Antalarmin, a putative CRH-RI antagonist, has transient reinforcing effects in rhesus monkeys.

abstract：:Development of tolerance to neuroleptic compounds tested in the conditional avoidance model was investigated. Since tolerance may manifest itself by a diminished potency and/or a shortened duration of effect, the complete time course of effect was registered in these experiments. Rats were pretreated approximately 2 w...

journal_title：Psychopharmacology

authors： Danneskiold-Samsøoe P,Pedersen V

更新日期：1976-12-21 00:00:00

abstract：:Functional antagonists at the N-methyl-D-aspartate (NMDA) receptor complex produce anti-depressant-like actions in preclinical models. Thus, an injection of a glycine partial agonist (1-aminocyclopropanecarboxylic acid; ACPC), a competitive NMDA antagonist (2-amino-7-phosphonoheptanoic acid; AP-7) or a use-dependent c...

journal_title：Psychopharmacology

authors： Skolnick P,Miller R,Young A,Boje K,Trullas R

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Chronic nicotine administration decreases the functioning of the cystine-glutamate antiporter system x(c)- which is hypothesized to promote nicotine-taking and nicotine-seeking behaviors. N-acetylcysteine (NAC), a cystine pro-drug, increases the activity of the cystine-glutamate antiporter system x(c)-. Thus,...

journal_title：Psychopharmacology

authors： Ramirez-Niño AM,D'Souza MS,Markou A

更新日期：2013-01-01 00:00:00

abstract：RATIONALE:It has been proposed that cannabinoid-1 receptor inverse agonists might be effective for smoking cessation. We evaluated this hypothesis with the cannabinoid-1 receptor inverse agonist taranabant. METHODS:Adults who smoked > or =10 cigarettes a day for >1 year and had an expired CO level of > or =10 ppm part...

journal_title：Psychopharmacology

authors： Morrison MF,Ceesay P,Gantz I,Kaufman KD,Lines CR

更新日期：2010-04-01 00:00:00

abstract：:The effects of lormetazepam (0.03 mg/kg IV) a benzodiazepine (BZ) derivative in combination with ZK 93 426 (0.04 mg/kg IV) a beta-carboline, benzodiazepine receptor antagonist were evaluated in humans. Independently, the effects of ZK 93 426 on its own were investigated. A psychometric test battery to evaluate sedatio...

journal_title：Psychopharmacology

authors： Duka T,Goerke D,Dorow R,Höller L,Fichte K

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Several lines of evidence have indicated that the central histaminergic system might be involved in learning and memory OBJECTIVES:The aim of the present study was to ascertain the impact on memory processes of putative histaminergic-cholinergic interactions in the nucleus basalis magnocellularis (NBM) of th...

journal_title：Psychopharmacology

authors： Orsetti M,Ferretti C,Gamalero R,Ghi P

更新日期：2002-01-01 00:00:00

abstract：RATIONALE:Repeated methamphetamine (MA) use leads to increases in the incentive motivational properties of the drug as well as cognitive impairments. These behavioral alterations persist for some time following abstinence, and neuroadaptations in the structure and function of the prefrontal cortex (PFC) are particularl...

journal_title：Psychopharmacology

authors： Janetsian SS,Linsenbardt DN,Lapish CC

更新日期：2015-06-01 00:00:00

abstract：:These experiments examined the neurochemical mechanisms involved in the development and expression of place conditioning produced by heroin. Conditioned place preferences (CPP) lasting up to 8 weeks were obtained with doses of 50-1000 micrograms/kg heroin, using a regimen shown not to produce physical dependence. Nalo...

journal_title：Psychopharmacology

authors： Hand TH,Stinus L,Le Moal M

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Dopamine innervation of the nucleus accumbens is thought to have a major role in the biological processes underlying cocaine self-administration. Recent data suggest that dopamine innervation of the ventral pallidum (VP) may also play an important role. OBJECTIVES:This experiment was initiated to assess extr...

journal_title：Psychopharmacology

authors： Sizemore GM,Co C,Smith JE

更新日期：2000-07-01 00:00:00

abstract：RATIONALE:Executive function impairment, as classically assessed using the Wisconsin Card Sort Test or intradimensional/extradimensional tests, is a key feature of schizophrenia but remains inadequately treated by existing therapies. Recently, however, erythropoietin has been shown to improve attentional set-shifting p...

