The role of PKC signaling in CRF-induced modulation of startle.

abstract：:The effects of pindolol on the prolactin (PRL) and growth hormone (GH) responses to intravenous tryptophan (LTP) were studied in eight healthy male volunteers. Pindolol pretreatment (40 mg over 48 h) markedly attenuated the GH response to LTP and modestly, but significantly, reduced the LTP-induced increase in plasma ...

journal_title：Psychopharmacology

authors： Smith CE,Ware CJ,Cowen PJ

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:The occurrence of methamphetamine (METH) use by the smoking route is increasing. A nonhuman primate model for examining the reinforcing effects of smoked METH would be valuable for testing potential interventions for treating METH abuse disorders. OBJECTIVE:The purpose of the present study was to examine the...

journal_title：Psychopharmacology

authors： Newman JL,Carroll ME

更新日期：2006-10-01 00:00:00

abstract：RATIONALE:The nicotine delivery rate is a key feature of tobacco product design, yet there have been limited human studies examining the effects of nicotine as a function of delivery rate. OBJECTIVE:We developed an intravenous nicotine infusion protocol to evaluate differential effects of nicotine delivery rate on sub...

journal_title：Psychopharmacology

authors： Jensen KP,Valentine G,Gueorguieva R,Sofuoglu M

更新日期：2020-05-01 00:00:00

abstract：:After publication of this paper, the authors determined an error in the calculation of the norepinephrine standard concentrations for the HPLC calibration curves. ...

journal_title：Psychopharmacology

authors： Shnitko TA,Taylor SC,Stringfield SJ,Zandy SL,Cofresí RU,Doherty JM,Lynch WB,Boettiger CA,Gonzales RA,Robinson DL

更新日期：2018-09-01 00:00:00

abstract：:Male Sprague-Dawley rats were evaluated between ages 18 and 825 days for responses to doses of haloperidol (0 and 0.05-10 mg/kg, IP). Catalepsy, ptosis, and inhibition of general motor activity showed steady decreases in sensitivity to the drug with age during the first 1.5 years of maturation, while rats older than 1...

journal_title：Psychopharmacology

authors： Campbell A,Baldessarini RJ

更新日期：1981-01-01 00:00:00

abstract：:The i.v. pentylenetetrazol seizure threshold was increased by 2.5 mg/kg and decreased by 15 mg/kg of a single (+)-amphetamine dose. After 7 consecutive days of amphetamine administration, tolerance developed to the decrease but not to the increase in seizure threshold. At 12--48 h after the last dose of 2.5 mg/kg seiz...

journal_title：Psychopharmacology

authors： Riffee WH,Gerald MC

更新日期：1977-01-31 00:00:00

abstract：INTRODUCTION:Genetic causes, or predisposition, are increasingly accepted to be part of the ethiopathogenesis of many neuropsychiatric diseases. While genes can be studied in any type of cells, their physiological function in human brain cells is difficult to evaluate, particularly in living subjects. METHODS:As a fir...

journal_title：Psychopharmacology

authors： Dage JL,Colvin EM,Fouillet A,Langron E,Roell WC,Li J,Mathur SX,Mogg AJ,Schmitt MG,Felder CC,Merchant KM,Isaac J,Broad LM,Sher E,Ursu D

更新日期：2014-03-01 00:00:00

abstract：:The novel nicotinic agonist 1-acetyl-4-methylpiperazine (AMP) has been studied in ligand-binding and behavioural studies. AMP methiodide potently inhibited [3H]-(-)-nicotine and [125I]-alpha-bungarotoxin binding to P2 membranes from rat brain and [125I]-alpha-bungarotoxin binding to rat skeletal muscles. AMP HCl also ...

journal_title：Psychopharmacology

authors： Garcha HS,Thomas P,Spivak CE,Wonnacott S,Stolerman IP

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:(+/-)-3,4-methylenedioxymethamphet-amine (MDMA; 'ecstasy'), a commonly used recreational drug, has typically been found to be related to poor cognitive function in humans. However, cannabis consumption may not have been adequately controlled for in these studies. OBJECTIVE:The present study was designed to f...

journal_title：Psychopharmacology

authors： Croft RJ,Mackay AJ,Mills AT,Gruzelier JG

更新日期：2001-01-01 00:00:00

abstract：RATIONALE:Atypical antipsychotic drugs are classically associated with lower propensity to extrapyramidal symptoms (EPS) and hyperprolactinemia than typical antipsychotic drugs. It has not been clarified why some atypical antipsychotic drugs, such as amisulpride, induce prolactin plasma concentration (PRL) elevation, b...

