Morphine and shuttle-box self-stimulation in the rat: a model for euphoria.

abstract：:There is a latency period of several weeks before the onset of clinical effect of antidepressant drugs. The detailed mechanisms underlying drug-induced adaptive neuronal changes are not known. To elucidate the involvement of changes in gene expression of candidate transcription factors, we treated rats for 21 days wit...

journal_title：Psychopharmacology

authors： Bjartmar L,Johansson IM,Marcusson J,Ross SB,Seckl JR,Olsson T

更新日期：2000-07-01 00:00:00

abstract：RATIONALE:Although newer interview methods such as Structured Interview Guide for the Montgomery-Asberg Depression Rating Scale (SIGMA; MADRS) with audiotaping and Rater Applied Performance Scale (RAPS) appraisal have been introduced to improve reliability of ratings in antidepressant clinical trials, there is limited ...

journal_title：Psychopharmacology

authors： Khan A,Faucett J,Brown WA

更新日期：2014-11-01 00:00:00

abstract：:Methamphetamine (MAP: 1 and 2 mg/kg SC) and caffeine (CAF: 1, 3, 10 and 30 mg/kg SC) dose-dependently increased ambulation in mice. Repeated administration (5 times at 3 to 4-day intervals) of MAP, but not CAF, induced sensitization to its effect. Furthermore, the mice repeatedly receiving CAF showed no significant ch...

journal_title：Psychopharmacology

authors： Kuribara H

更新日期：1994-10-01 00:00:00

abstract：:Two experiments were conducted to study the effects of anxiogenic drugs on dopamine release and metabolism in nucleus accumbens. Microdialysis probes were implanted into the nucleus accumbens, and rats were tested the day after implantation. In the first experiment, groups of rats received injections of saline, 1.25 o...

journal_title：Psychopharmacology

authors： McCullough LD,Salamone JD

更新日期：1992-01-01 00:00:00

abstract：:A modified hyponeophagia test is described as an animal model of anxiety. The effects of 0, 0.3, 1.0, 3.0 and 10 mg/kg diazepam, given both acutely and for 7 days pretest, were assessed in rats. Acutely, diazepam reduced hyponeophagia over the dose range 0.3-3.0 mg/kg but 10.0 mg/kg produced sedation and large variabi...

journal_title：Psychopharmacology

authors： Shephard RA,Broadhurst PL

更新日期：1982-01-01 00:00:00

abstract：:Experiments assessed the development of tolerance to morphine stimulus control during treatment with selected maintenance doses of morphine. Separate groups of rats were trained to discriminate saline and either 3.2 mg/kg or 5.6 mg/kg morphine under fixed-ratio schedules of food delivery. Dose-response functions for g...

journal_title：Psychopharmacology

authors： Young AM,Sannerud CA,Steigerwald ES,Doty MD,Lipinski WJ,Tetrick LE

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Cocaethylene is a pharmacologically active homolog and metabolite of cocaine, formed by transesterification of cocaine in the presence of ethanol. Here we relate findings from a randomized, placebo-controlled, double-blind study in which we examined the physiological and subjective effects and pharmacokinetic...

journal_title：Psychopharmacology

authors： Hart CL,Jatlow P,Sevarino KA,McCance-Katz EF

更新日期：2000-04-01 00:00:00

abstract：RATIONALE:Benzodiazepine agonists characteristically increase food intake in humans and non-human subjects, and the underlying mechanisms of this effect are not understood completely. OBJECTIVE:Compounds with selectivity for GABAA receptor subtypes were used to evaluate the role of GABAA receptors containing alpha1 an...

journal_title：Psychopharmacology

authors： Duke AN,Platt DM,Cook JM,Huang S,Yin W,Mattingly BA,Rowlett JK

更新日期：2006-08-01 00:00:00

abstract：RATIONALE:Synthesis of ligands inactive or with low activity at α₁ GABA(A) receptors has become the key concept for development of novel, more tolerable benzodiazepine (BZ)-like drugs. WYS8, a remarkably (105 times) α₁-subtype selective partial positive modulator, may serve as a pharmacological tool for refining the ro...

journal_title：Psychopharmacology

authors： Joksimović S,Varagic Z,Kovačević J,Van Linn M,Milić M,Rallapalli S,Timić T,Sieghart W,Cook JM,Savić MM

更新日期：2013-11-01 00:00:00

abstract：:The serotonin 5-HT(3) receptor is thought to play a role in the reward pathway and drug abuse by modulating dopamine release within the mesolimbic pathway. Dopamine release stimulated by cocaine and methamphetamine is blocked by administration of 5-HT(3) receptor antagonists. Animal studies demonstrate that 5-HT(3) re...

