The effects of morphine and scopolamine on auditory discrimination in squirrel monkeys.

abstract：:Rats were presented with noise bursts alone or noise bursts 60 ms after presentation of either a 60 dB or an 80 dB prepulse after injection of the dopamine agonists apomorphine (3 mg/kg) or d-amphetamine (4 mg/kg), the glycine antagonist strychnine (1.5 mg/kg) or the alpha 2 antagonist yohimbine (5 mg/kg). Presentatio...

journal_title：Psychopharmacology

authors： Davis M

更新日期：1988-01-01 00:00:00

abstract：:The novel nicotinic agonist 1-acetyl-4-methylpiperazine (AMP) has been studied in ligand-binding and behavioural studies. AMP methiodide potently inhibited [3H]-(-)-nicotine and [125I]-alpha-bungarotoxin binding to P2 membranes from rat brain and [125I]-alpha-bungarotoxin binding to rat skeletal muscles. AMP HCl also ...

journal_title：Psychopharmacology

authors： Garcha HS,Thomas P,Spivak CE,Wonnacott S,Stolerman IP

更新日期：1993-01-01 00:00:00

abstract：:The effect of lithium on serotonin (5-HT)-mediated responses in the brain was assessed by measuring changes in the prolactin (PRL) and growth hormone (GH) responses to L-tryptophan (LTP) in eight normal subjects. On the 4th day of lithium treatment the PRL responses were significantly enhanced, and this enhancement wa...

journal_title：Psychopharmacology

authors： Glue PW,Cowen PJ,Nutt DJ,Kolakowska T,Grahame-Smith DG

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Training in research ethics is crucial for psychiatric investigators. Addressing ethical dimensions of human subjects research requires knowledge about the rules and norms governing research; sensitivity to ethical implications of actions; and skills in ethics problem solving. Investigators in training who ar...

journal_title：Psychopharmacology

authors： Chen DT

更新日期：2003-12-01 00:00:00

abstract：:The differential sensitivity of young and elderly healthy adults to the impairment effects of benzodiazepines was assessed by tasks with several levels of difficulty. Using a double-blind procedure, single doses of placebo, alprazolam (0.75 and 1.5 mg) and triazolam (0.25 and 0.5 mg) were ingested orally by 10 young m...

journal_title：Psychopharmacology

authors： Nikaido AM,Ellinwood EH Jr,Heatherly DG,Gupta SK

更新日期：1990-01-01 00:00:00

abstract：:Corticotropin releasing factor (CRF), a neuropeptide secreted by hypothalamic and extrahypothalamic neurons, is thought to mediate stress-related behaviors. The tension reduction hypothesis suggests that ethanol drinking reduces stress; that drinking is reinforced by this reduced stress; and that the probability of dr...

journal_title：Psychopharmacology

authors： Bell SM,Reynolds JG,Thiele TE,Gan J,Figlewicz DP,Woods SC

更新日期：1998-09-01 00:00:00

abstract：:The effects of pindolol on the prolactin (PRL) and growth hormone (GH) responses to intravenous tryptophan (LTP) were studied in eight healthy male volunteers. Pindolol pretreatment (40 mg over 48 h) markedly attenuated the GH response to LTP and modestly, but significantly, reduced the LTP-induced increase in plasma ...

journal_title：Psychopharmacology

authors： Smith CE,Ware CJ,Cowen PJ

更新日期：1991-01-01 00:00:00

abstract：:Pretreatment of rats with hydantoin (75 mg/kg, PO, an anticonvulsant), trihexyphenidyl (10 mg/kg, SC, a muscarinic cholinergic antagonist), or piperonyl butoxide (500 mg/kg, PO, a metabolic inhibitor) had no effect on the whole blood or brain tissue levels of orally administered DDT (75 mg/kg) or its metabolites DDD a...

journal_title：Psychopharmacology

authors： Herr DW,Hong JS,Chen P,Tilson HA,Harry GJ

更新日期：1986-01-01 00:00:00

abstract：:Animal and human studies have demonstrated that, depending upon the sequence of alcohol presentation, long-term memory of events can either be enhanced or diminished. In the present study a similar phenomenon is demonstrated in the neuronal excitability of slices of hippocampus from guinea pig brains. Alcohol given af...

journal_title：Psychopharmacology

authors： Oliver AP,Parker ES,Wyatt RJ

更新日期：1984-01-01 00:00:00

abstract：:Most post-mortem autoradiographic studies have described striatal dopamine D(2) receptor up-regulation due to chronic neuroleptic exposure. The aim of our study was to compare in-vivo striatal D(2) receptor density in neuroleptic-naive and neuroleptic-free schizophrenic patients. We included 28 young (mean age: 28+/-8...

