Abstract:
:Ibogaine is currently being investigated for its potential use as an anti-addictive agent. In the present study we sought to determine whether prior morphine exposure influences the ability of ibogaine to inhibit morphine-induced locomotor stimulation. Female Sprague-Dawley rats were pretreated once a day for 1-4 days with morphine (5, 10, 20 or 30 mg/kg, i.p.) or saline and then received ibogaine (40 mg/kg, i.p.) 5 h after the last morphine pretreatment dose. Compared to rats pretreated with saline, rats pretreated with morphine (10, 20 or 30 mg/kg, i.p.) before ibogaine (40 mg/kg, i.p.) showed a significant reduction in morphine-induced (5 mg/kg, i.p.) locomotor stimulation when tested 29 h after ibogaine administration. Furthermore, this effect was apparent over a range of ibogaine (5-60 mg/kg, i.p.) and morphine test (2.5-5 mg/kg, i.p.) dosages. Doses of ibogaine (5 and 10 mg/kg, i.p.) which alone were inactive inhibited morphine-induced locomotor activity when rats had been pretreated with morphine. These results, showing that morphine pre-exposure affects ibogaine activity, suggest that variable histories of opioid exposure might account for individual differences in the efficacy of ibogaine to inhibit opioid addiction.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Pearl SM,Johnson DW,Glick SDdoi
10.1007/BF02246495subject
Has Abstractpub_date
1995-10-01 00:00:00pages
470-5issue
4eissn
0033-3158issn
1432-2072journal_volume
121pub_type
杂志文章abstract::In previous research, sensitization of stereotypy induced by injections of 2.5 mg/kg amphetamine did not interfere with subsequent tolerance development to the hypophagic effect of 2 mg/kg. This study examined the effect of a higher sensitizing dose. Rats given intermittent injections of 5 mg/kg amphetamine and then c...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050788
更新日期:1998-12-01 00:00:00
abstract::Continuous low-level (0.825 mg/kg/h for 20 h) administration of AP through SC in-dwelling silicone reservoirs in the rat induced behavioral and biochemical changes that were similar to those induced by low levels (0.1 mg/kg) of acutely administered AP (decreased behavioral activity and decreased dopamine metabolism in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427314
更新日期:1985-01-01 00:00:00
abstract::The effect of electroconvulsive shock (ECS) on the responsiveness to pain (measured by the hot-plate test) and on the characteristics of L-type calcium channels (measured as [3H]nitrendipine binding sites) in the cortex and hippocampus was tested on the Wistar rat. In animals receiving a single ECS, the calcium channe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244133
更新日期:1990-01-01 00:00:00
abstract::The effect of lithium on serotonin (5-HT)-mediated responses in the brain was assessed by measuring changes in the prolactin (PRL) and growth hormone (GH) responses to L-tryptophan (LTP) in eight normal subjects. On the 4th day of lithium treatment the PRL responses were significantly enhanced, and this enhancement wa...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00179198
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:Atypical antipsychotic drugs are classically associated with lower propensity to extrapyramidal symptoms (EPS) and hyperprolactinemia than typical antipsychotic drugs. It has not been clarified why some atypical antipsychotic drugs, such as amisulpride, induce prolactin plasma concentration (PRL) elevation, b...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1826-6
更新日期:2004-09-01 00:00:00
abstract::It was shown previously that behavioural effects of apomorphine (locomotor activation and stereotyped behaviour) can be conditioned when they are associated with well-defined environmental stimuli. In the present study, the hypothesis was tested that glutamatergic mechanisms play an important role either in formation ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244064
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:A dopamine receptor 4 variable number tandem repeat (DRD4 VNTR) polymorphism has been related to reactivity to smoking cues among smokers, but the effect of this genetic variation on brain responses to smoking cues has not been evaluated. OBJECTIVES:The present study evaluated the relationship between carryi...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-007-0860-6
更新日期:2007-11-01 00:00:00
abstract::Buprenorphine, a partial mu opioid agonist, is an experimental medication under development for the treatment of opioid dependence as an alternative to methadone maintenance. The present study examined the relationship between level of opioid physical dependence and response to buprenorphine administration as part of ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02246290
更新日期:1995-06-01 00:00:00
abstract:RATIONALE:In an animal model for vulnerability to drug abuse, rats that are more reactive to a novel environment (high responders, HRs) are more sensitive to behavioral effects of psychostimulants than are less reactive rats (low responders, LRs). In a companion article, we reported that HRs and LRs differ in sensitivi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1921-8
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND AND RATIONALE:Despite the popularity of polysubstance abuse among recreational methylendioxymethamphetamine (MDMA) users, relatively few controlled experimental studies have documented the neurobehavioral effects of MDMA in combination with other abused substances. OBJECTIVE:In this study, the combined acut...
