Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats.

abstract：RATIONALE:In Koriat's accessibility model (Koriat, Psychol Rev, 100:609-639, 1993; Koriat, J Exp Psychol Gen, 124:311-333, 1995), when a person fails to recall a required target, he or she can nevertheless provide some partial information about the target. Moreover, individuals are able to provide feeling-of-knowing (F...

journal_title：Psychopharmacology

authors： Izaute M,Bacon E

更新日期：2006-11-01 00:00:00

abstract：RATIONALE:The P3 is a ubiquitous component of stimulus-driven neural activity that can be observed in scalp electrophysiological recordings. Multiple lines of evidence suggest an important role for the noradrenergic system in the generation of the P3. However, pharmacological studies of the P3 using noradrenergic manip...

journal_title：Psychopharmacology

authors： de Rover M,Brown SB,Band GP,Giltay EJ,van Noorden MS,van der Wee NJ,Nieuwenhuis S

更新日期：2015-09-01 00:00:00

abstract：RATIONALE:Heavy ecstasy use in humans has been associated with cognitive impairments and changes in cognitive brain function supposedly due to damage to the serotonin system. There is concern that even a single dose of 3,4-methylenedioxymethamphetamine may be neurotoxic, but very little is known about the consequences ...

journal_title：Psychopharmacology

authors： Jager G,de Win MM,Vervaeke HK,Schilt T,Kahn RS,van den Brink W,van Ree JM,Ramsey NF

更新日期：2007-08-01 00:00:00

abstract：:A study was performed to examine behavioral response to a challenge of selective dopamine D-1 and D-2 agonists in rats previously sensitized by subchronic administration of methamphetamine or cocaine. Rats in three groups received repeated injections (IP) of saline, methamphetamine (4 mg/kg/day) or cocaine (20 mg/kg/d...

journal_title：Psychopharmacology

authors： Ujike H,Akiyama K,Otsuki S

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Recent studies have suggested that the salutary actions of clozapine in schizophrenia may be due to selective activation of M(1) muscarinic receptors by clozapine and/or its major active metabolite N-desmethylclozapine. OBJECTIVE:We systematically tested this hypothesis by screening a large number of psychoa...

journal_title：Psychopharmacology

authors： Davies MA,Compton-Toth BA,Hufeisen SJ,Meltzer HY,Roth BL

更新日期：2005-04-01 00:00:00

abstract：AIM:Excess consumption of alcohol leads to impaired cognition and decision making; hence, alcohol-containing products and advertising contain warning messages about the adverse effects of excess drinking. However, there is a need to understand how alcohol influences the processing of advisory messages. METHOD:The curr...

journal_title：Psychopharmacology

authors： Phillips JG,Ogeil RP

更新日期：2010-03-01 00:00:00

abstract：:The antagonist effects of clocinnamox were evaluated against opioid agonists, acting at mu, kappa and delta-receptors, in rhesus monkeys (n = 3-4) responding under a fixed-ratio 30 (FR 30) schedule for food delivery. Clocinnamox (0.032-0.1 mg/kg) dose-dependently antagonized fentanyl (0.001-0.32 mg/kg) after either a ...

journal_title：Psychopharmacology

authors： Butelman ER,Negus SS,Lewis JW,Woods JH

更新日期：1996-02-01 00:00:00

abstract：:There have been a number of claims that high-dose administration of cocaine to rats leads to neurotoxic effects on dopamine neurons. In this study possible neurotoxic effects on monoamine neurons were examined by measuring the effects of cocaine (35 mg/kg daily for 10 days) on the binding of radioligands to uptake sit...

journal_title：Psychopharmacology

authors： Benmansour S,Tejani-Butt SM,Hauptmann M,Brunswick DJ

更新日期：1992-01-01 00:00:00

abstract：:Amitriptyline and zimelidine significantly reduce the uptake of 5-HT into the blood platelets of depressive patients. The degree of inhibition is significantly correlated with the plasma drug level of amitriptyline. No significant relationship could be detected between the degree of inhibition of uptake and therapeuti...

journal_title：Psychopharmacology

authors： Coppen A,Rama Rao VA,Swade C,Wood K

更新日期：1979-05-25 00:00:00

abstract：:Dose-dependent effects of intravenously administered lorazepam on haemodynamic fluctuations were studied by means of spectral analysis, in order to elucidate sympathetic and parasympathetic components in cardiovascular control during situations of rest and mental stress after benzodiazepine administration. In a double...

