Clonidine and diazepam have differential effects on tests of attention and learning.

abstract：:Experiments assessed the development of tolerance to morphine stimulus control during treatment with selected maintenance doses of morphine. Separate groups of rats were trained to discriminate saline and either 3.2 mg/kg or 5.6 mg/kg morphine under fixed-ratio schedules of food delivery. Dose-response functions for g...

journal_title：Psychopharmacology

authors： Young AM,Sannerud CA,Steigerwald ES,Doty MD,Lipinski WJ,Tetrick LE

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Coping styles are fundamental characteristics of behavior that affect susceptibility to, and resilience during, mental and physical illness. Shifts from passive to active coping are considered therapeutic goals in many stress-related disorders, but the neural control of coping is poorly understood. Based on e...

journal_title：Psychopharmacology

authors： Haller J,Goldberg SR,Pelczer KG,Aliczki M,Panlilio LV

更新日期：2013-12-01 00:00:00

abstract：:Pigeons were trained to peck each of two response keys. Periods during which pecks on one key (the food key) produced access to grain according to a random-ratio 80 schedule alternated irregularly with periods during which food-key responses had no scheduled consequences (extinction). Both keys remained amber unless a...

journal_title：Psychopharmacology

authors： Dearing ME,Branch MN

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Previous experiments have shown that d-amphetamine disrupts timing behaviour in rats. It has been proposed that d-amphetamine's effects reflect a reduction in the period of the pacemaker of the hypothetical internal clock. However, some studies have obtained conflicting results. OBJECTIVE:To examine the effe...

journal_title：Psychopharmacology

authors： Chiang TJ,Al-Ruwaitea AS,Mobini S,Ho MY,Bradshaw CM,Szabadi E

更新日期：2000-06-01 00:00:00

abstract：RATIONALE:Nicotine and nicotinic agonists have been shown to improve attentional function. Nicotinic receptors are easily desensitized, and all nicotinic agonists are also desensitizing agents. Although both receptor activation and desensitization are components of the mechanism that mediates the overall effects of nic...

journal_title：Psychopharmacology

authors： Rezvani AH,Cauley M,Xiao Y,Kellar KJ,Levin ED

更新日期：2013-03-01 00:00:00

abstract：:Physostigmine (1.0mg) or placebo were administered intravenously over 1-h period to seven male normal volunteers beginning 35 min after sleep onset. The results indicate that physostigmine induced the onset of REM sleep but did not significantly alter the duration of individual REM sleep periods. Physostigmine signifi...

journal_title：Psychopharmacology

authors： Gillin JC,Sitaram N,Mendelson WB,Wyatt RJ

更新日期：1978-06-15 00:00:00

abstract：RATIONALE:Opioid antagonism reduces the consumption of palatable foods in humans but the neural substrates implicated in these effects are less well understood. OBJECTIVES:The aim of the present study was to examine the effects of the opioid antagonist, naltrexone, on neural response to rewarding and aversive sight an...

journal_title：Psychopharmacology

authors： Murray E,Brouwer S,McCutcheon R,Harmer CJ,Cowen PJ,McCabe C

更新日期：2014-11-01 00:00:00

abstract：:Four benzodiazepine tranquilizers have been tested, alone or in combination with scopolamine, on the spontaneous locomotor activity of BALB/c mice. Scopolamine-induced locomotor stimulation was enhanced by chlordiazepoxide, diazepam, and medazepam, but not by bromazepam. These effects are similar to those exerted by t...

journal_title：Psychopharmacology

authors： Sansone M

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:The gut microbiota is increasingly recognized as a potential mediator of psychiatric diseases. Depressed patients have been shown to have a different microbiota composition compared with healthy controls, and several lines of research now aim to restore this dysbiosis. To develop novel treatments, preclinical...

journal_title：Psychopharmacology

authors： Tillmann S,Abildgaard A,Winther G,Wegener G

更新日期：2019-05-01 00:00:00

abstract：:Two 2-(di-n-propylamino)tetralin (DPAT) compounds, 8-OH-DPAT and 5-OH-DPAT, with reported effects on central 5-HT and DA receptors respectively, were tested for their effects on the acoustic startle response in rats. 8-OH-DPAT was given in doses of 0.25-2.0 mg/kg IP and 5-OH-DPAT in doses of 1.0-8.0 mg/kg IP. Both com...

