) triazolam and DMI given alone and in...

journal_title：Psychopharmacology

authors： Kusaka M,Horikawa A,Meshi T,Maruyama Y

更新日期：1980-01-01 00:00:00

abstract：:There have been a number of claims that high-dose administration of cocaine to rats leads to neurotoxic effects on dopamine neurons. In this study possible neurotoxic effects on monoamine neurons were examined by measuring the effects of cocaine (35 mg/kg daily for 10 days) on the binding of radioligands to uptake sit...

journal_title：Psychopharmacology

authors： Benmansour S,Tejani-Butt SM,Hauptmann M,Brunswick DJ

更新日期：1992-01-01 00:00:00

abstract：:Quantitative receptor autoradiography was used to study the effects of the selective serotonin reuptake inhibitors citalopram and fluoxetine and the tricyclic antidepressant imipramine on the regulation of beta 1-adrenergic receptors in the rat brain. Rats were treated with saline, citalopram (10 mg kg-1), fluoxetine ...

journal_title：Psychopharmacology

authors： Pälvimäki EP,Laakso A,Kuoppamäki M,Syvälahti E,Hietala J

更新日期：1994-08-01 00:00:00

abstract：RATIONALE:Reelin, a large extracellular matrix glycoprotein, is down-regulated in the brain of schizophrenic patients and of heterozygous reeler mice (rl/+). The behavioral phenotype of rl/- mice, however, matches only partially the schizophrenia hallmarks. OBJECTIVES:We recently reported (Marrone et al., Eur J Neuros...

journal_title：Psychopharmacology

authors： Ammassari-Teule M,Sgobio C,Biamonte F,Marrone C,Mercuri NB,Keller F

更新日期：2009-06-01 00:00:00

abstract：:Rats were trained in a Y-maze on a two-choice simultaneous black-white discrimination with either black or white as S+. Animals were then transferred to one of three discrimination tasks. In task 1 (New S-), a new stimulus, either vertical or horizontal stripes, was substituted for the original S-. In task 2 (New S+),...

journal_title：Psychopharmacology

authors： Weiner I,Feldon J,Ben-Horin E

更新日期：1987-01-01 00:00:00

abstract：:Various dopamine receptor antagonists have divergent clinical and neurochemical properties. The relative ability of anticholinergics (benztropine and scopolamine) to reverse these drugs was assessed in squirrel monkeys and rats performing a Sidman avoidance task. In monkeys, benztropine markedly attenuated the effects...

journal_title：Psychopharmacology

authors： Liebman JM,Neale R,Noreika L,Braunwalder A

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Piper methysticum extract (kava kava) possesses numerous therapeutic properties, but it is unknown which of its principle constituents (kavalactones) subserve such effects. OBJECTIVES:This experiment sought to characterize the putative anxiolytic properties of P. methysticum extract and its six principle kav...

journal_title：Psychopharmacology

authors： Smith KK,Dharmaratne HR,Feltenstein MW,Broom SL,Roach JT,Nanayakkara NP,Khan IA,Sufka KJ

更新日期：2001-04-01 00:00:00

abstract：:Male Sprague-Dawley rats were evaluated between ages 18 and 825 days for responses to doses of haloperidol (0 and 0.05-10 mg/kg, IP). Catalepsy, ptosis, and inhibition of general motor activity showed steady decreases in sensitivity to the drug with age during the first 1.5 years of maturation, while rats older than 1...

journal_title：Psychopharmacology

authors： Campbell A,Baldessarini RJ

更新日期：1981-01-01 00:00:00

abstract：:Three recently arrived drug naive Cebus apella monkeys with "spontaneous" stereotyped oral movements were treated with apomorphine and haloperidol using a wide dose range. Low doses of apomorphine (0.05-0.1 mg/kg) suppressed the oral stereotypies without affecting normal behaviour such as grooming and scratching. High...

journal_title：Psychopharmacology

authors： Korsgaard S,Povlsen UJ,Randrup A

更新日期：1985-01-01 00:00:00

abstract：:Male rats of the Long-Evans strain were divided into two equal groups of nine each and given either 7.0 mg/kg trimethyltin (TMT) or 0.9% saline by intragastric gavage. The pattern of self-selection of alcohol in concentrations of 3%--30% was examined in both groups at 21 and 150 days following the gavage. The TMT-trea...

journal_title：Psychopharmacology

authors： Myers RD,Swartzwelder HS,Dyer RS

更新日期：1982-01-01 00:00:00