Neuroendocrine effects of apomorphine in chronic schizophrenic patients under long-term neuroleptic therapy and after drug withdrawal: relations to psychopathology and tardive dyskinesia.

abstract：RATIONALE:Acute tryptophan depletion (ATD) is a widely used method to study the role of serotonin (5-HT) in affect and cognition. ATD results in a strong but transient decrease in plasma tryptophan and central 5-HT synthesis and availability. Although its use is widespread, the evidence that the numerous functional eff...

journal_title：Psychopharmacology

authors： van der Plasse G,Meerkerk DT,Lieben CK,Blokland A,Feenstra MG

更新日期：2007-12-01 00:00:00

abstract：:Rats were trained to discriminate fenfluramine (1.0 mg/kg) from saline in a two-lever drug discrimination task. The dose-response curve for this discrimination was orderly with an ED50 of about one-half of the training dose (0.52 mg/kg). In substitution tests, indirect (p-chloroamphetamine) and direct (quipazine, MK-2...

journal_title：Psychopharmacology

authors： White FJ,Appel JB

更新日期：1981-01-01 00:00:00

abstract：:Seven neuroleptic-free schizophrenic patients received bromocriptine and eight schizophrenic patients received CF 25-397, both ergot derivatives with dopamine agonist activity. Psychosis failed to improve in response to either drug at the relatively low doses administered. Unlike the antipsychotic property of apomorph...

journal_title：Psychopharmacology

authors： Tamminga CA,Schaffer MH

更新日期：1979-01-01 00:00:00

abstract：RATIONALE:Epilepsy is a debilitating seizure disorder that affects approximately 50 million people. Noradrenaline reduces neuronal excitability, has anticonvulsant effects and is protective against seizure onset. OBJECTIVE:We investigated the role of α2-adrenoceptors in vivo in a neonatal domoic acid (DOM) rat model o...

journal_title：Psychopharmacology

authors： Thomsen MB,Lillethorup TP,Jakobsen S,Nielsen EH,Simonsen M,Wegener G,Landau AM,Tasker RA

更新日期：2016-10-01 00:00:00

abstract：RATIONALE:Cocaine (COC), ethanol (EtOH), and methamphetamine (MA) are widely abused substances and share the ability to induce behavioral stimulation in mice and humans. Understanding the biological basis of behavioral stimulation to COC, EtOH, and MA may provide a greater understanding of drug and alcohol abuse. OBJE...

journal_title：Psychopharmacology

authors： Kamens HM,Phillips TJ

更新日期：2008-02-01 00:00:00

abstract：RATIONALE:Previous observations revealed that defeated and subsequently individually housed rats do not display behavioral anticipatory responses to the conditioned presentation of a bell/light stimulus associated with free access to a 5% sucrose solution reward. The absence of the appetitive responses suggests a decre...

journal_title：Psychopharmacology

authors： Von Frijtag JC,Van den Bos R,Spruijt BM

更新日期：2002-07-01 00:00:00

abstract：:Quetiapine (Seroquel, ICI 204,636) is an atypical antipsychotic that is effective in the treatment of both positive and negative symptoms of schizophrenia, and has a low propensity to cause extrapyramidal symptoms. The compound has a relatively short plasma elimination half-life (approximately 7 h). However, since dop...

journal_title：Psychopharmacology

authors： King DJ,Link CG,Kowalcyk B

更新日期：1998-05-01 00:00:00

abstract：:Amphetamine stimulates locomotor activity, in large part by activating central dopaminergic systems. Serotonin shares on overlapping distribution with dopamine and has been shown to modulate dopaminergic function and dopamine-mediated behaviors. The present study examined whether increasing serotonergic function, via ...

journal_title：Psychopharmacology

authors： Sills TL,Greenshaw AJ,Baker GB,Fletcher PJ

更新日期：1999-02-01 00:00:00

abstract：:Basal morning humoral (H)-endorphin blood levels were assessed in ten autistic patients, 12 chronic schizophrenic patients and 11 healthy control subjects. Four autistic patients and four schizophrenic patients were drug free for at least 6 months while all other psychiatric patients were under treatment with antidopa...

journal_title：Psychopharmacology

authors： Weizman R,Weizman A,Tyano S,Szekely G,Weissman BA,Sarne Y

更新日期：1984-01-01 00:00:00

abstract：:Offensive and defensive components of aggressive behavior were determined in resident and intruder mice. Withdrawal aggression was measured after the removal of a subcutaneous morphine pellet or after precipitation by naloxone in naive mice and after removal of a morphine pellet in mice with prior fighting experience....

