Instinctive predatory behavior of the ferret (Putorius putorius furo L.) modified by chlordiazepoxide hydrochloride (Librium).

abstract：:The behavioral performance of inbred mouse strains was examined in animal models of anxiety to evaluate the potential contribution of genetic factors to fear-motivated behaviors. The preference that randomly bred mice and rats exhibit for the enclosed as opposed to the open arms of an elevated maze has been considered...

journal_title：Psychopharmacology

authors： Trullas R,Skolnick P

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Cocaine and opioids are often co-abused. As yet, however, there is no clear evidence that the drugs interact to make the mixture a more effective reinforcer. OBJECTIVE:The present study examined the relative reinforcing potency and maximum effectiveness of the cocaine-opioid combination in monkeys given a ch...

journal_title：Psychopharmacology

authors： Freeman KB,Woolverton WL

更新日期：2011-05-01 00:00:00

abstract：RATIONALE:Treatment of the most widely abused drugs, nicotine and alcohol, is hampered by high rates of relapse. Varenicline tartrate, an α4β2 nicotinic receptor partial agonist, is currently prescribed as a smoking cessation aid. However, there is emerging evidence that it may also modulate alcohol seeking and cogniti...

journal_title：Psychopharmacology

authors： Wouda JA,Riga D,De Vries W,Stegeman M,van Mourik Y,Schetters D,Schoffelmeer AN,Pattij T,De Vries TJ

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Abnormalities of membrane phospholipid metabolism have been described in Alzheimer's disease (AD). We investigated, with the aid of (31)P magnetic resonance spectroscopy, the in vivo intracerebral availability of phosphomonoesters (PME) and phosphodiesters (PDE) in patients with AD. METHODS:Eighteen outpati...

journal_title：Psychopharmacology

authors： Forlenza OV,Wacker P,Nunes PV,Yacubian J,Castro CC,Otaduy MC,Gattaz WF

更新日期：2005-07-01 00:00:00

abstract：:The effects of six putative dopamine receptor agonists on exploratory behaviour in rats were assessed: pergolide, (+)- and (-)-3-PPP, bromocriptine, mesulergine and CQ 32-084. Behaviour was automatically recorded in a holeboard apparatus and the data were analysed by the novel multivariate statistical method of partia...

journal_title：Psychopharmacology

authors： Ståhle L,Ungerstedt U

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:The integrity of cortical cholinergic transmission is vital to attentional processing. A growing literature suggests that alterations in attentional processing accompany addictive drug use. This study examined the effects of acute and repeated administration of nicotine on cortical acetylcholine release. OBJ...

journal_title：Psychopharmacology

authors： Arnold HM,Nelson CL,Sarter M,Bruno JP

更新日期：2003-02-01 00:00:00

abstract：:Keypecking in one group of pigeons was maintained under schedules in which food was presented only when a specified number of responses was followed by a 30-s pause without a response. d-Amphetamine and pentobarbital increased low rates of responding (and, thus, decreased food presentation) only after initial injectio...

journal_title：Psychopharmacology

authors： Smith JB,McKearney JW

更新日期：1977-07-18 00:00:00

abstract：OBJECTIVES:In recent years, there has been growing research interest in using nicotine replacement medications to aid smoking reduction prior to a quit attempt. Gaining a better understanding of how treatments influence smoking reduction may allow for better tailoring of treatments and, ultimately, better cessation out...

journal_title：Psychopharmacology

authors： Lu W,Chappell K,Walters JAE,Jacobson GA,Patel R,Schüz N,Ferguson SG

更新日期：2017-07-01 00:00:00

abstract：RATIONALE:Individual differences in the rate of nicotine metabolism (RNM) could be related to dependence and success in stopping smoking. A range of studies have examined RNM measured by the ratio of trans-3'-hydroxycotinine and cotinine in body fluids (the ratio). A systematic review of this literature is needed to dr...

journal_title：Psychopharmacology

authors： West O,Hajek P,McRobbie H

更新日期：2011-11-01 00:00:00

abstract：RATIONALE:Catecholamine transmission modulates numerous cognitive and reward-related processes that can subserve more complex functions such as cost/benefit decision making. Dopamine has been shown to play an integral role in decisions involving reward uncertainty, yet there is a paucity of research investigating the c...

