Interaction of triazolam with desipramine. Effects of single and repeated treatment on certain pharmacologic responses and brain catecholamine levels.

abstract：:m-Chlorophenylpiperazine (mCPP), a major metabolite of the atypical antidepressant trazadone, has been observed to produce marked physiological and behavioral effects in both humans and animals. These effects have been attributed to the interaction of mCPP with serotonergic receptors. The present study was designed to...

journal_title：Psychopharmacology

authors： Fiorella D,Rabin RA,Winter JC

更新日期：1995-05-01 00:00:00

abstract：RATIONALE:Electrophysiological studies have identified a scalp potential, the late positive potential (LPP), which is modulated by the emotional intensity of observed stimuli. Previous work has shown that the LPP reflects the modulation of activity in extrastriate visual cortical structures, but little is known about t...

journal_title：Psychopharmacology

authors： de Rover M,Brown SB,Boot N,Hajcak G,van Noorden MS,van der Wee NJ,Nieuwenhuis S

更新日期：2012-02-01 00:00:00

abstract：:The effects of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801, on cocaine self-administration were investigated. Forty-six male Wistar rats were trained to intravenously self-administer four unit doses of cocaine (0.19, 0.38, 0.75 and 1.5 mg/kg per injection) on a progressive-ratio schedule...

journal_title：Psychopharmacology

authors： Ranaldi R,French E,Roberts DC

更新日期：1996-11-01 00:00:00

abstract：RATIONALE:Synergistic or supra-additive interactions between the anorectics (dex)fenfluramine and phentermine have been reported previously in the rat and in the clinic. Studies with 5-HT2C antagonists and 5-HT2C knockouts have demonstrated dexfenfluramine hypophagia in the rodent to be mediated by actions at the 5-HT2...

journal_title：Psychopharmacology

authors： Grottick AJ,Whelan K,Sanabria EK,Behan DP,Morgan M,Sage C

更新日期：2015-06-01 00:00:00

abstract：:The behavioral consequences of prolonged continuous exposure to cocaine were examined in rhesus monkeys. Operant behavior was sampled for 0.5 h every 6 h, and cocaine was continuously infused through an intravenous catheter. Cocaine (4.0-32 mg/kg/day) initially caused reductions in the rate of responding for food and ...

journal_title：Psychopharmacology

authors： Woolverton WL,Kleven MS

更新日期：1988-01-01 00:00:00

abstract：:The role of the nucleus accumbens septi (ACB) and corpus striatum (CPU) in self-stimulation were investigated by injecting directly or indirectly acting stimulant drugs or a dopamine-(DA)-receptor blocking agent into each site bilaterally. d-Amphetamine (68 nmol) facilitated hypothalamic self-stimulation when injected...

journal_title：Psychopharmacology

authors： Stephens DN,Herberg LJ

更新日期：1977-08-31 00:00:00

abstract：RATIONALE:N-methyl-D-aspartate (NMDA) receptors play crucial roles in learning and memory, but the role of each NMDA receptor subtype in a specific cognitive process is unclear. Non-selective blockers of NMDA receptor are used to model the cognitive impairment in schizophrenia and Alzheimer's disease. Counter-intuitive...

journal_title：Psychopharmacology

authors： Kumar G,Olley J,Steckler T,Talpos J

更新日期：2015-11-01 00:00:00

abstract：RATIONALE:The present series of experiments was conducted in order to assess the nature of dopaminergic modulation of the acoustic startle response using agonists and antagonists specific for dopamine D1 and D2 receptors. OBJECTIVES:The objective of the present study was to demonstrate an enhancement of the acoustic s...

journal_title：Psychopharmacology

authors： Meloni EG,Davis M

更新日期：1999-06-01 00:00:00

abstract：:Serotonin receptors of the 5HT2 type were labeled on platelet membranes using tritiated ketanserin. Blood was collected from the umbilical cord of newborns and venous samples were collected from 6-year-old children as well as junior-high and high school students (ages 13 through 18) to determine age-related changes in...

journal_title：Psychopharmacology

authors： Biegon A,Greuner N

更新日期：1992-01-01 00:00:00

abstract：:Serotonin(5-HT)-stimulated intracellular calcium(Ca) mobilization was measured in the platelets of depressed patients to assess 5-HT2 receptor function. The 5-HT-induced Ca response was significantly higher in unmedicated patients with bipolar depression and melancholic major depression than in those with non-melancho...

