Abstract：
RATIONALE:Previously, we have shown that d-amphetamine (AMPH) was more potent than d-methamphetamine (METH) at increasing extracellular levels of dopamine (DA) in the prefrontal cortex (PFC) at doses that had similar effects in the nucleus accumbens. Since working memory depends on PFC DA, it was postulated that AMPH would also be more potent than METH at affecting working memory. OBJECTIVE:To determine if AMPH is more potent than METH at affecting working memory. METHODS:Working memory was measured in adult female Sprague-Dawley rats using a delayed-alternation T-maze task with multiple delays (1, 10, 60 s) and food rewards. The percentage of food rewards consumed was also recorded. Animals were tested with METH and AMPH before and after a chronic protocol, with measurements of locomotor activity used to test for pharmacological tolerance or sensitization. The effects of METH and AMPH on extinction were also examined by omitting the food rewards from the T-maze. RESULTS. Both METH and AMPH produced dose-related bimodal effects on working memory at the intermediate delay (10 s); however, AMPH was more potent than METH. Both METH and AMPH initially also decreased the percentage of food rewards consumed in the T-maze. After chronic testing, animals displayed tolerance to both the working memory impairments and the reduction in food reward intake produced by AMPH. Animals did not display significant tolerance to the effects of METH on food reward consumption and performed worse in the T-maze after chronic testing. METH, but not AMPH, interfered with extinction. CONCLUSIONS:These results indicate that METH and AMPH differ in altering working memory and the expression of tolerance, perhaps due to differences in behavioral inhibition.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Shoblock JR,Maisonneuve IM,Glick SDdoi
10.1007/s00213-003-1522-ysubject
Has Abstractpub_date
2003-11-01 00:00:00pages
150-6issue
2eissn
0033-3158issn
1432-2072journal_volume
170pub_type
杂志文章abstract：RATIONALE:It is important to study age-related differences that may put adolescents at risk for alcohol-related problems. Adolescents seem less sensitive to the aversive effects of ethanol than adults. Less is known of appetitive effects of ethanol and stress modulation of these effects. OBJECTIVES:This study aims to ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3163-0
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Rats reared in social isolation exhibit various cognitive and behavioural abnormalities in adulthood. However, impulsivity following this treatment still remains unclear, especially in response to medications used in attention deficit hyperactivity disorder, such as amphetamine. METHODS:Using an isolation-r...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4579-8
更新日期：2017-05-01 00:00:00
abstract：RATIONALE:Nicotine and other agonists of nicotinic cholinergic receptors (nAChR) have been shown to improve performance in specific memory domains in rodents and monkeys. Such beneficial effects are observed in preclinical models of age-related cognitive decline, stimulating interest in nAChR ligands as possible therap...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1804-z
更新日期：2004-09-01 00:00:00
abstract：:The aim of the present study was to investigate the locomotor stimulant effects of the atypical antipsychotic agent, olanzapine, in mice depleted of their dopamine by reserpine and alpha-methyl-DL-p-tyrosine pretreatment. Olanzapine (0.5, 1 and 2 mg/kg) dose-dependently increased locomotor activity, which was complete...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050877
更新日期：1999-02-01 00:00:00
abstract：RATIONALE:Mice are useful tools for dissecting genetic and environmental factors in relation to the study of attention and impulsivity. The five-choice serial reaction time task (5CSRTT) paradigm has been well established in rats, but its transferability to mice is less well documented. OBJECTIVES:This study aims to s...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-011-2560-5
更新日期：2012-01-01 00:00:00
abstract：:Administration of various doses of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) to rats produced dose-related decreases in 1-h food intake in the food-deprived paradigm. Pretreatment with spiperone (5-HT1A/5-HT2/D2 antagonist), propranolol or CGP361A (beta-adrenoceptor antagonists that also have binding affinit...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02247721
更新日期：1992-01-01 00:00:00
abstract：:The neurochemical specificity of physiological, biochemical, and psychological responses to dextroamphetamine was tested by pretreating volunteers with haloperidol (0.014 mg/kg IM), propranolol (0.1 mg/kg IV), thymoxamine (0.1 mg/kg IV), or placebo prior to 0.3 mg/kg IV amphetamine. Healthy volunteers (N = 12) partici...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00427446
