Effects of delta-aminolaevulinic acid administration on social behaviour in the laboratory mouse.

abstract：:To investigate the role of D1 dopamine receptors in the discriminative stimulus effects of cocaine, two rhesus monkeys were trained in a two-lever, food-reinforced, drug discrimination paradigm to discriminate cocaine (0.2 mg/kg, IM) from saline. Administration of various doses of cocaine resulted in a dose-related in...

journal_title：Psychopharmacology

authors： Kleven MS,Anthony EW,Goldberg LI,Woolverton WL

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Clinical observations have shown that pain sensitivity is altered in some schizophrenic patients. OBJECTIVES:To study alterations in pain sensitivity, the ketamine model in schizophrenia research was employed. MATERIALS AND METHODS:Rats were subchronically injected with the dissociative anaesthetic ketamine...

journal_title：Psychopharmacology

authors： Becker A,Grecksch G,Schröder H

更新日期：2006-12-01 00:00:00

abstract：RATIONALE:Nicotine replacement is commonly used to treat tobacco use in heavy-drinking smokers. However, few studies have examined the effect of nicotine replacement on subjective and physiological responses to alcohol and alcohol drinking behavior. OBJECTIVE:The primary aim of this within-subject, double-blind study ...

journal_title：Psychopharmacology

authors： McKee SA,O'Malley SS,Shi J,Mase T,Krishnan-Sarin S

更新日期：2008-02-01 00:00:00

abstract：:In the majority of Parkinson's disease (PD) patients, long-term dopamine (DA) replacement therapy leads to dyskinesia characterized by abnormal involuntary movements (AIMs). There are various mechanisms of dyskinesia, such as the sensitization of striatal DA D1 receptors (D1R) and upregulation of DA D3 receptors (D3R)...

journal_title：Psychopharmacology

authors： Lanza K,Chemakin K,Lefkowitz S,Saito C,Chambers N,Bishop C

更新日期：2020-01-01 00:00:00

abstract：RATIONALE:We have shown that differences in the level of neural activation to stimuli associated with smoking vs. natural rewards, a biomarker related to reward sensitivity, predict treatment outcome. OBJECTIVES:This paper examined whether this biomarker moderates the impact of bupropion or varenicline on smoking cess...

journal_title：Psychopharmacology

authors： Cinciripini PM,Green CE,Robinson JD,Karam-Hage M,Engelmann JM,Minnix JA,Wetter DW,Versace F

更新日期：2017-06-01 00:00:00

abstract：:The modulation of spontaneous (social and individual) behaviour as a function of the age of the rat (1, 3, 6, 12, 18 and 24 months) and of scopolamine dose (0.1, 0.2, 0.3 and 0.5 mg/kg) was studied. Observations were conducted during the dark phase of the reverse light/dark schedule using a reintroduction procedure. R...

journal_title：Psychopharmacology

authors： Soffié M,Bronchart M

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Stress is associated with cognitive and emotional dysfunction, and increases risk for a variety of psychological disorders, including depression and posttraumatic stress disorder. Prefrontal cortex is critical for executive function and emotion regulation, is a target for stress hormones, and is implicated i...

journal_title：Psychopharmacology

authors： Wellman CL,Moench KM

更新日期：2019-01-01 00:00:00

abstract：RATIONALE:It has been proposed that brain aldehyde dehydrogenase (ALDH) plays a role in the modulation of some psychopharmacological effects of ethanol. Diethyldithiocarbamate (DDTC), an ALDH inhibitor, elevates blood acetaldehyde levels in the presence of ethanol. Concurrent administration with 4-methylpyrazole (4-MP)...

journal_title：Psychopharmacology

authors： Escarabajal MD,Aragon CM

更新日期：2002-04-01 00:00:00

abstract：RATIONALE:During the last few decades, alcohol use disorders (AUD) have reached an epidemic prevalence, yet social influences on alcoholism have not been fully addressed. Several factors can modulate alcohol intake. On one hand, stress can reinforce ethanol-induced behaviors and be an important component in AUD and alc...

journal_title：Psychopharmacology

authors： Bahi A,Dreyer JL

更新日期：2020-03-01 00:00:00

abstract：:Fifty-nine depressed female inpatients were treated with 100 mg amitriptyline (AMT) IM for 4 weeks. Depression ratings and determinations of the parent drug and nortriptyline (NT) were performed weekly. No direct relationship between plasma AMT + NT concentrations and therapeutic response was apparent, but beneficial ...

journal_title：Psychopharmacology

authors： Corona GL,Cucchi ML,Frattini P,Santagostino G,Schinelli S,Zerbi F,Savoldi F

