Abstract:
:The effects of bilateral nucleus accumbens microinjections of d-ala-met-enkephalinamide (DALA) were assessed in behavioral activation and lateral hypothalamic self-stimulation (LHSS) rate-frequency curve-shift paradigms in normal and accumbens 6-OHDA (4.0 micrograms) treated rats. Microinjections of DALA (2.5 micrograms/microliters) in the behavioral activation paradigm had little effect on normal activity; however, DALA administered to 6-OHDA treated rats produced a significant overall increase in locomotion. The 6-OHDA DALA-induced locomotion effect peaked at 2 weeks after 6-OHDA treatment and then returned to baseline levels by week 5 post-treatment. Using LHSS, DALA tested over a range of doses (2.5, 5, 10, 20 micrograms/microliters) displayed a weak biphasic reward effect only at the highest dose, which was characterized by an initial suppression followed by an elevation. DALA significantly depressed initial operant motor/performance in LHSS in a dose dependent fashion. Microinjections of the normally ineffective low dose of DALA (2.5 micrograms/microliters) following accumbens 6-OHDA treatment produced a significant LHSS reward decrease 2 weeks post-treatment, while LHSS motor/performance was relatively unaffected. Results are discussed in terms of opiate-dopamine and limbic-motor interactions.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Johnson PL,Stellar JRdoi
10.1007/BF02244999subject
Has Abstractpub_date
1994-05-01 00:00:00pages
665-71issue
4eissn
0033-3158issn
1432-2072journal_volume
114pub_type
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journal_title:Psychopharmacology
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1979-02-28 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1998-11-01 00:00:00
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更新日期:2001-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2007-03-01 00:00:00
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更新日期:1982-01-01 00:00:00
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