Abstract:
:Effects of the dopamine D2 receptor antagonist sulpiride and the D1 antagonist SCH-23390 were examined, in rats, in two-bottle preference tests (sucrose versus water) and in single-bottle tests, at different sucrose concentrations. Both drugs decreased sucrose intake in single bottle tests, at low sucrose concentrations, but had no effect at high concentrations; reducing drive level had exactly the opposite pattern of effects. In two-bottle tests, both drugs reduced preference for the weakest sucrose concentration (0.7%) but increased preference for the strongest concentration (34%). The effects of antagonizing either subtype of DA receptor appear to be similar to those of reducing the concentration of sucrose.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Muscat R,Willner Pdoi
10.1007/BF00634461subject
Has Abstractpub_date
1989-01-01 00:00:00pages
98-102issue
1eissn
0033-3158issn
1432-2072journal_volume
99pub_type
杂志文章abstract::Acamprosate (calcium-acetyl homotaurinate) is a new compound used in the treatment of alcohol abuse. Because of the putative link between alcoholism and the endogenous opioid systems in both humans and laboratory animals, we tested in rats the effects of acamprosate on behavioral and neurochemical effects of opioid dr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050730
更新日期:1998-10-01 00:00:00
abstract:RATIONALE:The ultra-short-acting mu opioid agonist analgesic/anesthetic remifentanil (RMF) is extremely rapidly eliminated from blood (half-life in rats, 0.3-0.7 min). This extremely fast elimination is thought to be the main reason why RMF maintains such high rates of responding in animal operant-conditioning models o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0180-7
更新日期:2005-12-01 00:00:00
abstract:RATIONALE:Prior research suggests that high levels of acetylcholine (ACh) in the nucleus accumbens (NAc) are associated with aversive states such as morphine withdrawal, but this has not been tested for nicotine withdrawal. OBJECTIVES:The goal was to test the hypothesis that acute nicotine decreases extracellular ACh ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100781
更新日期:2001-08-01 00:00:00
abstract::The topography of stereotyped behaviour produced by apomorphine in rats was studied by using either a scoring system, based on observation in a wire cage, or by quantification of horizontal and vertical activities, and of the total distances run in an open field, using an automatic recording system. The latter design ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00172869
更新日期:1986-01-01 00:00:00
abstract::Normal unoperated rats were tested for rotation (i.e., circling behavior) in a spherical "rotometer" and dose-response relationships were generated using d-amphetamine, apomorphine, L-Dopa, haloperidol, and scopolamine. The rotation induced by amphetamine was significantly antagonized by alpha-methyl-p-tyrosine and ha...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427609
更新日期:1976-06-23 00:00:00
abstract::The glutamatergic cortico-striatal and subthalamo-entopeduncular pathways are both overactive in parkinsonism. Previous behavioural investigations have shown that intra-entopeduncular injection of either NMDA-site or glycine-site antagonists results in alleviation of parkinsonian symptoms, although injection of the fo...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246054
更新日期:1995-05-01 00:00:00
abstract::The pharmacokinetics of flumazenil in the rat were determined after 2.5 mg/kg intravenous and 25 mg/kg oral administration. Following intravenous administration flumazenil was rapidly eliminated with an extremely short terminal half-life (mean +/- SE, n = 8) of 8.3 +/- 0.3 min due to a large total blood clearance of 1...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244294
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:Several studies have suggested that modulation of the glutamatergic system via metabotropic glutamate receptors (mGlu) could be a new and efficient way to achieve antipsychotic-like activity. OBJECTIVES:Here, we decided to investigate the possible role of the group III mGlu receptor ligands, LSP1-2111, the g...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2502-2
更新日期:2012-04-01 00:00:00
abstract:RATIONALE:Diazepam, a benzodiazepine with a relatively rapid onset of clinical effects, has been associated with suicide and other self-aggressive acts. The evidence for this association, however, comes exclusively from retrospective non-experimental studies. Although suggestive, the results of these studies do not sup...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-004-1966-8
更新日期:2005-02-01 00:00:00
abstract::Primiparous rats received 0.05, 0.25, 0.50, or 1.50 mg d-amphetamine/kg body weight, injected IP, when offspring reached 3-4 and 10-11 days of age. A multidimensional analysis of their maternal behavior revealed that at doses as low as 0.25 mg/kg, amphetamine had a disruptive effect on mother-pup intercontact interval...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00435314
更新日期:1980-01-01 00:00:00
abstract:RATIONALE:The majority of volumetric magnetic resonance imaging (MRI) studies of the hippocampus in patients with bipolar disorder (BD) show no differences in hippocampal volume between patients and healthy controls. Significant variability, however, exists in the medication status of patients included in these studies...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0906-9
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Several theories propose alternative explanations for drug addiction. OBJECTIVES:We propose a general theory of transition to addiction that synthesizes knowledge generated in the field of addiction into a unitary explanatory frame. MAJOR PRINCIPLES OF THE THEORY:Transition to addiction results from a sequ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3224-4
更新日期:2013-10-01 00:00:00
abstract:RATIONALE:Abnormalities of cortical evoked potentials and background electroencephalographic (EEG) frequencies occur in several psychiatric disorders, some of which, especially depression, are associated with hypercortisolaemia. However, there have been few investigations of the effects of exogenously administered cort...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130000528
更新日期:2000-09-01 00:00:00
abstract:RATIONALE:It has been suggested that the antipsychotic effect of antipsychotics is mediated by the antagonism of the dopamine D2 receptor in the limbic-cortical regions. Risperidone has an atypical property, but its effect on limbic-cortical regions has not been evaluated. OBJECTIVES:In this study, we examined the rel...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130000643
