Abstract：
:The behavioral effects of the benzodiazepine (BZP)-receptor partial inverse agonists, beta-CCE and FG 7142, are reviewed and the claim that these compounds possess "anxiogenic" properties is examined. Results obtained from human studies and global observations in animals, as well as those from experiments on aggression in animals or from studies of pentylenetetrazole discrimination cannot be considered conclusive. Contradictory findings have been obtained in studies using animal testing procedures derived from BZP-sensitive models of anxiety and in newer experimental situations and these are discussed from various theoretical perspectives: (1) the ability of the models to measure increased anxiety; (2) the possible ability of the drugs to reveal latent anxiety which generalizes from a punished to an otherwise non-fearful component of a testing procedure ("spreading anxiety"); (3) anxiety produced by a pro- or pre-convulsant state. Finally, several hypotheses are considered to account for the behavioral effects of beta-CCE and FG 7142 without assuming anxiogenic properties. These include the possible existence of different forms of anxiety, rate dependency, and drug-induced motivational changes. It is concluded that available data are insufficient to strongly support the notion that FG 7142 and beta-CCE are the anxiogenic drugs "par excellence" they are often claimed to be.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Thiébot MH,Soubrié P,Sanger Ddoi
10.1007/BF00212837subject
Has Abstractpub_date
1988-01-01 00:00:00pages
452-63issue
4eissn
0033-3158issn
1432-2072journal_volume
94pub_type
杂志文章,评审abstract：RATIONALE/OBJECTIVES:Both the neuropeptide S (NPS) system and antagonism at the adenosine A2A receptor (e.g., by caffeine) were found to play a crucial role in the mediation of arousal and anxiety/panic in animal and human studies. Furthermore, a complex interaction of the neuropeptide S and the adenosinergic system ha...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2678-0
更新日期：2012-08-01 00:00:00
abstract：:Brain 5-hydroxytryptamine (5-HT) was depleted in rats by intraventricular injection with 5,7-dihyroxytryptamine (5,7-DHT) prior to feeding rats a liquid diet containing ethanol. After withdrawal of ethanol, withdrawal reactions were significantly less severe in 5-HT-depleted rats than control rats. Sleeping times afte...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427597
更新日期：1980-01-01 00:00:00
abstract：:Nine depressed patients were treated with alaproclate, a selective 5-HT uptake inhibitor, for 3 weeks in a dose of 400 mg daily. The pupillary responses to tyramine, phenylephrine, and pilocarpine eye drops were measured on consecutive days before, after 1 week and after 3 weeks of treatment. The tyramine-induced mydr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427324
更新日期：1985-01-01 00:00:00
abstract：:Pigeons trained under a two-key drug discrimination procedure eventually learned to discriminate 5 mg/kg phenytoin from saline injections. When 1.25-20 mg/kg doses of phenytoin were substituted for the training dose, the percentage of responses directed to the phenytoin-appropriate key varied directly with dose. Chlor...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433021
更新日期：1983-01-01 00:00:00
abstract：:The study compares the behavioral profiles induced in rats (N = 118) by the D2-dopaminergic receptor agonist quinpirole (0.03 and 0.5 mg/kg), and the D1-agonist SKF38393 (1.25-40 mg/kg), and both agonists administered together. Locomotion and snout contact frequency were reduced by the low but increased by the high do...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244813
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:Perphenazine, a classical antipsychotic drug, has the potential to induce extrapyramidal side effects (EPS). Dopaminergic and serotonergic pathways are involved in the therapeutic and adverse effects of the drug. OBJECTIVES:To evaluate the impact of polymorphisms in the dopamine D(2) and D(3) and serotonin 2...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-006-0622-x
更新日期：2007-03-01 00:00:00
abstract：:The behavioral responses to separate and combined administration of the D1 agonist SKF-38393 and the D2 agonist quinpirole following acute dopamine (DA) depletion via alpha-methyl-p-tyrosine (AMPT) or AMPT/reserpine were examined in infant (10-day-old) and weanling (21-day-old) rat pups. At both ages, AMPT pretreatmen...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244963