journal_title：Psychopharmacology

authors： Bressan RA,Erlandsson K,Spencer EP,Ell PJ,Pilowsky LS

更新日期：2004-09-01 00:00:00

abstract：:Ethologic analysis has been used to study the behavioural effects following injection of delta-aminolaevulinic acid (ALA) in mice. After a dose level of 1.6 mmol ALA/kg, male and female mice showed periods of immobility and scanned less frequently than saline-injected controls. Exploration of the cage was significantl...

journal_title：Psychopharmacology

authors： Cutler MG,Moore MR,Ewart FG

更新日期：1979-03-22 00:00:00

abstract：RATIONALE:Genetically determined differences in susceptibility to drug-induced sensitization could be related to risk for drug consumption. OBJECTIVES:Studies were performed to determine whether selective breeding could be used to create lines of mice with different magnitudes of locomotor sensitization to methampheta...

journal_title：Psychopharmacology

authors： Scibelli AC,McKinnon CS,Reed C,Burkhart-Kasch S,Li N,Baba H,Wheeler JM,Phillips TJ

更新日期：2011-04-01 00:00:00

abstract：RATIONALE:Glucocorticoids have been shown to affect declarative memory, an explicit form of memory for facts and events operated by medial temporal lobe structures. Recent neuroimaging data suggest that the medial temporal lobe (including the hippocampus) is also active in implicit sequence learning. OBJECTIVES:The ai...

journal_title：Psychopharmacology

authors： Römer S,Schulz A,Richter S,Lass-Hennemann J,Schächinger H

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:The rise in heroin addiction has heightened the need for novel and effective treatments. Physical exercise has been shown as an effective treatment for stimulant abuse in clinical and pre-clinical research. However, this treatment has not yet been tested on opioid addiction. This study examined the effects o...

journal_title：Psychopharmacology

authors： Smethells JR,Greer A,Dougen B,Carroll ME

更新日期：2020-02-01 00:00:00

abstract：RATIONALE:Pharmacological agents used in the treatment of anxiety have been reported to decrease threat relevant processing in patients and healthy controls, suggesting a potentially relevant mechanism of action. However, the effects of the anxiolytic diazepam have typically been examined at sedative doses, which do no...

journal_title：Psychopharmacology

authors： Murphy SE,Downham C,Cowen PJ,Harmer CJ

更新日期：2008-09-01 00:00:00

abstract：:In a one-trial step-through passive avoidance task, pretraining administration of ethanol was shown to decrease the latencies to step through at both training (day 1) and testing (day 2) for both rats and mice. A detailed analysis of these effects showed that they differed from those reported previously by others. The...

journal_title：Psychopharmacology

authors： Bammer G,Chesher GB

更新日期：1982-01-01 00:00:00

abstract：:The present study was undertaken to evaluate the effects of single and repeated doses of triazolam (1 mg/kg IP) and desipramine (DMI) (10 mg/kg IP) alone and in combination on certain pharmacologic responses and brain catecholamine levels in rats. The significant findings were: (1) triazolam and DMI given alone and in...

journal_title：Psychopharmacology

authors： Kusaka M,Horikawa A,Meshi T,Maruyama Y

更新日期：1980-01-01 00:00:00

abstract：:Naloxone, an opioid receptor antagonist, attenuates a wide range of behavioral effects of d-amphetamine, such as the stimulation of motor activity. To investigate the pharmacological selectivity of the naloxone/amphetamine interaction, we assessed the effects of naloxone (5.0 mg/kg SC) upon motor activity induced in r...

journal_title：Psychopharmacology

authors： Jones DN,Holtzman SG

更新日期：1994-03-01 00:00:00

abstract：RATIONALE:The zebrafish dopaminergic system is thought to be evolutionarily conserved and may be amenable to pharmacological manipulation using drugs developed for mammalian receptors. However, only few studies have examined the role of specific receptor subtypes in behaviour of adult zebrafish. OBJECTIVES:The objecti...

journal_title：Psychopharmacology

authors： Tran S,Nowicki M,Muraleetharan A,Gerlai R

更新日期：2015-02-01 00:00:00

abstract：:Pigeons trained under a two-key drug discrimination procedure eventually learned to discriminate 5 mg/kg phenytoin from saline injections. When 1.25-20 mg/kg doses of phenytoin were substituted for the training dose, the percentage of responses directed to the phenytoin-appropriate key varied directly with dose. Chlor...

