Abstract：
:Offensive and defensive components of aggressive behavior were determined in resident and intruder mice. Withdrawal aggression was measured after the removal of a subcutaneous morphine pellet or after precipitation by naloxone in naive mice and after removal of a morphine pellet in mice with prior fighting experience. In naive mice, removal of a morphine pellet led to increases in attack bites and threats but naloxone-precipitated withdrawal led to decreases in these behaviors and to increases in defensive posturing, escape attempts and vocalizations. Prior fighting experience abolished the enhanced attack behaviors of resident mice following morphine pellet removal, but led to heightened defensive behavior in intruder mice. The behavior of intruder mice appeared more sensitive to naloxone administration than the behavior of resident mice; naloxone influenced not only intruder defensive behavior, but also other non-aggressive behaviors. The social role of the drug recipient and his prior history of aggressive behavior are important determinants of morphine and naloxone effects on aggression.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Kantak KM,Miczek KAdoi
10.1007/BF00174059subject
Has Abstractpub_date
1986-01-01 00:00:00pages
451-6issue
4eissn
0033-3158issn
1432-2072journal_volume
90pub_type
杂志文章abstract：RATIONALE:Both methylphenidate (MPH), a catecholamine reuptake blocker, and guanfacine, an alpha2A agonist, are used to treat attention-deficit hyperactivity disorder (ADHD). Childhood impulsivity, including delay discounting, is associated with increased substance use during adolescence. These effects can be mitigated...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5096-0
更新日期：2019-02-01 00:00:00
abstract：:Antipsychotic drugs, such as haloperidol and risperidone, are used in long-term treatment of psychiatric patients and thus increase the risk of obesity and other metabolic dysfunctions. Available evidence suggests that these drugs have pro-inflammatory effect, which contributes to the establishment of endocrine distur...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4079-7
更新日期：2016-05-01 00:00:00
abstract：:The purpose of this study was to assess the effects of acute nicotine administration, following a 12-h cigarette deprivation period, using a computerized performance assessment battery (PAB). The PAB was comprised of five tasks which were selected to reflect a variety of complex acquired behaviors, sometimes referred ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00443406
更新日期：1989-01-01 00:00:00
abstract：RATIONALE:Paired-associate learning (PAL), as part of the Cambridge Neuropsychological Test Automated Battery, is able to predict who from an at-risk population will develop Alzheimer's disease. Schizophrenic patients are also impaired on this same task. An automated rodent model of PAL would be extremely beneficial in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-009-1526-3
更新日期：2009-07-01 00:00:00
abstract：:The behavioural effects of increasing doses of apomorphine and haloperidol were observed in a group of six marmosets. Behaviour was classified quantitatively into categories: Locomotion, inactivity, checking (small head movements), social interaction and purposeful activities. Statistical analysis revealed that apomor...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431987
更新日期：1979-01-01 00:00:00
abstract：:The 2-[14C]deoxyglucose method was used to compare the effects of the acute administration of cocaine by two different routes, intravenous and intraperitoneal, on rates of local cerebral glucose utilization in freely moving rats. Doses were initially chosen on the basis of their ability to elicit equivalent increases ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244931
更新日期：1993-01-01 00:00:00
abstract：RATIONALE:When paired with training, substances that increase monoaminergic transmission in the brain support motor and language learning in healthy subjects and in rehabilitation after brain lesions. OBJECTIVES:To test the hypotheses that enhancement of central norepinephrine by the selective norepinephrine reuptake ...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-006-0420-5
更新日期：2006-08-01 00:00:00
abstract：RATIONALE:(+/-) 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is an amphetamine analog and drug of abuse. In animals, MDMA damages brain serotonin (5-HT) neurons at doses that overlap with those used recreationally by some humans. To date, few functional sequelae of MDMA-induced 5-HT damage have been identified. ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050967
