Increased or decreased locomotor response in rats following repeated administration of apomorphine depends on dosage interval.

abstract：:The serotonin 5-HT(3) receptor is thought to play a role in the reward pathway and drug abuse by modulating dopamine release within the mesolimbic pathway. Dopamine release stimulated by cocaine and methamphetamine is blocked by administration of 5-HT(3) receptor antagonists. Animal studies demonstrate that 5-HT(3) re...

journal_title：Psychopharmacology

authors： Allan AM,Galindo R,Chynoweth J,Engel SR,Savage DD

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:Recent data suggest that 5-HT7 receptors (5-HT7R) are involved in memory processes and, particularly, those related to novelty-induced arousal, even though this remains so far speculative and controversial. In order to assess the role of 5-HT7R in episodic-like memory, mice were administered 5-carboxamidotryp...

journal_title：Psychopharmacology

authors： Freret T,Paizanis E,Beaudet G,Gusmao-Montaigne A,Nee G,Dauphin F,Bouet V,Boulouard M

更新日期：2014-01-01 00:00:00

abstract：:A novel form of experimentally-induced conflict behavior based on the conditioned suppression of drinking (CSD) is described and compared with two conventional animal models of human anxiety--a modified Geller-Seifter and an Estes-Skinner (Conditioned Emotional Response) procedure. The CSD procedure offered significan...

journal_title：Psychopharmacology

authors： Kilts CD,Commissaris RL,Rech RH

更新日期：1981-01-01 00:00:00

abstract：:The effects of ethanol have been studied in three strains of mice (DBA 2J, albino, and C57 BL/6J) having different populations of opiate receptors. Acute ethanol treatment induces a significant increase in striatal dopamine metabolism only in the mouse strains (C57 and albino) that are rich in enkephalinergic receptor...

journal_title：Psychopharmacology

authors： Barbaccia ML,Reggiani A,Spano PF,Trabucchi M

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Past research has found that exposure to alcohol cues causes a narrowing of attentional scope and enhances the neural responses associated with approach motivation. OBJECTIVE:The current research sought to determine if a manipulated broadened (global) attentional scope would reduce approach-motivated neural ...

journal_title：Psychopharmacology

authors： Ryerson NC,Neal LB,Gable PA

更新日期：2017-04-01 00:00:00

abstract：:Chronic oral administration of cannabis extract to rats (daily delta 9-tetrahydrocannabinol dose 20 mg/kg) was examined in three experiments for its residual effect on radial-arm maze learning following a 1-month drug-free period. Learning a simple eight-arm maze was significantly impaired in rats treated for either 6...

journal_title：Psychopharmacology

authors： Stiglick A,Kalant H

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Dysfunction of executive neuropsychological performance, mediated by the prefrontal cortex, has been the central focus of recent attention deficit/ hyperkinetic disorder (AD-HKD) research. The role of other potential neuropsychological "risk factors", such as recognition memory, remains understudied. Further,...

journal_title：Psychopharmacology

authors： Rhodes SM,Coghill DR,Matthews K

更新日期：2004-09-01 00:00:00

abstract：:Growth hormone (hGH) responses to centrally acting dopamine agonists were used as indices of CNS dopaminergic function in order to test hypotheses implicating dopaminergic alteration in the etiopathology of schizophrenia. Apomorphine, a direct acting dopamine receptor agonist, and L-Dopa, an indirect agonist dependent...

journal_title：Psychopharmacology

authors： Rotrosen J,Angrist BM,Gershon S,Sachar EJ,Halpern FS

更新日期：1976-12-21 00:00:00

abstract：RATIONALE:Both central serotonergic and nicotinic systems play important roles in a variety of neurobehavioral functions; however, the interactions of these two systems have not been fully characterized. The current study served to determine the impact of a relatively selective 5-HT2A receptor antagonist, ketanserin, o...

journal_title：Psychopharmacology

authors： Rezvani AH,Caldwell DP,Levin ED

更新日期：2005-05-01 00:00:00

abstract：RATIONALE:Alteration of dopamine neurotransmission in the prefrontal cortex, especially hypofunction of dopamine D1 receptors, contributes to psychotic symptoms and cognitive deficit in schizophrenia. D1 receptors signal through the cAMP/PKA second messenger cascade, which is modulated by phosphodiesterase (PDE) enzyme...