journal_title：Psychopharmacology

authors： Allan AM,Galindo R,Chynoweth J,Engel SR,Savage DD

更新日期：2001-10-01 00:00:00

abstract：RATIONALE:Performance on progressive ratio schedules has been proposed as a means of assessing the effects of drugs on the value or "efficacy" of reinforcers. A mathematical model affords a basis for quantifying the effects of drugs on progressive ratio schedule performance. According to this model, the relation betwee...

journal_title：Psychopharmacology

authors： Zhang Z,Rickard JF,Asgari K,Body S,Bradshaw CM,Szabadi E

更新日期：2005-05-01 00:00:00

abstract：RATIONALE:A deficit in attention and information processing has been considered a central feature in schizophrenia, which might lead to stimulus overload and cognitive fragmentation. It has been shown that patients with schizophrenia display a relative inability to gate incoming stimuli. Thus, patients repeatedly subje...

journal_title：Psychopharmacology

authors： Klamer D,Pålsson E,Revesz A,Engel JA,Svensson L

更新日期：2004-11-01 00:00:00

abstract：RATIONALE:Previous studies from our laboratory and others have indicated a role for the hypothalamo-pituitary-adrenal (HPA) axis in the extinction/reinstatement animal model of cocaine relapse OBJECTIVE:This present study was designed to investigate the potential role for the HPA axis in the cue- and methamphetamine-i...

journal_title：Psychopharmacology

authors： Moffett MC,Goeders NE

更新日期：2007-02-01 00:00:00

abstract：RATIONALE:Recent findings have shown a complexly regulated 5-HT system as it is linked to different kinds of aggression. OBJECTIVE:We focus on (1) phasic and tonic changes of 5-HT and (2) state and trait of aggression, and emphasize the different receptor subtypes, their role in specific brain regions, feed-back regul...

journal_title：Psychopharmacology

authors： Takahashi A,Quadros IM,de Almeida RM,Miczek KA

更新日期：2011-02-01 00:00:00

abstract：:In order to study experimental alcohol intake that leads to heightened aggression, we established ethanol self-administration in aggressive rats. The focus was on low doses of self-administered ethanol and to assess their effects on aggressive behavior in resident rats, using a limited access paradigm followed by a 5-...

journal_title：Psychopharmacology

authors： van Erp AM,Miczek KA

更新日期：1997-06-01 00:00:00

abstract：:Marked changes in biophysical properties, including structural order, have been observed in the hydrophobic core of cell membranes exposed to phenothiazines in vitro. In this study, similar changes are reported in vivo in cell membranes from the brains of rats treated with phenothiazines at doses thought to yield tiss...

journal_title：Psychopharmacology

authors： Cohen BM,Zubenko GS

更新日期：1985-01-01 00:00:00

abstract：:The glutamatergic cortico-striatal and subthalamo-entopeduncular pathways are both overactive in parkinsonism. Previous behavioural investigations have shown that intra-entopeduncular injection of either NMDA-site or glycine-site antagonists results in alleviation of parkinsonian symptoms, although injection of the fo...

journal_title：Psychopharmacology

authors： Carroll CB,Holloway V,Brotchie JM,Mitchell IJ

更新日期：1995-05-01 00:00:00

abstract：:Administration of drugs that reduce the influence of dopamine at its receptor site can lead to postsynaptic supersensitivity, whereas treatment with dopamine (DA) agonists can cause postsynaptic subsensitivity. Both unaltered and enhanced postsynaptic responses to DA have been shown after pretreatment with DA agonists...

journal_title：Psychopharmacology

authors： Castro R,Abreu P,Calzadilla CH,Rodriguez M

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:Virtually all cocaine self-administration studies have used a "unit dose" as a reinforcing stimulus; the subject is a passive recipient of an experimenter-selected dose. OBJECTIVES:The present experiments examined the consequence of requiring the subject to actively determine the dose and speed of each injec...

journal_title：Psychopharmacology

authors： Roberts DCS,Zimmer BA

更新日期：2020-09-01 00:00:00

abstract：RATIONALE:A recent report described sex differences in the effects of nicotine use and withdrawal on prepulse inhibition of acoustic startle (PPI), but no sex differences in PPI in non-smokers. OBJECTIVE:To determine whether previously reported male>female acoustic PPI reflect sex differences in smoking effects on PPI...

journal_title：Psychopharmacology

authors： Swerdlow NR,Geyer MA,Hartman PL,Sprock J,Auerbach PP,Cadenhead K,Perry W,Braff DL

