Normal prolactin responses in tardive dyskinesia.

abstract：:The metabolism of the tricyclic antidepressants amitriptyline (AMI), imipramine (IMI), chlorimipramine (CMI) and some of their metabolites was studied in vitro in isolated liver microsomes of female Spraque-Dawley rats. Nine metabolites of AMI, seven metabolites of IMI, and 11 metabolites of CMI were quantitatively de...

journal_title：Psychopharmacology

authors： Krüger R,Hölzl G,Kuss HJ,Schefold L

更新日期：1986-01-01 00:00:00

abstract：:Male Sprague-Dawley rats were evaluated between ages 18 and 825 days for responses to doses of haloperidol (0 and 0.05-10 mg/kg, IP). Catalepsy, ptosis, and inhibition of general motor activity showed steady decreases in sensitivity to the drug with age during the first 1.5 years of maturation, while rats older than 1...

journal_title：Psychopharmacology

authors： Campbell A,Baldessarini RJ

更新日期：1981-01-01 00:00:00

abstract：:The anti-withdrawal effect of clonidine was studied using quasi-morphine abstinence behaviour induced by dipropylacetate (DPA) in naive rats. Clonidine potently suppressed body shakes and locomotor activity (ID50 30 and 40 micrograms/kg IP respectively). Phenoxybenzamine and prazosine did not antagonize the anti-withd...

journal_title：Psychopharmacology

authors： van der Laan JW,Weick G,Hillen FC

更新日期：1983-01-01 00:00:00

abstract：:Rats were presented with noise bursts alone or noise bursts 60 ms after presentation of either a 60 dB or an 80 dB prepulse after injection of the dopamine agonists apomorphine (3 mg/kg) or d-amphetamine (4 mg/kg), the glycine antagonist strychnine (1.5 mg/kg) or the alpha 2 antagonist yohimbine (5 mg/kg). Presentatio...

journal_title：Psychopharmacology

authors： Davis M

更新日期：1988-01-01 00:00:00

abstract：:Recent studies indicate that morphine dependence, assessed as the severity of naloxone-precipitated opiate withdrawal in rats, is attenuated by dizocipline, a non-competitive, excitatory amino acid antagonist. Because ethanol is a putative excitatory amino acid antagonist, the present study compared the effects of co-...

journal_title：Psychopharmacology

authors： Shoemaker WJ,Kosten TA,Muly SM

更新日期：1997-11-01 00:00:00

abstract：RATIONALE:Repetitive cocaine exposure has been shown to induce GABAergic thalamic alterations. Given the key role of T-type (Ca(V)3) calcium channels in thalamocortical physiology, the direct involvement of these calcium channels in cocaine-mediated effects needs to be further explored. OBJECTIVE:The objective of this...

journal_title：Psychopharmacology

authors： Bisagno V,Raineri M,Peskin V,Wikinski SI,Uchitel OD,Llinás RR,Urbano FJ

更新日期：2010-10-01 00:00:00

abstract：:Supersensitivity to serotonin during migraine attack has been previously observed. Since the attack has been attributed to a critical lowering of morphine-like factors, we can expect serotonin supersensitivity during morphine abstinence. Slight signs of morphine abstinence have also been induced in volunteers after mi...

journal_title：Psychopharmacology

authors： Sicuteri F,Del Bianco PL,Anselmi B

更新日期：1979-10-01 00:00:00

abstract：RATIONALE:The development and validation of animal models of the cognitive impairments of schizophrenia have remained challenging subjects. OBJECTIVE:We review evidence from a series of experiments concerning an animal model that dissociates between the disruption of attentional capacities during acute illness periods...

journal_title：Psychopharmacology

authors： Sarter M,Martinez V,Kozak R

更新日期：2009-01-01 00:00:00

abstract：:A technique is described for studying exploratory as well as stereotyped behaviour in rats using an automated hole-board. Both visual and automated recordings can be employed using the technique. Hole dipping is monitored automatically using an infra-red detector system. Repetitive patterns of hole-dipping are used as...

journal_title：Psychopharmacology

authors： Makanjuola RO,Hill G,Maben I,Dow RC,Ashcroft GW

更新日期：1977-05-09 00:00:00

abstract：:Twenty-one (three groups of seven), men and women, 25-50 years of age were studied to determine whether or not rebound insomnia would increase the likelihood of self administering a benzodiazepine (triazolam 0.25 mg) hypnotic. The groups compared were patients with insomnia and disturbed sleep, insomnia and normal sle...