更新日期：1990-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVE:Schizophrenia displays sex differences in many aspects. Decreased brain-derived neurotrophic factor (BDNF) levels have been reported to be associated with high body weight or obesity as well as other psychopathological aspects in schizophrenia patients. This study aimed to explore sex difference...

journal_title：Psychopharmacology

authors： Yang F,Wang K,Du X,Deng H,Wu HE,Yin G,Ning Y,Huang X,Teixeira AL,de Quevedo J,Soares JC,Li X,Lang X,Zhang XY

更新日期：2019-02-01 00:00:00

abstract：:Two experiments were conducted to study the effects of anxiogenic drugs on dopamine release and metabolism in nucleus accumbens. Microdialysis probes were implanted into the nucleus accumbens, and rats were tested the day after implantation. In the first experiment, groups of rats received injections of saline, 1.25 o...

journal_title：Psychopharmacology

authors： McCullough LD,Salamone JD

更新日期：1992-01-01 00:00:00

abstract：:Low doses of 8-OH-DPAT (62.5-250 micrograms/kg) were reinforcing in the place preference conditioning procedure, while a higher dose (1 mg/kg) supported a conditioned place aversion. The 5-HT synthesis inhibitor PCPA, and the DA antagonists pimozide and sulpiride, had no effect when administered alone, but abolished t...

journal_title：Psychopharmacology

authors： Papp M,Willner P

更新日期：1991-01-01 00:00:00

abstract：:Nine depressed patients were treated with alaproclate, a selective 5-HT uptake inhibitor, for 3 weeks in a dose of 400 mg daily. The pupillary responses to tyramine, phenylephrine, and pilocarpine eye drops were measured on consecutive days before, after 1 week and after 3 weeks of treatment. The tyramine-induced mydr...

journal_title：Psychopharmacology

authors： Thompson C,Checkley SA

更新日期：1985-01-01 00:00:00

abstract：:Administration of drugs that reduce the influence of dopamine at its receptor site can lead to postsynaptic supersensitivity, whereas treatment with dopamine (DA) agonists can cause postsynaptic subsensitivity. Both unaltered and enhanced postsynaptic responses to DA have been shown after pretreatment with DA agonists...

journal_title：Psychopharmacology

authors： Castro R,Abreu P,Calzadilla CH,Rodriguez M

更新日期：1985-01-01 00:00:00

abstract：:It has been proposed that serotonin (5-HT) antagonists counteract neuroleptic-induced extrapyramidal symptoms by disinhibition of dopamine activity. The effects of the 5-HT antagonist mianserin, the anticholinergic drug procyclidine and placebo were evaluated in 16 psychiatric patients with chronic neuroleptic-induced...

journal_title：Psychopharmacology

authors： Korsgaard S,Friis T

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Cotreatment with clorgyline shifts the development of sensitization to the D2/D3 dopamine receptor agonist quinpirole from locomotion to mouthing, an effect apparently unrelated to the monoamine oxidase inhibition property of clorgyline. This phenomenon was demonstrated in rats examined in small activity cham...

journal_title：Psychopharmacology

authors： Dvorkin A,Culver KE,Szechtman H

更新日期：2006-07-01 00:00:00

abstract：RATIONALE:Cortisol hypersecretion is regarded as important in the pathophysiology of major depression. However, recent studies in community-based samples have been inconclusive. OBJECTIVE:To determine whether acutely depressed, medication-free subjects show an exaggerated release of cortisol in saliva in relation to a...

journal_title：Psychopharmacology

authors： Bhagwagar Z,Hafizi S,Cowen PJ

更新日期：2005-10-01 00:00:00

abstract：RATIONALE:The precise neural circuitry that encodes fear memory and its extinction within the brain are not yet fully understood. Fearful memories can be persistent, resistant to extinction, and associated with psychiatric disorders, especially post-traumatic stress disorder (PTSD). Here, we investigated the microtopog...

journal_title：Psychopharmacology

authors： Jacques A,Chaaya N,Hettiarachchi C,Carmody ML,Beecher K,Belmer A,Chehrehasa F,Bartlett S,Battle AR,Johnson LR

更新日期：2019-01-01 00:00:00

abstract：RATIONALE:The party drug ecstasy is frequently used in combination with other drugs like marihuana and alcohol. In addition, a substantial proportion of the MDMA users has claimed to drive a car when under the influence of MDMA and/or other drugs. OBJECTIVE:To assess the effects of MDMA and alcohol, combined and alone...

