Abstract:
:Growth hormone (hGH) responses to centrally acting dopamine agonists were used as indices of CNS dopaminergic function in order to test hypotheses implicating dopaminergic alteration in the etiopathology of schizophrenia. Apomorphine, a direct acting dopamine receptor agonist, and L-Dopa, an indirect agonist dependent upon presynaptic conversion to dopamine for its action, both elicited elevations in plasma hGH in most young male schizophrenic- and control-subjects. A highly significant difference was seen between the distribution of hGH responses to apomorphine for schizophrenics and that for controls. Unusually high hGH response to apomorphine was seen in schizophrenics who subsequently failed to respond to neuroleptic therapy; intermediate hGH response was seen in controls; and low hGH response was seen in subsequent neuroleptic responders; differences in hGH response were statistically significant for all intergroup comparisons. No such differences were seen between responses of individuals to L-Dopa and to apomorphine. The findings suggest that the variability of hGH response to apomorphine is a reflection of dopamine receptor sensitivity, and that this variability may be an index of non-endocrine related dopaminergic sensitivity. They are consistent with hypotheses relating schizophrenia to alteration in dopamine receptors, although the type of receptor and the direction of alteration may be complex.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Rotrosen J,Angrist BM,Gershon S,Sachar EJ,Halpern FSdoi
10.1007/BF00426313subject
Has Abstractpub_date
1976-12-21 00:00:00pages
1-7issue
1eissn
0033-3158issn
1432-2072journal_volume
51pub_type
杂志文章abstract:RATIONALE:There is an emerging body of evidence that implicates a crucial role of γ-aminobutyric acid subtype A (GABAA) receptors in modulating the rewarding effects of a number of abused drugs. Modulation of GABAA receptors may therefore represent a novel drug-class independent mechanism for the development of abuse t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4155-z
更新日期:2016-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00
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更新日期:2006-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF02244335
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pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00174698
更新日期:1988-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-3877-2
更新日期:2015-07-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2008-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00212851
更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00451687
更新日期:1989-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-006-0359-6
更新日期:2006-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-004-1921-8
更新日期:2004-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00427828
更新日期:1983-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF02246668
更新日期:1996-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-018-5135-x
更新日期:2019-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-008-1083-1
更新日期:2008-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00432365
更新日期:1980-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1393-3
更新日期:2009-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00423313
更新日期:1976-07-09 00:00:00
abstract::The effects of a new alpha-2 adrenoceptor antagonist on erectile function was assessed in 12 normal volunteers (mean age 28.7, range 20-42), using a double blind, placebo controlled design with two doses of drug and three testing sessions. The drug was administered by intravenous infusion and erectile responses to ero...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245569
更新日期:1994-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4361-3
更新日期:2016-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF00212837
更新日期:1988-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02247385
更新日期:1996-08-01 00:00:00
abstract::Monoamine neurotransmitter systems, along with cholinergic systems, are known to play important roles in cognition, and are disrupted in at least some patients with dementia of the Alzheimer type (DAT). This suggests that monoamine-enhancing drugs might ameliorate cognitive symptoms in certain patients with DAT. L-Dep...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00216016
更新日期:1987-01-01 00:00:00