journal_title：Psychopharmacology

authors： Montes DR,Stopper CM,Floresco SB

更新日期：2015-08-01 00:00:00

abstract：:Chlordiazepoxide (5 and 10 mg/kg) and diazepam (2.5 mg/kg) reduced the latency to eat and enhanced feeding response to familiar food in a food-preference test. The increased feeding response resulted from an increased frequency of individual eating episodes (bouts) without significant change in the episode duration. E...

journal_title：Psychopharmacology

authors： Cooper SJ

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Many previous studies have reported that alcohol and cannabis produce additive psychomotor effects in acute combination, but few have explicitly tested whether chronic exposure to cannabis, in the absence of acute administration, alters the effects of alcohol on psychomotor performance. OBJECTIVES:To test wh...

journal_title：Psychopharmacology

authors： Wright A,Terry P

更新日期：2002-03-01 00:00:00

abstract：RATIONALE:Each year, over 300,000 individuals in the USA enter treatment for cannabis use disorder (CUD). The development of effective pharmacotherapy for CUD is a priority. OBJECTIVE:This placebo-controlled study examined the effects of zolpidem alone and in combination with nabilone on cannabis withdrawal and a labo...

journal_title：Psychopharmacology

authors： Herrmann ES,Cooper ZD,Bedi G,Ramesh D,Reed SC,Comer SD,Foltin RW,Haney M

更新日期：2016-07-01 00:00:00

abstract：RATIONALE:Understanding of the mechanisms of biotransformation of antidepressant drugs, and of their capacity to interact with other medications, is of direct relevance to rational clinical psychopharmacology. OBJECTIVES:To determine the human cytochromes P450 mediating the metabolism of nefazodone, and the inhibitory...

journal_title：Psychopharmacology

authors： von Moltke LL,Greenblatt DJ,Granda BW,Grassi JM,Schmider J,Harmatz JS,Shader RI

更新日期：1999-07-01 00:00:00

abstract：:Clonidine is a clinically used antihypertensive which has been suggested to produce physiological changes in children after exposure in utero. The aim of our study was to test the hypothesis that chronic exposure of the developing brain to an alpha 2-adrenergic agonist like clonidine would influence the adult neuroche...

journal_title：Psychopharmacology

authors： Feenstra MG,van Galen H,Boer GJ

更新日期：1992-01-01 00:00:00

abstract：:The administration of large doses of probenecid has been used to study the central nervous system metabolism of catecholamines and indoleamines in patients with affective disease. It has been reported that alterations of the binding of L-tryptophan to plasma albumin binding sites occur during probenecid administration...

journal_title：Psychopharmacology

authors： Dunner DL,Heiber S,Perel JM

更新日期：1977-08-16 00:00:00

abstract：RATIONALE:Concurrent abuse of cocaine and heroin is a common form of polydrug abuse, but the interactions between the reinforcing effects of cocaine and heroin are poorly understood. Dose-addition analysis is a tool for the quantitative assessment of drug interactions, but this analysis has not been applied to evaluati...

journal_title：Psychopharmacology

authors： Negus SS

更新日期：2005-06-01 00:00:00

abstract：RATIONALE:Preclinical studies indicate that gonadal hormones are important determinants of drug self-administration. To date, little is known about the influence of sex and estrous cycle on drug self-administration in ecologically relevant social contexts. OBJECTIVE:The objective of this study was to examine the role ...

journal_title：Psychopharmacology

authors： Lacy RT,Strickland JC,Feinstein MA,Robinson AM,Smith MA

更新日期：2016-09-01 00:00:00

abstract：:Sibutramine hydrochloride, a novel monoamine reuptake inhibitor antidepressant, has been studied to determine whether it alters dopaminergic function in the brain. Its effects have been compared with bupropion, a dopamine reuptake inhibitor, and methamphetamine, a dopamine reuptake inhibitor and releasing agent. Sibut...

journal_title：Psychopharmacology

authors： Heal DJ,Frankland AT,Gosden J,Hutchins LJ,Prow MR,Luscombe GP,Buckett WR

更新日期：1992-01-01 00:00:00

abstract：:Marked changes in biophysical properties, including structural order, have been observed in the hydrophobic core of cell membranes exposed to phenothiazines in vitro. In this study, similar changes are reported in vivo in cell membranes from the brains of rats treated with phenothiazines at doses thought to yield tiss...

