Nicotine effects on learning in zebrafish: the role of dopaminergic systems.

abstract：:The cholinergic hypothesis of Alzheimer's disease (AD) has strongly influenced research on learning and memory over the last decade. However, there has been limited success treating AD dementia with cholinomimetics. Furthermore, there are indications that other neurotransmitter systems affected by this disease may be ...

journal_title：Psychopharmacology

authors： Camacho F,Smith CP,Vargas HM,Winslow JT

更新日期：1996-04-01 00:00:00

abstract：RATIONALE:Manipulations of the endocannabinoid system could potentially produce therapeutic effects with minimal risk of adverse cannabis-like side effects. Inhibitors of fatty acid amide hydrolase (FAAH) increase endogenous levels of the cannabinoid-receptor agonist, anandamide, and show promise for treating a wide ra...

journal_title：Psychopharmacology

authors： Panlilio LV,Thorndike EB,Nikas SP,Alapafuja SO,Bandiera T,Cravatt BF,Makriyannis A,Piomelli D,Goldberg SR,Justinova Z

更新日期：2016-05-01 00:00:00

abstract：RATIONALE:A previously reported pharmacokinetic interaction between bromperidol and carbamazepine, an inducer of cytochrome P450 (CYP) 3A4, suggests possible involvement of CYP3A4 in the metabolism of bromperidol. OBJECTIVE:We investigated pharmacokinetic interaction between bromperidol and itraconazole, a potent inhi...

journal_title：Psychopharmacology

authors： Furukori H,Kondo T,Yasui N,Otani K,Tokinaga N,Nagashima U,Kaneko S,Inoue Y

更新日期：1999-07-01 00:00:00

abstract：:Most post-mortem autoradiographic studies have described striatal dopamine D(2) receptor up-regulation due to chronic neuroleptic exposure. The aim of our study was to compare in-vivo striatal D(2) receptor density in neuroleptic-naive and neuroleptic-free schizophrenic patients. We included 28 young (mean age: 28+/-8...

journal_title：Psychopharmacology

authors： Lomeña F,Catafau AM,Parellada E,Bernardo M,Font M,Gutiérrez F,Pavía J

更新日期：2004-03-01 00:00:00

abstract：:Dopaminergic involvement in the regulation of operant behavior was examined by monitoring responding after administration of different dopaminergic agonists. A chain schedule of reinforcement was used to classify the effects of these agonists in long-tailed macaques (Macaca fascicularis). The schedule included the fol...

journal_title：Psychopharmacology

authors： Dooley DJ,Bowden DM

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Abnormalities of membrane phospholipid metabolism have been described in Alzheimer's disease (AD). We investigated, with the aid of (31)P magnetic resonance spectroscopy, the in vivo intracerebral availability of phosphomonoesters (PME) and phosphodiesters (PDE) in patients with AD. METHODS:Eighteen outpati...

journal_title：Psychopharmacology

authors： Forlenza OV,Wacker P,Nunes PV,Yacubian J,Castro CC,Otaduy MC,Gattaz WF

更新日期：2005-07-01 00:00:00

abstract：RATIONALE:There is a close relationship between arousal and pupil diameter, decrease in the level of arousal being accompanied by constriction of the pupil (miosis), probably reflecting the attenuation of sympathetic outflow as sedation sets in. Paradoxically, sedation induced by benzodiazepines is not accompanied by m...

journal_title：Psychopharmacology

authors： Hou RH,Samuels ER,Langley RW,Szabadi E,Bradshaw CM

更新日期：2007-11-01 00:00:00

abstract：:The in vivo potency of mazindol for binding to striatal dopamine transporters (DAT) was assessed by [123I]beta-CIT ([123I]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane) single photon emission computed tomography (SPECT). Cocaine-dependent subjects (n = 12) underwent three SPECT scans; one before, between, and after s...

journal_title：Psychopharmacology

authors： Malison RT,McCance E,Carpenter LL,Baldwin RM,Seibyl JP,Price LH,Kosten TR,Innis RB

更新日期：1998-06-01 00:00:00

abstract：RATIONALE:Oleoyl glycine (OlGly), a recently discovered fatty acid amide that is structurally similar to N- acylethanolamines, which include the endocannabinoid, anandamide (AEA), as well as endogenous peroxisome proliferator-activated receptor alpha (PPARα) agonists oleoylethanolamide (OEA) and palmitoylethanolamide (...

journal_title：Psychopharmacology

authors： Petrie GN,Wills KL,Piscitelli F,Smoum R,Limebeer CL,Rock EM,Humphrey AE,Sheppard-Perkins M,Lichtman AH,Mechoulam R,Di Marzo V,Parker LA