journal_title：Psychopharmacology

authors： Roehrs T,Merlotti L,Zorick F,Roth T

更新日期：1992-01-01 00:00:00

abstract：:The effects of fixed-ratio (FR) size, scopolamine, and the interactions between FR size and scopolamine were investigated in male F344 rats on working memory as assessed by spatial alternation behavior maintained under FR schedules of food presentation where the interval between trials was varied among values of 2, 4,...

journal_title：Psychopharmacology

authors： Shannon HE,Bemis KG,Hart JC

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Chronic nicotine administration decreases the functioning of the cystine-glutamate antiporter system x(c)- which is hypothesized to promote nicotine-taking and nicotine-seeking behaviors. N-acetylcysteine (NAC), a cystine pro-drug, increases the activity of the cystine-glutamate antiporter system x(c)-. Thus,...

journal_title：Psychopharmacology

authors： Ramirez-Niño AM,D'Souza MS,Markou A

更新日期：2013-01-01 00:00:00

abstract：RATIONALE:Recent studies have shown that metabotropic glutamate receptor 5 (mGluR5) can modulate N-methyl-D-aspartate (NMDA) receptor function in vivo. For example, the mGluR5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP) can potentiate PCP (phencyclidine)-evoked hyperactivity and PCP-induced disruptions in pr...

journal_title：Psychopharmacology

authors： Campbell UC,Lalwani K,Hernandez L,Kinney GG,Conn PJ,Bristow LJ

更新日期：2004-09-01 00:00:00

abstract：:It was the aim of the present study to determine the affinities of four neuroleptics and five antidepressants for histamine H3 receptors. In rat brain cortex membranes, the specifically bound [3H]-N alpha-methylhistamine was monophasically displaced by clozapine (pKi 6.15). The other drugs did not completely displace ...

journal_title：Psychopharmacology

authors： Kathmann M,Schlicker E,Göthert M

更新日期：1994-12-01 00:00:00

abstract：:In a placebo-controlled study, we investigated the influence of nicotine on late-day aviation performance in 15 non-smoking subjects. In a within-subjects design, subjects were tested on 2 days, each lasting 8 h and consisting of three 75-min simulator flights (late-afternoon practice, evening test, night test). Prior...

journal_title：Psychopharmacology

authors： Mumenthaler MS,Taylor JL,O'Hara R,Yesavage JA

更新日期：1998-11-01 00:00:00

abstract：:Monoamine oxidases A and B (MAO-A and B) catalyze the oxidative catabolism of biogenic amines and xenobiotics. Investigation of these mitochondrial membrane proteins shows that they differ in substrate preference, inhibitor specificity, tissue and neuronal cell distribution, immunological properties, and nucleotide an...

journal_title：Psychopharmacology

authors： Kwan SW,Bergeron JM,Abell CW

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Traumatic events are associated with alcohol use problems with increased alcohol craving as a potential mediator. There is still a lack of knowledge regarding the causal nature of this association and its underlying mechanisms. This study investigated the effects of acute trauma exposure on alcohol craving i...

journal_title：Psychopharmacology

authors： Trautmann S,Kräplin A,Dieterich R,Richter J,Muehlhan M

更新日期：2018-10-01 00:00:00

abstract：:In a one-trial step-through passive avoidance task, pretraining administration of ethanol was shown to decrease the latencies to step through at both training (day 1) and testing (day 2) for both rats and mice. A detailed analysis of these effects showed that they differed from those reported previously by others. The...

journal_title：Psychopharmacology

authors： Bammer G,Chesher GB

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Both central serotonergic and nicotinic systems play important roles in a variety of neurobehavioral functions; however, the interactions of these two systems have not been fully characterized. The current study served to determine the impact of a relatively selective 5-HT2A receptor antagonist, ketanserin, o...

journal_title：Psychopharmacology

authors： Rezvani AH,Caldwell DP,Levin ED

更新日期：2005-05-01 00:00:00

abstract：RATIONALE:So-called atypical antipsychotics (AAPs) are associated with varying levels of weight gain and associated metabolic disturbances, which in patients with serious mental illness (SMI) have been linked to non-compliance and poor functional outcomes. Mechanisms underlying AAP-induced metabolic abnormalities are o...

journal_title：Psychopharmacology

authors： Benarroch L,Kowalchuk C,Wilson V,Teo C,Guenette M,Chintoh A,Nesarajah Y,Taylor V,Selby P,Fletcher P,Remington GJ,Hahn MK