journal_title：Psychopharmacology

authors： Kuroiwa M,Snyder GL,Shuto T,Fukuda A,Yanagawa Y,Benavides DR,Nairn AC,Bibb JA,Greengard P,Nishi A

更新日期：2012-02-01 00:00:00

abstract：:The administration of large doses of probenecid has been used to study the central nervous system metabolism of catecholamines and indoleamines in patients with affective disease. It has been reported that alterations of the binding of L-tryptophan to plasma albumin binding sites occur during probenecid administration...

journal_title：Psychopharmacology

authors： Dunner DL,Heiber S,Perel JM

更新日期：1977-08-16 00:00:00

abstract：RATIONALE:Despite animal evidence that methylenedioxymethamphetamine (ecstasy) causes lasting damage in brain regions related to long-term memory, results regarding human memory performance have been variable. This variability may reflect the cognitive complexity of the memory tasks. However, previous studies have test...

journal_title：Psychopharmacology

authors： Brown J,McKone E,Ward J

更新日期：2010-03-01 00:00:00

abstract：:Effects of two dosages of rubidium chloride on exploration, locomotion, rearing and immobility were assessed for male and female rats in an exploration box and an open field. In contrast to previous findings, rubidium was found to decrease locomotion and rearing in the exploratory box, and also to decrease locomotion ...

journal_title：Psychopharmacology

authors： Syme GJ,Syme LA

更新日期：1979-03-22 00:00:00

abstract：:The results confirm that NMDA receptor blockade can result in improved retention performance of mice in step-down passive avoidance. A series of behavioural variations and analyses revealed that memory in the task depended mainly on the appearance of the grid that had been associated with shock, rather than on the exe...

journal_title：Psychopharmacology

authors： Weiskrantz L,Mondadori C

更新日期：1991-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:We previously found that systemic injections of the 5-HT uptake blocker fluoxetine attenuate intermittent footshock stress-induced reinstatement of alcohol seeking in rats, while inhibition of 5-HT neurons in the median raphe induces reinstatement of alcohol seeking. In this study, we further e...

journal_title：Psychopharmacology

authors： Lê AD,Funk D,Harding S,Juzytsch W,Fletcher PJ,Shaham Y

更新日期：2006-05-01 00:00:00

abstract：:Oral administration of the serotonin (5-HT) precursor L-5-hydroxytryptophan (5-HTP), 200 mg, significantly increased plasma cortisol levels in man. L-5-HTP had no significant effect on the plasma prolactin levels. A borderline effect of 5-HTP on plasma ACTH levels was found. Pretreatment with the 5-HT2/5-HT1c antagoni...

journal_title：Psychopharmacology

authors： Lee MA,Nash JF,Barnes M,Meltzer HY

更新日期：1991-01-01 00:00:00

abstract：:In the forced swimming-induced immobility (despair) test model, adenosine, and 2-chloroadenosine treatment prolonged the immobilization period in mice. Dipyridamole, which is known to inhibit adenosine uptake, potentiated the adenosine effect. The purinoceptor antagonists caffeine and theophylline blocked purine nucle...

journal_title：Psychopharmacology

authors： Kulkarni SK,Mehta AK

更新日期：1985-01-01 00:00:00

abstract：:Shaking movements of the body, similar to that made by a dog when wet ('wet-dog shakes'), occur in rats in response to pharmacological stimuli and in response to stimuli associated with cold and skin irritation. In this study, shaking movements, elicited by a variety of stimuli, were inhibited by central administratio...

journal_title：Psychopharmacology

authors： Wei ET

更新日期：1983-01-01 00:00:00

abstract：:ApolipoproteinE (ApoE) genotype has recently been identified as a major risk factor for Alzheimer's disease (AD) but the mechanism(s) by which ApoE isoforms influence this disease remain unclear. Recent studies suggest that mice deficient in ApoE may exhibit impaired central cholinergic function. Since this neurotrans...

journal_title：Psychopharmacology

authors： Anderson R,Higgins GA

更新日期：1997-07-01 00:00:00

abstract：:A modified hyponeophagia test is described as an animal model of anxiety. The effects of 0, 0.3, 1.0, 3.0 and 10 mg/kg diazepam, given both acutely and for 7 days pretest, were assessed in rats. Acutely, diazepam reduced hyponeophagia over the dose range 0.3-3.0 mg/kg but 10.0 mg/kg produced sedation and large variabi...

