Abstract:
RATIONALE:Recent findings have shown a complexly regulated 5-HT system as it is linked to different kinds of aggression. OBJECTIVE:We focus on (1) phasic and tonic changes of 5-HT and (2) state and trait of aggression, and emphasize the different receptor subtypes, their role in specific brain regions, feed-back regulation and modulation by other amines, acids and peptides. RESULTS:New pharmacological tools differentiate the first three 5-HT receptor families and their modulation by GABA, glutamate and CRF. Activation of 5-HT(1A), 5-HT(1B) and 5-HT(2A/2C) receptors in mesocorticolimbic areas, reduce species-typical and other aggressive behaviors. In contrast, agonists at 5-HT(1A) and 5-HT(1B) receptors in the medial prefrontal cortex or septal area can increase aggressive behavior under specific conditions. Activation of serotonin transporters reduce mainly pathological aggression. Genetic analyses of aggressive individuals have identified several molecules that affect the 5-HT system directly (e.g., Tph2, 5-HT(1B), 5-HT transporter, Pet1, MAOA) or indirectly (e.g., Neuropeptide Y, αCaMKII, NOS, BDNF). Dysfunction in genes for MAOA escalates pathological aggression in rodents and humans, particularly in interaction with specific experiences. CONCLUSIONS:Feedback to autoreceptors of the 5-HT(1) family and modulation via heteroreceptors are important in the expression of aggressive behavior. Tonic increase of the 5-HT(2) family expression may cause escalated aggression, whereas the phasic increase of 5-HT(2) receptors inhibits aggressive behaviors. Polymorphisms in the genes of 5-HT transporters or rate-limiting synthetic and metabolic enzymes of 5-HT modulate aggression, often requiring interaction with the rearing environment.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Takahashi A,Quadros IM,de Almeida RM,Miczek KAdoi
10.1007/s00213-010-2000-ysubject
Has Abstractpub_date
2011-02-01 00:00:00pages
183-212issue
2-3eissn
0033-3158issn
1432-2072journal_volume
213pub_type
杂志文章,评审abstract:RATIONALE:Buprenorphine is a low-efficacy mu opioid agonist that can reduce drug taking in opioid abusers; however, the mechanism by which buprenorphine modifies the actions of other drug taking and the consequences of repeated treatment with buprenorphine are not fully understood. OBJECTIVE:The purposes of this study...
journal_title:Psychopharmacology
pub_type: 杂志文章
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abstract:RATIONALE:Convulsions associated with cocaine toxicity are a serious aspect of cocaine-related emergency room incidents. Seizures can result from a single high dose of cocaine, and evidence is accumulating that correlates repetitive administration of sub-convulsive doses of cocaine with a decreased seizure threshold, a...
journal_title:Psychopharmacology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Psychopharmacology
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doi:10.1007/BF02246099
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1992-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2002-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432774
更新日期:1982-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1977-11-15 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1979-03-29 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2006-06-01 00:00:00