更新日期：1984-01-01 00:00:00
abstract：RATIONALE:The indirect dopamine agonist methylphenidate remediates cognitive deficits in psychopathology, but the individual characteristics that determine its effects on the brain are not known. OBJECTIVES:We aimed to determine whether targeted dopaminergically modulated traits and individual differences could predic...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-016-4307-9
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Acute administration of selective serotonin and noradrenaline re-uptake blockers to healthy volunteers affects the processing of emotional information but it is not known if similar effects occur with antidepressants acting through other pharmacological mechanisms. Mirtazapine is a clinically established ant...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-008-1410-6
更新日期：2009-05-01 00:00:00
abstract：RATIONALE:Central application of MTII, a melanocortin 3/4 receptor agonist, reduces food intake. The behavioral mechanisms underlying the anorexia, however, have not been evaluated. OBJECTIVES:We examined the ingestive behavioral effects of MTII at the microstructural level using two complementary approaches. METHODS...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1022-5
更新日期：2002-04-01 00:00:00
abstract：RATIONALE:Though interoceptive properties of antidepressants have been described, discriminative stimulus (DS) properties of mirtazapine, which does not affect monoamine reuptake, remain uncharacterized. OBJECTIVES:The objectives of the study are to train rats to recognize a mirtazapine DS, then perform substitution s...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1259-8
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVES:To investigate the relationship between benzodiazepine and risk of developing pneumonia in patients with schizophrenia, whose benzodiazepine dosage and usage frequency was higher than that of the general population. METHODS:We conducted a nested case-control study to assess the association between benzodiaz...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5039-9
更新日期：2018-11-01 00:00:00
abstract：:Two 2-(di-n-propylamino)tetralin (DPAT) compounds, 8-OH-DPAT and 5-OH-DPAT, with reported effects on central 5-HT and DA receptors respectively, were tested for their effects on the acoustic startle response in rats. 8-OH-DPAT was given in doses of 0.25-2.0 mg/kg IP and 5-OH-DPAT in doses of 1.0-8.0 mg/kg IP. Both com...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427793
更新日期：1983-01-01 00:00:00
abstract：BACKGROUND:Although ethanol is frequently used in combination with other psychoactive drugs, the behavioral and pharmacological reasons for this form of polydrug abuse have not been well described. MATERIALS AND METHODS:Rhesus monkeys with indwelling intravenous catheters produced intravenous injections of ethanol (50...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-0809-9
更新日期：2007-09-01 00:00:00
abstract：:Intracerebroventricular injections of gamma-aminobutyric acid (GABA) and of the GABA-transaminase inhibitor, ethanolamine-O-sulphate (EOS), decreased the food intake of freely-fed (GABA and EOS) and food-deprived rats (EOS). The effect, still evident 24 h after treatment, was not decreased by the GABA receptor-blocker...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432135
更新日期：1980-01-01 00:00:00
abstract：RATIONALE:Robust intravenous (i.v.) nicotine self-administration (SA) in rats has been reported by several laboratories, including our own, using fixed ratio (FR) schedules of reinforcement. Studies on other drugs of abuse, however, suggest that progressive ratio (PR) schedules may provide additional information not ga...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051153
更新日期：1999-11-01 00:00:00
abstract：RATIONALE AND OBJECTIVE:Drug-associated memories are hypothesized to underlie the high risk of relapse in addiction. Recent studies show that post-retrieval extinction training erases fear memories by reconsolidation blockade. Here, we examine the efficacy of this non-invasive procedure in rats with drug-associated mem...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-011-2545-4
更新日期：2012-05-01 00:00:00
abstract：RATIONAL:Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors. OBJECTIVES:We investigated the role of leptin and ghrelin in the augmentation of heroin seekin...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05415-9
更新日期：2020-03-01 00:00:00
