Abstract:
OBJECTIVE:To evaluate prospectively interferon alpha (IFN-alpha) associated effects on cerebral glucose metabolism and its correlation to neuropsychiatric symptoms during low-dose IFN-alpha-treatment. METHODS:Eleven patients treated with low-dose IFN-alpha for chronic hepatitis C were prospectively evaluated by neuropsychiatric tests and cerebral [18F]deoxyglucose positron emission tomography (FDG-PET) before and in the 12th week of treatment. PET images were spatially normalized, corrected for variance in global activity and pixel-based t-statistics were calculated for each set of PET scans using SPM96 software. Pixel-cluster with P<0.001 for hypo- or hypermetabolism were displayed in parametric images. Covariance analysis with neuropsychiatric tests was calculated for each cluster. RESULTS:In week 12 of IFN-alpha treatment, significant hypometabolism with a decrease of local activity ranging from 8 to 12% was found in all patients bilaterally in the prefrontal cortex (BA 9), which correlated in a covariate analysis with changes in depression score as measured by Beck's Depression Inventory. Additionally, hypermetabolism with a maximum increase in local activity of 6-8% was seen in all patients in putamina as well as the left occipital region (BA 18). Before IFN-alpha treatment, only 1/11 patient showed depressive symptomatology. After 3 months of treatment, 6/11 patients were classified as having mild to moderate depressive symptoms (P<0.1; Wilcoxon test). CONCLUSIONS:Low-dose IFN-alpha therapy is associated with significant prefrontal hypometabolism. This hypometabolism covaried with depression score, but was even found in clinically non-depressed patients. These findings may reflect a possible predisposing factor for IFN-alpha associated neuropsychiatric syndromes and might contribute to a pathophysiological model of affective disorders, as endogenous IFN-alpha levels are elevated in a subset of psychotic patients during acute disease.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Juengling FD,Ebert D,Gut O,Engelbrecht MA,Rasenack J,Nitzsche EU,Bauer J,Lieb Kdoi
10.1007/s002130000549subject
Has Abstractpub_date
2000-11-01 00:00:00pages
383-9issue
4eissn
0033-3158issn
1432-2072journal_volume
152pub_type
临床试验,杂志文章abstract::Carbachol, muscarine, eserine and neostigmine injected into the cerebral ventricles of conscious cats evoked emotional behaviour with aggression, autonomic and motor phenomena as well as clonic-tonic convulsions. The main and the most impressive feature of the gross behavioural effects of intraventricular carbachol, m...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427131
更新日期:1979-04-11 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02311180
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00427969
更新日期:1983-01-01 00:00:00
abstract::Human CSF cyclic AMP and cyclic GMP have been measured as possible indicators of activity of central neurotransmitter-sensitive adenylate or guanylate cyclase. In an attempt to help to identify the specific neurotransmitter systems of origin of human CSF cyclic AMP and GMP, we studied Parkinson patients with and with...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427396
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1995-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2009-05-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2014-08-01 00:00:00
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更新日期:1988-01-01 00:00:00
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更新日期:2019-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-009-1546-z
更新日期:2009-08-01 00:00:00
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doi:10.1007/s00213-009-1489-4
更新日期:2009-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00310519
更新日期:1986-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1979-04-25 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00442567
更新日期:1989-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2011-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-04-01 00:00:00
abstract::Nicotine (6 mg/kg/day) was administered subcutaneously via Alzet osmotic pumps to rats for 28 days. Nociception was measured by the hot-plate and tail-flick methods. A significant antinociceptive effect was demonstrated during the first week of the treatment; after that tolerance developed, lasting for the remaining p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245428
更新日期:1992-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2000-07-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2014-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
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更新日期:1992-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-07-01 00:00:00