journal_title:Psychopharmacology
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doi:10.1007/s00213-009-1774-2
更新日期:2010-03-01 00:00:00
abstract::Effects of the dopamine D2 receptor antagonist sulpiride and the D1 antagonist SCH-23390 were examined, in rats, in two-bottle preference tests (sucrose versus water) and in single-bottle tests, at different sucrose concentrations. Both drugs decreased sucrose intake in single bottle tests, at low sucrose concentratio...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00634461
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Endogenous γ-aminobutyric acidA receptor (GABAAR)-active neurosteroids (e.g., allopregnanolone) regulate central nervous system excitability and many physiological functions, so fluctuations are implicated in several neuropsychiatric disorders. Pertinently, evidence supports an inverse relationship between en...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4671-0
更新日期:2017-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00423259
更新日期:1976-07-28 00:00:00
abstract::Basal morning humoral (H)-endorphin blood levels were assessed in ten autistic patients, 12 chronic schizophrenic patients and 11 healthy control subjects. Four autistic patients and four schizophrenic patients were drug free for at least 6 months while all other psychiatric patients were under treatment with antidopa...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427687
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:The C57BL/6 is one of the most widely used mouse strains in behavioral, pharmacological, and genetic research but little is known about their response on tests for antidepressant drugs. OBJECTIVES:The behavior of C57BL/6 mice, and mice from other strains, was examined in the tail suspension test (TST), a com...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100687
更新日期:2001-04-01 00:00:00
abstract:RATIONALE:Cognitive rehabilitation is now recognized as an important tool in the treatment of schizophrenia, and findings in this area are emerging rapidly. There is a need for a systematic review of the effects of the different training programs. OBJECTIVES:To review quantitatively the controlled studies on cognitive...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-002-1326-5
更新日期:2003-09-01 00:00:00
abstract:RATIONALE:A substantial portion of cigarette smokers prefer menthol-flavored cigarettes. To date, however, no studies have examined whether menthol in cigarettes has central pharmacological effects. OBJECTIVE:We investigated psychophysiological and subjective effects of smoking menthol versus non-menthol cigarettes in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050947
更新日期:1999-04-01 00:00:00
abstract:RATIONALE:In patients, ketamine is a fast-acting antidepressant that can induce long-lasting symptom relief. Similar rapid effects have been reported in rodents, but reports of lasting effects are limited. OBJECTIVES:We sought to extend past findings by examining dose-response curves that overlap with the individual d...
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pub_type: 杂志文章
doi:10.1007/s00213-011-2169-8
更新日期:2011-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3042-8
更新日期:2013-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0600-3
更新日期:2007-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2002-10-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:1986-01-01 00:00:00
abstract:RATIONALE:The intake of psychostimulant drugs may induce cognitive dysfunction and negative affective-like states, and is associated with increased activity of stress-responsive systems. The corticotropin-releasing factor (CRF) system mediates neuroendocrine, behavioural and autonomic responses to stressors, and might ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3534-1
更新日期:2014-10-01 00:00:00
abstract:RATIONALE:Most adult smokers start smoking during their adolescence. This adolescent initiation may be due to multiple factors, but little evidence is available regarding whether their brains are differentially sensitive to the addictive effects of nicotine during adolescence. OBJECTIVE:To test the hypothesis that ado...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1758-6
更新日期:2004-07-01 00:00:00
abstract::Two experiments were conducted to assess the acute behavioral effects of triazolam and temazepam in healthy, non-drug abusing men in double-blind, placebo-controlled, crossover trials, where all subjects received all possible doses. These drugs were compared to examine allegations that triazolam produces greater behav...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02244887
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:Reduction of body temperature is used as predictor of psychotropic drug action. The cutaneous circulation functions as a heat-loss component of temperature regulation. Clozapine and olanzapine reverse hyperthermia and sympathetically-mediated cutaneous vasoconstriction induced by MDMA (3,4-methylenedioxymetha...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1850-6
更新日期:2004-10-01 00:00:00
abstract::Methamphetamine (MAP: 1 and 2 mg/kg SC) and caffeine (CAF: 1, 3, 10 and 30 mg/kg SC) dose-dependently increased ambulation in mice. Repeated administration (5 times at 3 to 4-day intervals) of MAP, but not CAF, induced sensitization to its effect. Furthermore, the mice repeatedly receiving CAF showed no significant ch...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245053
更新日期:1994-10-01 00:00:00
abstract::Peak saccadic eye movement velocity (SEV) and average smooth pursuit gain (SP) are reduced in a dose-dependent manner by diazepam and provide reliable, quantitative measures of benzodiazepine agonist effects. To evaluate the specificity of these eye movement effects for agents acting at the central GABA-benzodiazepine...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245956
更新日期:1995-04-01 00:00:00
abstract:RATIONALE:Zidovudine (AZT) and lamivudine (3TC) are nucleoside analogues administered prenatally in clinical practice, separately or in combination, as antiretroviral drugs to prevent HIV mother-to-child transmission by inhibiting viral reverse transcriptase. In animal studies pre- and/or perinatal exposure to AZT and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000585
更新日期:2001-02-01 00:00:00
abstract::Depression in children is currently an area of considerable controversy, as is the use of potent psychopharmacologic agents in children. Since EEG sleep techniques have proven to be useful in understanding the mechanisms of depression in adults and in predicting their response to antidepressants, a pilot study employi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432281
更新日期:1979-01-31 00:00:00