journal_title：Psychopharmacology

authors： Lomeña F,Catafau AM,Parellada E,Bernardo M,Font M,Gutiérrez F,Pavía J

更新日期：2004-03-01 00:00:00

abstract：RATIONALE:The motivational impetuses underlying self-administration of cocaine and other drugs of abuse are not fully understood. One emerging factor is affect. Both positive and negative affective states have been hypothesized to influence drug seeking and drug taking. In parallel, it has been posited that the ultraso...

journal_title：Psychopharmacology

authors： Barker DJ,Root DH,Ma S,Jha S,Megehee L,Pawlak AP,West MO

更新日期：2010-09-01 00:00:00

abstract：RATIONALE:Central cannabinoid systems have been implicated in appetite regulation through the hyperphagic effects of exogenous and endogenous cannabinoids. These effects may involve activation of reward systems and be mediated in part by opioidergic processes. OBJECTIVE:Cannabinoid-opioid interactions in feeding were ...

journal_title：Psychopharmacology

authors： Kirkham TC,Williams CM

更新日期：2001-01-01 00:00:00

abstract：:Pigs trained to avoid shocks by crossing a barrier in a shuttle-box according to a continuous avoidance procedure were submitted to a Pavlovian discriminative fear-conditioning procedure in which a tone was always followed by unavoidable shock (CS+) and another tone never followed by shock (CS-). The presentation of t...

journal_title：Psychopharmacology

authors： Dantzer R,Mormede P

更新日期：1976-08-26 00:00:00

abstract：:Rats chronically treated with increasing daily doses of delta 9-tetrahydrocannabinol (delta 9-THC) for up to 5 or 10 days exhibit a withdrawal-like behavioural response when challenged with clomipramine, a potent inhibitor of serotonin (5-hydroxytryptamine) reuptake, at the time when the next injection of delta 9-THC ...

journal_title：Psychopharmacology

authors： Verberne AJ,Taylor DA,Fennessy MR

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Electrophysiological studies have identified a scalp potential, the late positive potential (LPP), which is modulated by the emotional intensity of observed stimuli. Previous work has shown that the LPP reflects the modulation of activity in extrastriate visual cortical structures, but little is known about t...

journal_title：Psychopharmacology

authors： de Rover M,Brown SB,Boot N,Hajcak G,van Noorden MS,van der Wee NJ,Nieuwenhuis S

更新日期：2012-02-01 00:00:00

abstract：:Male volunteer subjects smoked one marijuana cigarette containing 100, 200, or 250 micrograms/kg delta-9-tetrahydrocannabinol (THC) and were tested on three perceptual-motor performance measures related to driving. Performance was measured and blood samples were collected for 24 h after smoking. The covariation betwee...

journal_title：Psychopharmacology

authors： Barnett G,Licko V,Thompson T

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:Drugs that rapidly increase dopamine levels have an increased risk of abuse. Dasotraline (DAS) is a dopamine and norepinephrine reuptake inhibitor characterized by slow oral absorption with low potential for abuse. However, it remains unclear whether intravenous (i.v.) administration would facilitate the rapi...

journal_title：Psychopharmacology

authors： Lew R,Constantinescu CC,Holden D,Carson RE,Carroll V,Galluppi G,Koblan KS,Hopkins SC

更新日期：2020-11-01 00:00:00

abstract：RATIONALE:Most adult smokers start smoking during their adolescence. This adolescent initiation may be due to multiple factors, but little evidence is available regarding whether their brains are differentially sensitive to the addictive effects of nicotine during adolescence. OBJECTIVE:To test the hypothesis that ado...

journal_title：Psychopharmacology

authors： Belluzzi JD,Lee AG,Oliff HS,Leslie FM

更新日期：2004-07-01 00:00:00

abstract：:The inferior colliculus is involved in conveying auditory information of an aversive nature to higher cortical structures. Gradual increases in the electrical stimulation of this structure produce progressive aversive responses from vigilance, through freezing, until escape. Recently, we have shown that microinjection...

journal_title：Psychopharmacology

authors： Pandossio JE,Brandão ML

更新日期：1999-03-01 00:00:00

abstract：:The purpose of this study was to examine the relationship between the development of tolerance to ethanol and the hypothalamic-pituitary-adrenal cortex (H-P-AC) system by modifying the H-P-AC system through the use of a synthetic glucocorticoid, dexamethasone. Also this study determined whether repeated drug administr...

