Abstract:
:Serotonin is a neurotransmitter that is widely distributed throughout the central nervous system. The role of serotonin in schizophrenia is still unclear. Postmortem studies of serotonin receptor subtypes in schizophrenia have been inconclusive for the most part. The most promising findings involve a reduction in 5-HT2 receptors and 5-HT reuptake sites in the prefrontal cortex of schizophrenic patients. In this paper we review the function, distribution and pharmacological characteristics of serotonin receptors. Postmortem studies are also reviewed, focusing upon the role of these receptors in schizophrenia.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Ohuoha DC,Hyde TM,Kleinman JEdoi
10.1007/BF02245003subject
Has Abstractpub_date
1993-01-01 00:00:00pages
S5-15issue
1 Suppleissn
0033-3158issn
1432-2072journal_volume
112pub_type
杂志文章,评审abstract:RATIONALE:Successive negative contrast (SNC) describes a change in the behaviour of an animal following a downshift in the quantitative or qualitative value of an expected reward. This behavioural response has been hypothesised to be linked to affective state, with negative states associated with larger and/or prolonge...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-3905-2
更新日期:2015-08-01 00:00:00
abstract::Brain 5-hydroxytryptamine (5-HT) was depleted in rats by intraventricular injection with 5,7-dihyroxytryptamine (5,7-DHT) prior to feeding rats a liquid diet containing ethanol. After withdrawal of ethanol, withdrawal reactions were significantly less severe in 5-HT-depleted rats than control rats. Sleeping times afte...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427597
更新日期:1980-01-01 00:00:00
abstract::Several behaviors associated with the serotonin syndrome have been reported in rats following administration of the 5-HT1A receptor agonist 8-OH-DPAT. The present investigation approached this phenomenon from an ethopharmacological perspective, and provided a detailed temporal analysis of the behavioral effects of thi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247363
更新日期:1993-01-01 00:00:00
abstract::Peak saccadic eye movement velocity (SEV) and average smooth pursuit gain (SP) are reduced in a dose-dependent manner by diazepam and provide reliable, quantitative measures of benzodiazepine agonist effects. To evaluate the specificity of these eye movement effects for agents acting at the central GABA-benzodiazepine...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245956
更新日期:1995-04-01 00:00:00
abstract:RATIONALE:Spontaneous fluctuations in the size of the pupil in darkness are a recognized index of sleepiness, and these fluctuations can be quantitatively measured using the pupillographic sleepiness test (PST). The central noradrenergic system is believed to play a role in the maintenance of alertness, and there is ev...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130000398
更新日期:2000-05-01 00:00:00
abstract::In squirrel monkeys trained to discriminate between two tones, morphine consistently increased the percent of response failures during tone periods; however, it had no consistent effect on the percent correct responses. In contrast, scopolamine decreased percent correct responses as well as increasing percent response...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428404
更新日期:1985-01-01 00:00:00
abstract:RATIONALE:The low self-administration (LS)/Kgras (LS) and high self-administration (HS)/Kgras (HS) rat lines were generated by selective breeding for low- and high-intravenous cocaine self-administration, respectively, from a common outbred Wistar stock (Crl:WI). This trait has remained stable after 13 generations of b...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4640-7
更新日期:2017-08-01 00:00:00
abstract::The novel dopamine autoreceptor antagonists (-)-DS 121 and (+)-UH 232 were tested for their ability to alter cocaine self-administration behavior in rats reinforced on a progressive ratio (PR) schedule. (-)-DS 121 (15 mg/kg) and (+)-UH 232 (30 mg/kg) produced significant decreases in breaking point. (-)-DS 121 produce...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246149
更新日期:1995-07-01 00:00:00
abstract::Bromocriptine (0.5-6.0 mg/day) was administered to seven unmedicated chronic schizophrenic and two schizoaffective patients. Transient slight improvement was noted in four patients and marked improvement in one other. Clinical improvement was associated with nausea and drowsiness. These doses of bromocriptine stimulat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439271
更新日期:1983-01-01 00:00:00
abstract:RATIONALE:Previous studies from our laboratory and others have indicated a role for the hypothalamo-pituitary-adrenal (HPA) axis in the extinction/reinstatement animal model of cocaine relapse OBJECTIVE:This present study was designed to investigate the potential role for the HPA axis in the cue- and methamphetamine-i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0625-7
更新日期:2007-02-01 00:00:00
abstract::An error in Fig. 3 was introduced in the production process which the authors have asked to be rectified. Below is the correct figure. ...
