Abstract:
:The binding kinetics of tritiated quinuclidinyl benzilate (QNB) were studied in membrane preparations from human parotid and rabbit submandibular glands. Inhibition of 3H-QNB was then used to compare the anticholinergic activity of lofepramine, desipramine, imipramine and amitriptyline for muscarinic receptor in the salivary glands. The apparent dissociation constant (KD) for 3H-QNB binding in human parotid and rabbit submandibular gland was 33 and 61 pM and the Bmax value 507 and 169 f mol/mg protein, respectively. The mean values for the inhibition constant (Ki) for lofepramine, desipramine, imipramine and amitriptyline in human parotid gland were 285, 135, 102 and 13 nM, respectively. Very similar values were obtained for the rabbit submandibular gland. The binding affinity of tricyclic antidepressants for muscarinic cholinergic receptor sites in human parotid gland closely paralleled clinical data on the inhibition of salivary flow by these drugs.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Batra S,Biörklund Adoi
10.1007/BF00172861subject
Has Abstractpub_date
1986-01-01 00:00:00pages
1-4issue
1eissn
0033-3158issn
1432-2072journal_volume
90pub_type
杂志文章abstract::The behavioral responsiveness to challenge doses of the D2 agonist quinpirole was examined in 21-day-old normal offspring (experiment 1) as well as offspring exposed gestationally to cocaine (experiment 2). In both experiments weanling rats received a subcutaneous injection of 0 (0.9% saline), 0.04, 0.08, 0.5, or 1.0 ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245109
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:Approximately 20 million adults in the USA have an alcohol use disorder (AUD). There are clinical and preclinical data suggesting that psychedelics may have benefits for AUD. OBJECTIVE:To investigate the effects of the synthetic psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) on the behavioral effects of e...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05328-7
更新日期:2019-12-01 00:00:00
abstract::Risperidone, a new antipsychotic agent, was studied for its effects on spontaneous motor activity in rats in comparison with haloperidol. Motor activity was recorded via the optical scanning technique (horizontal and vertical activity) and via a recently developed technique based on the piezo-electric principle which,...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00172961
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:3,4-methylenedioxymethamphetamine (MDMA, ecstasy) produces an acute release of 5-HT in the brain, together with increased locomotion and hyperthermia. OBJECTIVE:This study examined whether the acute functional changes of locomotor activity and body temperature are related to enhanced 5-HT release induced by ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1921-9
更新日期:2011-02-01 00:00:00
abstract::Rats were trained on a fixed ratio 10, food-reinforced schedule to recognize a discriminative stimulus (DS) elicited by the selective serotonin (5-HT) reuptake inhibitor (SSRI), citalopram (2.5 mg/kg, IP). The preferential, high efficacy agonist at 5-HT2C receptors, Ro60-0175, dose-dependently generalized to citalopra...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050910
更新日期:1999-03-01 00:00:00
abstract:RATIONALE:Over the last decade, many new psychostimulant analogues have appeared on the recreational drug market and most are derivatives of amphetamine or cathinone. Another class of designer drugs is derived from the 2-aminoindan structural template. Several members of this class, including the parent compound 2-amin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05207-1
更新日期:2019-03-01 00:00:00
abstract:RATIONALE:N-methyl-D-aspartate (NMDA) receptor antagonists (e.g., PCP, ketamine) have been shown to impair learning/memory. Well documented in animal models, only limited research in humans has been reported. Findings to date are similar to results of animal studies; however, antagonists are typically administered befo...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-2179-5
更新日期:2005-07-01 00:00:00
abstract:RATIONALE:2-Bromoterguride, a dopamine D2 receptor partial agonist with antagonist properties at serotonin 5-HT2A receptors and α2C-adrenoceptors, meets the prerequisites of a putative atypical antipsychotic drug (APD). We recently showed that 2-bromoterguride is effective in tests of positive symptoms of schizophrenia...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4747-x
更新日期:2018-01-01 00:00:00
abstract:RATIONALE:Increased anxiety is a characteristic of the acute ethanol withdrawal syndrome. Repeated exposure of rats to withdrawal from chronic ethanol increases sensitivity to seizures. OBJECTIVES:We investigated whether repeated withdrawal experience increases withdrawal-induced anxiety and stress, and if it changes ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0301-3
更新日期:2006-04-01 00:00:00
abstract::There have been a number of claims that high-dose administration of cocaine to rats leads to neurotoxic effects on dopamine neurons. In this study possible neurotoxic effects on monoamine neurons were examined by measuring the effects of cocaine (35 mg/kg daily for 10 days) on the binding of radioligands to uptake sit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244815
更新日期:1992-01-01 00:00:00
abstract::Serotonin receptors of the 5HT2 type were labeled on platelet membranes using tritiated ketanserin. Blood was collected from the umbilical cord of newborns and venous samples were collected from 6-year-old children as well as junior-high and high school students (ages 13 through 18) to determine age-related changes in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245309
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:Observing responses bring sensory receptors into contact with environmental stimuli. In the observing-response procedure, periods in which an operant response (e.g. pressing a lever) is reinforced by drug deliveries alternate with periods in which this response is never reinforced (i.e. extinction). These alt...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1390-5
更新日期:2003-05-01 00:00:00
abstract:RATIONALE:Traditional remedies prepared from Ptychopetalum olacoides (PO) are used throughout the Amazon to alleviate age-related conditions. These formulas are mainly used by elders, and alleged effects may be related to the anticholinesterase properties identified in a standardized ethanol extract of this species [P....