journal_title：Psychopharmacology

authors： Wood WG

更新日期：1977-03-23 00:00:00

abstract：RATIONALE:Studies about whether or not the cognitive performance of women is influenced by changes in levels of sex steroid hormones across the menstrual cycle have produced ambiguous results. OBJECTIVES:This study tested whether flight simulator performance differs significantly between the menstrual and the luteal p...

journal_title：Psychopharmacology

authors： Mumenthaler MS,O'Hara R,Taylor JL,Friedman L,Yesavage JA

更新日期：2001-05-01 00:00:00

abstract：:The results confirm that NMDA receptor blockade can result in improved retention performance of mice in step-down passive avoidance. A series of behavioural variations and analyses revealed that memory in the task depended mainly on the appearance of the grid that had been associated with shock, rather than on the exe...

journal_title：Psychopharmacology

authors： Weiskrantz L,Mondadori C

更新日期：1991-01-01 00:00:00

abstract：:The present study was conducted to determine whether methadone maintenance alters the pharmacodynamic effects of single doses of cocaine. Twenty-two current users of IV cocaine who were not seeking treatment for their illicit cocaine use participated while living on a research unit. Eleven were maintained on methadone...

journal_title：Psychopharmacology

authors： Preston KL,Sullivan JT,Strain EC,Bigelow GE

更新日期：1996-01-01 00:00:00

abstract：RATIONALE:Executive function impairment, as classically assessed using the Wisconsin Card Sort Test or intradimensional/extradimensional tests, is a key feature of schizophrenia but remains inadequately treated by existing therapies. Recently, however, erythropoietin has been shown to improve attentional set-shifting p...

journal_title：Psychopharmacology

authors： Goetghebeur PJ,Lerdrup L,Sylvest A,Dias R

更新日期：2010-12-01 00:00:00

abstract：:Many behavioral effects of cocaine are attenuated by dopamine (DA) receptor antagonists. Yet, long-term DA antagonist administration enhances neuronal responsiveness to DA in several pathways, including the mesolimbic system. This study compared the effects of short-term versus long-term administration of the DA antag...

journal_title：Psychopharmacology

authors： Kosten TA,DeCaprio JL,Nestler EJ

更新日期：1996-12-01 00:00:00

abstract：:Intraperitoneal (IP) administration of the acetylcholinesterase inhibitor, soman (10-40 micrograms/kg), suppressed in a dose-related manner response rates in rats maintained under a multiple fixed-interval 50-s fixed-ratio 25 schedule of food delivery. Chronic administration of soman at weekly intervals resulted in to...

journal_title：Psychopharmacology

authors： Hymowitz N,Brezenoff HE,McGee J,Campbell K,Knight V

更新日期：1985-01-01 00:00:00

abstract：:Different groups of rats received combined or separate administration of different doses of piracetam (P1:100, P2:200, and P4:400 mg/kg) and choline (C1:100 and C2:200 mg/kg). Compared to control treatment, C1 significantly improved performance in a delayed alternation (DA) task, while P1, P2, P4 or P1C1 had no effect...

journal_title：Psychopharmacology

authors： Ennaceur A,Delacour J

更新日期：1987-01-01 00:00:00

abstract：:Platelet adenylate cyclase activity was measured in 16 control subjects and 16 patients who developed post-traumatic stress disorder (PTSD) as a result of damage inflicted on their homes during the Iraqi Scud missile attacks on Israel which occurred during the 1991 Gulf War. There were no differences in basal, NaF-sti...

journal_title：Psychopharmacology

authors： Weizmann R,Gur E,Laor N,Reiss A,Muller U,Yoresh A,Lerer B,Newman ME

更新日期：1994-04-01 00:00:00

abstract：RATIONALE:The endogenous cannabinoid system is thought to play a role in reinforcement processes. OBJECTIVES:We tested the effects of five doses of the cannabinoid receptor 1 (CB1) antagonist SR141716 [0, 0.3, 1, 3 and 10 mg/kg intraperitoneal (IP)] on intracranial self-stimulation at the level of the median forebrain...

journal_title：Psychopharmacology

authors： Deroche-Gamonet V,Le Moal M,Piazza PV,Soubrié P

更新日期：2001-09-01 00:00:00

abstract：:Augmentation with low-dose fluvoxamine (50-100 mg/day) to antipsychotic treatment may improve the negative symptoms in schizophrenic patients, but involves a risk of drug-drug interaction. We studied the effects of fluvoxamine on plasma concentrations of haloperidol and reduced haloperidol, and their clinical symptoms...

journal_title：Psychopharmacology

authors： Yasui-Furukori N,Kondo T,Mihara K,Inoue Y,Kaneko S

更新日期：2004-01-01 00:00:00