journal_title：Psychopharmacology

authors： Kantak KM,Miczek KA

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:The elevated plus-maze and the light/dark box are two established anxiety tests in rodents, which are useful to screen putative anxiogenic effects of drugs. OBJECTIVE:Caffeine is well known to promote anxious behaviour in humans and animal models, but the precise site of action of the drug is still a matter ...

journal_title：Psychopharmacology

authors： El Yacoubi M,Ledent C,Parmentier M,Costentin J,Vaugeois JM

更新日期：2000-02-01 00:00:00

abstract：RATIONALE:N-methyl-D-aspartate (NMDA) receptors play crucial roles in learning and memory, but the role of each NMDA receptor subtype in a specific cognitive process is unclear. Non-selective blockers of NMDA receptor are used to model the cognitive impairment in schizophrenia and Alzheimer's disease. Counter-intuitive...

journal_title：Psychopharmacology

authors： Kumar G,Olley J,Steckler T,Talpos J

更新日期：2015-11-01 00:00:00

abstract：RATIONALE:Results from clinical studies have shown that topiramate effectively reduces alcohol consumption in a population of heavy-drinking alcohol-dependent humans. OBJECTIVES:We undertook this preclinical study in order to establish topiramate's efficacy in a rodent model and to determine whether topiramate's effic...

journal_title：Psychopharmacology

authors： Breslin FJ,Johnson BA,Lynch WJ

更新日期：2010-01-01 00:00:00

abstract：RATIONALE:Varenicline is believed to work, in part, by reducing craving responses to smoking cues and by reducing general levels of craving; however, these hypotheses have never been evaluated with craving assessed in the natural environments of treatment-seeking smokers. OBJECTIVES:Ecological momentary assessment pro...

journal_title：Psychopharmacology

authors： Gass JC,Wray JM,Hawk LW,Mahoney MC,Tiffany ST

更新日期：2012-09-01 00:00:00

abstract：RATIONALE:Functional interactions between limbic regions that process emotions and frontal networks that guide response functions provide a substrate for emotional cues to influence behavior. Stimulation of postsynaptic α₂ adrenoceptors enhances the function of prefrontal regions in these networks. However, the impact ...

journal_title：Psychopharmacology

authors： Schulz KP,Clerkin SM,Fan J,Halperin JM,Newcorn JH

更新日期：2013-03-01 00:00:00

abstract：:5-Hydroxytryptamine1A (5-HT1A) receptors have been shown to be suppressed by corticosteroid hormones in a variety of animal experimental paradigms. It has been suggested that this effect may be central to the pathophysiology of severe clinical depressive illness, a condition in which 5-HT1A receptor function is reduce...

journal_title：Psychopharmacology

authors： Porter RJ,McAllister-Williams RH,Lunn BS,Young AH

更新日期：1998-10-01 00:00:00

abstract：RATIONALE:Cocaethylene is a pharmacologically active homolog and metabolite of cocaine, formed by transesterification of cocaine in the presence of ethanol. Here we relate findings from a randomized, placebo-controlled, double-blind study in which we examined the physiological and subjective effects and pharmacokinetic...

journal_title：Psychopharmacology

authors： Hart CL,Jatlow P,Sevarino KA,McCance-Katz EF

更新日期：2000-04-01 00:00:00

abstract：RATIONALE:Anxiety and aggression are associated with ethanol self-administration, but these behaviors can serve as either risk factors for or consequences of heavy drinking in rodents and humans. Baseline levels of aggressive-like and anxious-like behavior in non-human primates have not yet been characterized in relati...

journal_title：Psychopharmacology

authors： McClintick MN,Grant KA

更新日期：2016-12-01 00:00:00

abstract：:In a one-trial step-through passive avoidance task, pretraining administration of ethanol was shown to decrease the latencies to step through at both training (day 1) and testing (day 2) for both rats and mice. A detailed analysis of these effects showed that they differed from those reported previously by others. The...

journal_title：Psychopharmacology

authors： Bammer G,Chesher GB

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Nicotine improves cognitive function in a number of animal models including rats, mice, monkeys, and recently, zebrafish. The zebrafish model allows higher throughput and ease in discovering mechanisms of cognitive improvement. MATERIALS AND METHODS:To further characterize the neural bases of nicotine effect...