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1272-y
更新日期:2009-01-01 00:00:00
abstract:RATIONALE:It has been demonstrated that major differences between mice of the C57BL/6J and DBA/2J inbred strains for amphetamine-induced place conditioning (preference and avoidance, respectively) are evident in standard housing conditions but abolished by temporary restricted feeding. This gene-experience model may be...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1647-z
更新日期:2004-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:Drug-associated memories are hypothesized to underlie the high risk of relapse in addiction. Recent studies show that post-retrieval extinction training erases fear memories by reconsolidation blockade. Here, we examine the efficacy of this non-invasive procedure in rats with drug-associated mem...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2545-4
更新日期:2012-05-01 00:00:00
abstract::Changes in saccadic eye movements before and after up to 10 mg oral diazepam were measured electrooculographically in diazepam-naive humans. Diazepam produced dose-dependent increases in saccade duration and decreases in maximum saccade velocity over a 2--36 degrees range of saccade amplitudes. The magnitude of drug-i...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00427100
更新日期:1981-01-01 00:00:00
abstract::Two experiments were carried out on pigeons to assess the effects of acute ethanol (ETOH) administration on a delayed pair comparison procedure. ETOH disrupted performance at the two higher doses (1.0 and 2.0 g/kg, given orally). When the initial (zero delay) performance levels of treated and untreated birds were equa...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00434411
更新日期:1980-01-01 00:00:00
abstract::The behavioural effects of selective mu-, kappa- and delta-opioid agonists in 5-, 10- and 20-day-old rats were investigated by observational analysis. The predominant response to mu-agonists was behavioural depression. High doses (10 mg/kg IP) of morphine and DAGO (D-Ala2, NMe-Phe4, Glyol5-enkephalin) produced overt s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439459
更新日期:1989-01-01 00:00:00
abstract::The anxiolytic activity of diazepam (DZP) (0.25-1 mg/kg) was investigated in streptozotocin (STZ)-induced diabetic adult Charles Foster albino rats of either sex. Diabetes was induced by injecting STZ IP (50 mg/kg; in citrate buffer, pH 4.5). Experiments were performed 72 h later. The rats were subjected to various an...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050523
更新日期:1998-02-01 00:00:00
abstract::A novel self-stimulation methodology involving a fixed-interval (FI-5 s) schedule of reinforcement, microanalysis and threshold evaluation was used to investigate the effects of cocaine on rats lever pressing for electrical stimulation of the prefrontal cortex. Cocaine (15 mg/kg) increased medial prefrontal cortex (MP...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02801979
更新日期:1992-01-01 00:00:00
abstract::The effects of a new alpha-2 adrenoceptor antagonist on erectile function was assessed in 12 normal volunteers (mean age 28.7, range 20-42), using a double blind, placebo controlled design with two doses of drug and three testing sessions. The drug was administered by intravenous infusion and erectile responses to ero...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245569
更新日期:1994-08-01 00:00:00
abstract:INTRODUCTION:Nearly 25% of American adults remain regular smokers. Current smokers may be especially likely to possess characteristics that impair their ability to quit, such as impulsivity. Impulsive individuals may be overly prone to smoke because they are particularly drawn to rewarding stimuli and related cues. The...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-007-0832-x
更新日期:2007-10-01 00:00:00
abstract:RATIONALE:The noradrenergic and dopaminergic systems are targets for antidepressants and are stimulated by serotonergic antidepressant drugs. The COMT enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Clinical studies on the effect of rs4680 on antidep...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1381-7
更新日期:2009-03-01 00:00:00
abstract::The benzodiazepines are typified by a profile of side effects which includes drowsiness, ataxia and incoordination. Ro 15-1788, an imidazodiazepine derivative, exhibits marked antagonism of the behavioural and biochemical effects of the benzodiazepines in animals and man. It is devoid of any behavioural activity in an...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00427969
更新日期:1983-01-01 00:00:00
abstract::Previous studies indicate that some aspects of endotoxin-induced sickness behavior in rats may be mediated by interleukin-1 stimulated events and can be attenuated by corticosteroids, cyclooxygenase inhibitors and the interleukin-1-receptor antagonist. In the current studies, we replicate and extend these findings in ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050353
更新日期:1997-08-01 00:00:00
abstract:RATIONALE:Schizophrenia is a severe, persistent, and fairly common mental illness. Haloperidol is widely used and is effective against the symptoms of psychosis seen in schizophrenia. Chronic oral haloperidol administration decreased the number of astrocytes in the parietal cortex of macaque monkeys (Konopaske et al., ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3136-3
更新日期:2013-11-01 00:00:00
abstract:RATIONALE:Exercise stimulates the release of endogenous opioid peptides and increases nociceptive (i.e. pain) thresholds in both human and animal subjects. During chronic, long-term exercise, sensitivity to the effects of morphine and other mu opioids decreases, leading some investigators to propose that exercise may l...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1471-5
更新日期:2003-08-01 00:00:00
abstract::Different groups of rats received combined or separate administration of different doses of piracetam (P1:100, P2:200, and P4:400 mg/kg) and choline (C1:100 and C2:200 mg/kg). Compared to control treatment, C1 significantly improved performance in a delayed alternation (DA) task, while P1, P2, P4 or P1C1 had no effect...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00215480
更新日期:1987-01-01 00:00:00
abstract::Various doses of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, MK-801 (0.1-0.5 mg/kg) and ketamine (2.5-10 mg/kg), produced a dose-dependent increase in stereotypic behaviour in naive mice. MK-801 (0.1 mg/kg) and ketamine (2.5 mg/kg) potentiated the stereotypic response of apomorphine (0.1-0.5 ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245171
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the relationship between zolpidem use and the risk of acute pancreatitis in Taiwan. METHODS:In this population-based case-control study using the database from the Taiwan National Health Insurance Program from 2000 to 2011, we selected 4535 subjects aged 20-84 years ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3833-6
更新日期:2015-06-01 00:00:00