journal_title：Psychopharmacology

authors： Krafft K,Cleary J,Poling A

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:There is evidence that events early in post-weaning life influence brain development and subsequent adult behaviour and therefore play an important role in the causation of certain psychiatric disorders in later life. Exposing rodents to stressors during the juvenile period has been suggested as a model of in...

journal_title：Psychopharmacology

authors： Peleg-Raibstein D,Feldon J

更新日期：2011-03-01 00:00:00

abstract：RATIONALE:The experience of strong traumata leads to the formation of enduring fear memories that may degenerate into post-traumatic stress disorder. One of the most successful treatments for this condition consists of extinction training during which the repeated exposure to trauma-inducing stimuli in a safe environme...

journal_title：Psychopharmacology

authors： Silva BA,Burns AM,Gräff J

更新日期：2019-01-01 00:00:00

abstract：RATIONALE:Concurrent abuse of cocaine and heroin is a common form of polydrug abuse, but the interactions between the reinforcing effects of cocaine and heroin are poorly understood. Dose-addition analysis is a tool for the quantitative assessment of drug interactions, but this analysis has not been applied to evaluati...

journal_title：Psychopharmacology

authors： Negus SS

更新日期：2005-06-01 00:00:00

abstract：RATIONALE:Abstinence from drug occurs in human addicts for several reasons, including the avoidance of adverse consequences. OBJECTIVES:To explore a model of drug use in the face of adverse consequences in rats through intermittent punishment of drug seeking and to investigate whether the ability to withhold seeking r...

journal_title：Psychopharmacology

authors： Pelloux Y,Everitt BJ,Dickinson A

更新日期：2007-09-01 00:00:00

abstract：RATIONALE:Dopamine innervation of the nucleus accumbens is thought to have a major role in the biological processes underlying cocaine self-administration. Recent data suggest that dopamine innervation of the ventral pallidum (VP) may also play an important role. OBJECTIVES:This experiment was initiated to assess extr...

journal_title：Psychopharmacology

authors： Sizemore GM,Co C,Smith JE

更新日期：2000-07-01 00:00:00

abstract：:Tolerance to nicotine occurs in mice after its chronic administration. This tolerance is accompanied by an up-regulation of nicotinic receptors as assessed by the binding of (3H)-nicotine and alpha-(125I)-bungarotoxin (BTX). Past studies (Marks et al. 1983, 1986) have shown that the increase in BTX binding sites is mo...

journal_title：Psychopharmacology

authors： Miner LL,Collins AC

更新日期：1988-01-01 00:00:00

abstract：:Food reward has been associated with activation of noradrenergic mechanisms in the brain. Using rats trained to press a lever for food reward, we have investigated the effects of 6-hydroxydopamine lesions, which severly depleted hypothalamic noradrenaline, on the willingness of the rats to press the lever for food rew...

journal_title：Psychopharmacology

authors： Kruk ZL,Millar J

更新日期：1979-06-28 00:00:00

abstract：RATIONALE:Brain reward pathways implicated in addiction appear to be less reactive in regular drug users; behavioural manifestations may include decreased sensitivity to natural reinforcers. OBJECTIVES:This study aimed to replicate earlier findings of abstinence-associated incentive motivation deficits in smokers and ...

journal_title：Psychopharmacology

authors： Dawkins L,Powell JH,West R,Powell J,Pickering A

更新日期：2006-12-01 00:00:00

abstract：RATIONALE:Psychomotor stimulants can induce psychotic states in humans that closely resemble those observed in patients with idiopathic schizophrenia. Attentional and sensorimotor gating impairments are observed in schizophrenic patients using the latent inhibition (LI) and prepulse inhibition (PPI) behavioral assays, ...

journal_title：Psychopharmacology

authors： Russig H,Murphy CA,Feldon J

更新日期：2003-09-01 00:00:00

abstract：RATIONALE:Impulsive behaviour is a component of psychiatric disorders such as bipolar disorder, attention deficit hyperactivity disorder (ADHD), or personality disorders. Most experimental studies on impulsive behaviour punish impulsive choices by loss or delay of reward. In the present study, impulsive behaviour was p...

journal_title：Psychopharmacology

authors： Evenden J,Ko T

更新日期：2005-07-01 00:00:00