Effect of sub-chronic hydrocortisone on responses to amphetamine in normal male volunteers.

abstract：RATIONALE:Perphenazine, a classical antipsychotic drug, has the potential to induce extrapyramidal side effects (EPS). Dopaminergic and serotonergic pathways are involved in the therapeutic and adverse effects of the drug. OBJECTIVES:To evaluate the impact of polymorphisms in the dopamine D(2) and D(3) and serotonin 2...

journal_title：Psychopharmacology

authors： Gunes A,Scordo MG,Jaanson P,Dahl ML

更新日期：2007-03-01 00:00:00

abstract：RATIONALE:Indirect-acting serotonin (5-HT) receptor agonists can enhance the antinociceptive effects of morphine; however, the specific 5-HT receptor subtype(s) mediating this enhancement is not established. OBJECTIVE:This study examined interactions between morphine and both 5-HT(1A) and 5-HT(2A) receptor agonists in...

journal_title：Psychopharmacology

authors： Li JX,Shah AP,Patel SK,Rice KC,France CP

更新日期：2013-02-01 00:00:00

abstract：:Three-hour sessions of differential reinforcement of low-rate behavior (DRL 45-s) in rats were used to investigate alprazolam, caffeine, and their interactions at the onset, peak and disappearance of serum alprazolam, while caffeine level remained constant. The dose-response curve (DRC) method of Pöch permitted an ext...

journal_title：Psychopharmacology

authors： Lau CE,Wang J

更新日期：1996-07-01 00:00:00

abstract：:It has previously been shown that serotonergic [5-hydroxytryptamine (5-HT)] neurons of the median raphe nucleus (MR) are critically involved in the control of the hippocampal electroencephalogram (EEG). Activation of MR 5-HT neurons desynchronizes the hippocampal EEG, whereas inhibition of MR 5-HT activity produces hi...

journal_title：Psychopharmacology

authors： Kinney GG,Kocsis B,Vertes RP

更新日期：1995-08-01 00:00:00

abstract：:The effects of scopolamine, an anticholinergic drug, of trimipramine, a tricyclic antidepressant with both anticholinergic and sedative properties, of diazepam and a placebo, on explicit memory and repetition priming were assessed using a free-recall task and a word-stem completion task. Forty-eight healthy volunteers...

journal_title：Psychopharmacology

authors： Danion JM,Zimmermann MA,Willard-Schroeder D,Grangé D,Welsch M,Imbs JL,Singer L

更新日期：1990-01-01 00:00:00

abstract：:Basal morning humoral (H)-endorphin blood levels were assessed in ten autistic patients, 12 chronic schizophrenic patients and 11 healthy control subjects. Four autistic patients and four schizophrenic patients were drug free for at least 6 months while all other psychiatric patients were under treatment with antidopa...

journal_title：Psychopharmacology

authors： Weizman R,Weizman A,Tyano S,Szekely G,Weissman BA,Sarne Y

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:It is widely assumed that various forms of neural and behavioral plasticity, including sensitization, are strongly dependent on the activation of N-methyl-D-aspartate (NMDA)-receptors, but evidence also exists to suggest that not all forms of sensitization are unequivocally blocked by NMDA-receptor antagonism...

journal_title：Psychopharmacology

authors： Tzschentke TM,Schmidt WJ

更新日期：2000-08-01 00:00:00

abstract：:Diazepam-sensitive (DS) and -resistant (DR) mice were selectively bred for increased and reduced sensitivity to the ataxic effects of diazepam (40 mg/kg). Other response differences between DS and DR mice may reflect pleiotropic effects of the genes fixed during their selection. These mice were tested for their sensit...

journal_title：Psychopharmacology

authors： Phillips TJ,Gallaher EJ

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Research suggests the experimental manipulation of oxytocin facilitates positive interactions, cooperation, and trust. The mechanism by which oxytocin influences social behavior is not well understood. OBJECTIVE:We explored the hypothesis that oxytocin alters how people perceive themselves, which could be on...

journal_title：Psychopharmacology

authors： Cardoso C,Ellenbogen MA,Linnen AM

更新日期：2012-04-01 00:00:00

abstract：:Few studies have examined the association between ethanol use and cigarette smoking topography. In particular, no study has objectively investigated the relationship between chronic ethanol exposure and cigarette smoking. The aim of this study was to quantify the relationship between cigarette smoking and past and cur...