journal_title：Psychopharmacology

authors： Tulen JH,Mulder G,Pepplinkhuizen L,Man in 't Veld AJ,van Steenis HG,Moleman P

更新日期：1994-02-01 00:00:00

abstract：:The behavioural effects of selective mu-, kappa- and delta-opioid agonists in 5-, 10- and 20-day-old rats were investigated by observational analysis. The predominant response to mu-agonists was behavioural depression. High doses (10 mg/kg IP) of morphine and DAGO (D-Ala2, NMe-Phe4, Glyol5-enkephalin) produced overt s...

journal_title：Psychopharmacology

authors： Jackson HC,Kitchen I

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Successive negative contrast (SNC) describes a change in the behaviour of an animal following a downshift in the quantitative or qualitative value of an expected reward. This behavioural response has been hypothesised to be linked to affective state, with negative states associated with larger and/or prolonge...

journal_title：Psychopharmacology

authors： Phelps CE,Mitchell EN,Nutt DJ,Marston HM,Robinson ES

更新日期：2015-08-01 00:00:00

abstract：RATIONALE:Latent inhibition (LI), namely, poorer performance on a learning task involving a previously pre-exposed non-reinforced stimulus, is disrupted in the rat by the dopamine (DA) releaser amphetamine which produces and exacerbates psychotic (positive) symptoms, and this is reversed by treatment with typical and a...

journal_title：Psychopharmacology

authors： Weiner I

更新日期：2003-09-01 00:00:00

abstract：:The behavioral effects of the benzodiazepine (BZP)-receptor partial inverse agonists, beta-CCE and FG 7142, are reviewed and the claim that these compounds possess "anxiogenic" properties is examined. Results obtained from human studies and global observations in animals, as well as those from experiments on aggressio...

journal_title：Psychopharmacology

authors： Thiébot MH,Soubrié P,Sanger D

更新日期：1988-01-01 00:00:00

abstract：:The action of copper (CuSO4, 5 mg/kg, oral) on selected neuropharmacological actions of cannabis resin (CI, oral) was studied on albino rats and mice. Copper potentiated the barbiturate hypnosis-potentiating activity of CI in albino rats and mice and had no effect on hypothermic activity in albino rats. Single doses o...

journal_title：Psychopharmacology

authors： Singh PP,Das PK

更新日期：1978-04-11 00:00:00

abstract：RATIONALE:Elevated whole-blood serotonin (5-HT) is a robust biomarker in ~ 30% of patients with autism spectrum disorders, in which repetitive behavior is a core symptom. Furthermore, elevated whole-blood 5-HT has also been described in patients with pediatric obsessive-compulsive disorder. The 5-HT1B receptor is assoc...

journal_title：Psychopharmacology

authors： O'Reilly KC,Connor M,Pierson J,Shuffrey LC,Blakely RD,Ahmari SE,Veenstra-VanderWeele J

更新日期：2021-01-29 00:00:00

abstract：RATIONALE:The neuronal actions of methamphetamine (MA) include an increase in extracellular levels of monoamines, presumably via reverse transport involving the monoamine transporters. This action is thought to play an important role in the effects of MA. Therefore, in the present experiment, it was hypothesized that a...

journal_title：Psychopharmacology

authors： Ranaldi R,Anderson KG,Carroll FI,Woolverton WL

更新日期：2000-12-01 00:00:00

abstract：RATIONALE:Buprenorphine is a partial mu opioid agonist under development as a sublingual (SL) medication for opioid dependence treatment in the United States. Because buprenorphine may be abused, tablets combining buprenorphine with naloxone in a 4:1 ratio have been developed to reduce that risk. Low doses of injected ...

journal_title：Psychopharmacology

authors： Stoller KB,Bigelow GE,Walsh SL,Strain EC

更新日期：2001-03-01 00:00:00

abstract：RATIONALE:Cognitive rehabilitation is now recognized as an important tool in the treatment of schizophrenia, and findings in this area are emerging rapidly. There is a need for a systematic review of the effects of the different training programs. OBJECTIVES:To review quantitatively the controlled studies on cognitive...

journal_title：Psychopharmacology

authors： Krabbendam L,Aleman A

更新日期：2003-09-01 00:00:00

abstract：RATIONALE:Endogenous opioid systems within the mesencephalic periaqueductal gray matter (PAG) appear to be intricately involved in many affective, defensive, submissive, and reflexive responses, and these systems are activated by aversive stimuli. OBJECTIVES:The present experiments evaluated the influence of opioid re...

