Blockade of behavioral sensitization by MK-801: fact or artifact? A review of preclinical data.

abstract：RATIONALE:It has been suggested that the antipsychotic effect of antipsychotics is mediated by the antagonism of the dopamine D2 receptor in the limbic-cortical regions. Risperidone has an atypical property, but its effect on limbic-cortical regions has not been evaluated. OBJECTIVES:In this study, we examined the rel...

journal_title：Psychopharmacology

authors： Yasuno F,Suhara T,Okubo Y,Sudo Y,Inoue M,Ichimiya T,Tanada S

更新日期：2001-02-01 00:00:00

abstract：RATIONALE:Patients with obsessive compulsive disorder (OCD) demonstrate impaired cognition in some selected domains. Although serotoninergic dysfunction has been implicated in OCD, recent evidence suggests that dopamine may play a role as well. OBJECTIVE:The aim of the study was to evaluate learning and working memory...

journal_title：Psychopharmacology

authors： Morein-Zamir S,Craig KJ,Ersche KD,Abbott S,Muller U,Fineberg NA,Bullmore ET,Sahakian BJ,Robbins TW

更新日期：2010-10-01 00:00:00

abstract：RATIONALE:The N-methyl D-aspartate antagonist phencyclidine (PCP) is purported to mimic the negative, cognitive and positive symptoms of schizophrenia. Thus, acute and sub-chronic PCP treatment in rodents might produce anhedonia, a decrease in the pleasure produced by rewards. OBJECTIVES:Experiment 1 investigated whet...

journal_title：Psychopharmacology

authors： Lydall ES,Gilmour G,Dwyer DM

更新日期：2010-04-01 00:00:00

abstract：RATIONALE:Recent studies have shown that pharmacological inhibition of the 12-lipoxygenase pathway selectively blocks opioid inhibition of GABAergic synaptic currents. A similar mechanism has been shown for the regulation of glutamate release in the ventral tegmental area (VTA) during acute withdrawal from morphine, al...

journal_title：Psychopharmacology

authors： Walters CL,Wang BC,Godfrey M,Sun D,Funk CD,Blendy JA

更新日期：2003-11-01 00:00:00

abstract：RATIONALE:Previous work has shown that environmental enrichment alters amphetamine-induced locomotor activity and conditioned place preference. OBJECTIVE:The present study examined the effect of environmental enrichment on amphetamine self-administration. METHODS:Female and male rats were raised from 21 days of age i...

journal_title：Psychopharmacology

authors： Bardo MT,Klebaur JE,Valone JM,Deaton C

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:Recent data suggest that 5-HT7 receptors (5-HT7R) are involved in memory processes and, particularly, those related to novelty-induced arousal, even though this remains so far speculative and controversial. In order to assess the role of 5-HT7R in episodic-like memory, mice were administered 5-carboxamidotryp...

journal_title：Psychopharmacology

authors： Freret T,Paizanis E,Beaudet G,Gusmao-Montaigne A,Nee G,Dauphin F,Bouet V,Boulouard M

更新日期：2014-01-01 00:00:00

abstract：RATIONALE:Rats selectively bred for high saccharin (HiS) intake consume more alcohol and acquire intravenous (i.v.) cocaine self-administration more rapidly than their low saccharin (LoS)-consuming counterparts. The present experiment was designed to determine whether HiS and LoS rats differed in other aspects of drug ...

journal_title：Psychopharmacology

authors： Carroll ME,Anderson MM,Morgan AD

更新日期：2007-02-01 00:00:00

abstract：:Repeated amphetamine (AMPH) administration into the nucleus accumbens does not enhance (sensitize) the locomotor activity produced by a subsequent systemic AMPH challenge. We report here, however, that pretreatment with systemic injections of AMPH does produce a significant enhancement in the locomotor stimulant effec...

journal_title：Psychopharmacology

authors： Paulson PE,Robinson TE

更新日期：1991-01-01 00:00:00

abstract：:An error in Fig. 3 was introduced in the production process which the authors have asked to be rectified. Below is the correct figure. ...

journal_title：Psychopharmacology

authors： Bailey L,Taylor D

更新日期：2019-11-01 00:00:00

abstract：RATIONALE:Pairing rewarding outcomes with audiovisual cues in simulated gambling games increases risky choice in both humans and rats. However, the cognitive mechanism through which this sensory enhancement biases decision-making is unknown. OBJECTIVES:To assess the computational mechanisms that promote risky choice d...

