Abstract:
:Pigeons trained under a two-key drug discrimination procedure eventually learned to discriminate 5 mg/kg phenytoin from saline injections. When 1.25-20 mg/kg doses of phenytoin were substituted for the training dose, the percentage of responses directed to the phenytoin-appropriate key varied directly with dose. Chlorpromazine, d-amphetamine, diazepam, and phenobarbital failed to produce phenytoin-like patterns of responding.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Krafft K,Cleary J,Poling Adoi
10.1007/BF00433021subject
Has Abstractpub_date
1983-01-01 00:00:00pages
82-3issue
1eissn
0033-3158issn
1432-2072journal_volume
79pub_type
杂志文章abstract:RATIONALE:A dopamine receptor 4 variable number tandem repeat (DRD4 VNTR) polymorphism has been related to reactivity to smoking cues among smokers, but the effect of this genetic variation on brain responses to smoking cues has not been evaluated. OBJECTIVES:The present study evaluated the relationship between carryi...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-007-0860-6
更新日期:2007-11-01 00:00:00
abstract:RATIONALE:Enhancement of dopamine (DA) release by corticosteroids may be of aetiological importance in substance misuse. OBJECTIVES:To examine the effect of sub-chronic administration of hydrocortisone on the response to amphetamine in healthy male volunteers. METHODS:Following baseline assessment, 20 volunteers were...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-003-1609-5
更新日期:2004-02-01 00:00:00
abstract::These experiments were undertaken to determine if local injection of pilocarpine in the neostriatum of the rat produces oral motor activities that are similar to those produced by systemic administration. In the first experiment, IP administration of 2.0-8.0 mg/kg pilocarpine increased chewing movements and tongue pro...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247136
更新日期:1990-01-01 00:00:00
abstract::Mood disorders, despite the widespread availability of monoamine-based antidepressant treatments, are associated with persistently high rates of disability, together with elevated rates of mortality due to suicide, cardiovascular disease, and other causes. The development of more effective treatments has been hindered...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-016-4214-0
更新日期:2016-05-01 00:00:00
abstract:RATIONALE:Dopaminergic therapy improves some cognitive functions and worsens others in patients with Parkinson's disease (PD). These paradoxical effects are explained by the dopamine overdose hypothesis, which proposes that effects of dopaminergic therapy on a cognitive function is determined by the baseline dopamine l...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-016-4322-x
更新日期:2016-07-01 00:00:00
abstract::The effects of the benzomorphan antagonist Mr 2266 and the selective delta-antagonist ICI 154,129 on the body weight gain of 6-day-old suckling rat pups was observed. Mr 2266 significantly reduced body weight gain in these animals, though ICI 154,129 had no affect on this variable. These findings suggest that mu- and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432046
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:Pindolol has been reported to shorten the onset of antidepressant action of selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) as well as to increase their efficacy. It has been postulated that pindolol enhances the antidepressant effect of SSRIs by blocking somatodendritic 5-HT1A aut...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000470
更新日期:2000-07-01 00:00:00
abstract::Keypecking in one group of pigeons was maintained under schedules in which food was presented only when a specified number of responses was followed by a 30-s pause without a response. d-Amphetamine and pentobarbital increased low rates of responding (and, thus, decreased food presentation) only after initial injectio...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426485
更新日期:1977-07-18 00:00:00
abstract:RATIONALE:Higher rates of delay discounting, or impulsive choice, may be related to relapse during abstinence reinforcement interventions for cigarette smoking, and a transdermal nicotine patch may attenuate delay discounting. OBJECTIVE:The objectives of this study are to assess the relation between delay discounting ...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-006-0627-5
更新日期:2007-03-01 00:00:00
abstract:INTRODUCTION:The majority of individuals who suffer an episode of depression go on to experience recurrences. We have proposed, based upon the observation that reducing serotonin via acute tryptophan depletion (ATD) is more likely to induce negative mood in recovered depressed individuals than never depressed individua...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-009-1533-4
更新日期:2009-08-01 00:00:00
abstract::The results confirm that NMDA receptor blockade can result in improved retention performance of mice in step-down passive avoidance. A series of behavioural variations and analyses revealed that memory in the task depended mainly on the appearance of the grid that had been associated with shock, rather than on the exe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244300
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:Modafinil is a well-tolerated psychostimulant drug with low addictive potential that is used to treat patients with narcolepsy or attention deficit disorders and to enhance vigilance in sleep-deprived military personal. So far, understanding of the cognitive enhancing effects of modafinil and the relevant neu...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-004-1926-3
更新日期:2004-12-01 00:00:00
abstract::Rats were trained in a Y-maze on a two-choice simultaneous black-white discrimination with either black or white as S+. Animals were then transferred to one of three discrimination tasks. In task 1 (New S-), a new stimulus, either vertical or horizontal stripes, was substituted for the original S-. In task 2 (New S+),...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00179945
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:An acute challenge with delta-9-tetrahydrocannabinol (THC) can induce psychotic symptoms including delusions. High electroencephalography (EEG) frequencies, above 20 Hz, have previously been implicated in psychosis and schizophrenia. OBJECTIVES:The objective of this study is to determine the effect of intrav...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3684-1
更新日期:2015-02-01 00:00:00
abstract:RATIONALE:Treatment of the most widely abused drugs, nicotine and alcohol, is hampered by high rates of relapse. Varenicline tartrate, an α4β2 nicotinic receptor partial agonist, is currently prescribed as a smoking cessation aid. However, there is emerging evidence that it may also modulate alcohol seeking and cogniti...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2213-8
更新日期:2011-07-01 00:00:00
abstract::Administration of various doses of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) to rats produced dose-related decreases in 1-h food intake in the food-deprived paradigm. Pretreatment with spiperone (5-HT1A/5-HT2/D2 antagonist), propranolol or CGP361A (beta-adrenoceptor antagonists that also have binding affinit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247721
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:Numerous preclinical and clinical studies have reported the rapid and sustained antidepressant effects of the NMDA receptor antagonist ketamine. Because ketamine induces several undesirable and dangerous effects, a variety of strategies have been suggested to avoid such effects. OBJECTIVES:Here, we propose t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4325-7
更新日期:2016-08-01 00:00:00
abstract:RATIONALE:Comorbidity with gambling disorder (GD) and alcohol use disorder (AUD) is well documented. OBJECTIVE:The purpose of our study was to examine the influence of genetic alcohol drinking tendency on reward-guided decision making behavior of rats and the impact of dopamine releaser D-amphetamine on this behavior....
