Abstract:
:This study examined the possibility that amphetamine-induced stereotypy and facilitation of memory consolidation are both mediated by amphetamine's stimulation of dopaminergic activity in the caudate nucleus. In the first experiment, rats were given pairings of a tone and a shock followed by SC amphetamine (2 mg/kg). The amount of stereotypy and increased locomotor activity produced by the injection were measured immediately. Retention of the tone-shock association was evaluated 48 h later by observing the ability of the tone to suppress drinking. The degree of retention was significantly correlated with the amount of stereotypy but not with the amount of locomotion previously measured. In the second experiment, amphetamine was microinjected into the caudate nucleus (10 micrograms/microliters) and its ability to produce the same three behavioral effects was examined. These injections produced increased stereotypy and improved retention, but no increase in locomotion. The correlation of memory facilitation with stereotypy and the fact that both were produced by intracaudate amphetamine suggest that they may be mediated by the same neuropharmacological substrate, namely amphetamine-induced release of dopamine in the caudate.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Carr GD,White NMdoi
10.1007/BF00427774subject
Has Abstractpub_date
1984-01-01 00:00:00pages
203-9issue
3eissn
0033-3158issn
1432-2072journal_volume
82pub_type
杂志文章abstract::Amphetamine (AMP) administered in high doses suppresses feeding. However, in low doses AMP has been shown to both suppress and facilitate feeding. Further, there is some indication of individual differences in the feeding response to low doses of AMP. Evidence indicates that AMP's effects on feeding are dopamine-media...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244426
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:Acute ethanol administration induces hypothermia in genetically susceptible animals. Tolerance to this effect may develop with repeated administration. Allopregnanolone is an endogenously produced neuroactive steroid that acts at the GABA-A receptor. We postulated that allopregnanolone would induce hypothermi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1106-2
更新日期:2002-07-01 00:00:00
abstract:RATIONALE:Amphetamine administration has been found to affect the degree of cerebral dominance for motor control in animals. In humans, cerebral dopamine neurotransmission is also correlated to motor dominance. Since language dominance is related to motor dominance, amphetamine might also affect cerebral dominance for ...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0176-3
更新日期:2006-01-01 00:00:00
abstract::The exploratory behavior of pigs was studied in two successive daily 20-mn sessions in a two-compartment box by counting the number of crossings from one compartment to the other and observing the activity patterns. Injection of 1 mg/kg diazepam before the first session increased the number of crossings without affect...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431643
更新日期:1977-03-16 00:00:00
abstract:RATIONALE:Using a rat relapse model, recent studies reported time dependent increases in cocaine seeking induced by re-exposure to cocaine cues, but not cocaine itself, over withdrawal periods of up to 3 months. OBJECTIVES:In the present study, we explored the time course of cocaine seeking induced by priming injectio...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1861-3
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVES:Recent studies using positron emission tomography (PET) have established the relationship between an intravenous dose of cocaine and the percentage occupancy of the dopamine transporter in humans, and have documented the requirement of more than 50% occupancy for perception of the "high". The present experim...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051093
更新日期:1999-09-01 00:00:00
abstract:RATIONALE:Clinical observations have shown that pain sensitivity is altered in some schizophrenic patients. OBJECTIVES:To study alterations in pain sensitivity, the ketamine model in schizophrenia research was employed. MATERIALS AND METHODS:Rats were subchronically injected with the dissociative anaesthetic ketamine...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0557-2
更新日期:2006-12-01 00:00:00
abstract::Nine VA Medical Centers are participating in a 2-year double-blind placebo controlled study of antioxidant treatment for tardive dyskinesia (TD) conducted by the Department of Veteran Affairs Cooperative Studies Program. One of the principal outcome measures of this study is the score derived from the instrumental ass...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s002130050320
更新日期:1997-07-01 00:00:00
abstract::The effects of 4 weeks of treatment with the selective monoamine oxidase (MAO) inhibiting antidepressant clorgyline and pargyline on the sleep of affectively disordered patients were studied. Both inhibitors resulted in near total suppression of REM sleep, a decrease in total sleep time, and an increase in the percent...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00432251
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:Direct activation of the cannabinoid CB1 receptor in the dorsolateral periaqueductal gray (dlPAG) inhibits anxiety- and panic-related behaviours in experimental animals. It has remained unclear, however, whether the local endocannabinoid signalling is recruited as a protective mechanism against aversive stimu...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3793-x
更新日期:2015-05-01 00:00:00
abstract:RATIONALE:The characterization of self-administration (SA) under extended access conditions is necessary for the development of addiction models. OBJECTIVE:The purposes of this experiment were to investigate: (1) dose effects on the initiation of cocaine SA under extended access conditions; (2) predictable individual ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100744
更新日期:2001-08-01 00:00:00
abstract::5-Hydroxytryptamine1A (5-HT1A) receptors have been shown to be suppressed by corticosteroid hormones in a variety of animal experimental paradigms. It has been suggested that this effect may be central to the pathophysiology of severe clinical depressive illness, a condition in which 5-HT1A receptor function is reduce...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050711
更新日期:1998-10-01 00:00:00
abstract:RATIONALE:Dronabinol (Δ(9)tetrahydrocannabinol) is approved for HIV-related anorexia, yet, little is known about its effects in HIV-positive marijuana smokers. HIV-negative marijuana smokers require higher than recommended dronabinol doses to experience expected effects. OBJECTIVES:Employing a within-subjects, double-...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1995-4
更新日期:2010-12-01 00:00:00