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:The characterization of self-administration (SA) under extended access conditions is necessary for the development of addiction models. OBJECTIVE:The purposes of this experiment were to investigate: (1) dose effects on the initiation of cocaine SA under extended access conditions; (2) predictable individual ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100744
更新日期：2001-08-01 00:00:00
abstract：RATIONALE:Cocaethylene is a pharmacologically active homolog and metabolite of cocaine, formed by transesterification of cocaine in the presence of ethanol. Here we relate findings from a randomized, placebo-controlled, double-blind study in which we examined the physiological and subjective effects and pharmacokinetic...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002139900363
更新日期：2000-04-01 00:00:00
abstract：RATIONALE:Thousands of adolescents start smoking daily but information on the effects of tobacco exposure on this age group is scarce. Moreover, the available animal models rely on the effects of nicotine, neglecting other neuroactive components of tobacco. OBJECTIVES:We investigated the effects of exposure of adolesc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3801-1
更新日期：2015-05-01 00:00:00
abstract：RATIONALE:Convulsions associated with cocaine toxicity are a serious aspect of cocaine-related emergency room incidents. Seizures can result from a single high dose of cocaine, and evidence is accumulating that correlates repetitive administration of sub-convulsive doses of cocaine with a decreased seizure threshold, a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050027
更新日期：2000-01-01 00:00:00
abstract：RATIONALE:In Koriat's accessibility model (Koriat, Psychol Rev, 100:609-639, 1993; Koriat, J Exp Psychol Gen, 124:311-333, 1995), when a person fails to recall a required target, he or she can nevertheless provide some partial information about the target. Moreover, individuals are able to provide feeling-of-knowing (F...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-006-0492-2
更新日期：2006-11-01 00:00:00
abstract：:In squirrel monkeys trained to discriminate between two tones, morphine consistently increased the percent of response failures during tone periods; however, it had no consistent effect on the percent correct responses. In contrast, scopolamine decreased percent correct responses as well as increasing percent response...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00428404
更新日期：1985-01-01 00:00:00
abstract：OBJECTIVE:Several lines of evidence suggest that brain-derived neurotrophic factor (BDNF) plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. Schizophrenia has a range of cognitive deficits that may evolve from decreased BDNF, and this study examines this assoc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2643-y
更新日期：2012-07-01 00:00:00
abstract：RATIONALE:Neuromedin-U (NmU) is an agonist at NMU1R and NMU2R. The brain distribution of NmU and its receptors, in particular NMU2R, suggests widespread central roles for NmU. In agreement, centrally administered NmU affects feeding behaviour, energy expenditure and pituitary output. Further central nervous system (CNS...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1918-3
更新日期：2004-12-01 00:00:00
abstract：:The ability of delta 9-tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD), 11-OH THC and 8 alpha, 11-diOH THC to antagonise the abdominal constriction response in the mouse induced by formic acid, phenylquinone, 5-hydroxytryptamine, prostaglandin E1 (PGE1) and bradykinin was tested. THC was an effective a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432273
更新日期：1979-03-28 00:00:00
abstract：:Methaqualone produces a dose- and time-dependent increase in plasma corticosterone concentration in mice. Acute studies showed that this effect is largely independent of methaqualone-induced hypothermia but can be blocked by pretreatment with dexamethasone, thus demonstrating that the adrenal cortex is not being direc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426541
更新日期：1977-08-31 00:00:00
abstract：RATIONALE:A substantial body of research suggests that the neuropeptide oxytocin promotes social affiliative behaviors in a wide range of animals including humans. However, its antiaggressive action has not been unequivocally demonstrated in male laboratory rodents. OBJECTIVE:Our primary goal was to examine the putati...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3124-7
更新日期：2013-10-01 00:00:00
abstract：:The fatty acid specificity of the depressant actions associated with prostaglandin (PG) administration was studied in mice. Administration of PG-E2 (0.4 and 1.0 mg/kg) or PG-D2 (0.4 and 4 mg/kg) significantly potentiated pentobarbital sleeping time. Arachidonic acid (3.3 mg/kg) administration also significantly potent...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00555225