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-4847-2
更新日期:2018-05-01 00:00:00
abstract:RATIONALE:Understanding factors contributing to individual differences in vulnerability to opioid addiction is essential for developing more effective preventions and treatments, yet few reliable behavioral predictors of subsequent opioid self-administration have been identified in rodents. Sensitivity to the acute eff...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05532-w
更新日期:2020-08-01 00:00:00
abstract:RATIONALE:The low self-administration (LS)/Kgras (LS) and high self-administration (HS)/Kgras (HS) rat lines were generated by selective breeding for low- and high-intravenous cocaine self-administration, respectively, from a common outbred Wistar stock (Crl:WI). This trait has remained stable after 13 generations of b...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4640-7
更新日期:2017-08-01 00:00:00
abstract::Three adult baboons were trained using a psychophysical procedure to discriminate between different synthetic vowel sounds [symbol: see text]. Baboons pressed and held a lever down to produce a pulsed train of a single reference vowel that served as the standard stimulus. Animals were trained to release the lever only...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246089
更新日期:1995-11-01 00:00:00
abstract:RATIONALE:Cessation of daily caffeine consumption produces a withdrawal syndrome comprised of subjective symptoms and functional impairment. Few controlled studies have examined the physiological effects of caffeine withdrawal. OBJECTIVE:The present study examined the effect of caffeine withdrawal on cerebral blood fl...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050005
更新日期:2000-01-01 00:00:00
abstract::In neuroleptic therapy for psychotic illness, clinical improvement is produced more slowly than is central dopamine blockade, and its time course is highly variable between patients. A theory of neuroleptic-responsive psychotic illness thus requires more than dopamine blockade, though that appears to be the first step...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF00176470
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:Beneficial effects of nicotine on cognitive processes including attention have potential therapeutic uses and have been proposed as incentives for tobacco smoking. OBJECTIVES:To establish task conditions under which the effects of nicotine on attention are obtained reliably and to characterise such effects f...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1005-6
更新日期:2002-07-01 00:00:00
abstract:RATIONALE:Abstinence from drug occurs in human addicts for several reasons, including the avoidance of adverse consequences. OBJECTIVES:To explore a model of drug use in the face of adverse consequences in rats through intermittent punishment of drug seeking and to investigate whether the ability to withhold seeking r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0805-0
更新日期:2007-09-01 00:00:00
abstract:INTRODUCTION:Model psychosis is characterised by experimentally induced symptoms of withdrawal from reality, frequently accompanied by perceptual disturbances, thought disorders, delusional ideas and sometimes by hallucinations. These "altered states of consciousness" provide a long-standing and valid approach to enhan...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-009-1591-7
更新日期:2009-11-01 00:00:00
abstract::The behavioral effects following intrastriatal MPP+, the neurotoxic metabolite of MPTP, were evaluated in mice. Bilateral injections of 10 micrograms MPP+ to mice previously trained in the shuttle box paradigm produced a 66% decrease in striatal dopamine and significant deficits in all measures of conditioned avoidanc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00176480
更新日期:1987-01-01 00:00:00
abstract::NNC 756 is a new benzazepine with high affinity and selectivity for D1-dopamine receptors. In a double-blind, placebo controlled, cross-over study, positron emission tomography and the radioligand [11C]SCH 23390 were used to determine central D1-dopamine receptor occupancy after a single oral dose of 80 mg NNC 756 in ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02246046
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:The general premise that receptor theory provides a useful framework for understanding the behavioral effects of psychoactive drugs has been a central tenet of behavioral pharmacology. OBJECTIVES:The purpose of this review is to reiterate this basic theme and, in particular, the proposition that current con...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s002130000567
更新日期:2000-12-01 00:00:00
abstract::Serotonin(5-HT)-stimulated intracellular calcium(Ca) mobilization was measured in the platelets of depressed patients to assess 5-HT2 receptor function. The 5-HT-induced Ca response was significantly higher in unmedicated patients with bipolar depression and melancholic major depression than in those with non-melancho...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02245204
更新日期:1994-01-01 00:00:00