更新日期：1999-04-01 00:00:00
abstract：:Mice were trained on a one-trial inhibitory avoidance task and given immediate post-training intraperitoneal injections of cocaine (0.03-1.00 mg/kg). On a retention test 24 h later, the retention latencies of mice given the 0.10 mg/kg dose were significantly higher than those of the controls. The effect of cocaine on ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00589905
更新日期：1989-01-01 00:00:00
abstract：:The behavioral responses to separate and combined administration of the D1 agonist SKF-38393 and the D2 agonist quinpirole following acute dopamine (DA) depletion via alpha-methyl-p-tyrosine (AMPT) or AMPT/reserpine were examined in infant (10-day-old) and weanling (21-day-old) rat pups. At both ages, AMPT pretreatmen...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244963
更新日期：1992-01-01 00:00:00
abstract：:Patients who develop persistent parkinsonism while on chronic neuroleptic therapy may be predisposed towards the development of tardive dyskinesia (TD). We investigated this issue in an animal model of TD by examining the association between catalepsy and the syndrome of neuroleptic-induced vacuous chewing movements (...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245832
更新日期：1995-03-01 00:00:00
abstract：RATIONALE:Central CB1 cannabinoid receptors regulate anxiety-like and appetitive consummatory behaviors. Pharmacological antagonism/inverse-agonism of CB1 receptors increases anxiety and decreases appetitive behaviors; however, neither well-defined dose nor context dependence of these effects has been simultaneously as...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3042-8
更新日期：2013-08-01 00:00:00
abstract：RATIONALE:Schedule-induced polydipsia (SIP) is an established model for studying compulsive behaviour in rats. Serotoninergic drugs effectively reduce compulsive drinking on SIP, and high compulsive drinker rats selected by SIP have shown differences in serotoninergic brain activity. However, the specific serotoninergi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3699-7
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE:Acute diazepam administration has been shown to decrease plasma cortisol levels consistent with decreased activity of the hypothalamic-pituitary-adrenal axis, especially in individuals experiencing stress. However, the effects of chronic diazepam treatment on cortisol have been less studied, and the relations...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-004-1974-8
更新日期：2005-02-01 00:00:00
abstract：RATIONALE:Marijuana and alcohol, when used separately and in combination, contribute to automobile accidents and failed sobriety tests of standing balance. However, the extent to which the drugs have additive effects on both of these measures is unknown. OBJECTIVES:This study was designed to compare directly the separ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-002-1124-0
更新日期：2002-10-01 00:00:00
abstract：:In experiment 1, rats (n = 12) were trained to discriminate the benzodiazepine (BDZ) compound chlordiazepoxide (CDP, 20 mg/kg, IP) from saline in a two-lever food-reinforced procedure, and subsequently were tested for stimulus control with different doses of CDP, Ro 15-1788 (a proposed BDZ receptor antagonist) and Ro ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00652236
更新日期：1986-01-01 00:00:00
abstract：RATIONALE:In recent years, an increasing body of evidence points to the involvement of the glutamatergic system and specifically the glutamatergic ionotropic N-methyl-D-aspartate (NMDA) receptor in the pathophysiology of obsessive-compulsive disorder (OCD). OBJECTIVES:To test the role of NMDA receptors in compulsive b...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1808-9
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVES:To investigate the relationship between benzodiazepine and risk of developing pneumonia in patients with schizophrenia, whose benzodiazepine dosage and usage frequency was higher than that of the general population. METHODS:We conducted a nested case-control study to assess the association between benzodiaz...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5039-9
更新日期：2018-11-01 00:00:00
abstract：:SCH 39166 is the first selective D1-dopamine receptor antagonist developed for clinical trials in schizophrenia. SCH 39166 was evaluated as a radioligand for PET, labeled with 11C, and as a D1-dopamine receptor antagonist after single oral doses in healthy men. After intravenous injection of [11C]SCH 39166 distributio...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF02246067
