Lack of evidence for reduced prefrontal cortical serotonin and dopamine efflux after acute tryptophan depletion.

abstract：:To test the Pavlovian conditioning model of alcohol tolerance, two groups of eight male social drinkers each received five administrations of alcohol and five administrations of an equal volume of tonic each, on an alternating basis, during the initial 10-session tolerance development phase of the study. Group 1 recei...

journal_title：Psychopharmacology

authors： Shapiro AP,Nathan PE

更新日期：1986-01-01 00:00:00

abstract：:The administration of large doses of probenecid has been used to study the central nervous system metabolism of catecholamines and indoleamines in patients with affective disease. It has been reported that alterations of the binding of L-tryptophan to plasma albumin binding sites occur during probenecid administration...

journal_title：Psychopharmacology

authors： Dunner DL,Heiber S,Perel JM

更新日期：1977-08-16 00:00:00

abstract：RATIONALE:Antiepileptic drugs are known to produce side effects which may impair driving performance. Performance effects, however, may differ substantially between individual antiepileptic drugs. OBJECTIVE:To compare the effects of carbamazepine, remacemide, and placebo on actual driving performance during a 12-day i...

journal_title：Psychopharmacology

authors： Ramaekers G,Lamers J,Verhey F,Muntjewerff D,Mobbs E,Sanders N,Lewis M,Lockton A

更新日期：2002-01-01 00:00:00

abstract：:The modulation of spontaneous (social and individual) behaviour as a function of the age of the rat (1, 3, 6, 12, 18 and 24 months) and of scopolamine dose (0.1, 0.2, 0.3 and 0.5 mg/kg) was studied. Observations were conducted during the dark phase of the reverse light/dark schedule using a reintroduction procedure. R...

journal_title：Psychopharmacology

authors： Soffié M,Bronchart M

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Obsessive-compulsive disorder (OCD) gradually emerges and reaches clinical significance during early adulthood. Whether a predisposition for OCD manifests as binge eating disorder earlier during adolescence is proposed. OBJECTIVES:To further characterize how OCD-like behaviors increase across maturation and ...

journal_title：Psychopharmacology

authors： Freund N,Thompson BS,Norman KJ,Einhorn P,Andersen SL

更新日期：2015-09-01 00:00:00

abstract：RATIONALE:Although most opioid self-administration research has been conducted with laboratory animals, such research with humans is necessary to answer questions unique to human drug-taking behavior. OBJECTIVE:We investigated the influence of morphine dose and an alternative non-drug reinforcer on choice between morp...

journal_title：Psychopharmacology

authors： Heishman SJ,Schuh KJ,Schuster CR,Henningfield JE,Goldberg SR

更新日期：2000-02-01 00:00:00

abstract：:The effects of dopamine agonists on self-stimulation are a matter of considerable dispute. Apomorphine has variously been reported to inhibit, have no effect on, or to facilitate lever-press self-stimulation. To investigate the possibility that these discrepancies may reflect peculiarities of the lever-press test situ...

journal_title：Psychopharmacology

authors： Atrens DM,Becker FT,Hunt GE

更新日期：1980-01-01 00:00:00

abstract：:The effect of pretreatment with ritanserin, a potent and selective serotonin-S2 (5-HT2) receptor antagonist, on the prolactin (PRL) response to electroconvulsive therapy (ECT) was studied in seven female patients suffering from major depressive disorder. They were given either ECT alone, or ECT after 10 or 20 mg ritan...

journal_title：Psychopharmacology

authors： Papakostas Y,Markianos M,Papadimitriou G,Stefanis C

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Convulsions associated with cocaine toxicity are a serious aspect of cocaine-related emergency room incidents. Seizures can result from a single high dose of cocaine, and evidence is accumulating that correlates repetitive administration of sub-convulsive doses of cocaine with a decreased seizure threshold, a...

journal_title：Psychopharmacology

authors： Miller KA,Witkin JM,Ungard JT,Gasior M

更新日期：2000-01-01 00:00:00

abstract：RATIONALE:Deficits in response inhibition associated with heroin use could last several months after abstinence in heroin users, and their response inhibition can also be interfered with task-irrelevant drug-related cues. However, it is unclear whether exposure to drug-related cues affects subsequent response inhibitio...