journal_title：Psychopharmacology

authors： Keenan RM,Hatsukami DK,Pickens RW,Gust SW,Strelow LJ

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Deep brain stimulation (DBS) has achieved substantial success as a treatment for movement disorders such as Parkinson's disease. The therapeutic efficacy and relative lack of serious side effects resulted in the expansion of DBS into the treatment of many other diseases, including obsessive-compulsive disorde...

journal_title：Psychopharmacology

authors： Pierce RC,Vassoler FM

更新日期：2013-10-01 00:00:00

abstract：:The effects of amphetamine on the partial punishment effect (PPE) at one trial per day, were examined. Two groups of animals were trained to run in a straight alley. The continuously reinforced (CRF) group received food reward on every trial. The partially punished (PP) group received food reward on every trial but in...

journal_title：Psychopharmacology

authors： Weiner I,Bercovitz H,Feldon J

更新日期：1986-01-01 00:00:00

abstract：:Single-dose pharmacokinetics of alprazolam was studied in 42 normal male volunteers (14 Caucasians, 14 American-born Asians, and 14 foreign-born Asians), after both oral and parenteral (IV) administration of a small dose (0.5 mg) of the test drug. Asians manifested significantly higher Cmax, larger AUC, slower CL and ...

journal_title：Psychopharmacology

authors： Lin KM,Lau JK,Smith R,Phillips P,Antal E,Poland RE

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Animal studies indicate that dopamine pathways in the ventral striatum code for the motivational salience of both rewarding and aversive stimuli, but evidence for this mechanism in humans is less established. We have developed a functional magnetic resonance imaging (fMRI) model which permits examination of t...

journal_title：Psychopharmacology

authors： McCabe C,Huber A,Harmer CJ,Cowen PJ

更新日期：2011-09-01 00:00:00

abstract：:Central dopaminergic transmission has been implicated in memory processes. The present experiments examined the effects of several direct acting dopaminergic agents on performance of a delayed-non-match-to-sample radial arm maze task. Preadministration of apomorphine (D1-D2 agonist; 0.25, 0.5, and 1.0 mg/kg), quinpiro...

journal_title：Psychopharmacology

authors： Chrobak JJ,Napier TC

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:3,4-Methylenedioxymethamphetamine (MDMA or "ecstasy") causes serotonin neuron damage in laboratory animals. The serotonin system is known to be important in the regulation of mood. Previous research has shown that MDMA users score higher on self-report ratings of depression than controls. However, MDMA users ...

journal_title：Psychopharmacology

authors： Roiser JP,Sahakian BJ

更新日期：2004-05-01 00:00:00

abstract：:The protective effects of acute and chronic diazepam administration (4 mg/kg) against seizures induced by pentylenetetrazole (PTZ) and picrotoxin were investigated. Considering the incidence of tonic-clonic convulsions, tolerance to the protective effects of diazepam was evident by day 5 if the mice were challenged wi...

journal_title：Psychopharmacology

authors： File SE

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:Quetiapine extended release (XR) has been used to treat various psychiatric disorders, including depressive episodes associated with bipolar I and II disorders. Quetiapine XR is the first approved drug in China for the treatment of bipolar disorder. OBJECTIVES:The study evaluated the efficacy and safety of s...

journal_title：Psychopharmacology

authors： Li H,Gu N,Zhang H,Wang G,Tan Q,Yang F,Ning Y,Zhang H,Lu Z,Xu X,Shi J,Gao C,Li L,Zhang K,Tian H,Wang X,Li K,Li H,Xu Y,Xie S,Yu X

更新日期：2016-04-01 00:00:00

abstract：RATIONALE:Several antipsychotic drugs are metabolised by the polymorphic cytochrome P(450) CYP2D6. The impact of the polymorphism on the plasma levels and the occurrence of side effects have not been clearly established. OBJECTIVE:To investigate the impact of the CYP2D6 polymorphism on the steady-state plasma concentr...

journal_title：Psychopharmacology

authors： Jaanson P,Marandi T,Kiivet RA,Vasar V,Vään S,Svensson JO,Dahl ML

更新日期：2002-06-01 00:00:00

abstract：RATIONALE:Investigations of the neural consequences of the effects of cocaine on cognition have centered on specific brain circuits including prefrontal cortex, medial temporal lobe and striatum and their roles in controlling drug dependent behavior and addiction. These regions are critical to many aspects of drug abus...