journal_title：Psychopharmacology

authors： Langdon AJ,Hathaway BA,Zorowitz S,Harris CBW,Winstanley CA

更新日期：2019-08-01 00:00:00

abstract：:The aim of the present study was to investigate the locomotor stimulant effects of the atypical antipsychotic agent, olanzapine, in mice depleted of their dopamine by reserpine and alpha-methyl-DL-p-tyrosine pretreatment. Olanzapine (0.5, 1 and 2 mg/kg) dose-dependently increased locomotor activity, which was complete...

journal_title：Psychopharmacology

authors： Ninan I,Kulkarni SK

更新日期：1999-02-01 00:00:00

abstract：RATIONALE:Zidovudine (AZT) and lamivudine (3TC) are nucleoside analogues administered prenatally in clinical practice, separately or in combination, as antiretroviral drugs to prevent HIV mother-to-child transmission by inhibiting viral reverse transcriptase. In animal studies pre- and/or perinatal exposure to AZT and ...

journal_title：Psychopharmacology

authors： Ricceri L,Venerosi A,Valanzano A,Sorace A,Alleva E

更新日期：2001-02-01 00:00:00

abstract：RATIONALE:Children and adolescents will readily abuse household products that contain solvents such as toluene. It is likely that reinforcing exposures to toluene alter brain glucose metabolism. OBJECTIVE:Using an animal model of drug reinforcement, we sought to identify a metabolic signature of toluene abuse in the a...

journal_title：Psychopharmacology

authors： Schiffer WK,Lee DE,Alexoff DL,Ferrieri R,Brodie JD,Dewey SL

更新日期：2006-06-01 00:00:00

abstract：RATIONALE:Receptor mechanisms underlying the behavioral effects of clinically used nicotinic acetylcholine receptor agonists have not been fully established. OBJECTIVE:Drug discrimination was used to compare receptor mechanisms underlying the effects of smoking cessation aids. METHODS:Separate groups of male C57BL/6J...

journal_title：Psychopharmacology

authors： Cunningham CS,McMahon LR

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:This study aims to conduct an evidence review of the effectiveness, harms, and cost-effectiveness of pharmacogenomics-guided antidepressant treatment for major depressive disorder. METHODS:We searched MEDLINE®, the Cochrane Central Registry of Controlled Trials, and PsycINFO through February 2017. We used pr...

journal_title：Psychopharmacology

authors： Peterson K,Dieperink E,Anderson J,Boundy E,Ferguson L,Helfand M

更新日期：2017-06-01 00:00:00

abstract：:While chronic intermittent administration of stimulants often induces behavioral sensitization in adulthood, stimulant sensitization has rarely been reported prior to weaning [around postnatal day (P) 21]. Consistent pairing of drug administration with the test context often facilitates sensitization in adults, yet yo...

journal_title：Psychopharmacology

authors： Wood RD,Tirelli E,Snyder KJ,Heyser CJ,LaRocca TM,Spear LP

更新日期：1998-07-01 00:00:00

abstract：:Cebus apella monkeys were chronically administered the antipsychotic drug fluphenazine decanoate for periods ranging from 3.5 to 5.5 years. In the present study, four of these monkeys and two controls were tested for cognitive abilities on a spatial learning task, which consisted of an original discrimination and four...

journal_title：Psychopharmacology

authors： Levin ED,Gunne LM

更新日期：1989-01-01 00:00:00

abstract：:A review and meta-analysis by Hamer et al. (2006) showed that a single session of exercise can attenuate post-exercise blood pressure (BP) responses to stress, but no studies examined the effects among smokers or with brisk walking. Healthy volunteers (n=60), averaging 28 years of age and smoking 15 cigarettes daily, ...

journal_title：Psychopharmacology

authors： Taylor A,Katomeri M

更新日期：2006-01-01 00:00:00

abstract：RATIONALE:Antidepressants are known to modify human sleep patterns. OBJECTIVES:Duloxetine is a new antidepressant with a mechanism of action involving reuptake inhibition of both serotonin (5-HT) and norepinephrine (NE). In this study, the effects of two dosing regimens of duloxetine on sleep electroencephalography (E...

journal_title：Psychopharmacology

authors： Chalon S,Pereira A,Lainey E,Vandenhende F,Watkin JG,Staner L,Granier LA

更新日期：2005-02-01 00:00:00

abstract：:BALB/cJ, DBA/2J, and C57BL/6J mice were injected with caffeine and tested, in the five choice Yerkes-Thompson Bryant-Bovt Nitti apparatus for patterns discrimination, in two sets of experiments. In the first the patterns were opposite oriented oblique bars, in the second U-shaped figures, one opened toward the right, ...