journal_title：Psychopharmacology

authors： Svensson L,Ahlenius S

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:Clozapine is a unique antipsychotic with very low propensity to cause motor side effects. In contrast to most other antipsychotics that block more than 70% of dopamine D(2) receptors at therapeutic doses, clozapine occupies less than 70%. Furthermore, even at maximum occupancy, 70% is not exceeded. Several me...

journal_title：Psychopharmacology

authors： Suhara T,Okauchi T,Sudo Y,Takano A,Kawabe K,Maeda J,Kapur S

更新日期：2002-02-01 00:00:00

abstract：RATIONALE:Latent inhibition (LI), namely, poorer performance on a learning task involving a previously pre-exposed non-reinforced stimulus, is disrupted in the rat by the dopamine (DA) releaser amphetamine which produces and exacerbates psychotic (positive) symptoms, and this is reversed by treatment with typical and a...

journal_title：Psychopharmacology

authors： Weiner I

更新日期：2003-09-01 00:00:00

abstract：RATIONALE:The C57BL/6 is one of the most widely used mouse strains in behavioral, pharmacological, and genetic research but little is known about their response on tests for antidepressant drugs. OBJECTIVES:The behavior of C57BL/6 mice, and mice from other strains, was examined in the tail suspension test (TST), a com...

journal_title：Psychopharmacology

authors： Mayorga AJ,Lucki I

更新日期：2001-04-01 00:00:00

abstract：RATIONALE:Animal studies indicate that dopamine pathways in the ventral striatum code for the motivational salience of both rewarding and aversive stimuli, but evidence for this mechanism in humans is less established. We have developed a functional magnetic resonance imaging (fMRI) model which permits examination of t...

journal_title：Psychopharmacology

authors： McCabe C,Huber A,Harmer CJ,Cowen PJ

更新日期：2011-09-01 00:00:00

abstract：:The effect of the selective noradrenaline neurotoxin DSP4 on steady-state operant behaviour was examined using a quantitative behavioural paradigm based on Herrnstein's (1970) equation, which defines a hyperbolic relationship between steady-state response rate and reinforcement frequency in variable-interval schedules...

journal_title：Psychopharmacology

authors： Morley MJ,Shah K,Bradshaw CM,Szabadi E

更新日期：1988-01-01 00:00:00

abstract：:After publication of this paper, the authors determined an error in Fig. 2C. ...

journal_title：Psychopharmacology

authors： Zhang B,Xiong F,Ma Y,Li B,Mao Y,Zhou Z,Yu H,Li J,Li C,Fu J,Wang J,Zhao X

更新日期：2019-07-01 00:00:00

abstract：RATIONALE:Acid sensing ion channels (ASICs) are proton-gated ion channels located in the central and peripheral nervous systems. Of particular interest is ASIC1a, which is located in areas associated with fear and anxiety behaviors. Recent reports suggest a role for ASIC1a in preclinical models of fear conditioning and...

journal_title：Psychopharmacology

authors： Dwyer JM,Rizzo SJ,Neal SJ,Lin Q,Jow F,Arias RL,Rosenzweig-Lipson S,Dunlop J,Beyer CE

更新日期：2009-03-01 00:00:00

abstract：RATIONALE:Obsessive-compulsive disorder (OCD) gradually emerges and reaches clinical significance during early adulthood. Whether a predisposition for OCD manifests as binge eating disorder earlier during adolescence is proposed. OBJECTIVES:To further characterize how OCD-like behaviors increase across maturation and ...

journal_title：Psychopharmacology

authors： Freund N,Thompson BS,Norman KJ,Einhorn P,Andersen SL

更新日期：2015-09-01 00:00:00

abstract：RATIONALE:The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors. Different studies have demonstrated intracellular calcium (Ca(2+))-dependent activation of the PKA cascade after ethanol administration. Thu...

journal_title：Psychopharmacology

authors： Baliño P,Ledesma JC,Aragon CM

更新日期：2014-12-01 00:00:00

abstract：RATIONALE:Epidemiological studies of smokers suggest that there is a link between nicotine and depression. Nonetheless, few studies have examined the potential use of nicotinic ligands in the treatment of depression. OBJECTIVES:The goal of this study was to evaluate the effects of SIB-1508Y, a novel subtype-selective ...

journal_title：Psychopharmacology

authors： Ferguson SM,Brodkin JD,Lloyd GK,Menzaghi F

更新日期：2000-10-01 00:00:00

abstract：RATIONALE:Repeated exposure to psychostimulant drugs causes a long-lasting increase in the psychomotor and reinforcing effects of these drugs and an array of neuroadaptations. One such alteration is a hypersensitivity of striatal activity such that a low dose of amphetamine in sensitized animals produces dorsal striata...