更新日期：2019-09-01 00:00:00

abstract：:The i.v. pentylenetetrazol seizure threshold was increased by 2.5 mg/kg and decreased by 15 mg/kg of a single (+)-amphetamine dose. After 7 consecutive days of amphetamine administration, tolerance developed to the decrease but not to the increase in seizure threshold. At 12--48 h after the last dose of 2.5 mg/kg seiz...

journal_title：Psychopharmacology

authors： Riffee WH,Gerald MC

更新日期：1977-01-31 00:00:00

abstract：RATIONALE:Serotonin (5-HT) and norepinephrine (NE) re-uptake inhibitors (SNRIs) have been proposed to have a higher efficacy and/or faster onset of action than previously available antidepressants. OBJECTIVES:We examined in biochemical, electrophysiological and behavioural assays the antidepressant properties of (S)-(...

journal_title：Psychopharmacology

authors： Artaiz I,Zazpe A,Innerárity A,Del Olmo E,Díaz A,Ruiz-Ortega JA,Castro E,Pena R,Labeaga L,Pazos A,Orjales A

更新日期：2005-11-01 00:00:00

abstract：RATIONALE:Acute cocaine administration produces an initial rewarding state followed by a dysphoric/anxiogenic "crash." OBJECTIVE:The objective of this study was to determine whether individual differences in the relative value of cocaine's positive and negative effects would account for variations in subsequent drug s...

journal_title：Psychopharmacology

authors： Ettenberg A,Fomenko V,Kaganovsky K,Shelton K,Wenzel JM

更新日期：2015-07-01 00:00:00

abstract：:Aggressive rats could be differentiated from non-aggressive rats on a lower rate of rearing reactions in the open-field activity, as well as on a weaker aptitude for learning, increasing with the complication of the test. The two groups of rats had comparable activity, and a comparable response to pain. Apomorphine de...

journal_title：Psychopharmacology

authors： Senault B

更新日期：1976-07-09 00:00:00

abstract：RATIONALE:The beneficial effects of psychostimulant drugs in the treatment of psychiatric disorders occur because they increase the extracellular dopamine concentration by inhibiting re-uptake of extracellular dopamine at dopamine transporters. However, the psychological effects at low dopamine transporter occupancy ha...

journal_title：Psychopharmacology

authors： Kimura Y,Maeda J,Yamada M,Takahata K,Yokokawa K,Ikoma Y,Seki C,Ito H,Higuchi M,Suhara T

更新日期：2017-02-01 00:00:00

abstract：:The effects of eight serotonin (5-HT) receptor antagonists on the anorectic effect of d-fenfluramine (3.0 mg/kg, IP) were examined in a test of sweet mash consumption, using non-deprived male rats. d-Fenfluramine's effect was attenuated by the mixed 5-HT1/5-HT2 receptor antagonists, methiothepin and metergoline; by th...

journal_title：Psychopharmacology

authors： Neill JC,Cooper SJ

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Selective attention deficit, characterised by the inability to differentiate relevant from irrelevant information, is considered to underlie many cognitive deficits of schizophrenia, and appears to be only marginally responsive to treatment with current antipsychotics. OBJECTIVES:We compared the activity of ...

journal_title：Psychopharmacology

authors： Terranova JP,Chabot C,Barnouin MC,Perrault G,Depoortere R,Griebel G,Scatton B

更新日期：2005-08-01 00:00:00

abstract：:This study examined and compared withdrawal signs and symptoms from cessation of 0, 2 and 4 mg nicotine gum. In addition, a comparison was made between nicotine gum versus cigarette withdrawal symptoms. Smokers first underwent cigarette deprivation for 4 days and then were randomly assigned to 0 (N = 16), 2 (N = 25), ...

journal_title：Psychopharmacology

authors： Hatsukami DK,Skoog K,Huber M,Hughes J

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Previously, we have shown that d-amphetamine (AMPH) was more potent than d-methamphetamine (METH) at increasing extracellular levels of dopamine (DA) in the prefrontal cortex (PFC) at doses that had similar effects in the nucleus accumbens. Since working memory depends on PFC DA, it was postulated that AMPH w...

journal_title：Psychopharmacology

authors： Shoblock JR,Maisonneuve IM,Glick SD

更新日期：2003-11-01 00:00:00

abstract：:Following the stereotaxic implantation of chronic cannulae for intracerebroventricular (ICV) infusion, rats were given an alcohol preference test to establish their preferred concentration in comparison with water. After alcohol was removed, 15 mg/kg cyanamide was then injected subcutaneously for 4 days in order to ma...

journal_title：Psychopharmacology

authors： Miñano FJ,Myers RD

更新日期：1989-01-01 00:00:00

abstract：:Dosage regimen adjustments because of poor renal function are often assumed to be unnecessary for extensively metabolized antidepressants. This assumption is being increasingly questioned in recognition of the role of active drug metabolites. The purpose of this study was to assess the steady-state accumulation of the...

