Abstract:
RATIONALE:Although many studies have investigated the effects of gestational and lactational cocaine use on maternal behavior, few studies have examined the effects of prior adult cocaine use on maternal behavior. METHODS:In the current study, intraperitoneal cocaine or saline was administered to adult female rats for 10 days, treatments were stopped for 4 days, and the females were then mated. Litter size and weight were recorded on days 2 and 16 of lactation, and maternal care, maternal aggression, and light/dark box activity were assessed on days 2, 9, and 16 of lactation. RESULTS:The cocaine-treated females exhibited behavioral sensitization on treatment day 10. Mothers previously treated with cocaine retrieved pups more quickly, spent more time caring for the pups (increased pup retrieval, pup grooming, and crouching over the pups by the mother), and were more aggressive towards a male intruder compared to saline-treated control animals on day 2 of lactation. These effects were specific to maternal behavior, as other behaviors were mostly unaffected by prior cocaine treatment. Data from light/dark box tests indicate that cocaine did not affect activity in this test. There were few significant behavioral effects of prior cocaine treatment on lactation days 9 and 16. CONCLUSIONS:Prior cocaine use may have lasting effects on offspring care and maternal aggression, specifically during early lactation. The present data support the hypothesis that maternal behavior is increased by prior cocaine sensitization, possibly due to cross-sensitization between cocaine and the natural reward of maternal behavior.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Nephew BC,Febo Mdoi
10.1007/s00213-010-1777-zsubject
Has Abstractpub_date
2010-03-01 00:00:00pages
127-35issue
1eissn
0033-3158issn
1432-2072journal_volume
209pub_type
杂志文章abstract::The behavioral responsiveness to challenge doses of the D2 agonist quinpirole was examined in 21-day-old normal offspring (experiment 1) as well as offspring exposed gestationally to cocaine (experiment 2). In both experiments weanling rats received a subcutaneous injection of 0 (0.9% saline), 0.04, 0.08, 0.5, or 1.0 ...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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journal_title:Psychopharmacology
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abstract:RATIONALE:Modafinil is a well-tolerated psychostimulant drug with low addictive potential that is used to treat patients with narcolepsy or attention deficit disorders and to enhance vigilance in sleep-deprived military personal. So far, understanding of the cognitive enhancing effects of modafinil and the relevant neu...
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更新日期:2004-11-01 00:00:00
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更新日期:1991-01-01 00:00:00
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更新日期:2018-10-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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