abstract:RATIONALE:Neuroactive derivatives of steroid hormones, neurosteroids, can act on GABAA receptors (GABAARs) to potentiate the effects of GABA on these receptors. Neurosteroids become elevated to physiologically relevant levels under conditions characterized by increased steroid hormones. There is considerable evidence f...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-013-3423-z
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:People with schizophrenia exhibit a high obesity rate. However, little is known about the prevalence of obesity and its relationship with clinical symptoms and metabolic indicators in first-episode drug-naïve (FEDN) schizophrenia. METHODS:Demographic and lipid parameters were gathered from 297 FEDN schizophr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05727-1
更新日期:2020-11-25 00:00:00
abstract::Herrnstein's matching equation was used to analyze drug effects on performance in random interval reinforcement schedules. Pimozide caused effects compatible with both motor and motivational impairments, in a 5-component multiple schedule, a 3-schedule 3-day cycle (ALT-3), and a 2-schedule 2-day cycle (ALT-2). However...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244238
更新日期:1990-01-01 00:00:00
abstract::In the present pilot study, an attempt was made to shape and maintain cigarette smoking behavior in rhesus monkeys both with and without the simultaneous use of other reinforcers. Initially, 14 monkeys were trained to suck air and puff on cigarettes using sweetened liquid reinforcer. After smoking had been established...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431644
更新日期:1981-01-01 00:00:00
abstract::The effects of bromocriptine, lisuride and apomorphine on specific binding of 3H-spiroperidol to homogenates of rat caudate nucleus were studied. (+)-Butaclamol was used to define specific binding. Bromocriptine and lisuride inhibited binding markedly, in vitro and also 30 min after in vivo injection. Bromocriptine co...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432172
更新日期:1981-01-01 00:00:00
abstract::The central effects of acetylsalicylic acid (ASA) are discussed controversially. In animal models, it has been shown that ASA can interact with the central serotonergic and catecholaminergic neuronal system. However, the relevance of this interaction for humans is still unknown. We performed a study on the influence o...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050683
更新日期:1998-08-01 00:00:00
abstract::Withdrawal was precipitated by naloxone at different intervals, up to 22.5 h, following a last maintenance injection in morphine-dependent rats. Different symptoms of withdrawal were found to be preeminent following different morphine-naloxone intervals. Locomotor activity, jumping, and writhing were precipitated most...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426773
更新日期:1977-10-20 00:00:00
abstract:RATIONALE:A subset of male rats that self-administer 3,4-methylenedioxypyrovalerone (MDPV) have unusually high levels of drug intake; however, factor(s) that influence this behavior (e.g., reinforcement history and sex) are unknown. OBJECTIVES:Characterize the reinforcing potency and effectiveness of MDPV in female ra...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05726-2
更新日期:2020-11-24 00:00:00
abstract:RATIONALE:Experienced cannabis users demonstrate tolerance to some of the impairing acute effects of cannabis. OBJECTIVES:The present study investigates whether event-related potentials (ERPs) differ between occasional and heavy cannabis users after acute Δ9-tetrahydrocannabinol (THC) administration, as a result of to...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2479-x
更新日期:2012-03-01 00:00:00
abstract:RATIONALE:Understanding of the mechanisms of biotransformation of antidepressant drugs, and of their capacity to interact with other medications, is of direct relevance to rational clinical psychopharmacology. OBJECTIVES:To determine the human cytochromes P450 mediating the metabolism of nefazodone, and the inhibitory...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051039
更新日期:1999-07-01 00:00:00
abstract:RATIONALE:Combining neuroleptics with 5-HT1A ligands is thought to improve the preclinical profile of neuroleptics and may be of interest in the development of new compounds that have greater therapeutic potential and/or are better tolerated. OBJECTIVE:To examine 1) the ability of 5-HT1A ligands to alter the effects o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050972
更新日期:1999-05-01 00:00:00
abstract:RATIONALE:Although environmental enrichment renders rats more sensitive to the neurobehavioral effects of acute amphetamine, a previous study found that enriched rats self-administer less amphetamine than isolated rats at a low unit dose (0.03 mg/kg per infusion). In that study, however, acquisition of self-administrat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1134-y
更新日期:2002-08-01 00:00:00
abstract:RATIONALE:Gonadal steroid hormones altered opioid antinociception under some conditions in rodents, and we reported previously that chronic estradiol enhanced kappa but not mu opioid antinociception in ovariectomized rhesus monkeys. Sex differences have also been observed in the antinociceptive effects of opioid agonis...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100912
更新日期:2002-01-01 00:00:00
abstract:RATIONALE:Negative mood states are characterized by both stress hormone dysregulation and serotonergic dysfunction, reflected by altered thalamic serotonin transporter (5-HTT) levels. However, so far, no study examined the individual association between cortisol response and cerebral in vivo 5-HTT levels in patients su...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1903-y
更新日期:2011-02-01 00:00:00
abstract::In squirrel monkeys trained to discriminate between two tones, morphine consistently increased the percent of response failures during tone periods; however, it had no consistent effect on the percent correct responses. In contrast, scopolamine decreased percent correct responses as well as increasing percent response...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428404
更新日期:1985-01-01 00:00:00
abstract::The subtype of dopamine (DA) receptors mediating the yawning response to DA agonists was determined in rats. Yawning was elicited both by the mixed D1-D2 agonist apomorphine and by the specific D2 agonist LY 171555, but not by the selective D1 agonist SKF 38393. Both apomorphine- and LY 171555-induced yawning were ant...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00518186
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:Epidemiological studies of smokers suggest that there is a link between nicotine and depression. Nonetheless, few studies have examined the potential use of nicotinic ligands in the treatment of depression. OBJECTIVES:The goal of this study was to evaluate the effects of SIB-1508Y, a novel subtype-selective ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000531
更新日期:2000-10-01 00:00:00