journal_title：Psychopharmacology

authors： Su B,Li S,Yang L,Zheng M

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:Acute diazepam administration has been shown to decrease plasma cortisol levels consistent with decreased activity of the hypothalamic-pituitary-adrenal axis, especially in individuals experiencing stress. However, the effects of chronic diazepam treatment on cortisol have been less studied, and the relations...

journal_title：Psychopharmacology

authors： Pomara N,Willoughby LM,Sidtis JJ,Cooper TB,Greenblatt DJ

更新日期：2005-02-01 00:00:00

abstract：:It was shown previously that behavioural effects of apomorphine (locomotor activation and stereotyped behaviour) can be conditioned when they are associated with well-defined environmental stimuli. In the present study, the hypothesis was tested that glutamatergic mechanisms play an important role either in formation ...

journal_title：Psychopharmacology

authors： Welsch-Kunze S,Kuschinsky K

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:The purpose of the present investigation was to evaluate the effects of the D3 agonist (+/-)-7-hydroxy-dipropylaminotetralin (7-OH-DPAT), various dopamine (DA) agonists and DA antagonists on the antinociceptive effects of mu opioids. METHODS:Antinociception was assessed using a warm-water tail-withdrawal pro...

journal_title：Psychopharmacology

authors： Cook CD,Rodefer JS,Picker MJ

更新日期：1999-06-01 00:00:00

abstract：:Two experiments examined the effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid intake in water-deprived rats. In the first experiment, pretreatment with 3.0 or 10.0 mg/kg zolpidem IP was found to increase consumption of a novel glucose drink (3% d-glucose and 0.15 sodium saccharine w/v in wat...

journal_title：Psychopharmacology

authors： Stanhope KJ,Roe S,Dawson G,Draper F,Jackson A

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Research in pediatric psychopharmacology has expanded considerably in the last 10 years. Still, controversy remains about the effectiveness and safety of commonly used psychotropics and their role in child treatment, thus pointing to the need for more in-depth and targeted investigations. OBJECTIVES:To revie...

journal_title：Psychopharmacology

authors： Vitiello B

更新日期：2007-03-01 00:00:00

abstract：RATIONALE:Research suggests the experimental manipulation of oxytocin facilitates positive interactions, cooperation, and trust. The mechanism by which oxytocin influences social behavior is not well understood. OBJECTIVE:We explored the hypothesis that oxytocin alters how people perceive themselves, which could be on...

journal_title：Psychopharmacology

authors： Cardoso C,Ellenbogen MA,Linnen AM

更新日期：2012-04-01 00:00:00

abstract：:Augmentation with low-dose fluvoxamine (50-100 mg/day) to antipsychotic treatment may improve the negative symptoms in schizophrenic patients, but involves a risk of drug-drug interaction. We studied the effects of fluvoxamine on plasma concentrations of haloperidol and reduced haloperidol, and their clinical symptoms...

journal_title：Psychopharmacology

authors： Yasui-Furukori N,Kondo T,Mihara K,Inoue Y,Kaneko S

更新日期：2004-01-01 00:00:00

abstract：:The benzodiazepines are typified by a profile of side effects which includes drowsiness, ataxia and incoordination. Ro 15-1788, an imidazodiazepine derivative, exhibits marked antagonism of the behavioural and biochemical effects of the benzodiazepines in animals and man. It is devoid of any behavioural activity in an...

journal_title：Psychopharmacology

authors： Darragh A,Lambe R,O'Boyle C,Kenny M,Brick I

更新日期：1983-01-01 00:00:00

abstract：INTRODUCTION:Alterations in protein kinase (PKA) protein levels have been implicated in the regulation of responses to and development of cocaine addiction. However, the contribution of differences in PKA intracellular cascade to the known sex differences in responses to cocaine is not well understood. This study exami...

journal_title：Psychopharmacology

authors： Nazarian A,Sun WL,Zhou L,Kemen LM,Jenab S,Quinones-Jenab V

更新日期：2009-04-01 00:00:00

abstract：:A study was performed to examine behavioral response to a challenge of selective dopamine D-1 and D-2 agonists in rats previously sensitized by subchronic administration of methamphetamine or cocaine. Rats in three groups received repeated injections (IP) of saline, methamphetamine (4 mg/kg/day) or cocaine (20 mg/kg/d...

journal_title：Psychopharmacology

authors： Ujike H,Akiyama K,Otsuki S

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Psychopharmacology needs novel quantitative measures and theoretical approaches based on computational modelling that can be used to help translate behavioural findings from experimental animals to humans, including patients with neuropsychiatric disorders. OBJECTIVES:This brief review exemplifies this appro...

