Abstract:
:Plasma fluphenazine levels and plasma total neuroleptic activity (as quantitated by the neuroleptic receptor binding assay) were related to therapeutic response in 15 DSM-III schizophrenic patients who received a predetermined, fixed dose of fluphenazine for 14 days. Mean neuroleptic activity of the plasma was 84% greater than can be accounted for by the parent fluphenazine alone, and varied widely between patients. A sigmoidal relationship between total neuroleptic activity of plasma and response was found, with a continued plateau of response at higher total neuroleptic levels. Furthermore, the RBA data suggested (P less than 0.002) that two populations of drug-responsive schizophrenics exist which may be discriminated by the total D2 binding activity of plasma required for response.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Hitzemann RJ,Garver DL,Mavroidis M,Hirschowitz J,Zemlan FPdoi
10.1007/BF00181256subject
Has Abstractpub_date
1986-01-01 00:00:00pages
270-3issue
2eissn
0033-3158issn
1432-2072journal_volume
90pub_type
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更新日期:2004-12-01 00:00:00
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更新日期:1981-01-01 00:00:00
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更新日期:1999-05-01 00:00:00
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1007/BF02244989
更新日期:1994-05-01 00:00:00
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更新日期:2010-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2001-02-01 00:00:00
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更新日期:1998-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1990-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:1987-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
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更新日期:1992-01-01 00:00:00