Abstract:
RATIONALE:Opioid antagonism reduces the consumption of palatable foods in humans but the neural substrates implicated in these effects are less well understood. OBJECTIVES:The aim of the present study was to examine the effects of the opioid antagonist, naltrexone, on neural response to rewarding and aversive sight and taste stimuli. METHODS:We used functional magnetic resonance imaging (fMRI) to examine the neural responses to the sight and taste of pleasant (chocolate) and aversive (mouldy strawberry) stimuli in 20 healthy volunteers who received a single oral dose of naltrexone (50 mg) and placebo in a double-blind, repeated-measures cross-over, design. RESULTS:Relative to placebo, naltrexone decreased reward activation to chocolate in the dorsal anterior cingulate cortex and caudate, and increased aversive-related activation to unpleasant strawberry in the amygdala and anterior insula. CONCLUSIONS:These findings suggest that modulation of key brain areas involved in reward processing, cognitive control and habit formation such as the dorsal anterior cingulate cortex (dACC) and caudate might underlie reduction in food intake with opioid antagonism. Furthermore we show for the first time that naltrexone can increase activations related to aversive food stimuli. These results support further investigation of opioid treatments in obesity.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Murray E,Brouwer S,McCutcheon R,Harmer CJ,Cowen PJ,McCabe Cdoi
10.1007/s00213-014-3573-7subject
Has Abstractpub_date
2014-11-01 00:00:00pages
4323-35issue
22eissn
0033-3158issn
1432-2072journal_volume
231pub_type
杂志文章,随机对照试验abstract::Response decrements in an operant task produced by either extinction or by the dopamine receptor blocker pimozide were examined in three experiments which employed intermittent reinforcement schedules. In contrast to the congruency between these treatments previously observed following continuous reinforcement trainin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432365
更新日期:1980-01-01 00:00:00
abstract::Key-press responding of mice was maintained under a fixed-ratio (FR) 30-response schedule of food presentation. Successive 3-min periods during which the experimental chamber was illuminated and the schedule was in effect were preceded by 10-min time-out (TO) periods during which all lights were out and responses had ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00177563
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Central cannabinoid systems have been implicated in appetite regulation through the hyperphagic effects of exogenous and endogenous cannabinoids. These effects may involve activation of reward systems and be mediated in part by opioidergic processes. OBJECTIVE:Cannabinoid-opioid interactions in feeding were ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000596
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abstract:RATIONALE:The elevated plus-maze and the light/dark box are two established anxiety tests in rodents, which are useful to screen putative anxiogenic effects of drugs. OBJECTIVE:Caffeine is well known to promote anxious behaviour in humans and animal models, but the precise site of action of the drug is still a matter ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050037
更新日期:2000-02-01 00:00:00
abstract::Four macaques with lesions of dorsolateral frontal cortex and 4 normal monkeys were injected with 1 mg/kg d-amphetamine. Observations of social behaviors and motor activity were conducted over a 1-month period. The results of this experiment show a partial dissociation of effects of amphetamines on behavior of normal ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428704
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abstract::This study examined whether the anticholinergic potency of the clinically superior antipsychotic drug clozapine contributes to clozapine's anatomically-selective functional inhibition of the mesolimbic dopamine (DA) system, using an electrical brain-stimulation reward (BSR) paradigm in rats that has been previously sh...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246960
更新日期:1993-01-01 00:00:00
abstract::In a phase II study the antidepressive effect of citalopram, a selective and potent serotonin reuptake inhibitor, was examined in 20 endogenously and three non-endogenously depressed hospitalized patients. Four endogenously depressed patients dropped out due to deterioration early in the treatment period. The remainin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00464566
更新日期:1982-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1381-7
更新日期:2009-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2436-8
更新日期:2012-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2017-06-01 00:00:00
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doi:10.1007/s00213-006-0364-9
更新日期:2006-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427743
更新日期:1978-10-31 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1184-x
更新日期:2008-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429660
更新日期:1985-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0637-3
更新日期:2007-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-007-0801-4
更新日期:2007-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s00213-003-1711-8
更新日期:2004-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
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doi:10.1007/s00213-015-4074-z
更新日期:2016-01-01 00:00:00
abstract::Acute and chronic effects of ethosuximide (40, 80, and 120 mg/kg), phenytoin (2.5, 5, and 7.5 mg/kg), clonazepam (0.25, 0.5, and 0.75 mg/kg), and valproic acid (40, 80, and 120 mg/kg) were examined in pigeons performing under a delayed-matching-to-sample procedure. Acute administration of clonazepam or valproic acid p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00180828
更新日期:1986-01-01 00:00:00
abstract::Administration to mice of harmaline (100 mg/kg SC) resulted in a greater than two-fold increase in cyclic GMP in the cerebellum 15 min later. This response was inhibited by pretreatment 5 min before the harmaline with pentobarbital (ED50 6.5 mg/kg), chlormethiazole (ED50 10.4 mg/kg) and dizocilpine (ED50 0.5 mg/kg). H...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02257413
更新日期:1993-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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abstract::Cortical and hippocampal EEGs in animal models of schizophrenia were compared to those obtained with psychotomimetics or antipsychotic agents by utilizing power spectral analysis. Models of positive schizophrenic symptoms were created with methamphetamine (MAP) and cocaine, and a model of both negative and positive sy...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1997-06-01 00:00:00
abstract:RATIONALE:Opioid receptor antagonists reliably alter the expression or extinction of ethanol's conditioned motivational effects as indexed by the place conditioning procedure, suggesting endogenous opioids are normally involved. These studies examined how exogenous stimulation of opioid receptors alters ethanol's condi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05658-x
更新日期:2021-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02249332
更新日期:1994-04-01 00:00:00