journal_title：Psychopharmacology

authors： Goetghebeur PJ,Lerdrup L,Sylvest A,Dias R

更新日期：2010-12-01 00:00:00

abstract：:Tardive dyskinesia has been hypothesized to be caused by a neuroleptic-induced dopamine hypersensitivity in the nigrostriatal system. This study evaluated with dopamine antagonists the possibility that such dopamine hypersensitivity extends to the tuberoinfundibular dopamine (TIDA) system, which regulates, by inhibiti...

journal_title：Psychopharmacology

authors： Asnis GM,Sachar EJ,Langer G,Halpern FS,Fink M

更新日期：1979-01-01 00:00:00

abstract：:The predatory behavior of ferrets (Putorius putorius furo L.) consists mainly of instinctive behavioral patterns that are elicited by simple external stimuli. For the ferret, the time needed to catch and kill rats depends on the size of the rats in relation to that of the ferret. Killing success decreases with a relat...

journal_title：Psychopharmacology

authors： Apfelbach R

更新日期：1978-10-31 00:00:00

abstract：:In the majority of Parkinson's disease (PD) patients, long-term dopamine (DA) replacement therapy leads to dyskinesia characterized by abnormal involuntary movements (AIMs). There are various mechanisms of dyskinesia, such as the sensitization of striatal DA D1 receptors (D1R) and upregulation of DA D3 receptors (D3R)...

journal_title：Psychopharmacology

authors： Lanza K,Chemakin K,Lefkowitz S,Saito C,Chambers N,Bishop C

更新日期：2020-01-01 00:00:00

abstract：:The influence of practice while under intoxication was tested on the development of acute tolerance to the motor impairment effect of ethanol. In experiment 1, the motor impairment effect induced by an IP injection of 1.8 g/kg ethanol was quantified after various intervals in separate groups of animals. Lower impairme...

journal_title：Psychopharmacology

authors： Lê AD,Kalant H

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Alcohol-associated cues elicit craving in human addicts but little is known about craving mechanisms. Current animal models focus on relapse and this may confound the effect of environmental cues. OBJECTIVES. To develop a model to study the effects of environmental cues on alcohol consumption in animals not e...

journal_title：Psychopharmacology

authors： Pickering C,Liljequist S

更新日期：2003-07-01 00:00:00

abstract：:Systemic administration of RB 101, a complete inhibitor of the enkephalin degrading enzymes, has been reported to induce naltrindole-reversed antidepressant-like effects in the conditioned suppression of motility (CSM) test in mice. The selective CCKB antagonist L-365,260 also elicits the same naltrindole-blocked resp...

journal_title：Psychopharmacology

authors： Smadja C,Maldonado R,Turcaud S,Fournie-Zaluski MC,Roques BP

更新日期：1995-08-01 00:00:00

abstract：:Nine human subjects were exposed to a multiple fixed-ratio (FR) differential-reinforcement-of-low-rate (DRL) schedule of monetary reinforcement. Presses on a manipulandum requiring relatively high force were occasionally followed by an increased money total displayed on a computer screen. Subjects were exposed to the ...

journal_title：Psychopharmacology

authors： Rumbold GR,White JM

更新日期：1987-01-01 00:00:00

abstract：:The relationship between norepinephrine (NE) content in cortex and spinal cord and acoustic startle amplitude was investigated in two experiments. Administration of diethyldithiocarbamate (DDC) depressed startle amplitude at the same time and dose that it most severely depleted NE content. These results support the co...

journal_title：Psychopharmacology

authors： Storm JE,Millington WR,Fechter LD

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Pairing rewarding outcomes with audiovisual cues in simulated gambling games increases risky choice in both humans and rats. However, the cognitive mechanism through which this sensory enhancement biases decision-making is unknown. OBJECTIVES:To assess the computational mechanisms that promote risky choice d...

journal_title：Psychopharmacology

authors： Langdon AJ,Hathaway BA,Zorowitz S,Harris CBW,Winstanley CA

更新日期：2019-08-01 00:00:00

abstract：RATIONALE:3,4-Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone abused for its cocaine-like psychostimulant effects in "bath salts" products. While there are currently no pharmacotherapies for MDPV abuse, rodent studies suggest immunotherapy may offer a feasible treatment option. OBJECTIVES:These studies test...

journal_title：Psychopharmacology

authors： McClenahan SJ,Gunnell MG,Owens SM,Fantegrossi WE

更新日期：2020-09-01 00:00:00

abstract：RATIONALE:(+/-)-3,4-methylenedioxymethamphet-amine (MDMA; 'ecstasy'), a commonly used recreational drug, has typically been found to be related to poor cognitive function in humans. However, cannabis consumption may not have been adequately controlled for in these studies. OBJECTIVE:The present study was designed to f...