journal_title：Psychopharmacology

authors： Eddins D,Petro A,Williams P,Cerutti DT,Levin ED

更新日期：2009-01-01 00:00:00

abstract：:This research compares the effects, in mice and rats, of desmethylclomipramine (DCLOM) and clomipramine (CLOM). DCLOM antagonized the hypothermia induced in mice by reserpine or apomorphine to a much greater extent than CLOM. Reserpine ptosis in mice was depressed by DCLOM only. Similarly, only DCLOM was effective in ...

journal_title：Psychopharmacology

authors： Maj J,Stala L,Górka Z,Adamus A

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Methamphetamine (METH) is a powerfully addictive stimulant associated with serious health conditions. Accumulating evidence suggests a role of oxidative stress in METH-induced behavioral abnormalities. Sulforaphane (SFN), found in cruciferous vegetables, is a potent antioxidant. It is of interest to determine...

journal_title：Psychopharmacology

authors： Chen H,Wu J,Zhang J,Fujita Y,Ishima T,Iyo M,Hashimoto K

更新日期：2012-07-01 00:00:00

abstract：:This study describes specific behaviours in guinea-pigs after dopamine D-1 and D-2 receptor activation which differed to those described in other rodent species. Intraperitoneal (IP) administration of the dopamine D-2 receptor agonist quinpirole (1.5, 3 and 6 mg/kg) to guinea-pigs dose-dependently initiated locomotor ...

journal_title：Psychopharmacology

authors： Brent PJ

更新日期：1991-01-01 00:00:00

abstract：:The effects of alcohol on locomotor activity of group- and individually-housed mice were studied using direct ethological observations, including a detailed postural analysis and measures of both locomotion and immobility. Ethanol (0, 0.5, 1.0 and 2.0 g/kg, IP) was given to subjects placed alone in a novel cage, and v...

journal_title：Psychopharmacology

authors： Smoothy R,Berry MS

更新日期：1984-01-01 00:00:00

abstract：:Sibutramine hydrochloride, a novel monoamine reuptake inhibitor antidepressant, has been studied to determine whether it alters dopaminergic function in the brain. Its effects have been compared with bupropion, a dopamine reuptake inhibitor, and methamphetamine, a dopamine reuptake inhibitor and releasing agent. Sibut...

journal_title：Psychopharmacology

authors： Heal DJ,Frankland AT,Gosden J,Hutchins LJ,Prow MR,Luscombe GP,Buckett WR

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Cortical gamma-aminobutyric acid (GABA)ergic neurons contribute to the orchestration of pyramidal neuron population firing as follows: (1) by releasing GABA on GABA(A) and GABA(B) receptors, (2) by releasing reelin in the proximity of integrin receptors located on cortical pyramidal neuron dendritic spines, a...

journal_title：Psychopharmacology

authors： Guidotti A,Auta J,Davis JM,Dong E,Grayson DR,Veldic M,Zhang X,Costa E

更新日期：2005-07-01 00:00:00

abstract：:Different venlafaxine doses (1, 5, and 10 mg/kg) and saline solution were administered to ten male Wistar rats (Latin-Square design). Compared with saline, venlafaxine produced a dose-related suppression of REM sleep and an increase in wake time while slow wave sleep was reduced. This effect is similar to the one that...

journal_title：Psychopharmacology

authors： Salin-Pascual RJ,Moro-Lopez ML

更新日期：1997-02-01 00:00:00

abstract：RATIONALE:Human behavioral pharmacology studies can examine how medications that target different neurotransmitter systems influence different aspects of smoking. Naltrexone and bupropion have been shown to alter ad lib smoking behavior; however, medication effects on nicotine reward in a cigarette choice paradigm have...

journal_title：Psychopharmacology

authors： Rukstalis M,Jepson C,Strasser A,Lynch KG,Perkins K,Patterson F,Lerman C

更新日期：2005-06-01 00:00:00

abstract：RATIONALE:Animal models of relapse to drug abuse typically assess the ability of various manipulations to reinstate responding that has ceased due to non-reinforcement (extinction). However, there is a lack of information concerning the reinstatement of responding that has ceased for reasons other than extinction. OBJ...

journal_title：Psychopharmacology

authors： Panlilio LV,Thorndike EB,Schindler CW

更新日期：2003-07-01 00:00:00

abstract：RATIONALE:The noradrenergic and dopaminergic systems are targets for antidepressants and are stimulated by serotonergic antidepressant drugs. The COMT enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Clinical studies on the effect of rs4680 on antidep...

journal_title：Psychopharmacology

authors： Benedetti F,Colombo C,Pirovano A,Marino E,Smeraldi E

更新日期：2009-03-01 00:00:00