更新日期：2016-07-01 00:00:00

abstract：:Peripheral administration of the unsulphated cholecystokinin octapeptide (CCK-8us) led to an anxiogenic-like action in the elevated plus-maze model of anxiety in rats. Devazepide and L-365,260 showed potent anxiolytic-like effects at similar doses. The fact that devazepide is 1000 times more potent as a CCK-A receptor...

journal_title：Psychopharmacology

authors： Chopin P,Briley M

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Acute physical dependence refers to the withdrawal syndrome precipitated by an opioid antagonist administered several hours after either a single dose or a short-term infusion of an opioid agonist. OBJECTIVES:We examined the mechanism of nicotine-induced attenuation of naloxone-precipitated withdrawal syndro...

journal_title：Psychopharmacology

authors： Araki H,Kawakami KY,Jin C,Suemaru K,Kitamura Y,Nagata M,Futagami K,Shibata K,Kawasaki H,Gomita Y

更新日期：2004-02-01 00:00:00

abstract：:Basal morning humoral (H)-endorphin blood levels were assessed in ten autistic patients, 12 chronic schizophrenic patients and 11 healthy control subjects. Four autistic patients and four schizophrenic patients were drug free for at least 6 months while all other psychiatric patients were under treatment with antidopa...

journal_title：Psychopharmacology

authors： Weizman R,Weizman A,Tyano S,Szekely G,Weissman BA,Sarne Y

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Studies of ethanol's effects on TSH carried out during the daytime, when its secretion is at its nadir, do not reflect the true action of alcohol on TSH secretion since TSH peak occurs at night. OBJECTIVE:The present study investigated the effects of alcohol on the serum concentrations of TSH in healthy volu...

journal_title：Psychopharmacology

authors： Danel T,Touitou Y

更新日期：2003-11-01 00:00:00

abstract：RATIONALE:The progesterone metabolite 5alpha-pregnane-3alpha-ol-20-one (3alpha,5alpha-THP) is an important modulator of the hypothalamic-pituitary-adrenal axis and stress-induced corticosterone response. Typically, 3alpha,5alpha-THP levels are increased in response to acute stress, which may then reduce corticosterone ...

journal_title：Psychopharmacology

authors： Frye CA,Rhodes ME,Raol YH,Brooks-Kayal AR

更新日期：2006-06-01 00:00:00

abstract：RATIONALE:There is a growing concern over excessive caffeine use and development of caffeine use disorder in children. OBJECTIVES:This study aimed to identify the association between caffeine intake and cognitive functioning in children. METHODS:This study included 11,718 youths aged 9-10 years with cognitive and caf...

journal_title：Psychopharmacology

authors： Zhang H,Lee ZX,Qiu A

更新日期：2020-10-01 00:00:00

abstract：:Dopamine (DA), injected unilaterally into rat forebrain after pretreatment with a monoamine oxidase inhibitor, equipotently induced locomotor arousal when placed in the nucleus accumbens septi (a limbic site) and contralateral deviation of the head when placed in the corpus striatum (an extrapyramidal target); testing...

journal_title：Psychopharmacology

authors： Campbell A,Yeghiayan S,Baldessarini RJ,Neumeyer JL

更新日期：1991-01-01 00:00:00

abstract：:The aim of the present study was to investigate the locomotor stimulant effects of the atypical antipsychotic agent, olanzapine, in mice depleted of their dopamine by reserpine and alpha-methyl-DL-p-tyrosine pretreatment. Olanzapine (0.5, 1 and 2 mg/kg) dose-dependently increased locomotor activity, which was complete...

journal_title：Psychopharmacology

authors： Ninan I,Kulkarni SK

更新日期：1999-02-01 00:00:00

abstract：RATIONALE:Trichotillomania is characterized by repetitive pulling causing noticeable hair loss. Pharmacological treatment data for trichotillomania are limited. OBJECTIVE:Dronabinol appears to reduce the exocitotoxic damage caused by glutamate release in the striatum and offers promise in reducing compulsive behavior....

journal_title：Psychopharmacology

authors： Grant JE,Odlaug BL,Chamberlain SR,Kim SW

更新日期：2011-12-01 00:00:00

abstract：RATIONALE:Threatening social stimuli were used in this study as aversive conditions to test anxiety in lactating female mice. The odors of potential infanticidal males or the "stress odor" left by restrained mice represented two aversive conditions that have been suggested to modulate the time spent by the mothers to r...

journal_title：Psychopharmacology

authors： Mandillo S,D'Amato FR

更新日期：1999-10-01 00:00:00