Abstract:
:Development of tolerance to neuroleptic compounds tested in the conditional avoidance model was investigated. Since tolerance may manifest itself by a diminished potency and/or a shortened duration of effect, the complete time course of effect was registered in these experiments. Rats were pretreated approximately 2 weeks with daily oral doses of chlorprothixene (20 mg/kg), flupenthixol (10 mg/kg), fluphenazine (2.5 mg/kg), or haloperidol (10 mg/kg) or twice a week with piflutixol (0.31 mg/kg). Three days after withdrawal chlorprothixene and flupenthixon caused a slightly but significantly weaker inhibition of avoidance performance in rats pretreated with the respective compounds and compared with non-pretreated rats, the duration of effect was shortened. Six dasy after withdrawal of piflutixol the duration of effect of a dose of piflutixol causing maximum inhibition was significantly shortened, while no homologous tolerance could be demonstrated in fluphenazine-pretreated rats. Cross tolerance was found after haloperidol-pretreatment when the rats were tested with fluphenazine 6 days after withdrawal. Homologous piflutixol tolerance could be shown 4 weeks after withdrawal. These results indicate that it is possible to demonstrate a slight tolerance to the effect of neuroleptic compounds when these are tested in conditional avoidance experiments. The cause of this tolerance is discussed.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Danneskiold-Samsøoe P,Pedersen Vdoi
10.1007/BF00426314subject
Has Abstractpub_date
1976-12-21 00:00:00pages
9-14issue
1eissn
0033-3158issn
1432-2072journal_volume
51pub_type
杂志文章abstract::The authors review the literature regarding the pharmacokinetics of long-acting injectable neuroleptic drugs (LINS). There are important differences between LINS and oral neuroleptics that affect their pharmacokinetics. By avoiding first pass metabolism in gut and liver, LINS result in lower circulating concentrations...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF00441937
更新日期:1989-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00555225
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Anti-psychotic treatment appears to be associated with striatal volume increase, but how early this change occurs is still unknown. METHODS:A single prospective cohort of 20 anti-psychotic-naïve patients, newly diagnosed with schizophrenia, underwent magnetic resonance imaging brain scan at baseline. This w...
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pub_type: 杂志文章
doi:10.1007/s00213-009-1619-z
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130100824
更新日期:2001-09-01 00:00:00
abstract:RATIONALE:Some recent pharmacoepidemiological studies revealed an elevated risk of driving accidents after opioid analgesics uses. Among analgesics, codeine is often associated with paracetamol in numerous pharmaceutical specialties. OBJECTIVES:The objective of this study was to evaluate the dose-effect relationship o...
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00428404
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doi:10.1007/s00213-003-1769-3
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2299-z
更新日期:2011-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246263
更新日期:1995-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244975
更新日期:1992-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00422406
更新日期:1981-01-01 00:00:00
abstract::It was shown previously that behavioural effects of apomorphine (locomotor activation and stereotyped behaviour) can be conditioned when they are associated with well-defined environmental stimuli. In the present study, the hypothesis was tested that glutamatergic mechanisms play an important role either in formation ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244064
更新日期:1990-01-01 00:00:00
abstract::EEG measures have been shown to differ in human subjects who are at genetically increased risk for the development of alcoholism. In the present study, EEG was recorded in rats that were selectively bred for alcohol-preferring (P) and nonpreferring (NP) behaviors during an ethanol self-administration paradigm. In this...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244335
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:Several studies have suggested that modulation of the glutamatergic system via metabotropic glutamate receptors (mGlu) could be a new and efficient way to achieve antipsychotic-like activity. OBJECTIVES:Here, we decided to investigate the possible role of the group III mGlu receptor ligands, LSP1-2111, the g...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2502-2
更新日期:2012-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05522-y
更新日期:2020-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-1063-x
更新日期:2008-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05727-1
更新日期:2020-11-25 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02431537
更新日期:1988-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428038
更新日期:1978-09-15 00:00:00
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pub_type: 杂志文章
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更新日期:1996-05-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2016-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3042-8
更新日期:2013-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244090
更新日期:1991-01-01 00:00:00
abstract::It was the aim of the present study to determine the affinities of four neuroleptics and five antidepressants for histamine H3 receptors. In rat brain cortex membranes, the specifically bound [3H]-N alpha-methylhistamine was monophasically displaced by clozapine (pKi 6.15). The other drugs did not completely displace ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247479
更新日期:1994-12-01 00:00:00
abstract::In previous research, sensitization of stereotypy induced by injections of 2.5 mg/kg amphetamine did not interfere with subsequent tolerance development to the hypophagic effect of 2 mg/kg. This study examined the effect of a higher sensitizing dose. Rats given intermittent injections of 5 mg/kg amphetamine and then c...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050788
更新日期:1998-12-01 00:00:00
abstract::The action of copper (CuSO4, 5 mg/kg, oral) on selected neuropharmacological actions of cannabis resin (CI, oral) was studied on albino rats and mice. Copper potentiated the barbiturate hypnosis-potentiating activity of CI in albino rats and mice and had no effect on hypothermic activity in albino rats. Single doses o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432855
更新日期:1978-04-11 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2527-6
更新日期:2012-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245460
更新日期:1994-02-01 00:00:00
abstract::Nicotine (0.16--0.50 mg/kg, SC) was found to exert a potent antinociceptive action on thermal stimuli as measured by the tail-flick test. This antinociceptive action of nicotine could be blocked by centrally active nicotinic or muscarinic blockers implicating both classes of cholinergic receptors in this effect. Quate...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00492216
更新日期:1979-11-01 00:00:00
abstract::The interaction between pimozide (a selective D2-dopamine receptor antagonist) and d-amphetamine on the operant performance of rats maintained under variable-interval schedules of positive reinforcement was examined. In Experiment 1, eight rats responded under variable-interval 30-s and variable-interval 300-s. Pimozi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00217071
更新日期:1987-01-01 00:00:00