journal_title：Psychopharmacology

authors： Castellano C

更新日期：1977-03-16 00:00:00

abstract：RATIONALE:The role of pharmacotherapy in the treatment of major depressive disorder (MDD) in youth has received much attention in recent years due to concerns of efficacy and safety of the antidepressants for the treatment of MDD in youth. OBJECTIVES:This review describes the existing published and unpublished literat...

journal_title：Psychopharmacology

authors： Boylan K,Romero S,Birmaher B

更新日期：2007-03-01 00:00:00

abstract：RATIONALE:In animal studies, the common club drug 3,4-methylendioxymethamphetamine (MDMA, "Ecstasy") consistently caused a prolonged loss of presynaptic serotonergic neurons, and evidence suggests that MDMA consumption may also affect the human serotonergic system. Serotonin (5-HT) has been implicated in the regulation...

journal_title：Psychopharmacology

authors： Quednow BB,Kühn KU,Hoppe C,Westheide J,Maier W,Daum I,Wagner M

更新日期：2007-01-01 00:00:00

abstract：:Two enantiomers (1S and 1R) of delta-3-tetrahydrocannabinol were assayed in man for psychoactivity. The 1S enantiomer had definite psychic actions, qualitatively similar to those of delta-1-tetrahydrocannabinol, but quantitatively less potent (1:3 to 1:6). Adding the two enantiomers together did not increase the effec...

journal_title：Psychopharmacology

authors： Hollister LE,Gillespie HK,Mechoulam R,Srebnik M

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:The α7 nicotinic acetylcholine receptor (nAChR) has been implicated as a target in modulating nicotine reward. However, the effect of pharmacological agents that have been shown to alter the channel properties of the α7 nAChR is not well understood in nicotine reward. OBJECTIVES:This study aimed to investiga...

journal_title：Psychopharmacology

authors： Jackson A,Alkhlaif Y,Papke RL,Brunzell DH,Damaj MI

更新日期：2019-12-01 00:00:00

abstract：:The behavioral consequences of prolonged continuous exposure to cocaine were examined in rhesus monkeys. Operant behavior was sampled for 0.5 h every 6 h, and cocaine was continuously infused through an intravenous catheter. Cocaine (4.0-32 mg/kg/day) initially caused reductions in the rate of responding for food and ...

journal_title：Psychopharmacology

authors： Woolverton WL,Kleven MS

更新日期：1988-01-01 00:00:00

abstract：:The effects of d-fenfluramine and morphine on various nociceptive responses of rats were investigated. Unlike morphine, which inhibited all the responses examined, d-fenfluramine inhibited jumping and paw licking of rats on a hot plate, but did not increase the latency of tail withdrawal from hot water. The effects of...

journal_title：Psychopharmacology

authors： Rochat C,Cervo L,Romandini S,Samanin R

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Severe, traumatic stress or repeated exposure to stress can result in long-term deleterious effects, including hippocampal cell atrophy and death, which, in turn, result in memory impairments and behavioural abnormalities. The dopaminergic D(2) receptor agonist, bromocriptine, has been shown to modulate learn...

journal_title：Psychopharmacology

authors： Srikumar BN,Raju TR,Shankaranarayana Rao BS

更新日期：2007-08-01 00:00:00

abstract：RATIONALE:Piper methysticum extract (kava kava) possesses numerous therapeutic properties, but it is unknown which of its principle constituents (kavalactones) subserve such effects. OBJECTIVES:This experiment sought to characterize the putative anxiolytic properties of P. methysticum extract and its six principle kav...

journal_title：Psychopharmacology

authors： Smith KK,Dharmaratne HR,Feltenstein MW,Broom SL,Roach JT,Nanayakkara NP,Khan IA,Sufka KJ

更新日期：2001-04-01 00:00:00

abstract：:Ten rats were trained to lever press for food reward on a schedule of differential reinforcement of low rates of response with a 20-s criterion (DRL 20). Ten more were trained on a new schedule of punishment, designed to be comparable to DRL 20 - differential punishment of high rates of response (DPH 20). Under this s...

journal_title：Psychopharmacology

authors： Salmon P,Gray JA

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Emerging data indicate the neuromodulator adenosine may play a role in the therapeutics of schizophrenia. Adenosine A(2A) receptor stimulation exerts a functional antagonism at postsynaptic D(2) receptors. Data from animal models relevant to schizophrenia support a therapeutic effect of modulating adenosiner...

journal_title：Psychopharmacology

authors： Wonodi I,Gopinath HV,Liu J,Adami H,Hong LE,Allen-Emerson R,McMahon RP,Thaker GK

更新日期：2011-11-01 00:00:00