journal_title：Psychopharmacology

authors： Kusumi I,Koyama T,Yamashita I

更新日期：1994-01-01 00:00:00

abstract：RATIONALE:The endogenous opioid system has been implicated in substance abuse and response to pharmacotherapies for nicotine and alcohol addiction. We examined (1) the association of the functional OPRM1 A118G variant with the relative reinforcing value of nicotine and (2) the main and interacting effects of the mu-opi...

journal_title：Psychopharmacology

authors： Ray R,Jepson C,Patterson F,Strasser A,Rukstalis M,Perkins K,Lynch KG,O'Malley S,Berrettini WH,Lerman C

更新日期：2006-10-01 00:00:00

abstract：RATIONALE:Medication and illicit drugs can have detrimental side effects which impair driving performance. A drug's impairing potential should be determined by well-validated, reliable, and sensitive tests and ideally be calibrated by benchmark drugs and doses. To date, no consensus has been reached on the issue of whi...

journal_title：Psychopharmacology

authors： Jongen S,Vuurman E,Ramaekers J,Vermeeren A

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:This study aims to conduct an evidence review of the effectiveness, harms, and cost-effectiveness of pharmacogenomics-guided antidepressant treatment for major depressive disorder. METHODS:We searched MEDLINE®, the Cochrane Central Registry of Controlled Trials, and PsycINFO through February 2017. We used pr...

journal_title：Psychopharmacology

authors： Peterson K,Dieperink E,Anderson J,Boundy E,Ferguson L,Helfand M

更新日期：2017-06-01 00:00:00

abstract：RATIONALE:Rats selectively bred for high saccharin (HiS) intake consume more alcohol and acquire intravenous (i.v.) cocaine self-administration more rapidly than their low saccharin (LoS)-consuming counterparts. The present experiment was designed to determine whether HiS and LoS rats differed in other aspects of drug ...

journal_title：Psychopharmacology

authors： Carroll ME,Anderson MM,Morgan AD

更新日期：2007-02-01 00:00:00

abstract：:The mesolimbic dopamine (DA) system has been implicated in conditioned reward (CR), locomotor sensitization, and the reinforcing properties of psychomotor stimulants. Stimuli with formerly motivationally neutral properties that gain incentive properties by their predictive association with primary reinforcers are term...

journal_title：Psychopharmacology

authors： Taylor JR,Horger BA

更新日期：1999-02-01 00:00:00

abstract：RATIONALE:Threatening social stimuli were used in this study as aversive conditions to test anxiety in lactating female mice. The odors of potential infanticidal males or the "stress odor" left by restrained mice represented two aversive conditions that have been suggested to modulate the time spent by the mothers to r...

journal_title：Psychopharmacology

authors： Mandillo S,D'Amato FR

更新日期：1999-10-01 00:00:00

abstract：:We have previously obtained evidence that the mesoamygdaloid dopamine projection modulates the acquisition of a conditioned response (CR) elicited by presentation of a conditioned stimulus (CS) predicting the availability of a natural (sucrose) reward. This property was found to be dependent upon D3, but not D1 or D2,...

journal_title：Psychopharmacology

authors： Hitchcott PK,Phillips GD

更新日期：1998-12-01 00:00:00

abstract：:The effect of the selective noradrenaline neurotoxin DSP4 on steady-state operant behaviour was examined using a quantitative behavioural paradigm based on Herrnstein's (1970) equation, which defines a hyperbolic relationship between steady-state response rate and reinforcement frequency in variable-interval schedules...

journal_title：Psychopharmacology

authors： Morley MJ,Shah K,Bradshaw CM,Szabadi E

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Pharmacological agents used in the treatment of anxiety have been reported to decrease threat relevant processing in patients and healthy controls, suggesting a potentially relevant mechanism of action. However, the effects of the anxiolytic diazepam have typically been examined at sedative doses, which do no...

journal_title：Psychopharmacology

authors： Murphy SE,Downham C,Cowen PJ,Harmer CJ

更新日期：2008-09-01 00:00:00

abstract：RATIONALE:Subthreshold smokers (who smoke < or =5 cigarettes/day) experience withdrawal symptoms, yet they smoke less than is required to maintain serum nicotine levels. OBJECTIVES:For study 1, our aim was to determine (1) if adult subthreshold smokers report withdrawal symptoms; (2) how they rate symptom severity; (3...

journal_title：Psychopharmacology

authors： Fernando WW,Wellman RJ,Difranza JR

更新日期：2006-10-01 00:00:00

abstract：RATIONALE:The phenomenon of sensitization has been theoretically implicated in mediating various aspects of drug addiction. Recent dose-response studies demonstrated that pretreatment with the putative antiaddictive agent, ibogaine (IBO), and a synthetic iboga alkaloid congener, 18-methoxycoronaridine (18-MC), increase...