更新日期：1984-01-01 00:00:00
abstract：:Rats were made hyperphagic by 6-hydroxydopamine (6-OHDA) injected bilaterally into the ventral midbrain; then they were restricted to a 6 h/day feeding schedule and tested for appetite suppression with amphetamine and fenfluramine in randomized order. Amphetamine anorexia was diminished while fenfluramine anorexia was...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426393
更新日期：1984-01-01 00:00:00
abstract：:Serotonin is a neurotransmitter that is widely distributed throughout the central nervous system. The role of serotonin in schizophrenia is still unclear. Postmortem studies of serotonin receptor subtypes in schizophrenia have been inconclusive for the most part. The most promising findings involve a reduction in 5-HT...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/BF02245003
更新日期：1993-01-01 00:00:00
abstract：RATIONALE:The gut microbiota is increasingly recognized as a potential mediator of psychiatric diseases. Depressed patients have been shown to have a different microbiota composition compared with healthy controls, and several lines of research now aim to restore this dysbiosis. To develop novel treatments, preclinical...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5094-2
更新日期：2019-05-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Previous studies show that electrical stimulation of the ventral subiculum (vSub) can reinstate drug-seeking behavior in rats following extinction. This study examined whether vSub stimulation could also evoke reinitiation of d-amphetamine (d-AMPH) self-administration during voluntary abstinenc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1337-2
更新日期：2003-07-01 00:00:00
abstract：:The effect of the intravenous administration of ergot alkaloids on epileptic responses to intermittent photic stimulation )IPS) has been studied in adolescent baboons, Papio papio, from Senegal. Ergocornine, 1--2 mg/kg, produced marked autonomic and behavioural effects, slowed the EEG, and abolished myoclonic response...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426958
更新日期：1978-04-14 00:00:00
abstract：:Two experiments examined the effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid intake in water-deprived rats. In the first experiment, pretreatment with 3.0 or 10.0 mg/kg zolpidem IP was found to increase consumption of a novel glucose drink (3% d-glucose and 0.15 sodium saccharine w/v in wat...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245521
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:Although ethanol is frequently used in combination with other psychoactive drugs, the behavioral and pharmacological reasons for this form of polydrug abuse have not been well described. MATERIALS AND METHODS:Rhesus monkeys with indwelling intravenous catheters produced intravenous injections of ethanol (50...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-0809-9
更新日期：2007-09-01 00:00:00
abstract：:The effect of long-term treatment with clozapine in schizophrenia and schizoaffective disorder was evaluated in a retrospective study comprising 96 patients treated with the drug during the period 1974-1986 at the Psychiatric Research Center in Uppsala. All patients had previously been treated with different kinds of ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00442567
更新日期：1989-01-01 00:00:00
abstract：RATIONALE:The positive modulation of gamma-aminobutyric acid type-A (GABAA) receptors is a putative mechanism via which alcohol escalates aggressive behavior. Broad-spectrum benzodiazepine antagonists block alcohol-heightened aggression in rats and monkeys. However, the degree to which GABAA subunit composition plays a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1661-1
更新日期：2004-03-01 00:00:00
abstract：RATIONALE:Neuroactive derivatives of steroid hormones, neurosteroids, can act on GABAA receptors (GABAARs) to potentiate the effects of GABA on these receptors. Neurosteroids become elevated to physiologically relevant levels under conditions characterized by increased steroid hormones. There is considerable evidence f...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-013-3423-z
更新日期：2014-09-01 00:00:00
abstract：:The purpose of this study was to determine if multiple aspects of drug and food-reinforced behavior could be measured in a single study. Drug or food seeking can be observed under four conditions: 1) internal drug or food cues and external stimulus cues present; self-administration, 2) only internal cues present; prim...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050338
更新日期：1997-08-01 00:00:00