journal_title：Psychopharmacology

authors： Vivian JA,Miczek KA

更新日期：1999-09-01 00:00:00

abstract：:Mice were trained on a one-trial inhibitory avoidance task and given immediate post-training intraperitoneal injections of cocaine (0.03-1.00 mg/kg). On a retention test 24 h later, the retention latencies of mice given the 0.10 mg/kg dose were significantly higher than those of the controls. The effect of cocaine on ...

journal_title：Psychopharmacology

authors： Introini-Collison IB,McGaugh JL

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:3,4-Methylenedioxypyrovalerone (MDPV) and 3,4-methylenedioxy-N-methylcathinone (methylone) are synthetic drugs found in so-called "bath salts" products. Both drugs exert their effects by interacting with monoamine transporter proteins. MDPV is a potent uptake blocker at transporters for dopamine and norepinep...

journal_title：Psychopharmacology

authors： Schindler CW,Thorndike EB,Goldberg SR,Lehner KR,Cozzi NV,Brandt SD,Baumann MH

更新日期：2016-05-01 00:00:00

abstract：:Marked changes in biophysical properties, including structural order, have been observed in the hydrophobic core of cell membranes exposed to phenothiazines in vitro. In this study, similar changes are reported in vivo in cell membranes from the brains of rats treated with phenothiazines at doses thought to yield tiss...

journal_title：Psychopharmacology

authors： Cohen BM,Zubenko GS

更新日期：1985-01-01 00:00:00

abstract：:BALB/cJ, DBA/2J, and C57BL/6J mice were injected with caffeine and tested, in the five choice Yerkes-Thompson Bryant-Bovt Nitti apparatus for patterns discrimination, in two sets of experiments. In the first the patterns were opposite oriented oblique bars, in the second U-shaped figures, one opened toward the right, ...

journal_title：Psychopharmacology

authors： Castellano C

更新日期：1977-03-16 00:00:00

abstract：RATIONALE:It is widely assumed that various forms of neural and behavioral plasticity, including sensitization, are strongly dependent on the activation of N-methyl-D-aspartate (NMDA)-receptors, but evidence also exists to suggest that not all forms of sensitization are unequivocally blocked by NMDA-receptor antagonism...

journal_title：Psychopharmacology

authors： Tzschentke TM,Schmidt WJ

更新日期：2000-08-01 00:00:00

abstract：:NNC 756 is a new benzazepine with high affinity and selectivity for D1-dopamine receptors. In a double-blind, placebo controlled, cross-over study, positron emission tomography and the radioligand [11C]SCH 23390 were used to determine central D1-dopamine receptor occupancy after a single oral dose of 80 mg NNC 756 in ...

journal_title：Psychopharmacology

authors： Karlsson P,Farde L,Halldin C,Sedvall G,Ynddal L,Sloth-Nielsen M

更新日期：1995-05-01 00:00:00

abstract：:A number of clinically used benzodiazepines were tested for their effectiveness in blocking muscimol-induced myoclonic jerks in mice. Their ED50 values were determined from their dose-response curves. These data gave the following relative potencies with respect to diazepam: diazepam = 1, medazepam = 0.24, oxazepam = ...

journal_title：Psychopharmacology

authors： Menon MK,Vivonia CA,Haddox VG

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Contemporary animal models of cocaine addiction focus on increasing the amount of drug consumption to produce addiction-like behavior. However, another critical factor is the temporal pattern of consumption, which in humans is characterized by intermittency, both within and between bouts of use. OBJECTIVE:To...

journal_title：Psychopharmacology

authors： Kawa AB,Bentzley BS,Robinson TE

更新日期：2016-10-01 00:00:00

abstract：RATIONALE:Performance on progressive ratio schedules has been proposed as a means of assessing the effects of drugs on the value or "efficacy" of reinforcers. A mathematical model affords a basis for quantifying the effects of drugs on progressive ratio schedule performance. According to this model, the relation betwee...

journal_title：Psychopharmacology

authors： Zhang Z,Rickard JF,Asgari K,Body S,Bradshaw CM,Szabadi E

更新日期：2005-05-01 00:00:00

abstract：RATIONALE:Acute alcohol intoxication induces a selective impairment of recognition memory associated with conscious recollection whilst recognition based on familiarity is left intact. OBJECTIVES:We aimed to further elucidate the acute effects of alcohol on recognition memory by assessing three different doses of alco...

journal_title：Psychopharmacology

authors： Bisby JA,Leitz JR,Morgan CJ,Curran HV

更新日期：2010-01-01 00:00:00