Abstract:
:The number of nerve cells in two different areas of the corpus striatum (i.e., ventrolateral and dorsomedial) was estimated in rat brain after long-term (36 weeks) treatment with the neuroleptic flupenthixol. Nine rats were given weekly injections of 4 mg/kg flupenthixol dissolved in Viscoleo i.m., and seven rats received Viscoleo alone. Fourteen to 18 weeks after the last drug injection, the animals were decapitated and half of each brain was fixated with formalin for cell-count analysis and the remaining half used for a biochemical analysis (Nielsen, 1977). Separate cell counts in the ventrolateral and dorsomedial corpus striatum yielded a significant cell loss of approximately 10%, but only in the ventrolateral striatum of treated animals. These results suggest at least one concrete anatomical basis for the behavioral and biochemical deficits found in the same animals, as reported earlier. The results further suggest that persistent irreversible anatomical changes can follow long-term neuroleptic treatment. The inconsistencies of results regarding cell loss in the corpus striatum may be due to neglect of dorsal-ventral structural differences in corpus striatum.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Nielsen EB,Lyon Mdoi
10.1007/BF00428036subject
Has Abstractpub_date
1978-09-15 00:00:00pages
85-9issue
1eissn
0033-3158issn
1432-2072journal_volume
59pub_type
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journal_title:Psychopharmacology
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130050957
更新日期:1999-04-01 00:00:00
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更新日期:2004-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00181945
更新日期:1988-01-01 00:00:00
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更新日期:2011-07-01 00:00:00
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更新日期:2019-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02801979
更新日期:1992-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00431102
更新日期:1981-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428038
更新日期:1978-09-15 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1977-01-31 00:00:00