abstract：:Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-depend...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427798
更新日期：1983-01-01 00:00:00
abstract：:Voluntary consumption of alcohol by rats (i.e. in the absence of food or water deprivation, sweetening of the alcohol solution, etc.) that results in the attainment of behaviorally significant or pharmacologically detectable blood alcohol levels (BALs) has been difficult to demonstrate. In this study, we showed that f...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00177925
更新日期：1987-01-01 00:00:00
abstract：:The effects of dietary caffeine and the amount and palatability of food on the acquisition of cocaine (0.2 mg/kg) self-administration were examined. Using an autoshaping procedure, seven groups of 13 rats each were trained to press a lever resulting in a cocaine (0.2 mg/kg infusion under a fixed-ratio 1 (FR 1) schedul...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050596
更新日期：1998-05-01 00:00:00
abstract：RATIONALE:Many previous studies have reported that alcohol and cannabis produce additive psychomotor effects in acute combination, but few have explicitly tested whether chronic exposure to cannabis, in the absence of acute administration, alters the effects of alcohol on psychomotor performance. OBJECTIVES:To test wh...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-001-0955-4
更新日期：2002-03-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Footshock stress reliably reinstates heroin seeking in rats, but the time course of the development of this effect following drug withdrawal is not known. Here we studied the effect of intermittent footshock stress on reinstatement of heroin seeking following different withdrawal periods (1-66 ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100748
更新日期：2001-06-01 00:00:00
abstract：:Monoamine oxidase inhibitors (MAOIs) are widely accepted as effective antidepressants. Unfortunately their use has been limited by their capacity to potentiate dietary tyramine (the so called "cheese effect") and their interaction with other drugs. The latter poses a particular problem for patients undergoing anaesthe...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/BF02246234
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:The high prevalence of smoking and low cessation rates among individuals with schizophrenia and similar conditions are not well understood. Behavioral economics has been extensively applied to studying addictive behavior and may contribute to understanding smoking in this subpopulation. OBJECTIVES:This study...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-011-2185-8
更新日期：2011-07-01 00:00:00
abstract：RATIONALE:Obsessive-compulsive disorder (OCD) gradually emerges and reaches clinical significance during early adulthood. Whether a predisposition for OCD manifests as binge eating disorder earlier during adolescence is proposed. OBJECTIVES:To further characterize how OCD-like behaviors increase across maturation and ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-3967-1
更新日期：2015-09-01 00:00:00
abstract：RATIONALE:Preclinical studies indicate that gonadal hormones are important determinants of drug self-administration. To date, little is known about the influence of sex and estrous cycle on drug self-administration in ecologically relevant social contexts. OBJECTIVE:The objective of this study was to examine the role ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4368-9
更新日期：2016-09-01 00:00:00
abstract：:Sixty-two DSM III chronic schizophrenic inpatients were selected for a double-blind, placebo controlled, multi-centre, relapse prevention study of remoxipride, a selective dopamine (D2)-receptor antagonist. After a 1 month placebo washout, 23 patients had relapsed and were withdrawn. Of the remaining patients 19 were ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF02245134
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:Several antipsychotic drugs are metabolised by the polymorphic cytochrome P(450) CYP2D6. The impact of the polymorphism on the plasma levels and the occurrence of side effects have not been clearly established. OBJECTIVE:To investigate the impact of the CYP2D6 polymorphism on the steady-state plasma concentr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1059-5
更新日期：2002-06-01 00:00:00
abstract：:This experiment examined the effect of destruction of the ascending 5-hydroxytryptaminergic (5HTergic) pathways on performance in a free-operant timing schedule. Rats received either injections of 5,7-dihydroxytryptamine into the dorsal and median raphe nuclei or sham lesions. They were trained to press levers for a s...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050096
更新日期：1996-10-01 00:00:00