journal_title：Psychopharmacology

authors： Shephard RA,Broadhurst PL

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Limited access nicotine self-administration decreases hippocampal neurogenesis, providing a mechanism for the deleterious effects of nicotine on hippocampal neuronal plasticity. However, recent studies have shown that limited access nicotine self-administration does not exhibit key features of nicotine depend...

journal_title：Psychopharmacology

authors： Cohen A,Soleiman MT,Talia R,Koob GF,George O,Mandyam CD

更新日期：2015-01-01 00:00:00

abstract：:The binding kinetics of tritiated quinuclidinyl benzilate (QNB) were studied in membrane preparations from human parotid and rabbit submandibular glands. Inhibition of 3H-QNB was then used to compare the anticholinergic activity of lofepramine, desipramine, imipramine and amitriptyline for muscarinic receptor in the s...

journal_title：Psychopharmacology

authors： Batra S,Biörklund A

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects. OBJECTIVES:This double-blind study evaluated the acute and longer-term psychological effects of a high dose of psilocybin relative to a comparison compound administer...

journal_title：Psychopharmacology

authors： Griffiths RR,Richards WA,McCann U,Jesse R

更新日期：2006-08-01 00:00:00

abstract：RATIONALE:Cocaine (COC), ethanol (EtOH), and methamphetamine (MA) are widely abused substances and share the ability to induce behavioral stimulation in mice and humans. Understanding the biological basis of behavioral stimulation to COC, EtOH, and MA may provide a greater understanding of drug and alcohol abuse. OBJE...

journal_title：Psychopharmacology

authors： Kamens HM,Phillips TJ

更新日期：2008-02-01 00:00:00

abstract：RATIONALE:The P3 is a ubiquitous component of stimulus-driven neural activity that can be observed in scalp electrophysiological recordings. Multiple lines of evidence suggest an important role for the noradrenergic system in the generation of the P3. However, pharmacological studies of the P3 using noradrenergic manip...

journal_title：Psychopharmacology

authors： de Rover M,Brown SB,Band GP,Giltay EJ,van Noorden MS,van der Wee NJ,Nieuwenhuis S

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:This study aims to conduct an evidence review of the effectiveness, harms, and cost-effectiveness of pharmacogenomics-guided antidepressant treatment for major depressive disorder. METHODS:We searched MEDLINE®, the Cochrane Central Registry of Controlled Trials, and PsycINFO through February 2017. We used pr...

journal_title：Psychopharmacology

authors： Peterson K,Dieperink E,Anderson J,Boundy E,Ferguson L,Helfand M

更新日期：2017-06-01 00:00:00

abstract：RATIONALE:Many of the biochemical, physiological, and behavioral effects of ethanol are known to be mediated by ionotropic glutamate receptors. Emerging evidence implicates metabotropic glutamate receptors (mGluRs) in the biobehavioral effects of ethanol and other drugs of abuse, but there is little information regardi...

journal_title：Psychopharmacology

authors： Hodge CW,Miles MF,Sharko AC,Stevenson RA,Hillmann JR,Lepoutre V,Besheer J,Schroeder JP

更新日期：2006-01-01 00:00:00

abstract：:The novel nicotinic agonist 1-acetyl-4-methylpiperazine (AMP) has been studied in ligand-binding and behavioural studies. AMP methiodide potently inhibited [3H]-(-)-nicotine and [125I]-alpha-bungarotoxin binding to P2 membranes from rat brain and [125I]-alpha-bungarotoxin binding to rat skeletal muscles. AMP HCl also ...

journal_title：Psychopharmacology

authors： Garcha HS,Thomas P,Spivak CE,Wonnacott S,Stolerman IP

更新日期：1993-01-01 00:00:00

abstract：:Two principal oblique factors are identified in the Bass Social Acquiescence Scale, a measure previously shown to correlate positively with placebo response and negatively with anxiolytic drug response. The two factors appeared very similar in separate analyses of data from samples of 941 psychiatric outpatients and 1...

journal_title：Psychopharmacology

authors： McNair DM,Barrett JE

更新日期：1979-10-01 00:00:00

abstract：:A novel self-stimulation methodology involving a fixed-interval (FI-5 s) schedule of reinforcement, microanalysis and threshold evaluation was used to investigate the effects of cocaine on rats lever pressing for electrical stimulation of the prefrontal cortex. Cocaine (15 mg/kg) increased medial prefrontal cortex (MP...

journal_title：Psychopharmacology

authors： McGregor IS,Atrens DM,Jackson DM

更新日期：1992-01-01 00:00:00