journal_title：Psychopharmacology

authors： Croft RJ,Mackay AJ,Mills AT,Gruzelier JG

更新日期：2001-01-01 00:00:00

abstract：:Nine depressed patients were treated with alaproclate, a selective 5-HT uptake inhibitor, for 3 weeks in a dose of 400 mg daily. The pupillary responses to tyramine, phenylephrine, and pilocarpine eye drops were measured on consecutive days before, after 1 week and after 3 weeks of treatment. The tyramine-induced mydr...

journal_title：Psychopharmacology

authors： Thompson C,Checkley SA

更新日期：1985-01-01 00:00:00

abstract：:Chronic administration of the benzodiazepine (BZ) receptor agonist chlordiazepoxide (CDP) produced tolerance to its motor-impairing effects but little or no tolerance to its hypothermic effects or to its amnesic effects in the radial arm maze. Male Sprague-Dawley rats were pretreated for 14 days with CDP (25 mg/kg, b....

journal_title：Psychopharmacology

authors： Shumsky JS,Lucki I

更新日期：1994-06-01 00:00:00

abstract：:This study demonstrates that pre-exposure to stress influences subsequent effects of stress on pain sensitivity (stress-induced analgesia) and on plasma corticosterone and brain catecholamine activity. Animals exposed to a 30 min shock session (S1 = 8, 5.0 s shocks) 10 days earlier showed a significant attenuation of ...

journal_title：Psychopharmacology

authors： Caggiula AR,Antelman SM,Aul E,Knopf S,Edwards DJ

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Synthesis of ligands inactive or with low activity at α₁ GABA(A) receptors has become the key concept for development of novel, more tolerable benzodiazepine (BZ)-like drugs. WYS8, a remarkably (105 times) α₁-subtype selective partial positive modulator, may serve as a pharmacological tool for refining the ro...

journal_title：Psychopharmacology

authors： Joksimović S,Varagic Z,Kovačević J,Van Linn M,Milić M,Rallapalli S,Timić T,Sieghart W,Cook JM,Savić MM

更新日期：2013-11-01 00:00:00

abstract：:The effects of the CCKB-receptor agonist pentagastrin, a synthetic analogue of the cholecystokinin tetrapeptide (CCK-4), were studied in seven patients suffering from obsessive compulsive disorder (OCD) and seven healthy controls. All subjects were challenged with an IV dose of 0.6 micrograms/kg pentagastrin or placeb...

journal_title：Psychopharmacology

authors： de Leeuw AS,Den Boer JA,Slaap BR,Westenberg HG

更新日期：1996-08-01 00:00:00

abstract：:The ability of delta 9-tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD), 11-OH THC and 8 alpha, 11-diOH THC to antagonise the abdominal constriction response in the mouse induced by formic acid, phenylquinone, 5-hydroxytryptamine, prostaglandin E1 (PGE1) and bradykinin was tested. THC was an effective a...

journal_title：Psychopharmacology

authors： Sanders J,Jackson DM,Starmer GA

更新日期：1979-03-28 00:00:00

abstract：RATIONALE:The high prevalence of smoking and low cessation rates among individuals with schizophrenia and similar conditions are not well understood. Behavioral economics has been extensively applied to studying addictive behavior and may contribute to understanding smoking in this subpopulation. OBJECTIVES:This study...

journal_title：Psychopharmacology

authors： MacKillop J,Tidey JW

更新日期：2011-07-01 00:00:00

abstract：:Rat open field behavior is often used as a tool to study the behavioral effects of drugs. In this report, drug-induced patterns of locomotion in an open field were studied with the aid of a simple new statistic. Briefly, the animal's path through the open field is converted into a series of trips. Gamma (gamma) estima...

journal_title：Psychopharmacology

authors： Mueller K,Hollingsworth EM,Cross DR

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:In an animal model for vulnerability to drug abuse, rats that are more reactive to a novel environment (high responders, HRs) are more sensitive to behavioral effects of psychostimulants than are less reactive rats (low responders, LRs). In a companion article, we reported that HRs and LRs differ in sensitivi...

journal_title：Psychopharmacology

authors： White DA,Kalinichev M,Holtzman SG

更新日期：2004-12-01 00:00:00