journal_title：Psychopharmacology

authors： Cohen BM,Zubenko GS

更新日期：1985-01-01 00:00:00

abstract：:The effects of amphetamine on the partial punishment effect (PPE) at one trial per day, were examined. Two groups of animals were trained to run in a straight alley. The continuously reinforced (CRF) group received food reward on every trial. The partially punished (PP) group received food reward on every trial but in...

journal_title：Psychopharmacology

authors： Weiner I,Bercovitz H,Feldon J

更新日期：1986-01-01 00:00:00

abstract：:The augmentation effect of (-)pindolol as used in combination with SSRI to treat major depression has been ascribed to blocking of dorsal raphe nucleus cell body 5-HT autoreceptors. In this study, the radioligand [carbonyl-11C]WAY-100635 and positron emission tomography were used to establish whether pindolol at a cli...

journal_title：Psychopharmacology

authors： Andrée B,Thorberg SO,Halldin C,Farde L

更新日期：1999-06-01 00:00:00

abstract：RATIONALE:Buprenorphine is a partial mu opioid agonist under development as a sublingual (SL) medication for opioid dependence treatment in the United States. Because buprenorphine may be abused, tablets combining buprenorphine with naloxone in a 4:1 ratio have been developed to reduce that risk. Low doses of injected ...

journal_title：Psychopharmacology

authors： Stoller KB,Bigelow GE,Walsh SL,Strain EC

更新日期：2001-03-01 00:00:00

abstract：RATIONALE:It has been demonstrated that major differences between mice of the C57BL/6J and DBA/2J inbred strains for amphetamine-induced place conditioning (preference and avoidance, respectively) are evident in standard housing conditions but abolished by temporary restricted feeding. This gene-experience model may be...

journal_title：Psychopharmacology

authors： Orsini C,Buchini F,Piazza PV,Puglisi-Allegra S,Cabib S

更新日期：2004-03-01 00:00:00

abstract：RATIONALE:Whilst the deleterious effects of alcohol on retrospective remembering have been widely documented, no study has yet objectively determined alcohol's effects on prospective memory (PM)--remembering to do something in the future. OBJECTIVES:With this aim, the present study determined the acute effects of alco...

journal_title：Psychopharmacology

authors： Leitz JR,Morgan CJ,Bisby JA,Rendell PG,Curran HV

更新日期：2009-08-01 00:00:00

abstract：RATIONALE:A substantial body of research suggests that the neuropeptide oxytocin promotes social affiliative behaviors in a wide range of animals including humans. However, its antiaggressive action has not been unequivocally demonstrated in male laboratory rodents. OBJECTIVE:Our primary goal was to examine the putati...

journal_title：Psychopharmacology

authors： Calcagnoli F,de Boer SF,Althaus M,den Boer JA,Koolhaas JM

更新日期：2013-10-01 00:00:00

abstract：:Doses of eight phenylethylamines were substituted for cocaine on a drug-maintained behavior baseline in baboons. Intravenous infusions of drug were contingent upon completion of 160 lever presses (a 160-response fixed-ratio schedule; FR 160). A 3-h time-out period followed each infusion, permitting a maximum of 8 infu...

journal_title：Psychopharmacology

authors： Griffiths RR,Winger G,Brady JV,Snell JD

更新日期：1976-11-24 00:00:00

abstract：:The effect of the (+)- and (-)-enantiomers of 3-PPP [conventional and atypical dopamine (DA)-receptor active agent, respectively] were investigated in a commonly used animal model of anxiety: the Vogel licking-conflict test. Low doses (less than or equal to 0.5 mg/kg SC) of both 3-PPP enantiomers resulted in anti-conf...

journal_title：Psychopharmacology

authors： Hjorth S,Carlsson A,Engel JA

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Acute nicotine abstinence is associated with disruption of executive function and reward processes; however, the neurobiological basis of these effects has not been fully elucidated. METHODS:The effects of nicotine abstinence on brain function during reward-based probabilistic decision making were preliminar...

journal_title：Psychopharmacology

authors： Addicott MA,Baranger DA,Kozink RV,Smoski MJ,Dichter GS,McClernon FJ

更新日期：2012-01-01 00:00:00

abstract：:It has been shown that pretreatment with dopamine (DA) receptor blockers disrupts the effect of intravenously (IV) and intracerebrally (ICV), but not intraperitoneally (IP) administered cocaine on place preference conditioning (PPC). The present study was undertaken to further evaluate possible differences between IV ...

journal_title：Psychopharmacology

authors： Nomikos GG,Spyraki C

更新日期：1988-01-01 00:00:00