更新日期：1995-10-01 00:00:00
abstract：:Chronic nicotine infusion has been found in a series of studies in our laboratory to significantly improve choice accuracy of rats in the eight-arm radial maze. The current study was designed to compare the effects of chronic nicotine infusion on working and reference memory in a 16-arm radial maze. Nicotine was admin...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02805971
更新日期：1996-09-01 00:00:00
abstract：RATIONALE:Caffeine is commonly believed to offset the acute effects of alcohol, but some evidence suggests that cognitive processes remain impaired when caffeine and alcohol are coadministered. OBJECTIVES:No previous study has investigated the separate and joint effects of alcohol and caffeine on conflict monitoring a...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-016-4208-y
更新日期：2016-04-01 00:00:00
abstract：RATIONALE:C-reactive protein (CRP), an acute phase protein that is released in response to inflammatory stimuli, is implicated in Alzheimer's disease (AD). However, the role of CRP in memory deficits associated with AD remains unclear. OBJECTIVE:Experiments were carried out to determine whether CRP impaired memory and...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-009-1499-2
更新日期：2009-07-01 00:00:00
abstract：:The serotonergic agent meta-chlorophenylpiperazine (m-CPP) increases temperature and plasma ACTH and other hormones and decreases social interaction, locomotor activity and food intake in rats, most likely via stimulation of 5-HT2C receptors. Repeated daily administration of m-CPP to rats induces rapid tolerance to th...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02805987
更新日期：1996-09-01 00:00:00
abstract：OBJECTIVE:To evaluate prospectively interferon alpha (IFN-alpha) associated effects on cerebral glucose metabolism and its correlation to neuropsychiatric symptoms during low-dose IFN-alpha-treatment. METHODS:Eleven patients treated with low-dose IFN-alpha for chronic hepatitis C were prospectively evaluated by neurop...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s002130000549
更新日期：2000-11-01 00:00:00
abstract：RATIONALE:Pharmacological manipulation of serotonergic neurotransmission in healthy volunteers impacts on cognitive test performance. Specifically, markers of serotonin function are associated with attention and executive functioning, long-term memory, and general cognitive ability. The serotonin transporter (SERT) pro...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1926-4
更新日期：2011-02-01 00:00:00
abstract：RATIONALE:In cell culture systems, agonists can promote the phosphorylation and internalization of receptors coupled to G proteins (GPCR), leading to their desensitization. However, in the CNS opioid agonists promote a profound desensitization of their analgesic effects without diminishing the presence of their recepto...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-005-2248-9
更新日期：2005-06-01 00:00:00
abstract：:Four benzodiazepine tranquilizers have been tested, alone or in combination with scopolamine, on the spontaneous locomotor activity of BALB/c mice. Scopolamine-induced locomotor stimulation was enhanced by chlordiazepoxide, diazepam, and medazepam, but not by bromazepam. These effects are similar to those exerted by t...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433058
更新日期：1980-01-01 00:00:00
abstract：:The benzodiazepine diazepam and the benzodiazepine antagonist Ro 15-1788 were tested alone or in combination for their influence on scopolamine-induced locomotor stimulation in mice. The benzodiazepine antagonist had no effect by itself, but prevented the enhancement of scopolamine-induced locomotor stimulation produc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00464583
更新日期：1982-01-01 00:00:00
abstract：RATIONALE:Temporal differentiation in the free-operant psychophysical procedure is sensitive to the 5-hydroxytryptamine (5-HT)1A receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) and the 5-HT2 receptor agonist 2,5-dimethoxy-4-iodo-amphetamine (DOI); both drugs shift the psychophysical curve leftwards...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1871-1
更新日期：2004-11-01 00:00:00
abstract：:The effects of the CCKB-receptor agonist pentagastrin, a synthetic analogue of the cholecystokinin tetrapeptide (CCK-4), were studied in seven patients suffering from obsessive compulsive disorder (OCD) and seven healthy controls. All subjects were challenged with an IV dose of 0.6 micrograms/kg pentagastrin or placeb...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02247385
更新日期：1996-08-01 00:00:00