journal_title：Psychopharmacology

authors： Hampson RE,Porrino LJ,Opris I,Stanford T,Deadwyler SA

更新日期：2011-01-01 00:00:00

abstract：RATIONALE:Direct activation of the cannabinoid CB1 receptor in the dorsolateral periaqueductal gray (dlPAG) inhibits anxiety- and panic-related behaviours in experimental animals. It has remained unclear, however, whether the local endocannabinoid signalling is recruited as a protective mechanism against aversive stimu...

journal_title：Psychopharmacology

authors： Viana TG,Hott SC,Resstel LB,Aguiar DC,Moreira FA

更新日期：2015-05-01 00:00:00

abstract：:The present experiment examined effects of nicotine on body weight of male and female rats when Oreo cookies, potato chips, laboratory chow, and water were available. Body weight and eating behavior were measured for 17-day periods before, during, and after nicotine or saline administration. There was an inverse relat...

journal_title：Psychopharmacology

authors： Grunberg NE,Popp KA,Winders SE

更新日期：1988-01-01 00:00:00

abstract：:Plasma fluphenazine levels and plasma total neuroleptic activity (as quantitated by the neuroleptic receptor binding assay) were related to therapeutic response in 15 DSM-III schizophrenic patients who received a predetermined, fixed dose of fluphenazine for 14 days. Mean neuroleptic activity of the plasma was 84% gre...

journal_title：Psychopharmacology

authors： Hitzemann RJ,Garver DL,Mavroidis M,Hirschowitz J,Zemlan FP

更新日期：1986-01-01 00:00:00

abstract：:Depression is common in patients with senile dementia of the Alzheimer type (SDAT) and may precede the onset of the dementia; the underlying biological and neurotransmitter mechanisms may be common to both diseases, so far as norepinephrine lesions are concerned. The major routes of metabolism of amines in the brain u...

journal_title：Psychopharmacology

authors： Chan-Palay V

更新日期：1992-01-01 00:00:00

abstract：:The pharmacokinetics of flumazenil in the rat were determined after 2.5 mg/kg intravenous and 25 mg/kg oral administration. Following intravenous administration flumazenil was rapidly eliminated with an extremely short terminal half-life (mean +/- SE, n = 8) of 8.3 +/- 0.3 min due to a large total blood clearance of 1...

journal_title：Psychopharmacology

authors： Mandema JW,Gubbens-Stibbe JM,Danhof M

更新日期：1991-01-01 00:00:00

abstract：:Food reward has been associated with activation of noradrenergic mechanisms in the brain. Using rats trained to press a lever for food reward, we have investigated the effects of 6-hydroxydopamine lesions, which severly depleted hypothalamic noradrenaline, on the willingness of the rats to press the lever for food rew...

journal_title：Psychopharmacology

authors： Kruk ZL,Millar J

更新日期：1979-06-28 00:00:00

abstract：:Rats injected with doses of d-amphetamine 0--5.0 mg/kg were observed continuously in either an enclosed Y-maze or on an elevated Y-shaped platform. Patterns of increased walking and stereotypy were unaffected by the type of apparatus, but rearing remained totally suppressed at all dose levels on the elevated platform....

journal_title：Psychopharmacology

authors： Mumford L,Teixeira AR,Kumar R

更新日期：1979-04-25 00:00:00

abstract：:In order to assess the possible effects of central GABA activation on the consolidation of shock avoidance, the GABA-T inhibitor amino-oxyacetic acid (AOAA) was administered posttrial to adult male rats. Learning was assessed over nine widely spaced sessions of 20 trials each. AOAA-treated animals showed learning with...

journal_title：Psychopharmacology

authors： Katz RJ,Liebler L

更新日期：1978-03-01 00:00:00

abstract：:Rats were trained to discriminate between two compound stimulus arrays that included exteroceptive (ES) and interoceptive (IS) stimulus components. The ES components were illumination and tactile cues, and the IS components were produced by d-amphetamine (A) or Na pentobarbital (P) treatment (drug versus drug discrimi...

journal_title：Psychopharmacology

authors： Duncan PM

更新日期：1986-01-01 00:00:00

abstract：:The importance of brain noradrenaline synthesis and receptor activation for the hyperkinesia induced by carbidopa plus L-Dopa in reserpine-treated or normal mice was analyzed in four different models. After pretreatment with reserpine and the monoamine oxidase inhibitor nialamide, the hyperkinesia induced by L-Dopa (2...

journal_title：Psychopharmacology

authors： Andén NE,Strömbom U,Svensson TH

更新日期：1977-11-15 00:00:00