journal_title:Psychopharmacology
pub_type: 已发布勘误
doi:10.1007/s00213-019-05340-x
更新日期:2019-11-01 00:00:00
abstract:RATIONALE:The rapid membrane actions of neuroactive steroids, particularly via an enhancement of γ-aminobutyric acidA receptors (GABAARs), participate in the regulation of central nervous system excitability. Prior evidence suggests an inverse relationship between endogenous GABAergic neuroactive steroid levels and beh...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3618-y
更新日期:2014-09-01 00:00:00
abstract:INTRODUCTION:Model psychosis is characterised by experimentally induced symptoms of withdrawal from reality, frequently accompanied by perceptual disturbances, thought disorders, delusional ideas and sometimes by hallucinations. These "altered states of consciousness" provide a long-standing and valid approach to enhan...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-009-1591-7
更新日期:2009-11-01 00:00:00
abstract:RATIONALE:While reserpine-induced oral movements (OM), an animal model of tardive dyskinesia, are more persistent in old than in adult rats, old animals present spontaneous OM, which are phenomenologically similar to those presented by reserpine-treated adult rats. We postulate that these OM may be the result of oxidat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1081-7
更新日期:2002-06-01 00:00:00
abstract::In order to study trends in smoking withdrawal symptoms, 35 participants in a smoking cessation clinic completed four questionnaires daily for 2 weeks. The questionnaire dealt with a variety of symptoms which a factor analysis showed could be grouped into four factors: stimulation, desire to smoke, and physical and ps...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00634151
更新日期:1976-10-20 00:00:00
abstract:RATIONALE:Cocaine addiction is a relapsing psychiatric disorder with a high prevalence in developed countries. To date, the reinstatement model has been difficult to implement in mice. The design of an appropriate reinstatement model in mice is required in order to use genetically modified animals with the aim of clari...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1184-x
更新日期:2008-09-01 00:00:00
abstract::Supersensitivity to serotonin during migraine attack has been previously observed. Since the attack has been attributed to a critical lowering of morphine-like factors, we can expect serotonin supersensitivity during morphine abstinence. Slight signs of morphine abstinence have also been induced in volunteers after mi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433050
更新日期:1979-10-01 00:00:00
abstract:RATIONALE:There is a growing concern over excessive caffeine use and development of caffeine use disorder in children. OBJECTIVES:This study aimed to identify the association between caffeine intake and cognitive functioning in children. METHODS:This study included 11,718 youths aged 9-10 years with cognitive and caf...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05596-8
更新日期:2020-10-01 00:00:00
abstract::Normal unoperated rats were tested for rotation (i.e., circling behavior) in a spherical "rotometer" and dose-response relationships were generated using d-amphetamine, apomorphine, L-Dopa, haloperidol, and scopolamine. The rotation induced by amphetamine was significantly antagonized by alpha-methyl-p-tyrosine and ha...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427609
更新日期:1976-06-23 00:00:00
abstract:RATIONALE:Selective serotonin reuptake inhibitor (SSRI) antidepressants are increasingly prescribed during pregnancy. Changes in serotonergic signaling during human fetal development have been associated with changes in brain development and with changes in affective behavior in adulthood. The suprachiasmatic nucleus (...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05556-2
更新日期:2020-08-01 00:00:00
abstract:RATIONALE:The ultra-short-acting mu opioid agonist analgesic/anesthetic remifentanil (RMF) is extremely rapidly eliminated from blood (half-life in rats, 0.3-0.7 min). This extremely fast elimination is thought to be the main reason why RMF maintains such high rates of responding in animal operant-conditioning models o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0180-7
更新日期:2005-12-01 00:00:00
abstract:RATIONALE:Previous work has shown that clozapine suppressed tacrine-induced jaw movements at lower doses than those required for suppression of lever pressing. OBJECTIVE:The novel atypical antipsychotic olanzapine was assessed in these behavioral tests. METHODS:The effect of acute olanzapine on the suppression of tac...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051063
更新日期:1999-08-01 00:00:00
abstract:RATIONALE:Obsessive-compulsive disorder (OCD) gradually emerges and reaches clinical significance during early adulthood. Whether a predisposition for OCD manifests as binge eating disorder earlier during adolescence is proposed. OBJECTIVES:To further characterize how OCD-like behaviors increase across maturation and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-3967-1
更新日期:2015-09-01 00:00:00
abstract:RATIONALE:N-methyl-D-aspartate (NMDA) receptor antagonists (e.g., PCP, ketamine) have been shown to impair learning/memory. Well documented in animal models, only limited research in humans has been reported. Findings to date are similar to results of animal studies; however, antagonists are typically administered befo...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-2179-5
更新日期:2005-07-01 00:00:00
abstract::Intravenous cocaine self-administration behavior in rats was investigated using a progressive ratio (PR) schedule of reinforcement. The first response on the lever each day produced a drug infusion, whereupon the requirements of the schedule escalated with each reinforcement until the behavior extinguished. The final ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439560
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Zidovudine (AZT) and lamivudine (3TC) are nucleoside analogues administered prenatally in clinical practice, separately or in combination, as antiretroviral drugs to prevent HIV mother-to-child transmission by inhibiting viral reverse transcriptase. In animal studies pre- and/or perinatal exposure to AZT and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000585
更新日期:2001-02-01 00:00:00
abstract::Rats were maintained on a regimen of restricted access to water. Desipramine (DMI) IP 1 h prior to the access period dose-dependently reduced water intake. Following completion of the dose-response determination for the effect of desipramine or water intake, rats were divided into three groups for repeated administrat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431934
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:It is widely assumed that various forms of neural and behavioral plasticity, including sensitization, are strongly dependent on the activation of N-methyl-D-aspartate (NMDA)-receptors, but evidence also exists to suggest that not all forms of sensitization are unequivocally blocked by NMDA-receptor antagonism...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s002130000395
更新日期:2000-08-01 00:00:00
abstract::The number of nerve cells in two different areas of the corpus striatum (i.e., ventrolateral and dorsomedial) was estimated in rat brain after long-term (36 weeks) treatment with the neuroleptic flupenthixol. Nine rats were given weekly injections of 4 mg/kg flupenthixol dissolved in Viscoleo i.m., and seven rats rece...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428036
更新日期:1978-09-15 00:00:00
abstract:RATIONALE:Individuals with schizophrenia have high smoking-related morbidity and mortality rates and need powerful and innovative smoking cessation interventions. OBJECTIVES:This proof-of-concept study investigated the feasibility and initial efficacy of combining a contingency management intervention with bupropion t...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2282-8
更新日期:2011-09-01 00:00:00