journal_title：Psychopharmacology

authors： Kuypers KP,Samyn N,Ramaekers JG

更新日期：2006-09-01 00:00:00

abstract：:We examined whether any locus postsynaptic to the GABAergic striatonigral projection might be involved in the enhancement of behavioral response to dopaminergic stimulants induced by chronic treatment with either neuroleptic drugs or stimulants. Rats exposed chronically to either chlorpromazine or cocaine were tested ...

journal_title：Psychopharmacology

authors： Bachus SE,Gale K

更新日期：1988-01-01 00:00:00

abstract：:Buprenorphine, a partial mu opioid agonist, is an experimental medication under development for the treatment of opioid dependence as an alternative to methadone maintenance. The present study examined the relationship between level of opioid physical dependence and response to buprenorphine administration as part of ...

journal_title：Psychopharmacology

authors： Walsh SL,June HL,Schuh KJ,Preston KL,Bigelow GE,Stitzer ML

更新日期：1995-06-01 00:00:00

abstract：:Two groups of schizophrenic outpatients were treated with perphenazine decanoate (N = 20) and cis(z)-flupentixol decanoate (N = 24) respectively. Every 3 months the dose was gradually reduced until symptoms appeared that were suggestive of a prodromal phase of a psychotic episode. A slightly higher dose was then promp...

journal_title：Psychopharmacology

authors： Kistrup K,Gerlach J,Aaes-Jørgensen T,Larsen NE

更新日期：1991-01-01 00:00:00

abstract：:In squirrel monkeys trained to discriminate between two tones, morphine consistently increased the percent of response failures during tone periods; however, it had no consistent effect on the percent correct responses. In contrast, scopolamine decreased percent correct responses as well as increasing percent response...

journal_title：Psychopharmacology

authors： Milar KS,Dykstra LA

更新日期：1985-01-01 00:00:00

abstract：:Continuous low-level (0.825 mg/kg/h for 20 h) administration of AP through SC in-dwelling silicone reservoirs in the rat induced behavioral and biochemical changes that were similar to those induced by low levels (0.1 mg/kg) of acutely administered AP (decreased behavioral activity and decreased dopamine metabolism in...

journal_title：Psychopharmacology

authors： Davis RE,Sant WW,Ellison G

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:Ecstasy is a commonly used psychoactive drug with 3,4-methylenedioxymethamphetamine (MDMA) as the main content. Importantly, it has been suggested that use of MDMA may be neurotoxic particularly for serotonergic (5-hydroxytryptamine (5-HT)) neurons. In the past decades, several molecular imaging studies exami...

journal_title：Psychopharmacology

authors： Vegting Y,Reneman L,Booij J

更新日期：2016-10-01 00:00:00

abstract：RATIONALE:The effects of acute bouts of physical activity (PA) on Strength of Desire (SoD) and Desire to Smoke (DtS) using individual participant data (IPD) from 19 acute randomised controlled studies were quantified. However, there is a need to identify factors influencing this relationship. OBJECTIVES:To understand ...

journal_title：Psychopharmacology

authors： Haasova M,Warren FC,Ussher M,Janse Van Rensburg K,Faulkner G,Cropley M,Byron-Daniel J,Everson-Hock ES,Oh H,Taylor AH

更新日期：2014-04-01 00:00:00

abstract：RATIONALE:3-(4-Fluorophenylselenyl)-2,5-diphenylselenophene (F-DPS) is a promising organoselenium compound that shows antidepressant-like properties related to interaction with the serotonergic system. OBJECTIVES:In this study, a mouse model of anxiety/depressant-like behavior induced by long-term corticosterone treat...

journal_title：Psychopharmacology

authors： Gai BM,Bortolatto CF,Heck SO,Stein AL,Duarte MM,Zeni G,Nogueira CW

更新日期：2014-05-01 00:00:00

abstract：:Plasma fluphenazine levels and plasma total neuroleptic activity (as quantitated by the neuroleptic receptor binding assay) were related to therapeutic response in 15 DSM-III schizophrenic patients who received a predetermined, fixed dose of fluphenazine for 14 days. Mean neuroleptic activity of the plasma was 84% gre...

journal_title：Psychopharmacology

authors： Hitzemann RJ,Garver DL,Mavroidis M,Hirschowitz J,Zemlan FP

更新日期：1986-01-01 00:00:00

abstract：:In the studies reported here, we investigated the effects of nicotine on memory for unrelated word lists. Nicotine was delivered through cigarette smoking, and memory performance was assessed using both intentional and incidental recall tasks, and employing an additional, indirect measure of memory. We report the resu...

journal_title：Psychopharmacology

authors： Rusted J,Graupner L,Warburton D

更新日期：1995-06-01 00:00:00