journal_title：Psychopharmacology

authors： DeVane CL,Laizure SC,Cameron DF

更新日期：1986-01-01 00:00:00

abstract：:Two experiments investigated the effect of alcohol on retrieval of lexical information. In each, volunteers received alcohol (1 ml per kg body weight) in one session and no alcohol in another in counterbalanced order. Experiment 1 was a computerised version of the Mill Hill vocabulary test in which subjects were requi...

journal_title：Psychopharmacology

authors： Maylor EA,Rabbitt PM,Kingstone AF

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Many addictive drugs are known to have effects on learning and memory, and these effects could motivate future drug use. Specifically, addictive drugs may affect memory of emotional events and experiences in ways that are attractive to some users. However, few studies have investigated the effects of addictiv...

journal_title：Psychopharmacology

authors： Ballard ME,Gallo DA,de Wit H

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:Dysfunction of brain dopamine systems is involved in various neuropsychiatric disorders. Challenge studies with dopamine receptor agonists have been performed to assess dopamine receptor functioning, classically using the release of growth hormone (GH) from the hindbrain as primary outcome measure. The obj...

journal_title：Psychopharmacology

authors： Schellekens AF,Grootens KP,Neef C,Movig KL,Buitelaar JK,Ellenbroek B,Verkes RJ

更新日期：2010-01-01 00:00:00

abstract：RATIONALE:The efficacy of methadone for treating heroin dependence derives, in part, from suppression of opiate withdrawal and attenuation of the effects of heroin. OBJECTIVES:The purpose of this double-blind, within-subject, inpatient study was to determine whether larger doses of methadone, which are more effective ...

journal_title：Psychopharmacology

authors： Donny EC,Walsh SL,Bigelow GE,Eissenberg T,Stitzer ML

更新日期：2002-05-01 00:00:00

abstract：RATIONALE:Hypericum perforatum L., known as St. John's wort (SJW), is used as a phytotherapeutic agent for the treatment of mild to moderate forms of depression. OBJECTIVES:The aim of the present study was to evaluate the effect of SJW extract (STW 3-VI; 250 and 500 mg/kg; p.o.) and fluoxetine (10 mg/kg, p.o.) on gene...

journal_title：Psychopharmacology

authors： Jungke P,Ostrow G,Li JL,Norton S,Nieber K,Kelber O,Butterweck V

更新日期：2011-02-01 00:00:00

abstract：:A prospective, placebo-controlled, comparative evaluation was conducted on two widely prescribed, sympatholytic antihypertensive agents with known CNS effects. In order to separately assess these effects in younger and older male hypertensives, patients were assigned to either of two treatment studies based on age. Fo...

journal_title：Psychopharmacology

authors： Kostis JB,Rosen RC,Holzer BC,Randolph C,Taska LS,Miller MH

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:During the course of our investigation of antalarmin, a corticotropin-releasing hormone (CRH) antagonist, in rhesus monkeys, we noticed that large, intravenous doses of antalarmin resulted in behavioral changes that resembled intoxication. OBJECTIVES:Antalarmin was evaluated in rhesus monkeys for its reinfor...

journal_title：Psychopharmacology

authors： Broadbear JH,Winger G,Rice KC,Woods JH

更新日期：2002-11-01 00:00:00

abstract：:Chronic treatment of rats with the antipsychotic drug molindone (2.5 mg/kg) did not elicit behavioral supersensitivity to apomorphine (AP) (0.25 mg/kg) or increased striatal 3H-spiroperidol binding, whereas treatment with haloperidol (0.5-1.0 mg/kg) produced manifestations of dopaminergic supersensitivity in both para...

journal_title：Psychopharmacology

authors： Meller E

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Central CB1 cannabinoid receptors regulate anxiety-like and appetitive consummatory behaviors. Pharmacological antagonism/inverse-agonism of CB1 receptors increases anxiety and decreases appetitive behaviors; however, neither well-defined dose nor context dependence of these effects has been simultaneously as...

journal_title：Psychopharmacology

authors： Gamble-George JC,Conger JR,Hartley ND,Gupta P,Sumislawski JJ,Patel S

更新日期：2013-08-01 00:00:00

abstract：:Fluctuations in extracellular dopamine and DOPAC levels in nucleus accumbens septi (NAS) were monitored in 1-min microdialysis samples taken from rats engaged in intravenous cocaine self-administration. For four rats the dose per injection was fixed at 2.0 mg/kg; for four others the dose per injection was varied irreg...

journal_title：Psychopharmacology

authors： Wise RA,Newton P,Leeb K,Burnette B,Pocock D,Justice JB Jr

更新日期：1995-07-01 00:00:00