Abstract:
:Two experiments were conducted to assess the acute behavioral effects of triazolam and temazepam in healthy, non-drug abusing men in double-blind, placebo-controlled, crossover trials, where all subjects received all possible doses. These drugs were compared to examine allegations that triazolam produces greater behavioral impairment than temazepam. Drug effects were assessed during 4-h sessions using measures of recall, learning, psychomotor performance, and subject ratings assessing drug effects and abuse potential. In experiment 1, triazolam (0.25 and 0.5 mg/70 kg) produced greater behavioral impairment than temazepam (15 and 30 mg/70 kg). However, triazolam also produced greater increases than temazepam in subject ratings of drug strength, drunkenness and sleepiness, suggesting the dose ranges compared may not have been clinically equivalent. Experiment 2 was conducted to assess whether a higher dose of temazepam than tested in experiment 1 would produce levels of behavioral impairment comparable to those observed with triazolam in experiment 1. In experiment 2, the temazepam dose was increased to 60 mg/70 kg while the triazolam dose was 0.5 mg/70 kg which was the highest dose tested in experiment 1. These doses produced comparable increases in subject ratings of drug strength, drunkenness and sleepiness, but temazepam produced significantly more behavioral disruption than triazolam. These findings do not support the position that triazolam produces greater behavioral impairment than temazepam, and may even suggest that across a wide range of doses triazolam is less disruptive than temazepam.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Rush CR,Higgins ST,Hughes JR,Bickel WKdoi
10.1007/BF02244887subject
Has Abstractpub_date
1993-01-01 00:00:00pages
407-14issue
4eissn
0033-3158issn
1432-2072journal_volume
112pub_type
临床试验,杂志文章,随机对照试验abstract:RATIONALE:Accumulating evidence for the presence of GABA(A) ρ receptors within the amygdala which differ from other members of the GABA(A) receptor family in both subunit composition and functional properties has been recently obtained. OBJECTIVES:This work was conducted to study whether GABA(A) ρ receptors may have a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1973-x
更新日期:2010-12-01 00:00:00
abstract::Augmentation with low-dose fluvoxamine (50-100 mg/day) to antipsychotic treatment may improve the negative symptoms in schizophrenic patients, but involves a risk of drug-drug interaction. We studied the effects of fluvoxamine on plasma concentrations of haloperidol and reduced haloperidol, and their clinical symptoms...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-003-1567-y
更新日期:2004-01-01 00:00:00
abstract::We are performing a double-blind trial with inward psychiatric patients. The indication for our psychotropic or psychotherapeutic intervention is mainly severe depression (= major depressive disorders DSM III). For a 3-week trial course trazodone (400 mg daily), amitriptyline (150 mg/die) or placebo capsules were give...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00172621
更新日期:1988-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00428416
更新日期:1985-01-01 00:00:00
abstract::Lymphocyte beta adrenergic receptor binding using [125I]CNP was determined in patients with panic disorder (N = 4) or agoraphobia with panic attacks (N = 17) and age- and sex-matched healthy subjects (N = 22). The patients showed a significantly lower number of beta-adrenergic receptor binding sites and a significantl...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00735875
更新日期:1988-01-01 00:00:00
abstract::A placebo-controlled study with six normal volunteers was carried out using 1 mg haloperidol IM. In some EEG frequency bands, the power density due to haloperidol appeared to increase or decrease depending on the subject. Nevertheless, if the results of the six subjects are taken together, the effects of haloperidol a...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00431753
更新日期:1981-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244864
更新日期:1994-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
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更新日期:2003-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-020-05556-2
更新日期:2020-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1180-1
更新日期:2008-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00555228
更新日期:1984-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1984-7
更新日期:2011-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02801979
更新日期:1992-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4676-8
更新日期:2017-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00441949
更新日期:1989-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051077
更新日期:1999-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-004-2017-1
更新日期:2005-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-020-05605-w
更新日期:2020-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02253528
更新日期:1993-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
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更新日期:2009-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1999-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1999-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245696
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:Depressive disorders are conditions that often require continuous treatment, and it is therefore important to evaluate the consequences of prolonged administration. There are few studies assessing cognitive functions of depressed patients after long-term use of antidepressants. OBJECTIVES:This study evaluate...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0274-2
更新日期:2006-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245224
更新日期:1994-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
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更新日期:2007-04-01 00:00:00