journal_title：Psychopharmacology

authors： Szumlinski KK,Balogun MY,Maisonneuve IM,Glick SD

更新日期：2000-08-01 00:00:00

abstract：RATIONALE:Hypersignaling of corticotropin releasing factor (CRF) has been implicated in stress disorders; however, many of its downstream mechanisms of action remain unclear. In vitro, CRF1 receptor activation initiates multiple cell signaling cascades, including protein kinase A (PKA), protein kinase C (PKC), and mito...

journal_title：Psychopharmacology

authors： Toth M,Gresack JE,Hauger RL,Halberstadt AL,Risbrough VB

更新日期：2013-10-01 00:00:00

abstract：:The novel nicotinic agonist 1-acetyl-4-methylpiperazine (AMP) has been studied in ligand-binding and behavioural studies. AMP methiodide potently inhibited [3H]-(-)-nicotine and [125I]-alpha-bungarotoxin binding to P2 membranes from rat brain and [125I]-alpha-bungarotoxin binding to rat skeletal muscles. AMP HCl also ...

journal_title：Psychopharmacology

authors： Garcha HS,Thomas P,Spivak CE,Wonnacott S,Stolerman IP

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Alcohol and nicotine addiction are prevalent conditions that co-occur. Despite the prevalence of co-use, factors that influence the suppression and enhancement of concurrent alcohol and nicotine intake are largely unknown. OBJECTIVES:Our goals were to assess how nicotine abstinence and availability influence...

journal_title：Psychopharmacology

authors： DeBaker MC,Moen JK,Robinson JM,Wickman K,Lee AM

更新日期：2020-04-01 00:00:00

abstract：RATIONALE:The dopaminergic system has been proposed to mediate alcohol-induced locomotor activity, yet the mechanisms underlying this behavioral response remain poorly understood. OBJECTIVES:This study was conducted to investigate the role of dopamine D2-like receptors in mediating alcohol-induced behavioral responses...

journal_title：Psychopharmacology

authors： Tran S,Facciol A,Gerlai R

更新日期：2016-06-01 00:00:00

abstract：RATIONALE:The serotonin (5-HT) system is involved in pain modulation, and 5-HT receptor agonists can enhance antinociceptive effects of mu opioid receptor agonists. Less is known about the actions of 5-HT receptor agonists on other effects of opioids. OBJECTIVE:This study examined the effects of non-contingent and con...

journal_title：Psychopharmacology

authors： Maguire DR,Li JX,Koek W,France CP

更新日期：2013-01-01 00:00:00

abstract：RATIONALE:Despite consistent evidence of the familiality of substance misuse, the mechanisms by which family history (FH) increases the risk of addiction are not well understood. One behavioral trait that may mediate the risk for substance use and addiction is delay discounting (DD), which characterizes an individual's...

journal_title：Psychopharmacology

authors： VanderBroek L,Acker J,Palmer AA,de Wit H,MacKillop J

更新日期：2016-01-01 00:00:00

abstract：:In an attempt to define the nature of the involvement of delta 9-tetrahydrocannabinol (THC) with central cholinergic neurotransmission, the effects of THC on direct cholinergic stimulation of the rat brain were investigated. THC, in doses of 3 mg/kg and 6 mg/kg, administered intraperitoneally (i.p.), potentiated the e...

journal_title：Psychopharmacology

authors： Duncan GE,Dagirmanjian R

更新日期：1979-02-28 00:00:00

abstract：:Clozapine and molindone administered to mice for 21 days did not elevate the density of striatal 3H-spiperone binding sites at doses clinically equivalent to 1.5 mg/kg haloperidol, which elevated binding by 29%. Thioridazine (25 mg/kg) elevated binding by 25%. It appears that clinically equivalent doses of clozapine a...

journal_title：Psychopharmacology

authors： Severson JA,Robinson HE,Simpson GM

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Opioids remain the drugs of choice for treating moderate to severe pain, although adverse effects often limit use. Drugs acting concomitantly as agonists at μ opioid receptors and antagonists at δ opioid receptors produce antinociceptive effects with a reduced profile of adverse effects; one such drug, benzyl...

journal_title：Psychopharmacology

authors： Mada S,Gerak LR,Soyer A,Maguire DR,Hu Z,Minervini V,Cunningham CW,France CP

更新日期：2020-12-01 00:00:00