Abstract：
RATIONALE:Several lines of evidence have indicated that the central histaminergic system might be involved in learning and memory OBJECTIVES:The aim of the present study was to ascertain the impact on memory processes of putative histaminergic-cholinergic interactions in the nucleus basalis magnocellularis (NBM) of the rat. METHODS:The effects of thioperamide, a histamine H3-receptor antagonist, were studied on the memory performance of rats in a two-trial, delayed, place-recognition task. The drug was injected into the NBM area 2 min prior to the first trial (1.5, 7.5, and 37.5 ng/0.5 microl; pre-acquisition treatment), within 30 s from the end of the first trial (0.3, 1.5, 7.5, and 37.5 ng/0.5 microl; post-acquisition treatment), or 2 min prior to the second trial (1.5, 7.5, and 37.5 ng/0.5 microl; pre-retrieval treatment). RESULTS:Post-acquisition intra-NBM injections of 1.5 ng and 7.5 ng, but not of 0.3 ng and 37.5 ng thioperamide, significantly enhanced memory retention in treated rats. The histamine H(3)-receptor blocker exerted pro-cognitive effects only when administered post-acquisition, since both pre-acquisition and pre-retrieval treatments were ineffective. The post-acquisition effect of the drug was time dependent and disappeared when the drug was injected 90 min after the end of the first trial. The U-shaped dose-response relationship and the time dependency of the effect of thioperamide indicated that the drug acts on mechanisms involved in memory consolidation. CONCLUSIONS:The present findings demonstrate that the pro-cognitive effect of thioperamide is probably due to the modulation of post-acquisition memory processes through an action on the cholinergic basal forebrain. Our results indicate also that H3-antagonists may provide a useful approach for improving spatial recognition memory.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Orsetti M,Ferretti C,Gamalero R,Ghi Pdoi
10.1007/s002130100892subject
Has Abstractpub_date
2002-01-01 00:00:00pages
133-7issue
2eissn
0033-3158issn
1432-2072journal_volume
159pub_type
杂志文章abstract：:Metergoline given IP reduced the response to noxious stimulation in the mouse formalin test. Tolerance to this effect developed after a chronic treatment schedule consisting of ten daily injections of 5 mg/kg. Twenty four hours after the last injection a test dose of metergoline (2.5 mg/kg) reduced the licking time in...
journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：2011-11-01 00:00:00
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journal_title：Psychopharmacology
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doi：10.1007/BF00172861
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF02244252
更新日期：1991-01-01 00:00:00
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更新日期：1985-01-01 00:00:00
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更新日期：2019-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：1980-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00212767
更新日期：1988-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2003-11-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：1984-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050919
更新日期：1999-03-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050428
更新日期：1997-11-01 00:00:00