更新日期:2001-02-01 00:00:00
abstract::This was a 4-week, three-center, double-blind, randomized, parallel, placebo-controlled evaluation of the efficacy and safety of bupropion in hospitalized depressed patients. Results from 27 placebo and 48 bupropion-treated patients were analyzed for efficacy and safety. Assessments of efficacy and safety were made at...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00433415
更新日期:1983-01-01 00:00:00
abstract::The administration of trycyclic antidepressants followed by reserpine-like drugs elicits a pattern of stereotyped locomotor activity. Using desmethylimipramine (DMI) followed by tetrabenazine (TBZ), activity could be reliably elicited only in young rats, and only by using very high doses of TBZ. The latency of onset o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426790
更新日期:1978-06-15 00:00:00
abstract::Human eyeblink conditioning, a relatively simple form of learning and memory, has previously been shown to be impaired by the central and peripheral anticholinergic scopolamine. The present study compared the behavioral effects of scopolamine with the benzodiazepine lorazepam and a peripherally active anticholinergic,...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02246273
更新日期:1995-12-01 00:00:00
abstract::Rats were made hyperphagic by 6-hydroxydopamine (6-OHDA) injected bilaterally into the ventral midbrain; then they were restricted to a 6 h/day feeding schedule and tested for appetite suppression with amphetamine and fenfluramine in randomized order. Amphetamine anorexia was diminished while fenfluramine anorexia was...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426393
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:Drug addiction is a chronically relapsing disorder characterised by compulsive drug use and loss of control over drug intake. Although several theories propose impulsivity as a key component of addiction, the precise nature of this relationship remains unclear. OBJECTIVES:This study aims to investigate the s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2558-z
更新日期:2012-01-01 00:00:00
abstract::Risperidone, a new antipsychotic agent, was studied for its effects on spontaneous motor activity in rats in comparison with haloperidol. Motor activity was recorded via the optical scanning technique (horizontal and vertical activity) and via a recently developed technique based on the piezo-electric principle which,...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00172961
更新日期:1988-01-01 00:00:00
abstract::The effects of benzodiazepine (triazolam 0.25 and 0.50 mg) on different aspects of cognitive function were assessed. Triazolam impaired free recall and recognition of information presented after drug administration. In contrast to these impairments in explicit memory, a memory function that did not require conscious a...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245415
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:The endogenous cannabinoid system is thought to play a role in reinforcement processes. OBJECTIVES:We tested the effects of five doses of the cannabinoid receptor 1 (CB1) antagonist SR141716 [0, 0.3, 1, 3 and 10 mg/kg intraperitoneal (IP)] on intracranial self-stimulation at the level of the median forebrain...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100804
更新日期:2001-09-01 00:00:00
abstract::The intensity of the head-twitch response and the 5-hydroxytryptamine (5-HT) syndrome (tremor, fore-paw treading, head-weaving and hind-limb abduction) was measured in male CFLP mice following IP injection of 5 mg/kg 5-methoxy-N,N-dimethyltryptamine (5-MeODMT). The results of separate experiments carried out at 1.5-h ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431714
更新日期:1985-01-01 00:00:00
abstract:RATIONALE:A cue-modulated startle test recently confirmed that smoking cues in smokers may not be withdrawal-like and aversive as traditionally believed. OBJECTIVE:Analogous tests were applied to alcohol cues in inpatient alcoholics. METHODS:Twenty-six withdrawn alcoholics (18 men) were examined. Alcohol-related pict...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000508
更新日期:2000-09-01 00:00:00
abstract::Elderly normal volunteers (N = 12, mean age 70.4 years) were administered placebo or diazepam 2.5, 5, 10 mg in four consecutive sessions separated by at least a 1-week interval. Memory and psychomotor performance and plasma diazepam concentrations were assessed at baseline and at 1 and 3 h following drug administratio...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00555210
更新日期:1984-01-01 00:00:00
abstract::The behavioral responsiveness to challenge doses of the D2 agonist quinpirole was examined in 21-day-old normal offspring (experiment 1) as well as offspring exposed gestationally to cocaine (experiment 2). In both experiments weanling rats received a subcutaneous injection of 0 (0.9% saline), 0.04, 0.08, 0.5, or 1.0 ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245109
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:Repeated high doses of morphine in the rat cause stereotypic gnawing behavior that can be re-expressed by a low dose of morphine weeks and even months after the initial treatment. The determination of the role of serotonin in this sensitized morphine-induced behavior has both empirical and theoretical relevan...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051083
更新日期:1999-09-01 00:00:00
abstract:RATIONALE:Previous experiments have shown that d-amphetamine disrupts timing behaviour in rats. It has been proposed that d-amphetamine's effects reflect a reduction in the period of the pacemaker of the hypothetical internal clock. However, some studies have obtained conflicting results. OBJECTIVE:To examine the effe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000422
更新日期:2000-06-01 00:00:00
abstract::Supersensitivity to serotonin during migraine attack has been previously observed. Since the attack has been attributed to a critical lowering of morphine-like factors, we can expect serotonin supersensitivity during morphine abstinence. Slight signs of morphine abstinence have also been induced in volunteers after mi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433050
更新日期:1979-10-01 00:00:00
abstract::These experiments were undertaken to determine if local injection of pilocarpine in the neostriatum of the rat produces oral motor activities that are similar to those produced by systemic administration. In the first experiment, IP administration of 2.0-8.0 mg/kg pilocarpine increased chewing movements and tongue pro...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247136
更新日期:1990-01-01 00:00:00