Effects of dopamine receptor antagonists on sucrose consumption and preference.

Abstract:

:Effects of the dopamine D2 receptor antagonist sulpiride and the D1 antagonist SCH-23390 were examined, in rats, in two-bottle preference tests (sucrose versus water) and in single-bottle tests, at different sucrose concentrations. Both drugs decreased sucrose intake in single bottle tests, at low sucrose concentrations, but had no effect at high concentrations; reducing drive level had exactly the opposite pattern of effects. In two-bottle tests, both drugs reduced preference for the weakest sucrose concentration (0.7%) but increased preference for the strongest concentration (34%). The effects of antagonizing either subtype of DA receptor appear to be similar to those of reducing the concentration of sucrose.

journal_title

Psychopharmacology

authors

Muscat R,Willner P

doi

10.1007/BF00634461

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

98-102

issue

1

eissn

0033-3158

issn

1432-2072

journal_volume

99

pub_type

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