journal_title：Psychopharmacology

authors： Nordquist RE,Vanderschuren LJ,Jonker AJ,Bergsma M,de Vries TJ,Pennartz CM,Voorn P

更新日期：2008-05-01 00:00:00

abstract：:Ibogaine is currently being investigated for its potential use as an anti-addictive agent. In the present study we sought to determine whether prior morphine exposure influences the ability of ibogaine to inhibit morphine-induced locomotor stimulation. Female Sprague-Dawley rats were pretreated once a day for 1-4 days...

journal_title：Psychopharmacology

authors： Pearl SM,Johnson DW,Glick SD

更新日期：1995-10-01 00:00:00

abstract：RATIONALE:Intermittent footshock stress effectively reinstates extinguished heroin-, cocaine- and alcohol-taking behaviors, but not behaviors previously maintained by food reinforcers. Here we tested further the generality of the phenomenon of stress-induced reinstatement by determining the effect of footshock on reins...

journal_title：Psychopharmacology

authors： Buczek Y,Lê AD,Wang A,Stewart J,Shaham Y

更新日期：1999-05-01 00:00:00

abstract：:Mood disorders, despite the widespread availability of monoamine-based antidepressant treatments, are associated with persistently high rates of disability, together with elevated rates of mortality due to suicide, cardiovascular disease, and other causes. The development of more effective treatments has been hindered...

journal_title：Psychopharmacology

authors： Bhattacharya A,Derecki NC,Lovenberg TW,Drevets WC

更新日期：2016-05-01 00:00:00

abstract：:Young adult rats (5 months) were compared with aged (28 months) rats in their ability to learn and perform in a diazepam drug discrimination. Both groups of rats were drug naive at the onset of the experiment. Adult and aged animals learned to discriminate diazepam. In general, the response rates under both drug and v...

journal_title：Psychopharmacology

authors： Amrick CL,Bennett DA

更新日期：1987-01-01 00:00:00

abstract：:When tested in adulthood, male rats that had been treated daily with 50 mg/kg hydroxyzine HCl SC at 10--29 or 23--29 days of age were significantly facilitated in performance of delayed spontaneous alternation relative to saline-injected rats. Treatment at 10--16 days of age did not produce significant facilitation in...

journal_title：Psychopharmacology

authors： Isseroff A

更新日期：1980-01-01 00:00:00

abstract：:The behavioral profile of corticotropin-releasing factor (CRF) in mediating anxiogenic-like and aversive responses to stressors may be particularly relevant for dependence and withdrawal in drug-experienced organisms. Moreover, stressful aspects of drug exposure in the drug naive organism may also induce CRF system ac...

journal_title：Psychopharmacology

authors： Heinrichs SC,Klaassen A,Koob GF,Schulteis G,Ahmed S,De Souza EB

更新日期：1998-04-01 00:00:00

abstract：INTRODUCTION:The present study was designed to investigate the rewarding effects induced by tramadol and its active metabolite O-desmethyltramadol (M1) under a neuropathic pain-like state. RESULTS:In opioid receptor binding and G protein activation, we confirmed that M1, but not tramadol, showed mu-opioid receptor (MO...

journal_title：Psychopharmacology

authors： Nakamura A,Narita M,Miyoshi K,Shindo K,Okutsu D,Suzuki M,Higashiyama K,Suzuki T

更新日期：2008-10-01 00:00:00

abstract：:Ferret predation on rats was examined in an arena. One hour before the test one of the following drugs was administered. d-Amphetamine (0.8 and 1.4 mg/kg IM), MAPROTILINE (10 AND 40 Mg/kg orally), L-dopa (30 and 60 mg/kg orally), or haloperidol (0.14 and 0.6 mg/kg IM). Provided that capture was successful, the sequenc...

journal_title：Psychopharmacology

authors： Schmidt WJ

更新日期：1979-09-01 00:00:00

abstract：:The effect of ovarian steroids on the benzodiazepine receptor was assessed in the elevated plus-maze and, after restraint stress, in benzodiazepine receptor binding assays. Vehicle-treated proestrous rats displayed anxiolytic behavior, relative to diestrus or estrous rats. Anxiolytic behavior was observed after 1 or 2...

journal_title：Psychopharmacology

authors： Bitran D,Dowd JA

更新日期：1996-05-01 00:00:00