journal_title：Psychopharmacology

authors： Robbins TW,Cardinal RN

更新日期：2019-08-01 00:00:00

abstract：:A prospective study of response to treatment with nortriptyline was carried out in a group of 14 inpatients with mixed symptoms of depression and dementia. Platelet membrane fluidity, as reflected by the fluorescence anisotropy of DPH labeled membranes, was determined for all 14 drug-free subjects prior to treatment b...

journal_title：Psychopharmacology

authors： Zubenko GS,Reynolds CF 3rd,Perel JM,Decker C,Malinakova I

更新日期：1988-01-01 00:00:00

abstract：INTRODUCTION:The majority of individuals who suffer an episode of depression go on to experience recurrences. We have proposed, based upon the observation that reducing serotonin via acute tryptophan depletion (ATD) is more likely to induce negative mood in recovered depressed individuals than never depressed individua...

journal_title：Psychopharmacology

authors： Robinson OJ,Sahakian BJ

更新日期：2009-08-01 00:00:00

abstract：:When injected IP, the M1 muscarinic receptor antagonist pirenzepine dose-dependently induced a deficit in passive avoidance learning in rats. This activity was optimal at 75 mg/kg injected 1 h before the acquisition session. The deficit induced by pirenzepine was antagonized by oxotremorine (0.03-0.3 mg/kg SC) and phy...

journal_title：Psychopharmacology

authors： Worms P,Gueudet C,Pério A,Soubrié P

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Indirect-acting serotonin (5-HT) receptor agonists (e.g., selective 5-HT reuptake inhibitors [SSRI]) stimulate multiple 5-HT receptors, although the role of particular receptors as well as interaction(s) among different receptors in the therapeutic effects of SSRIs is not fully understood. OBJECTIVES:Relativ...

journal_title：Psychopharmacology

authors： Li JX,Crocker C,Koek W,Rice KC,France CP

更新日期：2011-02-01 00:00:00

abstract：:Measurements of the amplitude and latency of the P3b component of the event-related potential (ERP), simple reaction time (SRT) and four psychomotor tests (VAS, DSST, DSp and CFF) were made on 12 male subjects (aged 19-24 years) 1.0-1.5 and 4.0-4.5 h after single oral doses of triprolidine (7.5 mg), terfenadine (60 mg...

journal_title：Psychopharmacology

authors： Swire FM,Marsden CA,Barber C,Birmingham AT

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:The involvement of glutamate in fear extinction is perhaps the most promising in terms of facilitating clinical interventions for posttraumatic stress disorder (PTSD). This study was aimed at elucidating the possible role of zif268 on the D-cycloserine (DCS) facilitation effect on extinction. OBJECTIVE:We in...

journal_title：Psychopharmacology

authors： Wu IT,Tang TH,Ko MC,Chiu CY,Lu KT

更新日期：2015-10-01 00:00:00

abstract：RATIONALE:Pindolol has been reported to shorten the onset of antidepressant action of selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) as well as to increase their efficacy. It has been postulated that pindolol enhances the antidepressant effect of SSRIs by blocking somatodendritic 5-HT1A aut...

journal_title：Psychopharmacology

authors： Arborelius L,Linnér L,Wallsten C,Ahlenius S,Svensson TH

更新日期：2000-07-01 00:00:00

abstract：:We investigated the striatal dopamine-2 (D2) receptor occupancy caused by different antipsychotic substances in 18 psychotic patients (16 with schizophrenic and two with schizoaffective disorder according to DSM-IV) with single photon emission computed tomography (SPECT) using 123I-iodobenzamide (IBZM) as tracer subst...

journal_title：Psychopharmacology

authors： Küfferle B,Tauscher J,Asenbaum S,Vesely C,Podreka I,Brücke T,Kasper S

更新日期：1997-10-01 00:00:00

abstract：RATIONALE:N-methyl-D-aspartate (NMDA) receptors play crucial roles in learning and memory, but the role of each NMDA receptor subtype in a specific cognitive process is unclear. Non-selective blockers of NMDA receptor are used to model the cognitive impairment in schizophrenia and Alzheimer's disease. Counter-intuitive...

journal_title：Psychopharmacology

authors： Kumar G,Olley J,Steckler T,Talpos J

更新日期：2015-11-01 00:00:00