更新日期：1999-09-01 00:00:00

abstract：RATIONALE:Caveolin-1 (CAV1) is a structural protein critical for spatial organization of neuronal signaling molecules. Whether CAV1 is required for long-lasting neuronal plasticity remains unknown. OBJECTIVE AND METHODS:We sought to examine the effects of CAV1 knockout (KO) on functional plasticity and hypothesized th...

journal_title：Psychopharmacology

authors： Eisinger KRT,Chapp AD,Swanson SP,Tam D,Lopresti NM,Larson EB,Thomas MJ,Lanier LM,Mermelstein PG

更新日期：2020-09-01 00:00:00

abstract：RATIONALE:Understanding factors contributing to individual differences in vulnerability to opioid addiction is essential for developing more effective preventions and treatments, yet few reliable behavioral predictors of subsequent opioid self-administration have been identified in rodents. Sensitivity to the acute eff...

journal_title：Psychopharmacology

authors： Swain Y,Muelken P,Skansberg A,Lanzdorf D,Haave Z,LeSage MG,Gewirtz JC,Harris AC

更新日期：2020-08-01 00:00:00

abstract：RATIONALE:Schizophrenia is a complex psychiatric disorder comprised of three main classes of symptoms: positive, negative and cognitive symptoms. Currently, no approved treatment exists for the cognitive symptoms. There is thus a great need for research aiming at identifying novel targets for treatment of this indicati...

journal_title：Psychopharmacology

authors： Damgaard T,Plath N,Neill JC,Hansen SL

更新日期：2011-03-01 00:00:00

abstract：RATIONALE:Interrelationships between the discriminative stimulus and reinforcing properties of psychoactive drugs and the way in which they may interact to control drug intake are unclear. Studies have shown that drug history can influence the expression of drug-produced behavioral effects. OBJECTIVE:The present study...

journal_title：Psychopharmacology

authors： Childs E,Shoaib M,Stolerman IP

更新日期：2006-06-01 00:00:00

abstract：:The present report investigated several parametric and pharmacological aspects of the enhanced self-grooming behavior of rats following systemic administration of the selective D1 dopamine (DA) receptor agonist SKF 38393. The amount of time that rats spent grooming themselves was measured continuously for 30 min follo...

journal_title：Psychopharmacology

authors： Wachtel SR,Brooderson RJ,White FJ

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:3,4-Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone abused for its cocaine-like psychostimulant effects in "bath salts" products. While there are currently no pharmacotherapies for MDPV abuse, rodent studies suggest immunotherapy may offer a feasible treatment option. OBJECTIVES:These studies test...

journal_title：Psychopharmacology

authors： McClenahan SJ,Gunnell MG,Owens SM,Fantegrossi WE

更新日期：2020-09-01 00:00:00

abstract：:The effects of chronic desmethylimipramine (DMI) treatment on measures of incentive motivation for cocaine were assessed in order to investigate the predictive validity of the extinction/reinstatement model of drug craving. Rats were trained to respond for cocaine infusions (0.75 mg/kg per 0.1 ml i.v.) or received yok...

journal_title：Psychopharmacology

authors： Fuchs RA,Tran-Nguyen LT,Specio SE,Groff RS,Neisewander JL

更新日期：1998-01-01 00:00:00

abstract：RATIONALE:Somatostatin and its receptors have been localized in brain nuclei implicated in motor control, such as the striatum, nucleus accumbens, ventral pallidum, and globus pallidus (GP). OBJECTIVES:The objective of this study was to investigate the role of somatostatin receptors (sst(1,2,4)) in the GP on dopamine ...

journal_title：Psychopharmacology

authors： Marazioti A,Pitychoutis PM,Papadopoulou-Daifoti Z,Spyraki C,Thermos K

更新日期：2008-12-01 00:00:00

abstract：:Rats were trained on a fixed ratio 10, food-reinforced schedule to recognize a discriminative stimulus (DS) elicited by the selective serotonin (5-HT) reuptake inhibitor (SSRI), citalopram (2.5 mg/kg, IP). The preferential, high efficacy agonist at 5-HT2C receptors, Ro60-0175, dose-dependently generalized to citalopra...

journal_title：Psychopharmacology

authors： Millan MJ,Girardon S,Dekeyne A

更新日期：1999-03-01 00:00:00

abstract：:The exploratory behavior of pigs was studied in two successive daily 20-mn sessions in a two-compartment box by counting the number of crossings from one compartment to the other and observing the activity patterns. Injection of 1 mg/kg diazepam before the first session increased the number of crossings without affect...

journal_title：Psychopharmacology

authors： Dantzer R

更新日期：1977-03-16 00:00:00